-
1
-
-
0036889329
-
Cell-free replication of the hepatitis C virus subgenomic replicon
-
Ali, N., K. D. Tardif, and A. Siddiqui. 2002. Cell-free replication of the hepatitis C virus subgenomic replicon. J. Virol. 76:12001-12007.
-
(2002)
J. Virol
, vol.76
, pp. 12001-12007
-
-
Ali, N.1
Tardif, K.D.2
Siddiqui, A.3
-
2
-
-
0033932001
-
Recovery, persistence, and sequelae in hepatitis C virus infection: A perspective on long-term outcome
-
Alter, H. J., and L. B. Seeff. 2000. Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcome. Semin. Liver Dis. 20:17-35.
-
(2000)
Semin. Liver Dis
, vol.20
, pp. 17-35
-
-
Alter, H.J.1
Seeff, L.B.2
-
3
-
-
0032506055
-
Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′- deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
-
Arion, D., N. Kaushik, S. McCormick, G. Borkow, and M. A. Parniak. 1998. Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′- deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 37:15908-15917.
-
(1998)
Biochemistry
, vol.37
, pp. 15908-15917
-
-
Arion, D.1
Kaushik, N.2
McCormick, S.3
Borkow, G.4
Parniak, M.A.5
-
4
-
-
23744436747
-
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors
-
Biswal, B. K., M. M. Cherney, M. Wang, L. Chan, C. G. Yannopoulos, D. Bilimoria, O. Nicolas, J. Bedard, and M. N. James. 2005. Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J. Biol. Chem. 280:18202-18210.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 18202-18210
-
-
Biswal, B.K.1
Cherney, M.M.2
Wang, M.3
Chan, L.4
Yannopoulos, C.G.5
Bilimoria, D.6
Nicolas, O.7
Bedard, J.8
James, M.N.9
-
5
-
-
0037809239
-
Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs
-
Carroll, S. S., J. E. Tomassini, M. Bosserman, K. Getty, M. W. Stahlhut, A. B. Eldrup, B. Bhat, D. Hall, A. L. Simcoe, R. LaFemina, C. A. Rutkowski, B. Wolanski, Z. Yang, G. Migliaccio, R. De Francesco, L. C. Kuo, M. MacCoss, and D. B. Olsen. 2003. Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs. J. Biol. Chem. 278:11979-11984.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 11979-11984
-
-
Carroll, S.S.1
Tomassini, J.E.2
Bosserman, M.3
Getty, K.4
Stahlhut, M.W.5
Eldrup, A.B.6
Bhat, B.7
Hall, D.8
Simcoe, A.L.9
LaFemina, R.10
Rutkowski, C.A.11
Wolanski, B.12
Yang, Z.13
Migliaccio, G.14
De Francesco, R.15
Kuo, L.C.16
MacCoss, M.17
Olsen, D.B.18
-
6
-
-
1442277692
-
Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases
-
D'Abramo, C. M., L. Cellai, and M. Gotte. 2004. Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases. J. Mol. Biol. 337:1-14.
-
(2004)
J. Mol. Biol
, vol.337
, pp. 1-14
-
-
D'Abramo, C.M.1
Cellai, L.2
Gotte, M.3
-
7
-
-
23944482649
-
Challenges and successes in developing new therapies for hepatitis C
-
De Francesco, R., and G. Migliaccio. 2005. Challenges and successes in developing new therapies for hepatitis C. Nature 436:953-960.
-
(2005)
Nature
, vol.436
, pp. 953-960
-
-
De Francesco, R.1
Migliaccio, G.2
-
8
-
-
3242879168
-
Structural determinants and molecular mechanisms for the resistance of HIV-1 RT to nucleoside analogues
-
Deval, J., J. Courcambeck, B. Selmi, J. Boretto, and B. Canard. 2004. Structural determinants and molecular mechanisms for the resistance of HIV-1 RT to nucleoside analogues. Curr. Drug Metab. 5:305-316.
