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Volumn 41, Issue 4, 2013, Pages 951-955

Rheb and Rags come together at the lysosome to activate mTORC1

Author keywords

Amino acid; Lysosome; Mammalian target of rapamycin complex 1 (mTORC1); Rag; Rheb

Indexed keywords

AMINO ACID; GUANOSINE TRIPHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PEPTIDES AND PROTEINS; PROTEIN RAGS; RHEB PROTEIN; UNCLASSIFIED DRUG;

EID: 84880529632     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20130037     Document Type: Article
Times cited : (72)

References (56)
  • 1
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu, R., Efeyan, A. and Sabatini, D.M. (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 2
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N. and Sonenberg, N. (2004) Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 3
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara, K., Yonezawa, K., Weng, Q.P., Kozlowski, M.T., Belham, C. and Avruch, J. (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273, 14484-14494
    • (1998) J. Biol. Chem. , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 4
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
    • Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J. and Cantley, L.C. (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Mol. Cell 10, 151-162
    • (2002) Mol. Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 5
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J. and Guan, K.L. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657
    • (2002) Nat. Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 7
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo, L.J., Gao, X., Chiarelli, D.A., Li, L., Pan, D. and Edgar, B.A. (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5, 566-571
    • (2003) Nat. Cell Biol. , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 9
    • 21244480367 scopus 로고    scopus 로고
    • The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
    • Smith, E.M., Finn, S.G., Tee, A.R., Browne, G.J. and Proud, C.G. (2005) The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J. Biol. Chem. 280, 18717-18727
    • (2005) J. Biol. Chem. , vol.280 , pp. 18717-18727
    • Smith, E.M.1    Finn, S.G.2    Tee, A.R.3    Browne, G.J.4    Proud, C.G.5
  • 12
    • 84866431363 scopus 로고    scopus 로고
    • Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
    • Bar-Peled, L., Schweitzer, L.D., Zoncu, R. and Sabatini, D.M. (2012) Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150, 1196-1208
    • (2012) Cell , vol.150 , pp. 1196-1208
    • Bar-Peled, L.1    Schweitzer, L.D.2    Zoncu, R.3    Sabatini, D.M.4
  • 13
    • 80555143078 scopus 로고    scopus 로고
    • MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase
    • Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y. and Sabatini, D.M. (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase. Science 334, 678-683
    • (2011) Science , vol.334 , pp. 678-683
    • Zoncu, R.1    Bar-Peled, L.2    Efeyan, A.3    Wang, S.4    Sancak, Y.5    Sabatini, D.M.6
  • 16
    • 84862777407 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    • Han, J.M., Jeong, S.J., Park, M.C., Kim, G., Kwon, N.H., Kim, H.K., Ha, S.H., Ryu, S.H. and Kim, S. (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149, 410-424
    • (2012) Cell , vol.149 , pp. 410-424
    • Han, J.M.1    Jeong, S.J.2    Park, M.C.3    Kim, G.4    Kwon, N.H.5    Kim, H.K.6    Ha, S.H.7    Ryu, S.H.8    Kim, S.9
  • 17
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis, R.J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S. and Thompson, C.B. (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. U.S.A. 104, 19345-19350
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 20
    • 21244456553 scopus 로고    scopus 로고
    • Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
    • Long, X., Ortiz-Vega, S., Lin, Y. and Avruch, J. (2005) Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 280, 23433-23436
    • (2005) J. Biol. Chem. , vol.280 , pp. 23433-23436
    • Long, X.1    Ortiz-Vega, S.2    Lin, Y.3    Avruch, J.4
  • 21
    • 67649823420 scopus 로고    scopus 로고
    • Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein
    • Sato, T., Nakashima, A., Guo, L. and Tamanoi, F. (2009) Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J. Biol. Chem. 284, 12783-12791
    • (2009) J. Biol. Chem. , vol.284 , pp. 12783-12791
    • Sato, T.1    Nakashima, A.2    Guo, L.3    Tamanoi, F.4
  • 22
