Nutritionally mediated oxidative stress and inflammation

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Muñoz, Alexandra ^a   Costa, Max ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; ARACHIDONIC ACIDS; COMPLEX ROLES; HUMAN INTERVENTION; PERIPHERAL BLOOD MONONUCLEAR CELLS; PROINFLAMMATORY; TIME FRAME; UP-REGULATION;

GENE EXPRESSION; OILS AND FATS; PATHOLOGY; SATURATED FATTY ACIDS; UNSATURATED FATTY ACIDS;

OXIDATIVE STRESS;

ARACHIDONIC ACID; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; FISH OIL; GLUCOSE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; OLIVE OIL; SATURATED FATTY ACID; TUMOR NECROSIS FACTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ADIPOCYTE; CALORIC RESTRICTION; DIET; FOOD INTAKE; FRUIT; GENE EXPRESSION; HUMAN; INFLAMMATION; MACRONUTRIENT; NUTRIENT; OBESITY; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHYTONUTRIENT; REVIEW; UPREGULATION; VEGETABLE; FOOD; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY;

FOOD; HUMANS; INFLAMMATION; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; NF-KAPPA B; OXIDATIVE STRESS;

EID: 84880311913     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/610950     Document Type: Review

References (88)

1. Esposito K., Nappo F., Marfella R., Giugliano G., Giugliano F., Ciotola M., Quagliaro L., Ceriello A., Giugliano D., Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002 106 16 2067 2072 2-s2.0-0037109184 10.1161/01.CIR.0000034509.14906.AE (Pubitemid 35192812)
2. O'Keefe J. H., Gheewala N. M., O'Keefe J. O., Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. Journal of the American College of Cardiology 2008 51 3 249 255 2-s2.0-38149027125 10.1016/j.jacc.2007.10.016
3. van Gaal L. F., Mertens I. L., de Block C. E., Mechanisms linking obesity with cardiovascular disease. Nature 2006 444 7121 875 880 2-s2.0-33845914986 10.1038/nature05487 (Pubitemid 46028447)
4. Monnier L., Mas E., Ginet C., Michel F., Villon L., Cristol J. P., Colette C., Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. Journal of the American Medical Association 2006 295 14 1681 1687 2-s2.0-33645745733 10.1001/jama.295.14.1681
5. Ceriello A., Motz E., Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 5 816 823 2-s2.0-2442421194 10.1161/01.ATV.0000122852.22604.78 (Pubitemid 38620857)
6. Ott M., Gogvadze V., Orrenius S., Zhivotovsky B., Mitochondria, oxidative stress and cell death. Apoptosis 2007 12 5 913 922 2-s2.0-34247490186 10.1007/s10495-007-0756-2 (Pubitemid 46653300)
7. Yin F., Sancheti H., Cadenas E., Mitochondrial thiols in the regulation of cell death pathways. Antioxidants & Redox Signaling 2012 17 12 1714 1727
8. Andreyev A. Y., Kushnareva Y. E., Starkov A. A., Mitochondrial metabolism of reactive oxygen species. Biochemistry 2005 70 2 200 214 2-s2.0-17144422877 10.1007/s10541-005-0102-7 (Pubitemid 40512329)
9. Hotamisligil G. S., Inflammation and metabolic disorders. Nature 2006 444 7121 860 867 (Pubitemid 46024993)
10. Wright E., Scism-Bacon J. L., Glass L. C., Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. International Journal of Clinical Practice 2006 60 3 308 314 2-s2.0-33644766950 10.1111/j.1368-5031. 2006.00825.x (Pubitemid 43337611)
11. Chervona M. C. Y., Histone modifications and cancer: biomarkers of prognosis? American Journal of Cancer Research 2012 2 5 589 597
12. Kurdistani S. K., Histone modifications in cancer biology and prognosis. Epigenetics and Disease 2010 Basel, Switzerland Springer 91 106
13. Yang X.-J., Seto E., HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene 2007 26 37 5310 5318 (Pubitemid 47255917)
