Aging of the hematopoietic system

Current Opinion in Hematology

Volumn 20, Issue 4, 2013, Pages 355-361

  Snoeck, Hans Willem ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Aging; Development; Hematopoietic stem cells

Indexed keywords

AGING; CELL DAMAGE; CELL PROTECTION; DNA DAMAGE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HUMAN; INFLAMMATION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

AGING; CELL AGING; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS;

EID: 84880235551     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3283623c77     Document Type: Review

References (67)

1. Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell 2008; 132:681-696.
2. Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol 2009; 9:57-62.
3. Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004; 5:133-139.
4. Kollman C, Howe CW, Anasetti C, et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 2001; 98:2043-2051.
5. Harrison DE, Astle CM, Stone M. Numbers and functions of transplantable primitive immunohematopoietic stem cells. Effects of age. J Immunol 1989; 142:3833-3840.
6. Morrison SJ, Wandycz AM, Akashi K, et al. The aging of hematopoietic stem cells. Nat Med 1996; 2:1011-1016.
7. Dykstra B, Olthof S, Schreuder J, et al. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med 2011; 208:2691-2703.
8. Rossi DJ, Bryder D, Zahn JM, et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005; 102:9194-9199.
9. Harrison DE. Long-term erythropoietic repopulating ability of old, young, and fetal stem cells. J Exp Med 1983; 157:1496-1504.
10. Sudo K, Ema H, Morita Y, Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 2000; 192:1273-1280.
11. Beerman I, Bhattacharya D, Zandi S, et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci USA 2010; 107: 5465-5470.
12. Cho RH, Sieburg HB, Muller-Sieburg CE. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 2008; 111:5553-5561.
13. Liang Y, Van Zant G, Szilvassy SJ. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 2005; 106:1479-1487.
14. Beerman I, Bock C, Garrison BS, et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 2013; 12:413-425. Extensive characterization of differential methylation in young and aged HSCs, as well as HSCs that have undergone forced proliferation.
15. Kohler A, Schmithorst V, Filippi MD, et al. Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones. Blood 2009; 114:290-298.
16. Xing Z, Ryan MA, Daria D, et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 2006; 108:2190-2197.
17. Labrie JE 3rd, Sah AP, Allman DM, et al. Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice. J Exp Med 2004; 200:411-423.
18. Chinn IK, Blackburn CC, Manley NR, Sempowski GD. Changes in primary lymphoid organs with aging. Semin Immunol 2012; 24:309-320.
19. Sprent J, Surh CD. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat Immunol 2011; 12:478-484.
20. PangWW, Price EA, Sahoo D, et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA 2011; 108:20012-20017.
21. Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008; 371:1030-1043.
22. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med 2005; 352:804-815.
23. Duhren-von Minden M, Ubelhart R, Schneider D, et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012; 489:309-312
24. Kikushige Y, Ishikawa F, Miyamoto T, et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer cell 2011; 20:246-259.
25. Johnson SA, Rozzo SJ, Cambier JC. Aging-dependent exclusion of antigeninexperienced cells from the peripheral B cell repertoire. J Immunol 2002; 168:5014-5023.
26. Guerrettaz LM, Johnson SA, Cambier JC. Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc Natl Acad Sci USA 2008; 105:11898-11902.
27. Chambers SM, Shaw CA, Gatza C, et al. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 2007; 5:e201.
28. Gonzalo S. Epigenetic alterations in aging. J Appl Physiol 2010; 109:586-597.
29. Attema JL, Pronk CJ, Norddahl GL, et al. Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence. Oncogene 2009; 28: 2238-2243.
30. Florian MC, Dorr K, Niebel A, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012; 10:520-530
31. Rossi DJ, Bryder D, Seita J, et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447:725-729.
32. Takizawa H, Regoes RR, Boddupalli CS, et al. Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. J Exp Med 2011; 208:273-284.
