Solution structure of polytheonamide B, a highly cytotoxic nonribosomal polypeptide from marine sponge

Journal of the American Chemical Society

Volumn 132, Issue 37, 2010, Pages 12941-12945

  Hamada, Toshiyuki ^a,b,c   Matsunaga, Shigeki ^a   Fujiwara, Masako ^d,e   Fujita, Kenichi ^d   Hirota, Hiroshi ^c   Schmucki, Roland ^f   Güntert, Peter ^f   Fusetani, Nobuhiro ^a,g  

^a UNIVERSITY OF TOKYO   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c RIKEN YOKOHAMA INSTITUTE   (Japan)

^d JEOL LTD   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

^f GOETHE UNIVERSITY   (Germany)

^g HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC; CYTOTOXIC ACTIVITIES; ENERGY MINIMIZATION; GRAMICIDIN A; HELICAL STRUCTURES; HYDROPHILIC PORES; INNER DIAMETERS; L-AMINO ACIDS; MARINE SPONGE; MONOVALENT CATIONS; NMR SPECTROSCOPY; NONRIBOSOMAL PEPTIDE; POLYTHEONAMIDE B; SINGLE MOLECULE; SOLUTION STRUCTURES; STRUCTURE CALCULATION; THREE-DIMENSIONAL STRUCTURE; TRANSMEMBRANES;

AMINO ACIDS; BIOLOGICAL MEMBRANES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC ACIDS; PEPTIDES; POLYPEPTIDES;

CYTOTOXICITY;

CHLOROFORM; DOXORUBICIN; GRAMICIDIN A; METHANOL; POLYPEPTIDE; POLYTHEONAMIDE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; ENERGY; HYDROPHILICITY; MEMBRANE CHANNEL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPONGE (PORIFERA); STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

ANIMALS; BIOMIMETICS; CELL LINE, TUMOR; CELL MEMBRANE; INHIBITORY CONCENTRATION 50; ION CHANNELS; MICE; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANIC CHEMICALS; PEPTIDES; PORIFERA; PROTEIN CONFORMATION; PROTEINS; SOLUTIONS; SOLVENTS;

EID: 77956621008     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja104616z     Document Type: Article

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