-
1
-
-
0027373308
-
High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase
-
Boucher, C. A., N. Cammack, P. Schipper, R. Schuurman, P. Rouse, M. A. Wainberg, and J. M. Cameron. 1993. High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 37:2231-2234.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 2231-2234
-
-
Boucher, C.A.1
Cammack, N.2
Schipper, P.3
Schuurman, R.4
Rouse, P.5
Wainberg, M.A.6
Cameron, J.M.7
-
2
-
-
0026570624
-
Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects
-
Boucher, C. A., E. O'Sullivan, J. W. Mulder, C. Ramautarsing, P. Kellam, G. Darby, J. M. Lange, J. Goudsmit, and B. A. Larder. 1992. Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects. J. Infect. Dis. 165:105-110.
-
(1992)
J. Infect. Dis.
, vol.165
, pp. 105-110
-
-
Boucher, C.A.1
O'Sullivan, E.2
Mulder, J.W.3
Ramautarsing, C.4
Kellam, P.5
Darby, G.6
Lange, J.M.7
Goudsmit, J.8
Larder, B.A.9
-
3
-
-
0028952146
-
HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
-
Caffin, J. M. 1995. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267:483-489.
-
(1995)
Science
, vol.267
, pp. 483-489
-
-
Caffin, J.M.1
-
4
-
-
0023268502
-
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS related complex: A double-blind, placebo-controlled trial
-
Fischl, M., D. D. Richman, M. Grieco, et al. 1987. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS related complex: a double-blind, placebo-controlled trial. N. Engl. J. Med. 317:185-191.
-
(1987)
N. Engl. J. Med.
, vol.317
, pp. 185-191
-
-
Fischl, M.1
Richman, D.D.2
Grieco, M.3
-
5
-
-
0027363310
-
Human immunodeficiency virus type 1 pol gene mutations in an AIDS patient treated with multiple antiretroviral drugs
-
Fitzgibbon, J. E., A. E. Farnham, S. J. Sperber, H. Kim, and D. T. Dubin. 1993. Human immunodeficiency virus type 1 pol gene mutations in an AIDS patient treated with multiple antiretroviral drugs. J. Virol. 67:7271-7275.
-
(1993)
J. Virol.
, vol.67
, pp. 7271-7275
-
-
Fitzgibbon, J.E.1
Farnham, A.E.2
Sperber, S.J.3
Kim, H.4
Dubin, D.T.5
-
6
-
-
0342732408
-
Nucleoside monotherapy (MT) vs combination therapy (CT) in HIV infected adults: A randomised double blind placebo controlled trial in persons with CD4 counts between 200 and 500 cells/mm3
-
26 to 29 Sept. 1995, Copenhagen, Denmark
-
Hammer, S., D. Katzenstein, M. Hughes, H. Grundacker, M. Hirsch, and T. Merigan, for the ACTG 175 Study Team. 1995. Nucleoside monotherapy (MT) vs combination therapy (CT) in HIV infected adults: a randomised double blind placebo controlled trial in persons with CD4 counts between 200 and 500 cells/mm3. Presented at the 5th European Conference on Clinical Aspects and Treatment of HIV Infection, 26 to 29 Sept. 1995, Copenhagen, Denmark.
-
(1995)
5th European Conference on Clinical Aspects and Treatment of HIV Infection
-
-
Hammer, S.1
Katzenstein, D.2
Hughes, M.3
Grundacker, H.4
Hirsch, M.5
Merigan, T.6
-
7
-
-
0022404296
-
Infection of HTLV-III/ LAV in HTLV-1 carrying cells MT-2 and MT-4 and application in a plaque assay
-
Harada, S., Y. Koyanagi, and N. Yamamoto. 1985. Infection of HTLV-III/ LAV in HTLV-1 carrying cells MT-2 and MT-4 and application in a plaque assay. Science 229:563-566.
