-
1
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang H, Chopra R, Verdine GL, Harrison SC: Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 1998, 282:1669-1675.
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
2
-
-
0033621167
-
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with b-branched amino acids
-
Sarafianos SG, Das K, Clark AD Jr, Ding J, Boyer PL, Hughes SH, Arnold E: Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with b-branched amino acids. Proc Natl Acad Sci U S A 1999, 96:10027-10032.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 10027-10032
-
-
Sarafianos, S.G.1
Das, K.2
Clark Jr., A.D.3
Ding, J.4
Boyer, P.L.5
Hughes, S.H.6
Arnold, E.7
-
3
-
-
0035041976
-
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC)
-
Das K, Xiong X, Yang H, Westland CE, Gibbs CS, Sarafianos SG, Arnold E: Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC). J Virol 2001, 75:4771-4779.
-
(2001)
J Virol
, vol.75
, pp. 4771-4779
-
-
Das, K.1
Xiong, X.2
Yang, H.3
Westland, C.E.4
Gibbs, C.S.5
Sarafianos, S.G.6
Arnold, E.7
-
4
-
-
0030892246
-
Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years
-
Winters MA, Shafer RW, Jellinger RA, Mamtora G, Gingeras T, Merigan TC: Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years. Antimicrob Agents Chemother 1997, 41:757-762.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 757-762
-
-
Winters, M.A.1
Shafer, R.W.2
Jellinger, R.A.3
Mamtora, G.4
Gingeras, T.5
Merigan, T.C.6
-
5
-
-
0034088720
-
Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group
-
Harrigan PR, Stone C, Griffin P, Najera I, Bloor S, Kemp S, Tisdale M, Larder B: Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J Infect Dis 2000, 181:912-920.
-
(2000)
J Infect Dis
, vol.181
, pp. 912-920
-
-
Harrigan, P.R.1
Stone, C.2
Griffin, P.3
Najera, I.4
Bloor, S.5
Kemp, S.6
Tisdale, M.7
Larder, B.8
-
6
-
-
33747646240
-
Resistance development over 144 weeks in treatment-naive patients receiving tenofovir disoproxil fumarate or stavudine with lamivudine and efavirenz in Study 903
-
Margot NA, Lu B, Cheng A, Miller MD: Resistance development over 144 weeks in treatment-naive patients receiving tenofovir disoproxil fumarate or stavudine with lamivudine and efavirenz in Study 903. HIV Med 2006, 7:442-450.
-
(2006)
HIV Med
, vol.7
, pp. 442-450
-
-
Margot, N.A.1
Lu, B.2
Cheng, A.3
Miller, M.D.4
-
7
-
-
59649120492
-
Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1
-
Coutsinos D, Invernizzi CF, Xu H, Moisi D, Oliveira M, Brenner BG, Wainberg MA: Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1. J Virol 2009, 83:2029-2033.
-
(2009)
J Virol
, vol.83
, pp. 2029-2033
-
-
Coutsinos, D.1
Invernizzi, C.F.2
Xu, H.3
Moisi, D.4
Oliveira, M.5
Brenner, B.G.6
Wainberg, M.A.7
-
8
-
-
71749100912
-
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance
-
Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD Jr, Boyer PL, Hou X et al.: Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. J Biol Chem 2009, 284:35092-35100.
-
(2009)
J Biol Chem
, vol.284
, pp. 35092-35100
-
-
Das, K.1
Bandwar, R.P.2
White, K.L.3
Feng, J.Y.4
Sarafianos, S.G.5
Tuske, S.6
Tu, X.7
Clark Jr., A.D.8
Boyer, P.L.9
Hou, X.10
-
9
-
-
0033995190
-
HIV-1 reverse transcriptase (RT) genotype and susceptibility to RT inhibitors during abacavir monotherapy and combination therapy
-
Miller V, Ait-Khaled M, Stone C, Griffin P, Mesogiti D, Cutrell A, Harrigan R, Staszewski S, Katlama C, Pearce G et al.: HIV-1 reverse transcriptase (RT) genotype and susceptibility to RT inhibitors during abacavir monotherapy and combination therapy. AIDS 2000, 14:163-171.
-
(2000)
AIDS
, vol.14
, pp. 163-171
-
-
Miller, V.1
Ait-Khaled, M.2
Stone, C.3
Griffin, P.4
Mesogiti, D.5
Cutrell, A.6
Harrigan, R.7
Staszewski, S.8
Katlama, C.9
Pearce, G.10
-
10
-
-
1642543083
-
Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine
-
Stone C, Ait-Khaled M, Craig C, Griffin P, Tisdale M: Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine. Antimicrob Agents Chemother 2004, 48:1413-1415.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 1413-1415
-
-
Stone, C.1
Ait-Khaled, M.2
Craig, C.3
Griffin, P.4
Tisdale, M.5
-
11
-
-
0025950055
-
Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase
-
St Clair MH, Martin JL, Tudor-Williams G, Bach MC, Vavro CL, King DM, Kellam P, Kemp SD, Larder BA: Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 1991, 253:1557-1559.