14. McBrian M. A., Behbahan I. S., Ferrari R., Su T., Huang T. W., Li K., Hong C. S., Christofk H. R., Vogelauer M., Seligson D. B., Kurdistani S. K., Histone acetylation regulates intracellular pH. Molecular Cell 2013 49 2 310 321
15. Vogelauer M., Krall A. S., McBrian M. A., Li J.-Y., Kurdistani S. K., Stimulation of histone deacetylase activity by metabolites of intermediary metabolism. Journal of Biological Chemistry 2012 287 38 32006 32016
16. Demissie S., Levy D., Benjamin E. J., Cupples L. A., Gardner J. P., Herbert A., Kimura M., Larson M. G., Meigs J. B., Keaney J. F., Aviv A., Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 2006 5 4 325 330 2-s2.0-33746316181 10.1111/j.1474-9726.2006.00224.x (Pubitemid 44103248)
17. Rajagopalan H., Lengauer C., Aneuploidy and cancer. Nature 2004 432 7015 338 341 (Pubitemid 39551662)
18. Iyer A., Fairlie D. P., Prins J. B., Hammock B. D., Brown L., Inflammatory lipid mediators in adipocyte function and obesity. Nature Reviews Endocrinology 2010 6 2 71 82
19. Shoelson S. E., Herrero L., Naaz A., Obesity, inflammation, and insulin resistance. Gastroenterology 2007 132 6 2169 2180 2-s2.0-34247857663 10.1053/j.gastro.2007.03.059 (Pubitemid 46693756)
20. Henry S. L., Bensley J. G., Wood-Bradley R. J., Cullen-McEwen L. A., Bertram J. F., Armitage J. A., White adipocytes: more than just fat depots. The International Journal of Biochemistry and Cell Biology 2012 44 3 435 440
21. Goossens G. H., The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiology and Behavior 2008 94 2 206 218 2-s2.0-42949088997 10.1016/j.physbeh.2007.10.010 (Pubitemid 351615418)
22. Margioris A. N., Fatty acids and postprandial inflammation. Current Opinion in Clinical Nutrition and Metabolic Care 2009 12 2 129 137
23. Dickinson S., Hancock D. P., Petocz P., Ceriello A., Brand-Miller J., High-glycemic index carbohydrate increases nuclear factor- B activation in mononuclear cells of young, lean healthy subjects1-3. American Journal of Clinical Nutrition 2008 87 5 1188 1193 2-s2.0-43549113382 (Pubitemid 351679757)
24. Kallio P., Kolehmainen M., Laaksonen D. E., Kekäläinen J., Salopuro T., Sivenius K., Pulkkinen L., Mykkänen H. M., Niskanen L., Uusitupa M., Poutanen K. S., Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study. American Journal of Clinical Nutrition 2007 85 5 1417 1427 2-s2.0-34248344217 (Pubitemid 46740487)
25. Clément K., Viguerie N., Poitou C., Carette C., Pelloux V., Curat C. A., Sicard A., Rome S., Benis A., Zucker J. D., Vidal H., Laville M., Barsh G. S., Basdevant A., Stich V., Cancello R., Langin D., Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB Journal 2004 18 14 1657 1669 2-s2.0-7744226149 10.1096/fj.04-2204com (Pubitemid 39463705)
26. Crujeiras A. B., Parra D., Milagro F. I., Goyenechea E., Larrarte E., Margareto J., Martínez J. A., Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study. OMICS 2008 12 4 251 261 2-s2.0-57149109884 10.1089/omi.2008.0001 (Pubitemid 352773935)
27. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W., Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003 112 12 1796 1808 2-s2.0-0348230958 10.1172/JCI200319246 (Pubitemid 38063703)
28. Bastard J.-P., Jardel C., Bruckert E., Blondy P., Capeau J., Laville M., Vidal H., Hainque B., Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. Journal of Clinical Endocrinology and Metabolism 2000 85 9 3338 3342 2-s2.0-0033678516