-
(2004)
Curr. Drug Metab
, vol.5
, pp. 305-316
-
-
Deval, J.1
Courcambeck, J.2
Selmi, B.3
Boretto, J.4
Canard, B.5
-
9
-
-
23744452229
-
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site
-
Di Marco, S., C. Volpari, L. Tomei, S. Altamura, S. Harper, F. Narjes, U. Koch, M. Rowley, R. De Francesco, G. Migliaccio, and A. Carfi. 2005. Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site. J. Biol. Chem. 280:29765-29770.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 29765-29770
-
-
Di Marco, S.1
Volpari, C.2
Tomei, L.3
Altamura, S.4
Harper, S.5
Narjes, F.6
Koch, U.7
Rowley, M.8
De Francesco, R.9
Migliaccio, G.10
Carfi, A.11
-
10
-
-
14844283732
-
A relaxed discrimination of 2′-O-methyl-GTP relative to GTP between de novo and elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B
-
Dutartre, H., J. Boretto, J. C. Guillemot, and B. Canard. 2005. A relaxed discrimination of 2′-O-methyl-GTP relative to GTP between de novo and elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B. J. Biol. Chem. 280:6359-6368.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 6359-6368
-
-
Dutartre, H.1
Boretto, J.2
Guillemot, J.C.3
Canard, B.4
-
11
-
-
33845247515
-
General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2′-modified nucleotide analogues
-
Dutartre, H., C. Bussetta, J. Boretto, and B. Canard. 2006. General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2′-modified nucleotide analogues. Antimicrob. Agents Chemother. 50:4161-4169.
-
(2006)
Antimicrob. Agents Chemother
, vol.50
, pp. 4161-4169
-
-
Dutartre, H.1
Bussetta, C.2
Boretto, J.3
Canard, B.4
-
12
-
-
2942560771
-
Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs)
-
Goldschmidt, V., and R. Marquet. 2004. Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs). Int. J. Biochem. Cell Biol. 36:1687-1705.
-
(2004)
Int. J. Biochem. Cell Biol
, vol.36
, pp. 1687-1705
-
-
Goldschmidt, V.1
Marquet, R.2
-
13
-
-
33646516020
-
Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation
-
Gotte, M. 2006. Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation. Curr. Pharm. Des. 12:1867-1877.
-
(2006)
Curr. Pharm. Des
, vol.12
, pp. 1867-1877
-
-
Gotte, M.1
-
14
-
-
5644267113
-
Inhibition of HIV-1 reverse transcription: Basic principles of drug action and resistance. Expert Rev. Anti Infect
-
Gotte, M. 2004. Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance. Expert Rev. Anti Infect. Ther. 2:707-716.
-
(2004)
Ther
, vol.2
, pp. 707-716
-
-
Gotte, M.1
-
15
-
-
0038269108
-
Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives
-
Gu, B., V. K. Johnston, L. L. Gutshall, T. T. Nguyen, R. R. Gontarek, M. G. Darcy, R. Tedesco, D. Dhanak, K. J. Duffy, C. C. Kao, and R. T. Sarisky. 2003. Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives. J. Biol. Chem. 278:16602-16607.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 16602-16607
-
-
Gu, B.1
Johnston, V.K.2
Gutshall, L.L.3
Nguyen, T.T.4
Gontarek, R.R.5
Darcy, M.G.6
Tedesco, R.7
Dhanak, D.8
Duffy, K.J.9
Kao, C.C.10
Sarisky, R.T.11
-
16
-
-
0035919073
-
A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase
-
Hong, Z., C. E. Cameron, M. P. Walker, C. Castro, N. Yao, J. Y. Lau, and W. Zhong. 2001. A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology 285:6-11.
-
(2001)
Virology
, vol.285
, pp. 6-11
-
-
Hong, Z.1
Cameron, C.E.2
Walker, M.P.3
Castro, C.4
Yao, N.5
Lau, J.Y.6
Zhong, W.7
-
17
-
-
0034468107
-
Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase
-
Kao, C. C., X. Yang, A. Kline, Q. M. Wang, D. Barket, and B. A. Heinz. 2000. Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase. J. Virol. 74:11121-11128.