-
(1991)
Science
, vol.253
, pp. 1557-1559
-
-
St Clair, M.H.1
Martin, J.L.2
Tudor-Williams, G.3
Bach, M.C.4
Vavro, C.L.5
King, D.M.6
Kellam, P.7
Kemp, S.D.8
Larder, B.A.9
-
12
-
-
0027162732
-
Mechanism of resistance of human immunodeficiency virus type 1 to 20,30-dideoxyinosine
-
Martin JL, Wilson JE, Haynes RL, Furman PA: Mechanism of resistance of human immunodeficiency virus type 1 to 20,30-dideoxyinosine. Proc Natl Acad Sci U S A 1993, 90:6135-6139.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 6135-6139
-
-
Martin, J.L.1
Wilson, J.E.2
Haynes, R.L.3
Furman, P.A.4
-
13
-
-
0028940084
-
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
-
Shirasaka T, Kavlick MF, Ueno T, Gao WY, Kojima E, Alcaide ML, Chokekijchai S, Roy BM, Arnold E, Yarchoan R et al.: Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci U S A 1995, 92:2398-2402.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 2398-2402
-
-
Shirasaka, T.1
Kavlick, M.F.2
Ueno, T.3
Gao, W.Y.4
Kojima, E.5
Alcaide, M.L.6
Chokekijchai, S.7
Roy, B.M.8
Arnold, E.9
Yarchoan, R.10
-
14
-
-
0031802175
-
Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy
-
Kavlick MF, Wyvill K, Yarchoan R, Mitsuya H: Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy. J Infect Dis 1998, 177:1506-1513.
-
(1998)
J Infect Dis
, vol.177
, pp. 1506-1513
-
-
Kavlick, M.F.1
Wyvill, K.2
Yarchoan, R.3
Mitsuya, H.4
-
15
-
-
0034696648
-
Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis
-
Kaushik N, Talele TT, Pandey PK, Harris D, Yadav PN, Pandey VN: Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis. Biochemistry 2000, 39:2912-2920.
-
(2000)
Biochemistry
, vol.39
, pp. 2912-2920
-
-
Kaushik, N.1
Talele, T.T.2
Pandey, P.K.3
Harris, D.4
Yadav, P.N.5
Pandey, V.N.6
-
16
-
-
0036829992
-
The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alphaboranophosphate nucleotide analogues
-
Deval J, Selmi B, Boretto J, Egloff MP, Guerreiro C, Sarfati S, Canard B: The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alphaboranophosphate nucleotide analogues. J Biol Chem 2002, 277:42097-42104.
-
(2002)
J Biol Chem
, vol.277
, pp. 42097-42104
-
-
Deval, J.1
Selmi, B.2
Boretto, J.3
Egloff, M.P.4
Guerreiro, C.5
Sarfati, S.6
Canard, B.7
-
17
-
-
0347052875
-
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations
-
Deval J, White KL, Miller MD, Parkin NT, Courcambeck J, Halfon P, Selmi B, Boretto J, Canard B: Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations. J Biol Chem 2004, 279:509-516.
-
(2004)
J Biol Chem
, vol.279
, pp. 509-516
-
-
Deval, J.1
White, K.L.2
Miller, M.D.3
Parkin, N.T.4
Courcambeck, J.5
Halfon, P.6
Selmi, B.7
Boretto, J.8
Canard, B.9
-
18
-
-
0033064963
-
Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an in vitro competitive HIV-1 replication assay
-
Kosalaraksa P, Kavlick MF, Maroun V, Le R, Mitsuya H: Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an in vitro competitive HIV-1 replication assay. J Virol 1999, 73:5356-5363.
-
(1999)
J Virol
, vol.73
, pp. 5356-5363
-
-
Kosalaraksa, P.1
Kavlick, M.F.2
Maroun, V.3
Le Mitsuya, R.H.4
-
19
-
-
0037175023
-
Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir
-
Ray AS, Basavapathruni A, Anderson KS: Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir. J Biol Chem 2002, 277:40479-40490.
-
(2002)
J Biol Chem
, vol.277
, pp. 40479-40490
-
-
Ray, A.S.1
Basavapathruni, A.2
Anderson, K.S.3
-
20
-
-
0024310253
-
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
-
Larder BA, Kemp SD: Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 1989, 246:1155-1158.
-
(1989)
Science
, vol.246
, pp. 1155-1158
-
-
Larder, B.A.1
Kemp, S.D.2
-
21
-
-
0032506055
-
Phenotypic mechanism of HIV-1 resistance to 30-azido-30-deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
-
Arion D, Kaushik N, McCormick S, Borkow G, Parniak MA: Phenotypic mechanism of HIV-1 resistance to 30-azido-30-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 1998, 37:15908-15917.