29. Ghanim H., Aljada A., Hofmeyer D., Syed T., Mohanty P., Dandona P., Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 2004 110 12 1564 1571 2-s2.0-4644338458 10.1161/01.CIR.0000142055. 53122.FA (Pubitemid 39297977)
30. Lumeng C. N., Bodzin J. L., Saltiel A. R., Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Journal of Clinical Investigation 2007 117 1 175 184 2-s2.0-33846026712 10.1172/JCI29881 (Pubitemid 46048464)
31. Lumeng C. N., Delproposto J. B., Westcott D. J., Saltiel A. R., Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008 57 12 3239 3246 2-s2.0-58149347227 10.2337/db08-0872
32. Odegaard J. I., Ricardo-Gonzalez R. R., Goforth M. H., Morel C. R., Subramanian V., Mukundan L., Eagle A. R., Vats D., Brombacher F., Ferrante A. W., Chawla A., Macrophage-specific PPAR γ controls alternative activation and improves insulin resistance. Nature 2007 447 7148 1116 1120 2-s2.0-34347354309 10.1038/nature05894 (Pubitemid 47014427)
33. Satoh-Asahara N., Shimatsu A., Sasaki Y., Nakaoka H., Himeno A., Tochiya M., Kono S., Takaya T., Ono K., Wada H., Suganami T., Hasegawa K., Ogawa Y., Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care 2012 35 12 2631 2639
34. Esposito K., Pontillo A., Giugliano F., Giugliano G., Marfella R., Nicoletti G., Giugliano D., Association of low interleukin-10 levels with the metabolic syndrome in obese women. Journal of Clinical Endocrinology and Metabolism 2003 88 3 1055 1058 2-s2.0-0037342025 10.1210/jc.2002-021437 (Pubitemid 36337756)
35. Carvalho G. Q., Pereira P. F., Serrano H. M. S., do Franceschini S. C. C., de Paula S. O., Priore S. E., do Peluzio M. C. G., Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat. Applied Physiology, Nutrition and Metabolism 2010 35 4 464 470 2-s2.0-77958110826 10.1139/H10-033
36. Lago R., Gómez R., Lago F., Gómez-Reino J., Gualillo O., Leptin beyond body weight regulation-current concepts concerning its role in immune function and inflammation. Cellular Immunology 2008 252 1-2 139 145 2-s2.0-48149112746 10.1016/j.cellimm.2007.09.004
37. Lee Y. H., Nair S., Rousseau E., Allison D. B., Page G. P., Tataranni P. A., Bogardus C., Permana P. A., Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia 2005 48 9 1776 1783 2-s2.0-24944489239 10.1007/s00125-005-1867-3 (Pubitemid 41317831)
38. Hermsdorff H. H. M., Puchau B., Zulet M. A., Martínez J. A., Association of body fat distribution with proinflammatory gene expression in peripheral blood mononuclear cells from young adult subjects. OMICS 2010 14 3 297 307 2-s2.0-77954189297 10.1089/omi.2009.0125
39. Kliewer S. A., Sundseth S. S., Jones S. A., Brown P. J., Wisely G. B., Koble C. S., Devchand P., Wahli W., Willson T. M., Lenhard J. M., Lehmann J. M., Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ Proceedings of the National Academy of Sciences of the United States of America 1997 94 9 4318 4323 2-s2.0-0006132932 10.1073/pnas.94.9.4318 (Pubitemid 27194239)
40. Georgiadi A., Kersten S., Mechanisms of gene regulation by fatty acids. Advances in Nutrition 2012 3 2 127 134
41. Osborne T. F., Sterol regulatory element-binding proteins (SREBPS): key regulators of nutritional homeostasis and insulin action. Journal of Biological Chemistry 2000 275 42 32379 32382 2-s2.0-0034693259
42. Gao L., Wang J., Sekhar K. R., Yin H., Yared N. F., Schneider S. N., Sasi S., Dalton T. P., Anderson M. E., Chan J. Y., Morrow J. D., Freeman M. L., Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. Journal of Biological Chemistry 2007 282 4 2529 2537 2-s2.0-34047273206 10.1074/jbc.M607622200 (Pubitemid 47076775)