-
(2000)
J. Virol
, vol.74
, pp. 11121-11128
-
-
Kao, C.C.1
Yang, X.2
Kline, A.3
Wang, Q.M.4
Barket, D.5
Heinz, B.A.6
-
18
-
-
33645232568
-
The novel nucleoside analog R1479 (4′-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture
-
Klumpp, K., V. Leveque, S. Le Pogam, H. Ma, W. R. Jiang, H. Kang, C. Granycome, M. Singer, C. Laxton, J. Q. Hang, K. Sarma, D. B. Smith, D. Heindl, C. J. Hobbs, J. H. Merrett, J. Symons, N. Cammack, J. A. Martin, R. Devos, and I. Najera. 2006. The novel nucleoside analog R1479 (4′-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J. Biol. Chem. 281:3793-3799.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 3793-3799
-
-
Klumpp, K.1
Leveque, V.2
Le Pogam, S.3
Ma, H.4
Jiang, W.R.5
Kang, H.6
Granycome, C.7
Singer, M.8
Laxton, C.9
Hang, J.Q.10
Sarma, K.11
Smith, D.B.12
Heindl, D.13
Hobbs, C.J.14
Merrett, J.H.15
Symons, J.16
Cammack, N.17
Martin, J.A.18
Devos, R.19
Najera, I.20
more..
-
19
-
-
2942592468
-
Impact of the translocational equilibrium of HIV-1 reverse transcriptase on the efficiency of mismatch extensions and the excision of mispaired nucleotides
-
Marchand, B., and M. Gotte. 2004. Impact of the translocational equilibrium of HIV-1 reverse transcriptase on the efficiency of mismatch extensions and the excision of mispaired nucleotides. Int. J. Biochem. Cell Biol. 36:1823-1835.
-
(2004)
Int. J. Biochem. Cell Biol
, vol.36
, pp. 1823-1835
-
-
Marchand, B.1
Gotte, M.2
-
20
-
-
0042316944
-
Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance
-
Marchand, B., and M. Gotte. 2003. Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance. J. Biol. Chem. 278:35362-35372.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 35362-35372
-
-
Marchand, B.1
Gotte, M.2
-
21
-
-
34047257841
-
The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation
-
Marchand, B., E. P. Tchesnokov, and M. Gotte. 2007. The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation. J. Biol. Chem. 282:3337-3346.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 3337-3346
-
-
Marchand, B.1
Tchesnokov, E.P.2
Gotte, M.3
-
22
-
-
0034425841
-
Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2′-deoxynucleoside triphosphates
-
Meyer, P. R., S. E. Matsuura, R. F. Schinazi, A. G. So, and W. A. Scott. 2000. Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2′-deoxynucleoside triphosphates. Antimicrob. Agents Chemother. 44:3465-3472.
-
(2000)
Antimicrob. Agents Chemother
, vol.44
, pp. 3465-3472
-
-
Meyer, P.R.1
Matsuura, S.E.2
Schinazi, R.F.3
So, A.G.4
Scott, W.A.5
-
23
-
-
0032506228
-
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism
-
Meyer, P. R., S. E. Matsuura, A. G. So, and W. A. Scott. 1998. Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism. Proc. Natl. Acad. Sci. USA 95:13471- 13476.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13471-13476
-
-
Meyer, P.R.1
Matsuura, S.E.2
So, A.G.3
Scott, W.A.4
-
24
-
-
1542677267
-
-
Migliaccio, G., J. E. Tomassini, S. S. Carroll, L. Tomei, S. Altamura, B. Bhat, L. Bartholomew, M. R. Bosserman, A. Ceccacci, L. F. Colwell, R. Cortese, R. De Francesco, A. B. Eldrup, K. L. Getty, X. S. Hou, R. L. LaFemina, S. W. Ludmerer, M. MacCoss, D. R. McMasters, M. W. Stahlhut, D. B. Olsen, D. J. Hazuda, and O. A. Flores. 2003. Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro. J. Biol. Chem. 278:49164-49170.
-
Migliaccio, G., J. E. Tomassini, S. S. Carroll, L. Tomei, S. Altamura, B. Bhat, L. Bartholomew, M. R. Bosserman, A. Ceccacci, L. F. Colwell, R. Cortese, R. De Francesco, A. B. Eldrup, K. L. Getty, X. S. Hou, R. L. LaFemina, S. W. Ludmerer, M. MacCoss, D. R. McMasters, M. W. Stahlhut, D. B. Olsen, D. J. Hazuda, and O. A. Flores. 2003. Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro. J. Biol. Chem. 278:49164-49170.
