Peroxisome biogenesis

Annual Review of Cell and Developmental Biology

Volumn 17, Issue , 2001, Pages 701-752

  Purdue, P E ^a   Lazarow, P B ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Organelle assembly; Peroxin; PEX

Indexed keywords

CHAPERONE; MEMBRANE PROTEIN; PEROXIN; PROTEIN PEX11P; PROTEIN PEX16P; PROTEIN PEX19P; PROTEIN PEX3P; PROTEIN PEX5P; UNCLASSIFIED DRUG;

ANIMAL CELL; BIOGENESIS; CELL DIVISION; CELL PROLIFERATION; CELL STRUCTURE; CHO CELL; CONFERENCE PAPER; EUKARYOTE; MOLECULAR CLONING; MOLECULAR EVOLUTION; NOMENCLATURE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEIN TRANSPORT; REGULATORY MECHANISM; SPECIES DIFFERENCE;

ANIMALS; CHO CELLS; CRICETINAE; ENDOPLASMIC RETICULUM; EVOLUTION, MOLECULAR; HUMANS; MEMBRANE PROTEINS; MICROBODIES; MODELS, BIOLOGICAL; PEROXISOMAL DISORDERS; PEROXISOMES; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; TERMINOLOGY;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; EUKARYOTA;

EID: 0035184338     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.17.1.701     Document Type: Conference Paper

References (230)

