Regulation of alcohol oxidase 1 (AOX1) promoter and peroxisome biogenesis in different fermentation processes in Pichia pastoris

Journal of Biotechnology

Volumn 166, Issue 4, 2013, Pages 174-181

  Kim, Sehoon ^a,b   Warburton, Shannon ^a,b   Boldogh, Istvan ^c   Svensson, Cecilia ^c   Pon, Liza ^c   d'Anjou, Marc ^a,b   Stadheim, Terrance A ^a,b   Choi, Byung Kwon ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Columbia University ^*

^c NewYork Presbyterian Hospital   (United States)

Author keywords

AOX1 promoter; Peroxisome biogenesis; Pichia pastoris; Process conditions

Indexed keywords

AOX1 PROMOTER; METHANOL CONSUMPTION RATE; PEROXISOMAL TARGETING; PEROXISOME BIOGENESIS; PICHIA PASTORIS; PROCESS CONDITION; SPECIFIC PRODUCTIVITY; TRANSCRIPTIONAL REGULATION;

BATCH CELL CULTURE; CARBON; CYTOLOGY; FERMENTATION; GLUCOSE; MONOCLONAL ANTIBODIES; OXYGEN; PROCESS CONTROL; RECOMBINANT PROTEINS; YEAST;

METHANOL;

ALCOHOL OXIDASE; ALCOHOL OXIDASE 1; GLUCOSE; METHANOL; MONOCLONAL ANTIBODY; OXYGEN; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ARTICLE; BIOGENESIS; CARBON SOURCE; ENZYME REGULATION; FED BATCH CULTURE; FERMENTATION; NONHUMAN; PEROXISOME; PICHIA PASTORIS; PRIORITY JOURNAL;

AOX1 PROMOTER; METHANOL-LIMITED AT NORMOXIC CONDITION; ML; OL; OXYGEN-LIMITED CONDITION; PEROXISOME BIOGENESIS; PICHIA PASTORIS; PROCESS CONDITIONS; Q(M); Q(P); SML; SPECIFIC CONSUMPTION RATE OF METHANOL (MGG(-1)H(-1)); SPECIFIC PRODUCTIVITY OF A MONOCLONAL ANTIBODY (MGG(-1)H(-1)); SWITCHED FEEDING OF CARBON SOURCES UNDER CARBON-LIMITED AT NORMOXY;

ALDEHYDE OXIDASE; BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; CELLS, CULTURED; FERMENTATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSE; GREEN FLUORESCENT PROTEINS; METHANOL; OXYGEN; PEROXISOMES; PICHIA; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS;

EID: 84880379860     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2013.05.009     Document Type: Article

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