33. Wilson A, Laurenti E, Oser G, et al. Hematopoietic stemcells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008; 135:1118-1129.
34. Rossi L, Lin KK, Boles NC, et al. Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell 2012; 11:302-317. Outstanding systematic overview of mouse knockouts in which HSC function is affected.
35. Janzen V, Forkert R, Fleming HE, et al. Stem-cell ageing modified by the cyclindependent kinase inhibitor p16INK4a. Nature 2006; 443:421-426.
36. Calado RT, Young NS. Telomere diseases. N Engl J Med 2009; 361:2353-2365.
37. Savage SA, Bertuch AA. The genetics and clinical manifestations of telomere biology disorders. Genet Med 2010; 12:753-764.
38. Lansdorp PM. Role of telomerase in hematopoietic stem cells. Ann N Y Acad Sci 2005; 1044:220-227.
39. Wong KK, Maser RS, Bachoo RM, et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 2003; 421:643-648.
40. Allsopp RC, Morin GB, Horner JW, et al. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 2003; 9:369-371.
41. Franceschi C, Bonafe M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003; 31:457-461.
42. Franceschi C, Bonafe M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000; 18:1717-1720.
43. King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol 2011; 11:685-692.
44. Essers MA, Offner S, Blanco-Bose WE, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009; 458:904-908.
45. Baldridge MT, King KY, Boles NC, et al. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 2010; 465:793-797.
46. Feng CG, Weksberg DC, Taylor GA, et al. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2008; 2:83-89.
47. King KY, Baldridge MT, Weksberg DC, et al. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood 2011; 118:1525-1533.
48. Naka K, Hirao A. Maintenance of genomic integrity in hematopoietic stem cells. Int J Hematol 2011; 93:434-439.
49. Ito K, Hirao A, Arai F, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004; 431:997-1002.
50. Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007; 128:325-339.
51. Simsek T, Kocabas F, Zheng J, et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 2010; 7:380-390.
52. Warr MR, Binnewies M, Flach J, et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 2013; 494:323-327
53. Kenyon C. A pathway that links reproductive status to lifespan in Caenorhabditis elegans. Ann N Y Acad Sci 2010; 1204:156-162.
54. Mohrin M, Bourke E, Alexander D, et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell 2010; 7:174-185.
55. Wang J, Sun Q, Morita Y, et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell 2012; 148:1001-1014.
56. Rossi DJ, Seita J, Czechowicz A, et al. Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Cell Cycle 2007; 6:2371-2376.
57. Benz C, Copley MR, Kent DG, et al. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell 2012; 10:273-283. Rigorous analysis of the clonal composition of the HSC compartment during development and aging, showing that the emergence of myeloid biased clones starts in the fetal bone marrow.
58. Yuan Y, Shen H, Franklin DS, et al. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1- phase inhibitor, p18INK4C. Nat Cell Biol 2004; 6:436-442.
59. Montecino-Rodriguez E, Dorshkind K. Evolving patterns of lymphopoiesis from embryogenesis through senescence. Immunity 2006; 24:659-662.
60. Dominguez-Gerpe L, Rey-Mendez M. Evolution of the thymus size in response to physiological and random events throughout life. Microsc Res Tech 2003; 62:464-476.
61. Steinmann GG. Changes in the human thymus during aging. Current topics in pathology. Curr Top Pathol 1986; 75:43-88.
62. Ding L, Morrison SJ. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 2013; 495:231-235.
63. Greenbaum A, Hsu YM, Day RB, et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 2013; 495:227-230
64. Pollina EA, Brunet A. Epigenetic regulation of aging stem cells. Oncogene 2011; 30:3105-3126.
65. Okita K, Yamanaka S. Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci 2011; 366:2198-2207.
66. Wahlestedt M, Norddahl GL, Sten G, et al. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. Blood 2013. [Epub ahead of print]
67. Williams PD, Day T. Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence. Evolution 2003; 57:1478-1488.