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66. +-dependent isocitrate dehydrogenase
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68. Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
69. Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p
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72. Peroxisomal and mitochondrial defects in the cerebrohepato-renal syndrome
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75. A conserved tripeptide sorts proteins to peroxisomes
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89. Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery
90. A cytosolic protein contains a cryptic mitochondrial targeting signal
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98. Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources
99. Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein
100. Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p
101. Hansenula polymorpha Pex1p and Pex6p are peroxisome-associated AAA proteins that functionally and physically interact
102. Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles (peroxisomal ghosts), representing a novel complementation group in mammals
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104. Recognition of the peroxisomal targeting signal type 1 by the protein import receptor Pex5p
105. The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine: Glyoxylate aminotransferase
106. Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane
107. Analysis of the peroxisomal acyl-CoA oxidase gene product from Pichia pastoris and determination of its targeting signal
108. The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis
109. In mouse alpha-methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes
110. Identification and analysis of the plant peroxisomal targeting signal 1 receptor NtPEX5
111. Two independent peroxisomal targeting signals in catalase A of Saccharomyces cerevisiae
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113. Regulation of the peroxisomal beta-oxidation-dependent pathway by peroxisome proliferator-activated receptor alpha and kinases
114. The peroxisomal membrane
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117. Disorders of peroxisome biogenesis
118. Oilseed isocitrate lyases lacking their essential type 1 peroxisomal targeting signal are piggybacked to glyoxysomes
119. Inhibition of alanine: Glyoxylate aminotransferase 1 dimerization is a prerequisite for its peroxisome-to-mitochondrion mistargeting in primary hyperoxaluria type 1
120. Antibodies against Pex14p block ATP-independent binding of matrix proteins to peroxisomes in vitro
121. Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p
122. Binding of coatomer by the PEX11 C-terminus is not required for function
123. Redox-sensitive homodimerization of Pex11p: A proposed mechanism to regulate peroxisomal division
124. Pmp27 promotes peroxisomal proliferation
125. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes
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127. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly
128. An internal region of the peroxisomal membrane protein PMP47 is essential for sorting to peroxisomes
129. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells - The PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family
130. An oligomeric protein is imported into peroxisomes in vivo
131. The targeting and assembly of peroxisomal proteins: Some old rules do not apply
132. Carboxyl-terminal consensus Ser-Lys-Leu-related tripeptide of peroxisomal proteins functions in vitro as a minimal peroxisome-targeting signal
133. Peroxisome targeting signal of rat liver acyl-coenzyme A oxidase resides at the carboxy terminus
134. Mammalian alanine/glyoxylate aminotransferase 1 is imported into peroxisomes via the PTS1 translocation pathway. Increased degeneracy and context specificity of the mammalian PTS1 motif and implications for the peroxisome-to-mitochondrion mistargeting of AGT in primary hyperoxaluria type 1
135. Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor
136. Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes
137. Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G
138. Peroxisomal membrane protein Pmp47 is essential in the metabolism of middle-chain fatty acid in yeast peroxisomes and is associated with peroxisome proliferation
139. 31P NMR study of the internal pH of yeast peroxisomes
140. The endoplasmic reticulum in the Golgi zone and its relations to microbodies, Golgi apparatus and autophagic vacuoles in rat liver cells
141. The PAH2 gene is required for peroxisome assembly in the methylotrophic yeast Hansenula polymorpha and encodes a member of the tetratricopeptide repeat family of proteins
142. Mitochondrial targeting signal-induced conformational change and repression of the peroxisomal targeting signal of the precursor for rat liver serine:pyruvate/alanine:glyoxylate aminotransferase
143. Molecular anatomy of the peroxin Pex12p: Ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p
144. Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes: AA-CoA thiolase, HMG-CoA synthase, MPPD, and FPP synthase
145. Compartmentation of carbohydrate metabolism in trypanosomes
146. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p
147. Peroxisome biogenesis: Involvement of ARF and coatomer
148. The AAA team: Related ATPases with diverse functions
149. Cytosolic factors mediate protein insertion into the peroxisomal membrane
150. Targeting of the 22 kDa integral peroxisomal membrane protein
151. Characterization of intermediates in the process of plant peroxisomal protein import
152. Heat shock enhances the amount of prenylated Dnaj protein at membranes of glyoxysomes
153. Peroxisomal biogenesis: Multiple pathways of protein import
154. Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence
155. Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway
156. Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor
157. The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene
158. Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor Pex5p
159. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis
160. MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency
161. The Candida boidinii peroxisomal membrane protein Pmp30 has a role in peroxisomal proliferation and is functionally homologous to Pmp27 from Saccharomyces cerevisiae
162. Peroxisomal remnant structures in Hansenula polymorpha pex5 cells can develop into normal peroxisomes upon induction of the PTS2 protein amine oxidase
163. Overproduction of Pex5p stimulates import of alcohol oxidase and dihydroxyacetone synthase in a Hansenula polymorpha pex14 null mutant
164. Brefeldin A interferes with peroxisomal protein sorting in the yeast Hansenula polymorpha
165. Peroxisomal integral membrane proteins in control and Zellweger fibroblasts
166. Peroxisomal membrane ghosts in Zellweger syndrome-aberrant organelle assembly
167. Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface
168. Recombinant human peroxisomal targeting signal receptor PEX5 - Structural basis for interaction of PEX5 with PEX14
169. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane
170. Expression of PEX11β mediates peroxisome proliferation in the absence of extracellular stimuli
171. Peroxisomal ABC transporters
172. Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine
173. The peroxin Pex14p-cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis
174. Identification of PEX3 as the gene mutated in a Zellweger syndrome patient lacking peroxisomal remnant structures
175. Genetic basis of peroxisome-assembly mutants of humans, Chinese hamster ovary cells, and yeast: Identification of a new complementation group of peroxisome-biogenesis disorders apparently lacking peroxisomal-membrane ghosts
176. Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients
177. A novel, non-PTS1, peroxisomal import route dependent on the PTS1 receptor Pex5p
178. Acyl-CoA oxidase contains two targeting sequences each of which can mediate protein import into peroxisomes
179. A role for the peroxin Pex8p in Pex20p-dependent thiolase import into peroxisomes of the yeast Yarrowia lipolytica
180. Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris
181. Pex17p is required for import of both peroxisome membrane and lumenal protein and interacts with Pex19p and the peroxisome targeting signal-receptor docking complex in Pichia pastoris
182. The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane
183. Identification and characterization of the human peroxin PEX3
184. Peroxisome synthesis in the absence of preexisting peroxisomes
185. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis
186. Import of peroxisomal matrix and membrane proteins
187. Biosynthesis of membrane polypeptides of rat liver peroxisomes
188. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase
189. Tetratricopeptide repeat domain of Yarrowia lipolytica Pex5p is essential for recognition of the type 1 peroxisomal targeting signal but does not confer full biological activity on Pex5p
190. Pay32p of the yeast Yarrowia lipolytica is an intraperoxisomal component of the matrix protein translocation machinery
191. A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p
192. Sorting of peroxisomal and mitochondrial carnitine acetyltransferase isozymes in the diploid yeast, Candida tropicalis
193. Quantitative analysis of peroxisomal protein import in vitro
194. The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C-terminal tripeptide peroxisomal targeting signal
195. Peroxisomes in Saccharomyces cerevisiae: Immunofluorescence analysis and import of catalase A into isolated peroxisomes
196. Fusion of small peroxisomal vesicles in vitro reconstructs an early step in the in vivo multistep peroxisome assembly pathway of Yarrowia lipolytica
197. The endoplasmic reticulum plays an essential role in peroxisome biogenesis
198. Peroxisomal membrane fusion requires two AAA family ATPases, Pex1p and Pex6p
199. Pex20p of the yeast Yarrowia lipolytica is required for the oligomerization of thiolase in the cytosol and for its targeting to the peroxisome
200. Metabolic pathways in peroxisomes and glyoxysomes
201. Characterization of the signal peptide at the amino terminus of the rat peroxisomal 3-ketoacyl-CoA thiolase precursor
202. Peroxisome assembly factor-2, a putative ATPase cloned by functional complementation on a peroxisome-deficient mammalian cell mutant
203. Arabidopsis 22-kilodalton peroxisomal membrane protein. Nucleotide sequence analysis and biochemical characterization
204. Interaction of Pex5p, the type 1 peroxisome targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p
205. Biochemistry of peroxisomes
206. The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery
207. The Hansenula polymorpha PER3 gene is essential for the import of PTS1 proteins into the peroxisomal matrix
208. PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae
209. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions
210. Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiae
211. The significance of peroxisomes in the metabolism of one-carbon compounds in yeasts
212. The ATP-dependent translocation of phosphatidylserine to the mitochondria is a process that is restricted to the autologous organelle
213. Import of stably folded proteins into peroxisomes
214. Involvement of 70-kD heat-shock proteins in peroxisomal import
215. Biochemical analysis in peroxisomal disorders
216. The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and x escodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals
217. Cytosol-dependent peroxisomal protein import in a permeabilized cell system
218. The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes
219. Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris
220. Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders
221. Identification and characterization of the human orthologue of yeast pex14p
222. The glyoxysomal and plastid molecular chaperones (70-kDa heat shock protein) of watermelon cotyledons are encoded by a single gene
223. The plant PTS1 receptor: Similarities and differences to its human and yeast counterparts
224. Phospholipid transfer proteins
225. Increased amounts of HMG-CoA reductase induce "karmellae": A proliferation of stacked membrane pairs surrounding the yeast nucleus
226. The peroxisome biogenesis disorder group 4 gene, PX-AAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor
227. Formation of peroxisomes from peroxisomal ghosts in a peroxisome-deficient mammalian cell mutant upon complementation by protein microinjection
228. Ecilp uses a PTS1 to enter peroxisomes: Either its own or that of a partner, Dci1p
229. PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes
230. 2-terminal peptide