-
(1998)
Biochemistry
, vol.37
, pp. 15908-15917
-
-
Arion, D.1
Kaushik, N.2
McCormick, S.3
Borkow, G.4
Parniak, M.A.5
-
22
-
-
0032506228
-
Unblocking of chainterminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism
-
Meyer PR, Matsuura SE, So AG, Scott WA: Unblocking of chainterminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism. Proc Natl Acad Sci U S A 1998, 95:13471-13476.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 13471-13476
-
-
Meyer, P.R.1
Matsuura, S.E.2
So, A.G.3
Scott, W.A.4
-
23
-
-
77957797787
-
Structural basis of HIV-1 resistance to AZT by excision
-
Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL et al.: Structural basis of HIV-1 resistance to AZT by excision. Nat Struct Mol Biol 2010, 17:1202-1209.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 1202-1209
-
-
Tu, X.1
Das, K.2
Han, Q.3
Bauman, J.D.4
Clark Jr., A.D.5
Hou, X.6
Frenkel, Y.V.7
Gaffney, B.L.8
Jones, R.A.9
Boyer, P.L.10
-
24
-
-
0033165851
-
A mechanism of AZT resistance: An increase in nucleotidedependent primer unblocking by mutant HIV-1 reverse transcriptase
-
Meyer PR, Matsuura SE, Mian AM, So AG, Scott WA: A mechanism of AZT resistance: an increase in nucleotidedependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol Cell 1999, 4:35-43.
-
(1999)
Mol Cell
, vol.4
, pp. 35-43
-
-
Meyer, P.R.1
Matsuura, S.E.2
Mian, A.M.3
So, A.G.4
Scott, W.A.5
-
25
-
-
0035031936
-
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
-
Boyer PL, Sarafianos SG, Arnold E, Hughes SH: Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. J Virol 2001, 75:4832-4842.
-
(2001)
J Virol
, vol.75
, pp. 4832-4842
-
-
Boyer, P.L.1
Sarafianos, S.G.2
Arnold, E.3
Hughes, S.H.4
-
26
-
-
79952182044
-
Structures of reverse transcriptase pre-and postexcision complexes shed new light on HIV-1 AZT resistance
-
Scott WA: Structures of reverse transcriptase pre-and postexcision complexes shed new light on HIV-1 AZT resistance. Viruses 2011, 3:20-25.
-
(2011)
Viruses
, vol.3
, pp. 20-25
-
-
Scott, W.A.1
-
27
-
-
0026570624
-
Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects
-
Boucher CA, O'Sullivan E, Mulder JW, Ramautarsing C, Kellam P, Darby G, Lange JM, Goudsmit J, Larder BA: Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects. J Infect Dis 1992, 165:105-110.
-
(1992)
J Infect Dis
, vol.165
, pp. 105-110
-
-
Boucher, C.A.1
O'Sullivan, E.2
Mulder, J.W.3
Ramautarsing, C.4
Kellam, P.5
Darby, G.6
Lange, J.M.7
Goudsmit, J.8
Larder, B.A.9
-
28
-
-
0035837049
-
Evolution of AZT resistance in HIV-1: The 41-70 intermediate that is not observed in vivo has a replication defect
-
Jeeninga RE, Keulen W, Boucher C, Sanders RW, Berkhout B: Evolution of AZT resistance in HIV-1: the 41-70 intermediate that is not observed in vivo has a replication defect. Virology 2001, 283:294-305.
-
(2001)
Virology
, vol.283
, pp. 294-305
-
-
Jeeninga, R.E.1
Keulen, W.2
Boucher, C.3
Sanders, R.W.4
Berkhout, B.5
-
30
-
-
0031958266
-
Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro
-
Harrigan PR, Bloor S, Larder BA: Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro. J Virol 1998, 72:3773-3778.
-
(1998)
J Virol
, vol.72
, pp. 3773-3778
-
-
Harrigan, P.R.1
Bloor, S.2
Larder, B.A.3
-
31
-
-
33745778007
-
Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1
-
Hu Z, Giguel F, Hatano H, Reid P, Lu J, Kuritzkes DR: Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1. J Virol 2006, 80:7020-7027.
-
(2006)
J Virol
, vol.80
, pp. 7020-7027
-
-
Hu, Z.1
Giguel, F.2
Hatano, H.3
Reid, P.4
Lu, J.5
Kuritzkes, D.R.6
-
32
-
-
0033014502
-
HIV resistance to zidovudine: The role of pyrophosphorolysis
-
Arion D, Parniak MA: HIV resistance to zidovudine: the role of pyrophosphorolysis. Drug Resist Updat 1999, 2:91-95.
-
(1999)
Drug Resist Updat
, vol.2
, pp. 91-95
-
-
Arion, D.1
Parniak, M.A.2
-
33
-
-
0032701542
-
Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergoing combination therapy: Survey of 787 sequences
-
Yahi N, Tamalet C, Tourres C, Tivoli N, Ariasi F, Volot F, Gastaut JA, Gallais H, Moreau J, Fantini J: Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergoing combination therapy: survey of 787 sequences. J Clin Microbiol 1999, 37:4099-4106.
-
(1999)
J Clin Microbiol
, vol.37
, pp. 4099-4106
-
-
Yahi, N.1
Tamalet, C.2
Tourres, C.3
Tivoli, N.4
Ariasi, F.5
Volot, F.6
Gastaut, J.A.7
Gallais, H.8
Moreau, J.9
Fantini, J.10
-
34
-
-
19244372885
-
Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine
-
Garcia-Lerma JG, MacInnes H, Bennett D, Weinstock H, Heneine W: Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine. J Virol 2004, 78:7545-7552.