43. Francis H., Stevenson R., The longer-term impacts of Western diet on human cognition and the brain. Appetite 2013 63 119 128
44. Willcox D. C., Willcox B. J., Todoriki H., Suzuki M., The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. Journal of the American College of Nutrition 2009 28 4 500S 516S 2-s2.0-77951598531
45. Tilley S. L., Coffman T. M., Koller B. H., Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. Journal of Clinical Investigation 2001 108 1 15 23 2-s2.0-0034943516 10.1172/JCI200113416 (Pubitemid 32634916)
46. Miles E. A., Allen E., Calder P. C., In vitro effects of eicosanoids derived from different 20-carbon fatty acids on production of monocyte-derived cytokines in human whole blood cultures. Cytokine 2002 20 5 215 223 2-s2.0-0038564099 10.1006/cyto.2002.2007 (Pubitemid 37163474)
47. Samad T. A., Moore K. A., Sapirstein A., Billet S., Allchorne A., Poole S., Bonventre J. V., Woolf C. J., Interleukin-1 β -mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001 410 6827 471 475 2-s2.0-0035932121 10.1038/35068566 (Pubitemid 32240046)
48. Lee K.-M., Kang B.-S., Lee H.-L., Son S.-J., Hwang S.-H., Kim D.-S., Park J.-S., Cho H.-J., Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity. European Journal of Neuroscience 2004 19 12 3375 3381 (Pubitemid 38859555)
49. Greenhough A., Smartt H. J. M., Moore A. E., Roberts H. R., Williams A. C., Paraskeva C., Kaidi A., The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 2009 30 3 377 386 2-s2.0-62349138124 10.1093/carcin/bgp014
50. Hughes-Fulford M., Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis 2001 22 5 701 707 (Pubitemid 32447916)
51. Hughes-Fulford M., Li C.-F., Boonyaratanakornkit J., Sayyah S., Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer. Cancer Research 2006 66 3 1427 1433 2-s2.0-32944477374 10.1158/0008-5472.CAN-05-0914 (Pubitemid 43259923)
52. Rioux V., Legrand P., Saturated fatty acids: simple molecular structures with complex cellular functions. Current Opinion in Clinical Nutrition and Metabolic Care 2007 10 6 752 758 (Pubitemid 350293777)
53. Staiger K., Staiger H., Weigert C., Haas C., Häring H.-U., Kellerer M., Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor- B activation. Diabetes 2006 55 11 3121 3126 2-s2.0-33845512965 10.2337/db06-0188 (Pubitemid 44923651)
54. Harvey K. A., Walker C. L., Pavlina T. M., Xu Z., Zaloga G. P., Siddiqui R. A., Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth. Clinical Nutrition 2010 29 4 492 500
55. Murumalla R. K., Gunasekaran M. K., Fatty acids do not pay the toll: effect of SFA and PUFA on human adipose tissue and mature adipocytes inflammation. Lipids in Health and Disease 2012 11 article 175
56. Huang S., Rutkowsky J. M., Snodgrass R. G., Ono-Moore K. D., Schneider D. A., Newman J. W., Adams S. H., Hwang D. H., Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways. Journal of Lipid Research 2012 53 9 2002 2013
57. Hoenselaar R., Saturated fat and cardiovascular disease: the discrepancy between the scientific literature and dietary advice. Nutrition 2012 28 2 118 123
58. Takeuchi H., Sekine S., Kojima K., Aoyama T., The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation. Asia Pacific Journal of Clinical Nutrition 2008 17 1 320 323 2-s2.0-46049100264
59. Nagao K., Yanagita T., Medium-chain fatty acids: functional lipids for the prevention and treatment of the metabolic syndrome. Pharmacological Research 2010 61 3 208 212 2-s2.0-77649274673 10.1016/j.phrs.2009.11.007
