Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity

European Journal of Neuroscience

Volumn 19, Issue 12, 2004, Pages 3375-3381

  Lee, Kyung Min ^a   Kang, Bong Seok ^b   Lee, Hye Lim ^a   Son, Sun Joo ^a   Hwang, Sung Hun ^a   Kim, Dong Sun ^a   Park, Jae Sik ^a   Cho, Hee Jung ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

COX 2; IL 1 ; Inflammatory pain; NF kB; Spinal cord

Indexed keywords

CASPASE INHIBITOR; CYCLOOXYGENASE 2; DYNORPHIN; FREUND ADJUVANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PYRROLIDINE DITHIOCARBAMATE;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HYPERALGESIA; INFLAMMATION; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CYCLOOXYGENASE 2; ENKEPHALINS; ENZYME INHIBITORS; FREUND'S ADJUVANT; GENE EXPRESSION; HINDLIMB; HYPERALGESIA; INFLAMMATION; INJECTIONS, SPINAL; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; ISOENZYMES; MALE; NF-KAPPA B; PAIN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIALOGLYCOPROTEINS; SPINAL CORD; UP-REGULATION;

EID: 3042714222     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0953-816X.2004.03441.x     Document Type: Article

References (26)

1. Barnes, P.J. & Adcock, I.M. (1997) NF-kB: a pivotal role in asthma and a new target for therapy. Trends Pharmacol. Sci., 18, 46-50.
2. Chan, C.F., Sun, W.Z., Lin, J.K. & Lin-Shiau, S.Y. (2000) Activation of transcription factors of nuclear factor kappa B, activator protein-1 and octomer factors in hyperalgesia. Eur. J. Pharmacol., 402, 61-68.
3. Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M. & Yaksh, T.L. (1994) Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Meth., 53, 55-63.
4. Chiang, M.Y., Chan, H., Zounes, M.A., Freier, S.M., Lima, W.F. & Bennett, C.F. (1991) Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanism. J. Biol. Chem., 266, 18162.
5. Cooper, J.A. Jr, Parks, J.M., Carcelen, R., Kahlon, S.S., Sheffield, M. & Culbreth, R. (2000) Attenuation of interleukin-8 production by inhibiting nuclear factor-kappaB translocation using decoy oligonucleotides. Biochem. Pharmacol., 6, 605-613.
6. Cuzzocrea, S., Chatterjee, P.K., Mazzon, E., Dugo, L., Serraino, I., Britti, D., Mazzullo, G., Caputi, A.P. & Thiemermann, C. (2002) Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br. J. Pharmacol., 135, 496-510.
7. Dubner, R. & Ruda, M.A. (1992) Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci., 15, 96-103.
8. Erin, D.M., Carin, T., Marucia, C., Joseph, B., O'Connor, K., Stephen, P., Kevin, T., David, M., Steven, F.M. & Watkins, L. (2003) Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J. Neurosci., 23, 1026-1040.
9. Fiebich, B.L., Mueksch, B., Boehringer, M. & Hull, M. (2000) Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E (2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB. J. Neurochem., 75, 2020-2028.
10. Hargreaves, K., Dubner, R., Brown, F., Flores, C. & Joris, J. (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain, 32, 77-88.
11. Hylden, J.L., Nahin, R.L., Traub, R.J. & Dubner, R. (1991) Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons. Pain, 44, 187-193.
12. Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H. & Baeuerle, P.A. (1994) Constitutive NF-Kappa B activity in neurons. Mol. Cell. Biol., 14, 3981-3992.
13. Laughlin, T.M., Bethea, J.R., Yezierski, R.P. & Wilcox, G.L. (2000) Cytokine involvement in dynorphin-induced allodynia. Pain, 84, 159-167.
14. Laughlin, T.M., Larson, A.A. & Wilcox, G.L. (2001) Mechanisms of induction of persistent nociception by dynorphin. J. Pharmacol. Exp. Ther., 299, 6-11.
15. Ma, W. & Bisby, M.A. (1998) Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries. Brain Res., 797, 243-254.
16. O'Neil, L.A.J. & Kaltschmidt, C. (1997) NF-kB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci., 20, 252-258.
17. Reisinger, E.C., Kern, P., Ernst, M., Bock, P., Flad, H.D. & Dietich, M. (1990) Inhibition of HIV progression by dithiocarb. Lancet, 335, 679-682.
18. Sakaue, G., Shimaoka, M., Fukuoka, T., Hiroi, T., Inoue, T., Hashimoto, N., Sakaguchi, T., Sawa, Y., Morishita, R., Kiyono, H., Noguchi, K. & Mashimo, T. (2001) NF-kB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport, 12, 2079-2084.
19. Samad, T.A., Moore, K.A., Sapirstein, A., Billet, S., Allchorne, A., Poole, S., Bonventre, J.V. & Woolf, C.J. (2001) Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature, 410, 471-475.
20. Schenk, H., Klein, M., Erdbrügger, W., Dröge, W. & Schulze-Osthoff, K. (1994) Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kB and AP-1. Proc. Natl Acad. Sci. USA, 99, 1672-1676.
21. Schreck, R., Riber, P. & Bauerle, P.A. (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1. EMBO J., 10, 2247-2258.
22. Shen, Z., Peedikayil, J., Olson, G.K., Siebert, P.D. & Fang, Y. (2002) Multiple transcription factor profiling by enzyme-linked immunoassay. Biotechniques, 32, 1168-1170.
23. Sugiyo, S., Yonehara, N., Appenteng, K., Nokubi, T., Shigenaga, Y. & Takemura, M. (2001) Effects of intrathecal c-fos antisense oligodeoxynucleotide on adjuvant-induced thermal hyperalgesia. Exp. Brain Res., 140, 198-205.
24. Vanegas, H. & Schaible, H.G. (2001) Prostaglandins and cyclooxygenases in the spinal cord. Prog. Neurobiol., 64, 327-363.
25. Yamamoto, T. & Sakashita, Y (1998) Cox-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA. Neuroreport, 9, 3869-3873.
26. Yang, C.M., Chien, C.S., Hsiao, L.D., Luo, S.F. & Wang, C.C. (2002) Interleukin-1beta-induced cyclooxygenase-2 expression mediated through activation of p42/44 and p38 MAPKS, NF-kappaB pathways in canine tracheal smooth muscle. Cell Signal., 14, 899-911.