-
(2004)
J Virol
, vol.78
, pp. 7545-7552
-
-
Garcia-Lerma, J.G.1
MacInnes, H.2
Bennett, D.3
Weinstock, H.4
Heneine, W.5
-
35
-
-
0029843986
-
Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility
-
Harrigan PR, Kinghorn I, Bloor S, Kemp SD, Najera I, Kohli A, Larder BA: Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility. J Virol 1996, 70:5930-5934.
-
(1996)
J Virol
, vol.70
, pp. 5930-5934
-
-
Harrigan, P.R.1
Kinghorn, I.2
Bloor, S.3
Kemp, S.D.4
Najera, I.5
Kohli, A.6
Larder, B.A.7
-
36
-
-
10244227943
-
An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 30-azido-30-deoxythymidine
-
Hooker DJ, Tachedjian G, Solomon AE, Gurusinghe AD, Land S, Birch C, Anderson JL, Roy BM, Arnold E, Deacon NJ: An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 30-azido-30- deoxythymidine. J Virol 1996, 70:8010-8018.
-
(1996)
J Virol
, vol.70
, pp. 8010-8018
-
-
Hooker, D.J.1
Tachedjian, G.2
Solomon, A.E.3
Gurusinghe, A.D.4
Land, S.5
Birch, C.6
Anderson, J.L.7
Roy, B.M.8
Arnold, E.9
Deacon, N.J.10
-
37
-
-
0034329473
-
Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance
-
Mas A, Parera M, Briones C, Soriano V, Martinez MA, Domingo E, Menendez-Arias L: Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance. EMBO J 2000, 19:5752-5761.
-
(2000)
EMBO J
, vol.19
, pp. 5752-5761
-
-
Mas, A.1
Parera, M.2
Briones, C.3
Soriano, V.4
Martinez, M.A.5
Domingo, E.6
Menendez-Arias, L.7
-
38
-
-
0036720770
-
Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision
-
Boyer PL, Sarafianos SG, Arnold E, Hughes SH: Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision. J Virol 2002, 76:9143-9151.
-
(2002)
J Virol
, vol.76
, pp. 9143-9151
-
-
Boyer, P.L.1
Sarafianos, S.G.2
Arnold, E.3
Hughes, S.H.4
-
39
-
-
0037334586
-
Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation
-
Meyer PR, Lennerstrand J, Matsuura SE, Larder BA, Scott WA: Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation. J Virol 2003, 77:3871-3877.
-
(2003)
J Virol
, vol.77
, pp. 3871-3877
-
-
Meyer, P.R.1
Lennerstrand, J.2
Matsuura, S.E.3
Larder, B.A.4
Scott, W.A.5
-
40
-
-
1442349112
-
Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analogassociated mutations
-
White KL, Chen JM, Margot NA, Wrin T, Petropoulos CJ, Naeger LK, Swaminathan S, Miller MD: Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analogassociated mutations. Antimicrob Agents Chemother 2004, 48:992-1003.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 992-1003
-
-
White, K.L.1
Chen, J.M.2
Margot, N.A.3
Wrin, T.4
Petropoulos, C.J.5
Naeger, L.K.6
Swaminathan, S.7
Miller, M.D.8
-
41
-
-
0034469498
-
Relative replication fitness of a high-level 30-azido-30-deoxythymidine- resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr!Gly) at codon 69
-
Imamichi T, Berg SC, Imamichi H, Lopez JC, Metcalf JA, Falloon J, Lane HC: Relative replication fitness of a high-level 30-azido-30-deoxythymidine- resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr!Gly) at codon 69. J Virol 2000, 74:10958-10964.
-
(2000)
J Virol
, vol.74
, pp. 10958-10964
-
-
Imamichi, T.1
Berg, S.C.2
Imamichi, H.3
Lopez, J.C.4
Metcalf, J.A.5
Falloon, J.6
Lane, H.C.7
-
42
-
-
4444355318
-
Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision
-
Boyer PL, Imamichi T, Sarafianos SG, Arnold E, Hughes SH: Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. J Virol 2004, 78:9987-9997.
-
(2004)
J Virol
, vol.78
, pp. 9987-9997
-
-
Boyer, P.L.1
Imamichi, T.2
Sarafianos, S.G.3
Arnold, E.4
Hughes, S.H.5
-
43
-
-
34547647484
-
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase
-
Deval J, Powdrill MH, D'Abramo CM, Cellai L, Gotte M: Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother 2007, 51:2920-2928.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 2920-2928
-
-
Deval, J.1
Powdrill, M.H.2
D'Abramo, C.M.3
Cellai, L.4
Gotte, M.5
-
44
-
-
84873199670
-
NTP-mediated nucleotide excision activity of hepatitis C virus RNAdependent RNA polymerase
-
Jin Z, Leveque V, Ma H, Johnson KA, Klumpp K: NTP-mediated nucleotide excision activity of hepatitis C virus RNAdependent RNA polymerase. Proc Natl Acad Sci U S A 2013, 110:E348-E357.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
-
-
Jin, Z.1
Leveque, V.2
Ma, H.3
Johnson, K.A.4
Klumpp, K.5
-
45
-
-
84857955750
-
A quantitative basis for antiretroviral therapy for HIV-1 infection
-
Jilek BL, Zarr M, Sampah ME, Rabi SA, Bullen CK, Lai J, Shen L, Siliciano RF: A quantitative basis for antiretroviral therapy for HIV-1 infection. Nat Med 2012, 18:446-451.