-
(1985)
Science
, vol.229
, pp. 563-566
-
-
Harada, S.1
Koyanagi, Y.2
Yamamoto, N.3
-
8
-
-
34447490985
-
High level resistance to AZT in association with a leueine to tryptophan change at amino acid 210 of HIV-1 reverse transcriptase
-
Jan. 29-Feb. 2. Washington, D.C.
-
Hooker, D., G. Tachedjian, A. Soloman, A. Gurusinghe, S. Land, C. Birch, B. Roy, C. Tantillo, E. Arnold, and N, Deacon. High level resistance to AZT in association with a leueine to tryptophan change at amino acid 210 of HIV-1 reverse transcriptase. Presented at the 2nd National Conference on Human Retroviruses and Related Infections, Jan. 29-Feb. 2. Washington, D.C.
-
2nd National Conference on Human Retroviruses and Related Infections
-
-
Hooker, D.1
Tachedjian, G.2
Soloman, A.3
Gurusinghe, A.4
Land, S.5
Birch, C.6
Roy, B.7
Tantillo, C.8
Arnold, E.9
Deacon, N.10
-
9
-
-
0029057799
-
Early or deferred zidovudine therapy in HIV-infected patients without an AIDS-defining illness
-
Ioannidis, J. P., J. C. Cappelleri, J. Lau, P. R Skolnik, B. Melville, T. C. Chalmers, and H. S. Sacks. 1995. Early or deferred zidovudine therapy in HIV-infected patients without an AIDS-defining illness. Ann. Intern. Med. 122:856-66.
-
(1995)
Ann. Intern. Med.
, vol.122
, pp. 856-866
-
-
Ioannidis, J.P.1
Cappelleri, J.C.2
Lau, J.3
Skolnik, P.R.4
Melville, B.5
Chalmers, T.C.6
Sacks, H.S.7
-
10
-
-
8944225025
-
Safety and efficacy of lamivudine/zidovudine combination in antiretroviral naive HIV-1 infected patients: A comparison with zidovudine monotherapy
-
Katlama, C., D. Ingrand, C. Loveday, A. M. Hill, G. Pearce, H. McDade, and the Lamivudine European HIV Working Group. 1996. Safety and efficacy of lamivudine/zidovudine combination in antiretroviral naive HIV-1 infected patients: a comparison with zidovudine monotherapy. JAMA 276:118-125.
-
(1996)
JAMA
, vol.276
, pp. 118-125
-
-
Katlama, C.1
Ingrand, D.2
Loveday, C.3
Hill, A.M.4
Pearce, G.5
McDade, H.6
-
11
-
-
0026565278
-
Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
-
Kellam, P., C. A. Boucher, and B. A. Larder. 1992. Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Proc. Natl. Acid. Sci. USA 89:1934-1938.
-
(1992)
Proc. Natl. Acid. Sci. USA
, vol.89
, pp. 1934-1938
-
-
Kellam, P.1
Boucher, C.A.2
Larder, B.A.3
-
12
-
-
0027954914
-
Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance
-
Kellam, P., C. A. B. Boucher, J. M. G. H. Tijnagel, and B. A. Larder. 1994. Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance. J. Gen. Virol. 75:341-351.
-
(1994)
J. Gen. Virol.
, vol.75
, pp. 341-351
-
-
Kellam, P.1
Boucher, C.A.B.2
Tijnagel, J.M.G.H.3
Larder, B.A.4
-
13
-
-
0028085161
-
Recombinant virus assay: A rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates
-
Kellam, P., and B. A. Larder. 1994. Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates. Antimicrob. Agents Chemother. 38:23-30.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 23-30
-
-
Kellam, P.1
Larder, B.A.2
-
14
-
-
0028323494
-
Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase
-
Larder, B. A. 1995. Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase. J. Gen. Virol. 75:951-957.