60. van Dijk S. J., Feskens E. J. M., Bos M. B., Hoelen D. W. M., Heijligenberg R., Bromhaar M. G., de Groot L. C. P. G. M., de Vries J. H. M., Müller M., Afman L. A., A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome. American Journal of Clinical Nutrition 2009 90 6 1656 1664 2-s2.0-72749100942 10.3945/ajcn.2009.27792
61. Dandona P., Aljada A., Bandyopadhyay A., Inflammation: the link between insulin resistance, obesity and diabetes. Trends in Immunology 2004 25 1 4 7 2-s2.0-0348222671 10.1016/j.it.2003.10.013 (Pubitemid 38032801)
62. Brownlee M., Biochemistry and molecular cell biology of diabetic complications. Nature 2001 414 6865 813 820 2-s2.0-0035856980 10.1038/414813a (Pubitemid 34000785)
63. Marfella R., Esposito K., Giunta R., Coppola G., De Angelis L., Farzati B., Paolisso G., Giugliano D., Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsalinemia. Circulation 2000 101 19 2247 2251 2-s2.0-0034674003 (Pubitemid 30317125)
64. Benetou V., Trichopoulou A., Orfanos P., Naska A., Lagiou P., Boffetta P., Trichopoulos D., Conformity to traditional Mediterranean diet and cancer incidence: the Greek EPIC cohort. British Journal of Cancer 2008 99 1 191 195 2-s2.0-46349084356 10.1038/sj.bjc.6604418 (Pubitemid 351920219)
65. Willcox B. J., Willcox D. C., Todoriki H., Fujiyoshi A., Yano K., He Q., Curb J. D., Suzuki M., Caloric restriction, the traditional okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. Annals of the New York Academy of Sciences 2007 1114 434 455 2-s2.0-35948936851 10.1196/annals.1396.037 (Pubitemid 350070404)
66. Brattbakk H.-R., Arbo I., Aagaard S., Lindseth I., de Soysa A. K. H., Langaas M., Kulseng B., Lindberg F., Johansen B., Balanced caloric macronutrient composition downregulates immunological gene expression in human blood cells-adipose tissue diverges. OMICS 2013 17 1 41 52
67. Capel F., Viguerie N., Vega N., Dejean S., Arner P., Klimcakova E., Martinez J. A., Saris W. H. M., Holst C., Taylor M., Oppert J. M., Sørensen T. I. A., Clément K., Vidal H., Langin D., Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women. Journal of Clinical Endocrinology and Metabolism 2008 93 11 4315 4322 2-s2.0-57349147307 10.1210/jc.2008-0814 (Pubitemid 352789527)
68. Dankel S. N., Fadnes D. J., Stavrum A.-K., Stansberg C., Holdhus R., Hoang T., Veum V. L., Christensen B. J., Våge V., Sagen J. V., Steen V. M., Mellgren G., Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. Plos One 2010 5 6, article e11033 2-s2.0-77956197976 10.1371/journal.pone.0011033
69. Simopoulos A. P., The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine and Pharmacotherapy 2002 56 8 365 379 2-s2.0-0036776120 10.1016/S0753-3322(02)00253-6 (Pubitemid 35232740)
70. HM S., Deficiency of essential fatty acids and atherosclerosis, etcetera. The Lancet 1956 270 6919 381 383
71. Kromhout D., Yasuda S., Geleijnse J. M., Shimokawa H., Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work? European Heart Journal 2012 33 4 436 443
72. Weaver K. L., Ivester P., Seeds M., Case L. D., Arm J. P., Chilton F. H., Effect of dietary fatty acids on inflammatory gene expression in healthy humans. Journal of Biological Chemistry 2009 284 23 15400 15407
73. Duda M. K., O'Shea K. M., Stanley W. C., ω -3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential. Cardiovascular Research 2009 84 1 33 41 2-s2.0-70350601103 10.1093/cvr/cvp169
74. Fortin P. R., Lew R. A., Liang M. H., Wright E. A., Beckett L. A., Chalmers T. C., Sperling R. I., Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. Journal of Clinical Epidemiology 1995 48 11 1379 1390 2-s2.0-0028818261 10.1016/0895-4356(95)00028-3