-
(2012)
Nat Med
, vol.18
, pp. 446-451
-
-
Jilek, B.L.1
Zarr, M.2
Sampah, M.E.3
Rabi, S.A.4
Bullen, C.K.5
Lai, J.6
Shen, L.7
Siliciano, R.F.8
-
46
-
-
84860168379
-
Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility
-
Melikian GL, Rhee SY, Taylor J, Fessel WJ, Kaufman D, Towner W, Troia-Cancio PV, Zolopa A, Robbins GK, Kagan R et al.: Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. Antimicrob Agents Chemother 2012, 56:2305-2313.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 2305-2313
-
-
Melikian, G.L.1
Rhee, S.Y.2
Taylor, J.3
Fessel, W.J.4
Kaufman, D.5
Towner, W.6
Troia-Cancio, P.V.7
Zolopa, A.8
Robbins, G.K.9
Kagan, R.10
-
47
-
-
22544472176
-
Comparative selection of the K65R and M184V/I mutations in human immunodeficiency virus type 1-infected patients enrolled in a trial of first-line triple-nucleoside analog therapy (Tonus IMEA 021)
-
Delaunay C, Brun-Vezinet F, Landman R, Collin G, Peytavin G, Trylesinski A, Flandre P, Miller M, Descamps D: Comparative selection of the K65R and M184V/I mutations in human immunodeficiency virus type 1-infected patients enrolled in a trial of first-line triple-nucleoside analog therapy (Tonus IMEA 021). J Virol 2005, 79:9572-9578.
-
(2005)
J Virol
, vol.79
, pp. 9572-9578
-
-
Delaunay, C.1
Brun-Vezinet, F.2
Landman, R.3
Collin, G.4
Peytavin, G.5
Trylesinski, A.6
Flandre, P.7
Miller, M.8
Descamps, D.9
-
48
-
-
0036839746
-
Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R + M184V and their effects on enzyme function and viral replication capacity
-
White KL, Margot NA, Wrin T, Petropoulos CJ, Miller MD, Naeger LK: Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R + M184V and their effects on enzyme function and viral replication capacity. Antimicrob Agents Chemother 2002, 46:3437-3446.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3437-3446
-
-
White, K.L.1
Margot, N.A.2
Wrin, T.3
Petropoulos, C.J.4
Miller, M.D.5
Naeger, L.K.6
-
49
-
-
2942616457
-
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions
-
Deval J, Navarro JM, Selmi B, Courcambeck J, Boretto J, Halfon P, Garrido-Urbani S, Sire J, Canard B: A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions. J Biol Chem 2004, 279:25489-25496.
-
(2004)
J Biol Chem
, vol.279
, pp. 25489-25496
-
-
Deval, J.1
Navarro, J.M.2
Selmi, B.3
Courcambeck, J.4
Boretto, J.5
Halfon, P.6
Garrido-Urbani, S.7
Sire, J.8
Canard, B.9
-
50
-
-
1642528440
-
Replication-dependent 65R!K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V
-
Sharma PL, Nurpeisov V, Lee K, Skaggs S, Di San Filippo CA, Schinazi RF: Replication-dependent 65RK reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65!R + L74V. Virology 2004, 321:222-234.
-
(2004)
Virology
, vol.321
, pp. 222-234
-
-
Sharma, P.L.1
Nurpeisov, V.2
Lee, K.3
Skaggs, S.4
Di San Filippo, C.A.5
Schinazi, R.F.6
-
51
-
-
42149172733
-
Prevalence, genotypic associations and phenotypic characterization of K65R, L74V and other HIV-1 RT resistance mutations in a commercial database
-
McColl DJ, Chappey C, Parkin NT, Miller MD: Prevalence, genotypic associations and phenotypic characterization of K65R, L74V and other HIV-1 RT resistance mutations in a commercial database. Antivir Ther 2008, 13:189-197.
-
(2008)
Antivir Ther
, vol.13
, pp. 189-197
-
-
McColl, D.J.1
Chappey, C.2
Parkin, N.T.3
Miller, M.D.4
-
52
-
-
21444452131
-
The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations
-
Miranda LR, Gotte M, Liang F, Kuritzkes DR: The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations. Antimicrob Agents Chemother 2005, 49:2648-2656.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 2648-2656
-
-
Miranda, L.R.1
Gotte, M.2
Liang, F.3
Kuritzkes, D.R.4
-
53
-
-
34548313857
-
Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways
-
Van Laethem K, Pannecouque C, Vandamme AM: Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways. Infect Genet Evol 2007, 7:600-603.
-
(2007)
Infect Genet Evol
, vol.7
, pp. 600-603
-
-
Van Laethem, K.1
Pannecouque, C.2
Vandamme, A.M.3
-
54
-
-
79251583792
-
K70Q adds highlevel tenofovir resistance to 'Q151M complex' HIV reverse transcriptase through the enhanced discrimination mechanism
-
Hachiya A, Kodama EN, Schuckmann MM, Kirby KA, Michailidis E, Sakagami Y, Oka S, Singh K, Sarafianos SG: K70Q adds highlevel tenofovir resistance to 'Q151M complex' HIV reverse transcriptase through the enhanced discrimination mechanism. PLoS ONE 2011, 6:e16242.