-
-
-
-
25
-
-
0032816079
-
A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA
-
Oh, J. W., T. Ito, and M. M. Lai. 1999. A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA. J. Virol. 73:7694-7702.
-
(1999)
J. Virol
, vol.73
, pp. 7694-7702
-
-
Oh, J.W.1
Ito, T.2
Lai, M.M.3
-
26
-
-
4644257970
-
A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties
-
Olsen, D. B., A. B. Eldrup, L. Bartholomew, B. Bhat, M. R. Bosserman, A. Ceccacci, L. F. Colwell, J. F. Fay, O. A. Flores, K. L. Getty, J. A. Grobler, R. L. LaFemina, E. J. Markel, G. Migliaccio, M. Prhavc, M. W. Stahlhut, J. E. Tomassini, M. MacCoss, D. J. Hazuda, and S. S. Carroll. 2004. A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties. Antimicrob. Agents Chemother. 48:3944-3953.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 3944-3953
-
-
Olsen, D.B.1
Eldrup, A.B.2
Bartholomew, L.3
Bhat, B.4
Bosserman, M.R.5
Ceccacci, A.6
Colwell, L.F.7
Fay, J.F.8
Flores, O.A.9
Getty, K.L.10
Grobler, J.A.11
LaFemina, R.L.12
Markel, E.J.13
Migliaccio, G.14
Prhavc, M.15
Stahlhut, M.W.16
Tomassini, J.E.17
MacCoss, M.18
Hazuda, D.J.19
Carroll, S.S.20
more..
-
27
-
-
0042243502
-
Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis
-
Ranjith-Kumar, C. T., L. Gutshall, R. T. Sarisky, and C. C. Kao. 2003. Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis. J. Mol. Biol. 330:675-685.
-
(2003)
J. Mol. Biol
, vol.330
, pp. 675-685
-
-
Ranjith-Kumar, C.T.1
Gutshall, L.2
Sarisky, R.T.3
Kao, C.C.4
-
28
-
-
0042347690
-
Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis
-
Ray, A. S., E. Murakami, A. Basavapathruni, J. A. Vaccaro, D. Ulrich, C. K. Chu, R. F. Schinazi, and K. S. Anderson. 2003. Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis. Biochemistry 42:8831-8841.
-
(2003)
Biochemistry
, vol.42
, pp. 8831-8841
-
-
Ray, A.S.1
Murakami, E.2
Basavapathruni, A.3
Vaccaro, J.A.4
Ulrich, D.5
Chu, C.K.6
Schinazi, R.F.7
Anderson, K.S.8
-
29
-
-
0024853567
-
Herpes simplex virus type 1 and human DNA polymerase interactions with 2′-deoxyguanosine 5′-triphosphate analogues. Kinetics of incorporation into DNA and induction of inhibition
-
Reardon, J. E. 1989. Herpes simplex virus type 1 and human DNA polymerase interactions with 2′-deoxyguanosine 5′-triphosphate analogues. Kinetics of incorporation into DNA and induction of inhibition. J. Biol. Chem. 264:19039-19044.
-
(1989)
J. Biol. Chem
, vol.264
, pp. 19039-19044
-
-
Reardon, J.E.1
-
30
-
-
0037517079
-
Side effects of therapy for chronic hepatitis C
-
Russo, M. W., and M. W. Fried. 2003. Side effects of therapy for chronic hepatitis C. Gastroenterology 124:1711-1719.
-
(2003)
Gastroenterology
, vol.124
, pp. 1711-1719
-
-
Russo, M.W.1
Fried, M.W.2
-
31
-
-
18744365757
-
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA
-
Saraflanos, S. G., A. D. Clark, Jr., K. Das, S. Tuske, J. J. Birktoft, P. Ilankumaran, A. R. Ramesha, J. M. Sayer, D. M. Jerina, P. L. Boyer, S. H. Hughes, and E. Arnold. 2002. Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. EMBO J. 21:6614-6624.