75. Hirsch E., Katanaev V. L., Garlanda C., Azzolino O., Pirola L., Silengo L., Sozzani S., Mantovani A., Altruda F., Wymann M. P., Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science 2000 287 5455 1049 1052 2-s2.0-0034635452 10.1126/science.287.5455.1049 (Pubitemid 30094362)
76. Rommel C., Camps M., Ji H., PI3K δ and PI3K γ: partners in crime in inflammation in rheumatoid arthritis and beyond? Nature Reviews Immunology 2007 7 3 191 201
77. Martínez-González M. Á., de la Fuente-Arrillaga C., Nunez-Cordoba J. M., Basterra-Gortari F. J., Beunza J. J., Vazquez Z., Benito S., Tortosa A., Bes-Rastrollo M., Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study. BMJ 2008 336 7657 1348 1351 2-s2.0-46249088205 10.1136/bmj.39561.501007.BE (Pubitemid 351914624)
78. Estruch R., Ros E., Salas-Salvadó J., Covas D Pharm M. I., Corella D., Arós F., Gómez-Gracia E., Ruiz-Gutiérrez V., Fiol M., Lapetra J., Lamuela-Raventos R. M., Serra-Majem L., Pintó X., Basora J., Muñoz M. A., Sorlí J. V., Martínez J. A., Martínez-González M. A., Primary prevention of cardiovascular disease with a mediterranean diet. The New England Journal of Medicine 2013 368 14 1279 1290
79. Bogani P., Galli C., Villa M., Visioli F., Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis 2007 190 1 181 186 2-s2.0-33845420450 10.1016/j.atherosclerosis.2006.01.011 (Pubitemid 44908313)
80. Bellido C., López-Miranda J., Blanco-Colio L. M., Pérez-Martínez P., Muriana F. J., Martín-Ventura J. L., Marín C., Gómez P., Fuentes F., Egido J., Pérez- Jiménez F., Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor B in peripheral blood mononuclear cells from healthy men. American Journal of Clinical Nutrition 2004 80 6 1487 1491 2-s2.0-16544362069 (Pubitemid 41103844)
81. Camargo A., Ruano J., Fernandez J. M., Parnell L. D., Jimenez A., Santos-Gonzalez M., Marin C., Perez-Martinez P., Uceda M., Lopez-Miranda J., Perez-Jimenez F., Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics 2010 11 1, article 253 2-s2.0-77950930524 10.1186/1471-2164-11-253
82. Esposito K., Nappo F., Giugliano F., Giugliano G., Marfella R., Giugliano D., Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. American Journal of Clinical Nutrition 2003 77 1 139 143 2-s2.0-0037216365 (Pubitemid 36015383)
83. Hlebowicz J., Darwiche G., Björgell O., Almér L.-O., Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. American Journal of Clinical Nutrition 2007 85 6 1552 1556 2-s2.0-34250001148 (Pubitemid 46890423)
84. Qin B., Dawson H., Polansky M. M., Anderson R. A., Cinnamon extract attenuates TNF-alpha-induced intestinal lipoprotein ApoB48 overproduction by regulating inflammatory, insulin, and lipoprotein pathways in enterocytes. Hormone and Metabolic Research 2009 41 7 516 522 2-s2.0-70149094195 10.1055/s-0029-1202813
85. Markey O., McClean C. M., Medlow P., Davison G. W., Trinick T. R., Duly E., Shafat A., Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. Cardiovascular Diabetology 2011 10 1, article 78
86. Hermsdorff H. H. M., Zulet M. A., Puchau B., Martínez J. A., Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutrition and Metabolism 2010 7 article 42
87. Turnbaugh P. J., Ley R. E., Mahowald M. A., Magrini V., Mardis E. R., Gordon J. I., An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006 444 7122 1027 1031 2-s2.0-33845874101 10.1038/nature05414 (Pubitemid 46018515)
88. Vucenik I., Stains J. P., Obesity and cancer risk: evidence, mechanisms, and recommendations. Annals of the New York Academy of Sciences 2012 1271 1 37 43