    • 33747690458 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
    • Wang, L., Rhodes, C.J. and Lawrence, Jr, J.C. (2006) Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J. Biol. Chem. 281, 24293-24303
    • (2006) J. Biol. Chem. , vol.281 , pp. 24293-24303
    • Wang, L.1    Rhodes, C.J.2    Lawrence Jr., J.C.3
  • 23
    • 80055073635 scopus 로고    scopus 로고
    • The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling
    • Rapley, J., Oshiro, N., Ortiz-Vega, S. and Avruch, J. (2011) The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. J. Biol. Chem. 286, 38043-38053
    • (2011) J. Biol. Chem. , vol.286 , pp. 38043-38053
    • Rapley, J.1    Oshiro, N.2    Ortiz-Vega, S.3    Avruch, J.4
  • 27
    • 34548359244 scopus 로고    scopus 로고
    • PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
    • Fonseca, B.D., Smith, E.M., Lee, V.H., MacKintosh, C. and Proud, C.G. (2007) PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J. Biol. Chem. 282, 24514-24524
    • (2007) J. Biol. Chem. , vol.282 , pp. 24514-24524
    • Fonseca, B.D.1    Smith, E.M.2    Lee, V.H.3    Mackintosh, C.4    Proud, C.G.5
  • 28
    • 84855970149 scopus 로고    scopus 로고
    • Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila
    • Pallares-Cartes, C., Cakan-Akdogan, G. and Teleman, A.A. (2012) Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila. Dev. Cell 22, 172-182
    • (2012) Dev. Cell , vol.22 , pp. 172-182
    • Pallares-Cartes, C.1    Cakan-Akdogan, G.2    Teleman, A.A.3
  • 30
    • 36049043184 scopus 로고    scopus 로고
    • Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
    • Bai, X., Ma, D., Liu, A., Shen, X., Wang, Q.J., Liu, Y. and Jiang, Y. (2007) Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318, 977-980
    • (2007) Science , vol.318 , pp. 977-980
    • Bai, X.1    Ma, D.2    Liu, A.3    Shen, X.4    Wang, Q.J.5    Liu, Y.6    Jiang, Y.7
  • 31
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A. and Chen, J. (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294, 1942-1945
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 32
    • 79960387847 scopus 로고    scopus 로고
    • Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
    • Xu, L., Salloum, D., Medlin, P.S., Saqcena, M., Yellen, P., Perrella, B. and Foster, D.A. (2011) Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J. Biol. Chem. 286, 25477-25486
    • (2011) J. Biol. Chem. , vol.286 , pp. 25477-25486
    • Xu, L.1    Salloum, D.2    Medlin, P.S.3    Saqcena, M.4    Yellen, P.5    Perrella, B.6    Foster, D.A.7
  • 33
    • 84855731134 scopus 로고    scopus 로고
    • Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    • Yoon, M.S., Du, G., Backer, J.M., Frohman, M.A. and Chen, J. (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J. Cell Biol. 195, 435-447
    • (2011) J. Cell Biol. , vol.195 , pp. 435-447
    • Yoon, M.S.1    Du, G.2    Backer, J.M.3    Frohman, M.A.4    Chen, J.5
  • 34
    • 25444457577 scopus 로고    scopus 로고
    • HVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • Byfield, M.P., Murray, J.T. and Backer, J.M. (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280, 33076-33082
    • (2005) J. Biol. Chem. , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 35
    • 84859018387 scopus 로고    scopus 로고
    • Phospholipase D and mTORC1: Nutrients are what bring them together
    • Wiczer, B.M. and Thomas, G. (2012) Phospholipase D and mTORC1: nutrients are what bring them together. Sci. Signaling 5, pe13
    • (2012) Sci. Signaling , vol.5
    • Wiczer, B.M.1    Thomas, G.2
  • 37
    • 84878766832 scopus 로고    scopus 로고
    • Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
    • Raiborg, C., Schink, K.O. and Stenmark, H. (2013) Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic. FEBS J. 280, 2730-2742
    • (2013) FEBS J. , vol.280 , pp. 2730-2742
    • Raiborg, C.1    Schink, K.O.2    Stenmark, H.3
  • 38
    • 0013161392 scopus 로고    scopus 로고
    • Mechanisms of Ras protein targeting in mammalian cells
    • Silvius, J.R. (2002) Mechanisms of Ras protein targeting in mammalian cells. J. Membr. Biol. 190, 83-92
    • (2002) J. Membr. Biol. , vol.190 , pp. 83-92
    • Silvius, J.R.1
  • 39
    • 0028237671 scopus 로고
    • Rheb, a growth factor-and synaptic activity-regulated gene, encodes a novel Ras-related protein
    • Yamagata, K., Sanders, L.K., Kaufmann, W.E., Yee, W., Barnes, C.A., Nathans, D. and Worley, P.F. (1994) Rheb, a growth factor-and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 269, 16333-16339
    • (1994) J. Biol. Chem. , vol.269 , pp. 16333-16339