-
(2002)
EMBO J
, vol.21
, pp. 6614-6624
-
-
Saraflanos, S.G.1
Clark Jr., A.D.2
Das, K.3
Tuske, S.4
Birktoft, J.J.5
Ilankumaran, P.6
Ramesha, A.R.7
Sayer, J.M.8
Jerina, D.M.9
Boyer, P.L.10
Hughes, S.H.11
Arnold, E.12
-
32
-
-
0038521318
-
Trapping HIV-1 reverse transcriptase before and after translocation on DNA
-
Sarafianos, S. G., A. D. Clark, Jr., S. Tuske, C. J. Squire, K. Das, D. Sheng, P. Ilankumaran, A. R. Ramesha, H. Kroth, J. M. Sayer, D. M. Jerina, P. L. Boyer, S. H. Hughes, and E. Arnold. 2003. Trapping HIV-1 reverse transcriptase before and after translocation on DNA. J. Biol. Chem. 278:16280-16288.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 16280-16288
-
-
Sarafianos, S.G.1
Clark Jr., A.D.2
Tuske, S.3
Squire, C.J.4
Das, K.5
Sheng, D.6
Ilankumaran, P.7
Ramesha, A.R.8
Kroth, H.9
Sayer, J.M.10
Jerina, D.M.11
Boyer, P.L.12
Hughes, S.H.13
Arnold, E.14
-
33
-
-
23944506014
-
Global epidemiology of hepatitis C virus infection
-
Shepard, C. W., L. Finelli, and M. J. Alter. 2005. Global epidemiology of hepatitis C virus infection. Lancet Infect. Dis. 5:558-567.
-
(2005)
Lancet Infect. Dis
, vol.5
, pp. 558-567
-
-
Shepard, C.W.1
Finelli, L.2
Alter, M.J.3
-
34
-
-
0037721329
-
Canonical 3′-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase
-
Shim, J., G. Larson, V. Lai, S. Nairn, and J. Z. Wu. 2003. Canonical 3′-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase. Antivir. Res. 58:243-251.
-
(2003)
Antivir. Res
, vol.58
, pp. 243-251
-
-
Shim, J.1
Larson, G.2
Lai, V.3
Nairn, S.4
Wu, J.Z.5
-
35
-
-
0036631865
-
Selection of 3′-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase
-
Shim, J. H., G. Larson, J. Z. Wu, and Z. Hong. 2002. Selection of 3′-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase. J. Virol. 76:7030-7039.
-
(2002)
J. Virol
, vol.76
, pp. 7030-7039
-
-
Shim, J.H.1
Larson, G.2
Wu, J.Z.3
Hong, Z.4
-
36
-
-
23844479950
-
The 3′-azido group is not the primary determinant of 3′-azido-3′-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1
-
Sluis-Cremer, N., D. Arion, U. Parikh, D. Koontz, R. F. Schinazi, J. W. Mellors, and M. A. Parniak. 2005. The 3′-azido group is not the primary determinant of 3′-azido-3′-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. J. Biol. Chem. 280:29047-29052.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 29047-29052
-
-
Sluis-Cremer, N.1
Arion, D.2
Parikh, U.3
Koontz, D.4
Schinazi, R.F.5
Mellors, J.W.6
Parniak, M.A.7
-
37
-
-
18244380815
-
Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: Detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations
-
Smith, A. J., P. R. Meyer, D. Asthana, M. R. Ashman, and W. A. Scott. 2005. Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations. Antimicrob. Agents Chemother. 49:1761-1769.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 1761-1769
-
-
Smith, A.J.1
Meyer, P.R.2
Asthana, D.3
Ashman, M.R.4
Scott, W.A.5
-
38
-
-
0030991256
-
High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes
-
Smith, I. L., J. M. Cherrington, R. E. Jiles, M. D. Fuller, W. R. Freeman, and S. A. Spector. 1997. High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes. J. Infect. Dis. 176:69-77.
-
(1997)
J. Infect. Dis
, vol.176
, pp. 69-77
-
-
Smith, I.L.1
Cherrington, J.M.2
Jiles, R.E.3
Fuller, M.D.4
Freeman, W.R.5
Spector, S.A.6
-
39
-
-
0025317061
-
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Effect of pyrophosphorolysis and metal ions
-
Tabor, S., and C. C. Richardson. 1990. DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Effect of pyrophosphorolysis and metal ions. J. Biol. Chem. 265:8322-8328.
