Role of mitogen- and stress-activated kinases in ischemic injury

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 6, 2002, Pages 631-647

  Irving, Elaine A ^a   Bamford, Mark ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

ERK1 2; JNK; MAPK; Signaling pathways; Transient ischemia

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE;

BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; HUMAN; MITOGENESIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0036263403     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200206000-00001     Document Type: Review

References (115)

1. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase
2. p38 MAP kinase: Molecular target for the inhibition of pro-inflammatory cytokines
3. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac monocytes of neonatal rats
4. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia
5. PD-98059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
6. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation
7. Selective antagonism of endothelin-A-receptors improves outcome in both head trauma and focal stroke in rat
8. Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia
9. The MAP kinase cascades are activated during post-ischemic liver reperfusion
10. New inhibitors of p38 kinase
11. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart: p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion
12. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: An overview of a decade of research
13. Kidney ischemic preconditioning
14. Erks: A family of protein-serine/threonine kinases that are activated and tyrosine phopshorylated in response to insulin and NGF
15. Signalling pathways: Jack of all cascades
16. The p38-MAPK inhibitor, SB-203580, inhibits cardiac stress-activated protein kinases / c-Jun N-terminal kinases (SAPKs/JNKs)
17. Specificity and mechanism of action of some commonly used protein kinase inhibitors
18. The mitogen-activated kinase signal transduction pathway
19. Neuronal ischemic preconditioning
20. Mitogen and stress activated protein kinase-I (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
21. A cytoplasmic inhibitor of the JNK signal transduction pathway
22. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
23. Transient forebrain ischemia in the adult gerbil is associated with a complex c-jun response
24. p42 mitogen activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites
25. Interleukin-I activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
26. MNKI, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
27. Role of MAP kinase in neurons
28. Expression of cell death-associated phospho-c-jun and p53-activated gene 608 in hippocampal CAI neurons following global ischemia
29. Requirement for nitric oxide activation of p21 ras/extracellular regulated kinase in neuronal ischemic preconditioning
30. Ischemic tolerance in murine cortical cell culture: Critical role for NMDA receptors
31. Diphosphorylation of extracellular signal-regulated kinases and c-Jun N-terminal protein kinases in brain ischemic tolerance in rat
32. Extracellular signal-regulated kinase and c-Jun N-terminal protein kinases in ischemic tolerance
33. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
34. Paradoxical activation of Raf by a novel Raf inhibitor
35. Effect of SB-203580 on the activity of c-Raf in vitro and in vivo
36. Discovery of a novel, potent and Src family-selective tyrosine kinase inhibitor
37. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein
38. Inhibitors of the JNK signaling pathway
39. α-synuclein protects against oxidative stress via inactivation of the c-jun N-terminal kinase stress signalling pathway in neuronal cells
40. c-Jun N-terminal kianse (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion
41. Lasting N-terminal phosphorylation of c-jun and activation of c-jun N-terminal kinases after neuronal injury
42. Alteration of MAP kinase pathways after transient forebrain ischemia
43. MEK kinase activity is not necessary for Raf-1 function
44. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a
45. A novel mitogen-activated protein kinase is responsive to raf and mediates growth factor specificity
46. Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat
47. Neuroprotection with the MEK inhibitor U0126 following ischemic injury
48. Mechanisms of ischemic preconditioning
49. MK801, but not anisomycin, inhibits the induction of tolerance to ischaemia in the gerbil hippocampus
50. Effect of map kinase inhibition on spreading depression induced aquisition of ischemic tolerance
51. Molecular cloning of multiple slicing variants of JIP-1 preferentially expressed in brain
52. Spreading depression induces tolerance of cortical neurons to ischemia in rat brain
53. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
54. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
55. VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways
56. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphoprylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
57. Role of CSB/p38/RK stress response kinase in LPS and cytokine signalling mechanisms
58. Identification and characterization of a novel protein kinase involved in the regulation of inflammatory cytokine biosynthesis
59. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinase 1 and 2 via a MAPK kinase 6/p38-dependent pathway
60. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischaemia and reperfusion
61. Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to gluatamate in vitro and ischaemia in vivo
62. An inhibitor of p38 mitogenactivated protein kinase protects neonatal cardiac myocytes from ischemia
63. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
64. 3F12 SAP kinase
65. The effects of thrombin preconditioning on focal cerebral ischaemia in rats
66. Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats
67. Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway
68. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity
69. A MEK-1-specific inhibitor PD98059 attenuates hippocampal injury after global ischemia in the gerbil
70. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia
71. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke
72. Signalling through scaffold, anchoring and adaptor proteins
73. Uncoupling Rafl from MEK1/2 impairs only a subset of cellular responses to Raf activation
74. Non-specific effects of the MEK inhibitors PD098059 and U0126 on glutamate release from hippocampal synaptosomes
75. The stress-activate protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion
76. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
77. Organ preconditioning
78. Association of mitogen-activated protein kinase with the microtubule cytoskeleton
79. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
80. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for MAP kinase-dependent mechanism
81. PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of J-N-terminal kinase in HT29 cells
82. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultures cortical neurons
83. Signal transduction of ischemic preconditioning
84. Blockade of the MAP kinase pathway suppresses growth of colon tumours in vivo
85. Intracellular signaling pathways activated by neurotrophic factors
86. The MAPK signalling cascade
87. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
88. Changes in protein tyrosine phosphorylation in the rat brain following cerebral ischaemia in a model of ischaemic tolerance
89. Activation of the extracellular signal regulated protein kinase cascade in the hippocampal CA1 region in a rat model of global cerebral ischaemic preconditioning
90. Activation of the mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats
91. PACAP protects hippocampal neurons against apoptosis: Involvement of JNK/SAPK signalling pathway
92. TNF-alpha activates at least two apoptotic signalling cascades
93. Neurotrophic molecules: Strategies for designing effective therapeutic molecules in neurodegeneration
94. Neuronal protein kinase signalling cascades and excitotoxic cell death
95. Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus
96. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuronal cultures
97. FGF and stress regulated CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
98. Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischaemia in rats
99. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells: Comparison of the effects of nerve growth factor and epidermal growth factor
100. Neuroprotective effect of alpha-phenyl-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins
101. Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction
102. Activation of p38 MAPK in microglia after ischemia
103. Neuronal death and survival in two models of hypoxic-ischemic brain damage
104. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors
105. Activation of mitogen activated protein kinase after permanent cerebral artery occlusion in mouse brain
106. Attenuation of thrombin-induced brain edema by cerebral thrombin preconditioning
107. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
108. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation
109. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
110. Mitogen-activated protein kinase mdeiation of hemolysate-induced contraction in rabbit basilar artery
111. Mechanisms of endothelin-1 induced contraction in rabbit basilar artery