-
(2011)
PLoS ONE
, vol.6
-
-
Hachiya, A.1
Kodama, E.N.2
Schuckmann, M.M.3
Kirby, K.A.4
Michailidis, E.5
Sakagami, Y.6
Oka, S.7
Singh, K.8
Sarafianos, S.G.9
-
55
-
-
10744231684
-
Tenofovir resistance and resensitization
-
Wolf K, Walter H, Beerenwinkel N, Keulen W, Kaiser R, Hoffmann D, Lengauer T, Selbig J, Vandamme AM, Korn K et al.: Tenofovir resistance and resensitization. Antimicrob Agents Chemother 2003, 47:3478-3484.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 3478-3484
-
-
Wolf, K.1
Walter, H.2
Beerenwinkel, N.3
Keulen, W.4
Kaiser, R.5
Hoffmann, D.6
Lengauer, T.7
Selbig, J.8
Vandamme, A.M.9
Korn, K.10
-
56
-
-
27544431950
-
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT
-
White KL, Margot NA, Ly JK, Chen JM, Ray AS, Pavelko M, Wang R, McDermott M, Swaminathan S, Miller MD: A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT. AIDS 2005, 19:1751-1760.
-
(2005)
AIDS
, vol.19
, pp. 1751-1760
-
-
White, K.L.1
Margot, N.A.2
Ly, J.K.3
Chen, J.M.4
Ray, A.S.5
Pavelko, M.6
Wang, R.7
McDermott, M.8
Swaminathan, S.9
Miller, M.D.10
-
57
-
-
33646440592
-
The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations
-
Parikh UM, Bacheler L, Koontz D, Mellors JW: The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations. J Virol 2006, 80:4971-4977.
-
(2006)
J Virol
, vol.80
, pp. 4971-4977
-
-
Parikh, U.M.1
Bacheler, L.2
Koontz, D.3
Mellors, J.W.4
-
58
-
-
33845997466
-
Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors
-
Sluis-Cremer N, Sheen CW, Zelina S, Torres PS, Parikh UM, Mellors JW: Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 2007, 51:48-53.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 48-53
-
-
Sluis-Cremer, N.1
Sheen, C.W.2
Zelina, S.3
Torres, P.S.4
Parikh, U.M.5
Mellors, J.W.6
-
59
-
-
0029028067
-
Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
-
Larder BA, Kemp SD, Harrigan PR: Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science 1995, 269:696-699.
-
(1995)
Science
, vol.269
, pp. 696-699
-
-
Larder, B.A.1
Kemp, S.D.2
Harrigan, P.R.3
-
60
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
-
Spence RA, Kati WM, Anderson KS, Johnson KA: Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 1995, 267:988-993.
-
(1995)
Science
, vol.267
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anderson, K.S.3
Johnson, K.A.4
-
61
-
-
0029150042
-
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors
-
Rittinger K, Divita G, Goody RS: Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors. Proc Natl Acad Sci U S A 1995, 92:8046-8049.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 8046-8049
-
-
Rittinger, K.1
Divita, G.2
Goody, R.S.3
-
62
-
-
43449118968
-
Dynamic binding orientations direct activity of HIV reverse transcriptase
-
Abbondanzieri EA, Bokinsky G, Rausch JW, Zhang JX, Le Grice SF, Zhuang X: Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature 2008, 453:184-189.
-
(2008)
Nature
, vol.453
, pp. 184-189
-
-
Abbondanzieri, E.A.1
Bokinsky, G.2
Rausch, J.W.3
Zhang, J.X.4
Le Grice, S.F.5
Zhuang, X.6
-
63
-
-
56449114709
-
Slide into action: Dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates
-
Liu S, Abbondanzieri EA, Rausch JW, Le Grice SF, Zhuang X: Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates. Science 2008, 322:1092-1097.
-
(2008)
Science
, vol.322
, pp. 1092-1097
-
-
Liu, S.1
Abbondanzieri, E.A.2
Rausch, J.W.3
Le Grice, S.F.4
Zhuang, X.5
-
64
-
-
0026693137
-
Crystal structure at 3.5 A ° resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA: Crystal structure at 3.5 A ° resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 1992, 256:1783-1790.
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
65
-
-
0028947588
-
High resolution structures of HIV-1 RT from four RT-inhibitor complexes
-
Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D et al.: High resolution structures of HIV-1 RT from four RT-inhibitor complexes. Nat Struct Biol 1995, 2:293-302.
-
(1995)
Nat Struct Biol
, vol.2
, pp. 293-302
-
-
Ren, J.1
Esnouf, R.2
Garman, E.3
Somers, D.4
Ross, C.5
Kirby, I.6
Keeling, J.7
Darby, G.8
Jones, Y.9
Stuart, D.10
-
66
-
-
34547578940
-
Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses
-
Xia Q, Radzio J, Anderson KS, Sluis-Cremer N: Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Sci 2007, 16:1728-1737.