-
(1990)
J. Biol. Chem
, vol.265
, pp. 8322-8328
-
-
Tabor, S.1
Richardson, C.C.2
-
40
-
-
20944435839
-
Inhibitory effect of 2′-substituted nucleosides on hepatitis C virus replication correlates with metabolic properties in replicon cells
-
Tomassini, J. E., K. Getty, M. W. Stahlhut, S. Shim, B. Bhat, A. B. Eldrup, T. P. Prakash, S. S. Carroll, O. Flores, M. MacCoss, D. R. McMasters, G. Migliaccio, and D. B. Olsen. 2005. Inhibitory effect of 2′-substituted nucleosides on hepatitis C virus replication correlates with metabolic properties in replicon cells. Antimicrob. Agents Chemother. 49:2050-2058.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 2050-2058
-
-
Tomassini, J.E.1
Getty, K.2
Stahlhut, M.W.3
Shim, S.4
Bhat, B.5
Eldrup, A.B.6
Prakash, T.P.7
Carroll, S.S.8
Flores, O.9
MacCoss, M.10
McMasters, D.R.11
Migliaccio, G.12
Olsen, D.B.13
-
41
-
-
9144259740
-
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides
-
Tomei, L., S. Altamura, L. Bartholomew, M. Bisbocci, C. Bailey, M. Bosserman, A. Cellucci, E. Forte, I. Incitti, L. Orsatti, U. Koch, R. De Francesco, D. B. Olsen, S. S. Carroll, and G. Migliaccio. 2004. Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides. J. Virol. 78:938-946.
-
(2004)
J. Virol
, vol.78
, pp. 938-946
-
-
Tomei, L.1
Altamura, S.2
Bartholomew, L.3
Bisbocci, M.4
Bailey, C.5
Bosserman, M.6
Cellucci, A.7
Forte, E.8
Incitti, I.9
Orsatti, L.10
Koch, U.11
De Francesco, R.12
Olsen, D.B.13
Carroll, S.S.14
Migliaccio, G.15
-
42
-
-
0033916804
-
Epidemiology of hepatitis C: Geographic differences and temporal trends
-
Wasley, A., and M. J. Alter. 2000. Epidemiology of hepatitis C: geographic differences and temporal trends. Semin. Liver Dis. 20:1-16.
-
(2000)
Semin. Liver Dis
, vol.20
, pp. 1-16
-
-
Wasley, A.1
Alter, M.J.2
-
43
-
-
0034619946
-
Peginterferon alfa-2a in patients with chronic hepatitis C
-
Zeuzem, S., S. V. Feinman, J. Rasenack, E. J. Heathcote, M. Y. Lai, E. Gane, J. O'Grady, J. Reichen, M. Diago, A. Lin, J. Hoffman, and M. J. Brunda. 2000. Peginterferon alfa-2a in patients with chronic hepatitis C. N. Engl. J. Med. 343:1666-1672.
-
(2000)
N. Engl. J. Med
, vol.343
, pp. 1666-1672
-
-
Zeuzem, S.1
Feinman, S.V.2
Rasenack, J.3
Heathcote, E.J.4
Lai, M.Y.5
Gane, E.6
O'Grady, J.7
Reichen, J.8
Diago, M.9
Lin, A.10
Hoffman, J.11
Brunda, M.J.12
-
44
-
-
0033803374
-
Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase
-
Zhong, W., E. Ferrari, C. A. Lesburg, D. Maag, S. K. Ghosh, C. E. Cameron, J. Y. Lau, and Z. Hong. 2000. Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase. J. Virol. 74:9134-9143.
-
(2000)
J. Virol
, vol.74
, pp. 9134-9143
-
-
Zhong, W.1
Ferrari, E.2
Lesburg, C.A.3
Maag, D.4
Ghosh, S.K.5
Cameron, C.E.6
Lau, J.Y.7
Hong, Z.8
-
45
-
-
0033948907
-
De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase
-
Zhong, W., A. S. Uss, E. Ferrari, J. Y. Lau, and Z. Hong. 2000. De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase. J. Virol. 74:2017-2022.
-
(2000)
J. Virol
, vol.74
, pp. 2017-2022
-
-
Zhong, W.1
Uss, A.S.2
Ferrari, E.3
Lau, J.Y.4
Hong, Z.5
|