-
(1995)
J. Gen. Virol.
, vol.75
, pp. 951-957
-
-
Larder, B.A.1
-
15
-
-
0025138304
-
Susceptibility of zidovudine-sensitive and -resistant human immunodeficiency virus isolates to antiviral agents determined using a quantitative plaque reduction assay
-
Larder, B. A., B. Cheesbro, and D. D. Richman. 1990. Susceptibility of zidovudine-sensitive and -resistant human immunodeficiency virus isolates to antiviral agents determined using a quantitative plaque reduction assay. Antimicrob. Agents Chemother. 34:436-441.
-
(1990)
Antimicrob. Agents Chemother.
, vol.34
, pp. 436-441
-
-
Larder, B.A.1
Cheesbro, B.2
Richman, D.D.3
-
16
-
-
0024508058
-
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
-
Larder, B. A., G. Darby, and D. D. Richman. 1989. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 243:1731-1734.
-
(1989)
Science
, vol.243
, pp. 1731-1734
-
-
Larder, B.A.1
Darby, G.2
Richman, D.D.3
-
17
-
-
0024310253
-
Multiple mutations in HIV-1 reverse transcriptase confer high level resistance to zidovudine
-
Larder, B. A., and S. D. Kemp. 1989. Multiple mutations in HIV-1 reverse transcriptase confer high level resistance to zidovudine. Science 246:1155-1158.
-
(1989)
Science
, vol.246
, pp. 1155-1158
-
-
Larder, B.A.1
Kemp, S.D.2
-
18
-
-
0029028067
-
Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
-
Larder, B. A., S. D. Kemp, and P. R. Harrigan. 1995. Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science 269:696-699.
-
(1995)
Science
, vol.269
, pp. 696-699
-
-
Larder, B.A.1
Kemp, S.D.2
Harrigan, P.R.3
-
19
-
-
0027916595
-
Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing
-
Larder, B. A., A. Kohli, P. Kellam, S. D. Kemp, M. Kronick, and R. D. Henfrey. 1993. Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing. Nature (London) 365:671-673.
-
(1993)
Nature (London)
, vol.365
, pp. 671-673
-
-
Larder, B.A.1
Kohli, A.2
Kellam, P.3
Kemp, S.D.4
Kronick, M.5
Henfrey, R.D.6
-
20
-
-
0026655856
-
Characterization of HIV isolates arising after prolonged zidovudine therapy
-
Mayers, D. L., F. E. McCutchan, E. E. Sanders-Buell, L. I. Merritt, S. Dilworth, A. K. Fowler, C. A. Marks, N. M. Ruiz, D. D. Richman, C. R. Roberts, and D. S. Burke. 1992. Characterization of HIV isolates arising after prolonged zidovudine therapy. J. Acquired Immune Defic. Syndr. 5:749-759.
-
(1992)
J. Acquired Immune Defic. Syndr.
, vol.5
, pp. 749-759
-
-
Mayers, D.L.1
McCutchan, F.E.2
Sanders-Buell, E.E.3
Merritt, L.I.4
Dilworth, S.5
Fowler, A.K.6
Marks, C.A.7
Ruiz, N.M.8
Richman, D.D.9
Roberts, C.R.10
Burke, D.S.11
-
21
-
-
9444290697
-
Virologic and immunologic benefits of initial combination therapy with zidovudine and zalcitabine or didanosine compared to zidovudine monotherapy
-
in press
-
Schooley, R. T., C. Rameriez-Ronda, J. M. A. Lange, D. A. Cooper, J. Lavelle, L. Lefkowitz, M. Moore, B. A. Larder, M. St Clair, P. Reiss, R. McKinnis, K. N. Pennington, P. R. Harrigan, I. Kinghorn, H. Steel, J. F. Rooney, and the Wellcome Resistance Study Collaborative Group. Virologic and immunologic benefits of initial combination therapy with zidovudine and zalcitabine or didanosine compared to zidovudine monotherapy. J. Infect. Dis., in press.