    • Yamagata, K.1    Sanders, L.K.2    Kaufmann, W.E.3    Yee, W.4    Barnes, C.A.5    Nathans, D.6    Worley, P.F.7
  • 40
    • 33646143793 scopus 로고    scopus 로고
    • Localization of Rheb to the endomembrane is critical for its signaling function
    • Buerger, C., DeVries, B. and Stambolic, V. (2006) Localization of Rheb to the endomembrane is critical for its signaling function. Biochem. Biophys. Res. Commun. 344, 869-880
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 869-880
    • Buerger, C.1    Devries, B.2    Stambolic, V.3
  • 41
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A.L., Nada, S. and Sabatini, D.M. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 42
    • 75149142796 scopus 로고    scopus 로고
    • Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling
    • Hanker, A.B., Mitin, N., Wilder, R.S., Henske, E.P., Tamanoi, F., Cox, A.D. and Der, C.J. (2010) Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene 29, 380-391
    • (2010) Oncogene , vol.29 , pp. 380-391
    • Hanker, A.B.1    Mitin, N.2    Wilder, R.S.3    Henske, E.P.4    Tamanoi, F.5    Cox, A.D.6    Der, C.J.7
  • 45
    • 18244362311 scopus 로고    scopus 로고
    • Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
    • Saito, K., Araki, Y., Kontani, K., Nishina, H. and Katada, T. (2005) Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J. Biochem. (Tokyo) 137, 423-430
    • (2005) J. Biochem. (Tokyo) , vol.137 , pp. 423-430
    • Saito, K.1    Araki, Y.2    Kontani, K.3    Nishina, H.4    Katada, T.5
  • 46
    • 4444276510 scopus 로고    scopus 로고
    • Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
    • Li, Y., Inoki, K. and Guan, K.L. (2004) Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol. Cell. Biol. 24, 7965-7975
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7965-7975
    • Li, Y.1    Inoki, K.2    Guan, K.L.3
  • 47
    • 0034646618 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
    • Urano, J., Tabancay, A.P., Yang, W. and Tamanoi, F. (2000) The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J. Biol. Chem. 275, 11198-11206
    • (2000) J. Biol. Chem. , vol.275 , pp. 11198-11206
    • Urano, J.1    Tabancay, A.P.2    Yang, W.3    Tamanoi, F.4
  • 48
    • 27744569843 scopus 로고    scopus 로고
    • MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz, M.K., Ballif, B.A., Gygi, S.P. and Blenis, J. (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123, 569-580
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 51
    • 80052233389 scopus 로고    scopus 로고
    • Endosome maturation
    • Huotari, J. and Helenius, A. (2011) Endosome maturation. EMBO J. 30, 3481-3500
    • (2011) EMBO J. , vol.30 , pp. 3481-3500
    • Huotari, J.1    Helenius, A.2
  • 52
    • 84856228006 scopus 로고    scopus 로고
    • The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes
    • Takahashi, Y., Nada, S., Mori, S., Soma-Nagae, T., Oneyama, C. and Okada, M. (2012) The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes. Biochem. Biophys. Res. Commun. 417, 1151-1157
    • (2012) Biochem. Biophys. Res. Commun. , vol.417 , pp. 1151-1157
    • Takahashi, Y.1    Nada, S.2    Mori, S.3    Soma-Nagae, T.4    Oneyama, C.5    Okada, M.6
  • 53
    • 84871260456 scopus 로고    scopus 로고
    • Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
    • Ogmundsdóttir, M.H., Heublein, S., Kazi, S., Reynolds, B., Visvalingam, S.M., Shaw, M.K. and Goberdhan, D.C. (2012) Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLoS ONE 7, e36616
    • (2012) PLoS ONE , vol.7
    • Ogmundsdóttir, M.H.1    Heublein, S.2    Kazi, S.3    Reynolds, B.4    Visvalingam, S.M.5    Shaw, M.K.6    Goberdhan, D.C.7
  • 54
    • 77954757143 scopus 로고    scopus 로고
    • Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
    • Heublein, S., Kazi, S., Ogmundsdóttir, M.H., Attwood, E.V., Kala, S., Boyd, C.A., Wilson, C. and Goberdhan, D.C. (2010) Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. Oncogene 29, 4068-4079
    • (2010) Oncogene , vol.29 , pp. 4068-4079
    • Heublein, S.1    Kazi, S.2    Ogmundsdóttir, M.H.3    Attwood, E.V.4    Kala, S.5    Boyd, C.A.6    Wilson, C.7    Goberdhan, D.C.8
  • 55
    • 33745745910 scopus 로고    scopus 로고
    • A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast
    • Gao, M. and Kaiser, C.A. (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat. Cell Biol. 8, 657-667
    • (2006) Nat. Cell Biol. , vol.8 , pp. 657-667
    • Gao, M.1    Kaiser, C.A.2


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