-
(2007)
Protein Sci
, vol.16
, pp. 1728-1737
-
-
Xia, Q.1
Radzio, J.2
Anderson, K.S.3
Sluis-Cremer, N.4
-
67
-
-
0030596068
-
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant
-
Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL et al.: Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol 1996, 264:1085-1100.
-
(1996)
J Mol Biol
, vol.264
, pp. 1085-1100
-
-
Das, K.1
Ding, J.2
Hsiou, Y.3
Clark Jr., A.D.4
Moereels, H.5
Koymans, L.6
Andries, K.7
Pauwels, R.8
Janssen, P.A.9
Boyer, P.L.10
-
68
-
-
84856711380
-
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals nonnucleoside inhibition mechanism
-
Das K, Martinez SE, Bauman JD, Arnold E: HIV-1 reverse transcriptase complex with DNA and nevirapine reveals nonnucleoside inhibition mechanism. Nat Struct Mol Biol 2012, 19:253-259.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 253-259
-
-
Das, K.1
Martinez, S.E.2
Bauman, J.D.3
Arnold, E.4
-
69
-
-
33751529192
-
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097
-
Das K, Sarafianos SG, Clark AD Jr, Boyer PL, Hughes SH, Arnold E: Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. J Mol Biol 2007, 365:77-89.
-
(2007)
J Mol Biol
, vol.365
, pp. 77-89
-
-
Das, K.1
Sarafianos, S.G.2
Clark Jr., A.D.3
Boyer, P.L.4
Hughes, S.H.5
Arnold, E.6
-
70
-
-
0029147651
-
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication
-
Kleim JP, Bender R, Kirsch R, Meichsner C, Paessens A, Rosner M, Rubsamen-Waigmann H, Kaiser R, Wichers M, Schneweis KE et al.: Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother 1995, 39:2253-2257.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 2253-2257
-
-
Kleim, J.P.1
Bender, R.2
Kirsch, R.3
Meichsner, C.4
Paessens, A.5
Rosner, M.6
Rubsamen-Waigmann, H.7
Kaiser, R.8
Wichers, M.9
Schneweis, K.E.10
-
71
-
-
0037223722
-
Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication
-
Huang W, Gamarnik A, Limoli K, Petropoulos CJ, Whitcomb JM: Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication. J Virol 2003, 77:1512-1523.
-
(2003)
J Virol
, vol.77
, pp. 1512-1523
-
-
Huang, W.1
Gamarnik, A.2
Limoli, K.3
Petropoulos, C.J.4
Whitcomb, J.M.5
-
72
-
-
80055119045
-
Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations
-
Xu HT, Asahchop EL, Oliveira M, Quashie PK, Quan Y, Brenner BG, Wainberg MA: Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations. J Virol 2011, 85:11300-11308.
-
(2011)
J Virol
, vol.85
, pp. 11300-11308
-
-
Xu, H.T.1
Asahchop, E.L.2
Oliveira, M.3
Quashie, P.K.4
Quan, Y.5
Brenner, B.G.6
Wainberg, M.A.7
-
73
-
-
84862777419
-
Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: Pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials
-
Cohen CJ, Molina JM, Cahn P, Clotet B, Fourie J, Grinsztejn B, Wu H, Johnson MA, Saag M, Supparatpinyo K et al.: Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials. J Acquir Immune Defic Syndr 2012, 60:33-42.
-
(2012)
J Acquir Immune Defic Syndr
, vol.60
, pp. 33-42
-
-
Cohen, C.J.1
Molina, J.M.2
Cahn, P.3
Clotet, B.4
Fourie, J.5
Grinsztejn, B.6
Wu, H.7
Johnson, M.A.8
Saag, M.9
Supparatpinyo, K.10
-
74
-
-
0030586090
-
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: Implications of conformational changes for polymerization and inhibition mechanisms
-
Hsiou Y, Ding J, Das K, Clark AD Jr, Hughes SH, Arnold E: Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure 1996, 4:853-860.
-
(1996)
Structure
, vol.4
, pp. 853-860
-
-
Hsiou, Y.1
Ding, J.2
Das, K.3
Clark Jr., A.D.4
Hughes, S.H.5
Arnold, E.6
-
75
-
-
40349091258
-
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
-
Das K, Bauman JD, Clark AD Jr, Frenkel YV, Lewi PJ, Shatkin AJ, Hughes SH, Arnold E: High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Proc Natl Acad Sci U S A 2008, 105:1466-1471.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 1466-1471
-
-
Das, K.1
Bauman, J.D.2
Clark Jr., A.D.3
Frenkel, Y.V.4
Lewi, P.J.5
Shatkin, A.J.6
Hughes, S.H.7
Arnold, E.8
-
76
-
-
1842779905
-
Structural and energetic analyses of the effects of the K103N mutation of HIV-1 reverse transcriptase on efavirenz analogues
-
Udier-Blagovic M, Tirado-Rives J, Jorgensen WL: Structural and energetic analyses of the effects of the K103N mutation of HIV-1 reverse transcriptase on efavirenz analogues. J Med Chem 2004, 47:2389-2392.