-
J. Infect. Dis.
-
-
Schooley, R.T.1
Rameriez-Ronda, C.2
Lange, J.M.A.3
Cooper, D.A.4
Lavelle, J.5
Lefkowitz, L.6
Moore, M.7
Larder, B.A.8
St Clair, M.9
Reiss, P.10
McKinnis, R.11
Pennington, K.N.12
Harrigan, P.R.13
Kinghorn, I.14
Steel, H.15
Rooney, J.F.16
-
22
-
-
0029007143
-
Drug resistance and heterogeneous long-term virological responses of Human Immunodeficiency Virus Type-1 infected subjects to zidovudine and didanosine combination therapy
-
Shafer, R. W., A. K. N. Iversen, M. A. Winters, E. Aguiniga, D. A. Katzenstein, T. D. Merigan and the AIDS Clinical Trials Group 143 Virology Group. 1995. Drug resistance and heterogeneous long-term virological responses of Human Immunodeficiency Virus Type-1 infected subjects to zidovudine and didanosine combination therapy. J. Inf. Dis. 172:711-78.
-
(1995)
J. Inf. Dis.
, vol.172
, pp. 711-778
-
-
Shafer, R.W.1
Iversen, A.K.N.2
Winters, M.A.3
Aguiniga, E.4
Katzenstein, D.A.5
Merigan, T.D.6
-
23
-
-
8944245852
-
The safety and efficacy of lamivudine/zidovudinc combination vs zidovudine monotherapy in patients pretreated with zidovudine. with a CD4 cell count between 100-400: A randomised double blind controlled trial
-
Staszewski, S., C. Loveday, P. R. Harrigan, A. M. Hill, L. Verity, H. McDade, and the Lamivudine European HIV Working Group. 1996. The safety and efficacy of lamivudine/zidovudinc combination vs zidovudine monotherapy in patients pretreated with zidovudine. with a CD4 cell count between 100-400: a randomised double blind controlled trial. JAMA 276:111-117.
-
(1996)
JAMA
, vol.276
, pp. 111-117
-
-
Staszewski, S.1
Loveday, C.2
Harrigan, P.R.3
Hill, A.M.4
Verity, L.5
McDade, H.6
-
24
-
-
0027285372
-
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
-
Tisdale, M., S. D. Kemp, N. R. Parry, and B. A. Larder. 1993. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc. Natl. Acad. Sci. USA 90:5653-5656.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 5653-5656
-
-
Tisdale, M.1
Kemp, S.D.2
Parry, N.R.3
Larder, B.A.4
-
25
-
-
0025238899
-
Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter
-
Volberding, P. A., S. W. Lagakos, M. A. Koch, C. Pettinelli, M. W. Myers, D. K. Booth, H. H. Balfour, Jr., R. C. Reichman, J. A. Bartlett, M. S. Hirsch, et al. 1990. Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. N. Engl. J. Med. 322:941-949.
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 941-949
-
-
Volberding, P.A.1
Lagakos, S.W.2
Koch, M.A.3
Pettinelli, C.4
Myers, M.W.5
Booth, D.K.6
Balfour Jr., H.H.7
Reichman, R.C.8
Bartlett, J.A.9
Hirsch, M.S.10
-
26
-
-
0040878604
-
Preliminary results of the European/Australian DELTA trial: Based on data up to 31 May 1995
-
26 to 29 Sept. 1995, Copenhagen, Denmark
-
Yeni, P., on behalf of the DELTA International Co-ordinating Committee. 1995. Preliminary results of the European/Australian DELTA trial: based on data up to 31 May 1995. Presented at the 5th European Conference on Clinical Aspects and Treatment of HIV Infection, 26 to 29 Sept. 1995, Copenhagen, Denmark.
-
(1995)
5th European Conference on Clinical Aspects and Treatment of HIV Infection
-
-
Yeni, P.1
|