Selective Modification of the N-Terminal Structure of PolytheonamideB Significantly Changes its Cytotoxicity and Activity as an Ion Channel

ChemMedChem

Volumn 7, Issue 10, 2012, Pages 1770-1773

  Shinohara, Naoki ^a   Itoh, Hiroaki ^a   Matsuoka, Shigeru ^a   Inoue, Masayuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cytotoxic agents; Natural products; Nonribosomal peptides; Structure activity relationships; Synthetic ion channels

Indexed keywords

5,5 DIMETHYL 2 OXOHEXANOATE; AMINO ACID; ANTINEOPLASTIC AGENT; ION CHANNEL; NATURAL PRODUCT; POLYTHEONAMIDE B; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CHIRALITY; CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; ION CHANNELS; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SAFROLE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866763630     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200142     Document Type: Article

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