-
(2004)
J Med Chem
, vol.47
, pp. 2389-2392
-
-
Udier-Blagovic, M.1
Tirado-Rives, J.2
Jorgensen, W.L.3
-
77
-
-
33746838109
-
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138
-
Ren J, Nichols CE, Stamp A, Chamberlain PP, Ferris R, Weaver KL, Short SA, Stammers DK: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. FEBS J 2006, 273:3850-3860.
-
(2006)
FEBS J
, vol.273
, pp. 3850-3860
-
-
Ren, J.1
Nichols, C.E.2
Stamp, A.3
Chamberlain, P.P.4
Ferris, R.5
Weaver, K.L.6
Short, S.A.7
Stammers, D.K.8
-
78
-
-
79955434216
-
Crystal structure of tert-butyldimethylsilylspiroaminooxathioledioxide- thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket
-
Das K, Bauman JD, Rim AS, Dharia C, Clark AD Jr, Camarasa MJ, Balzarini J, Arnold E: Crystal structure of tert- butyldimethylsilylspiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. J Med Chem 2011, 54:2727-2737.
-
(2011)
J Med Chem
, vol.54
, pp. 2727-2737
-
-
Das, K.1
Bauman, J.D.2
Rim, A.S.3
Dharia, C.4
Clark Jr., A.D.5
Camarasa, M.J.6
Balzarini, J.7
Arnold, E.8
-
79
-
-
84868307748
-
Biochemical mechanism of HIV-1 resistance to rilpivirine
-
Singh K, Marchand B, Rai DK, Sharma B, Michailidis E, Ryan EM, Matzek KB, Leslie MD, Hagedorn AN, Li Z et al.: Biochemical mechanism of HIV-1 resistance to rilpivirine. J Biol Chem 2012, 287:38110-38123.
-
(2012)
J Biol Chem
, vol.287
, pp. 38110-38123
-
-
Singh, K.1
Marchand, B.2
Rai, D.K.3
Sharma, B.4
Michailidis, E.5
Ryan, E.M.6
Matzek, K.B.7
Leslie, M.D.8
Hagedorn, A.N.9
Li, Z.10
-
80
-
-
0142040125
-
The Y181C substitution in 30-azido-30-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 30-azido-30-deoxythymidine 50-monophosphateterminated primer
-
Selmi B, Deval J, Alvarez K, Boretto J, Sarfati S, Guerreiro C, Canard B: The Y181C substitution in 30-azido-30-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 30-azido-30-deoxythymidine 50-monophosphateterminated primer. J Biol Chem 2003, 278:40464-40472.
-
(2003)
J Biol Chem
, vol.278
, pp. 40464-40472
-
-
Selmi, B.1
Deval, J.2
Alvarez, K.3
Boretto, J.4
Sarfati, S.5
Guerreiro, C.6
Canard, B.7
-
81
-
-
79953745195
-
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: A systematic review and pooled analysis
-
Li JZ, Paredes R, Ribaudo HJ, Svarovskaia ES, Metzner KJ, Kozal MJ, Hullsiek KH, Balduin M, Jakobsen MR, Geretti AM et al.: Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis. JAMA 2011, 305:1327-1335.
-
(2011)
JAMA
, vol.305
, pp. 1327-1335
-
-
Li, J.Z.1
Paredes, R.2
Ribaudo, H.J.3
Svarovskaia, E.S.4
Metzner, K.J.5
Kozal, M.J.6
Hullsiek, K.H.7
Balduin, M.8
Jakobsen, M.R.9
Geretti, A.M.10
-
82
-
-
84869762811
-
Vaginal rings for delivery of HIV microbicides
-
Malcolm RK, Fetherston SM, McCoy CF, Boyd P, Major I: Vaginal rings for delivery of HIV microbicides. Int J Womens Health 2012, 4:595-605.
-
(2012)
Int J Womens Health
, vol.4
, pp. 595-605
-
-
Malcolm, R.K.1
Fetherston, S.M.2
McCoy, C.F.3
Boyd, P.4
Major, I.5
-
83
-
-
84859231900
-
2011 update of the drug resistance mutations in HIV-1
-
Johnson VA, Calvez V, Gunthard HF, Paredes R, Pillay D, Shafer R, Wensing AM, Richman DD: 2011 update of the drug resistance mutations in HIV-1. Top Antivir Med 2011, 19:156-164.
-
(2011)
Top Antivir Med
, vol.19
, pp. 156-164
-
-
Johnson, V.A.1
Calvez, V.2
Gunthard, H.F.3
Paredes, R.4
Pillay, D.5
Shafer, R.6
Wensing, A.M.7
Richman, D.D.8
-
84
-
-
79960381844
-
Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): A phase 3 randomised double-blind active-controlled trial
-
Molina JM, Cahn P, Grinsztejn B, Lazzarin A, Mills A, Saag M, Supparatpinyo K, Walmsley S, Crauwels H, Rimsky LT et al.: Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial. Lancet 2011, 378:238-246.
-
(2011)
Lancet
, vol.378
, pp. 238-246
-
-
Molina, J.M.1
Cahn, P.2
Grinsztejn, B.3
Lazzarin, A.4
Mills, A.5
Saag, M.6
Supparatpinyo, K.7
Walmsley, S.8
Crauwels, H.9
Rimsky, L.T.10
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