K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Hachiya, Atsuko ^a,b   Kodama, Eiichi N ^c   Schuckmann, Matthew M ^a   Kirby, Karen A ^a   Michailidis, Eleftherios ^a   Sakagami, Yasuko ^d   Oka, Shinichi ^b   Singh, Kamalendra ^a   Sarafianos, Stefan G ^a  

^a University of Missouri   (United States)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ADENOSINE TRIPHOSPHATE; DIDANOSINE; DNA; EFAVIRENZ; EMTRICITABINE; LAMIVUDINE; LOPINAVIR; NEVIRAPINE; RECOMBINANT ENZYME; STAVUDINE; TENOFOVIR DISOPROXIL; ZIDOVUDINE; ADENINE; DRUG DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR;

ANTIVIRAL ACTIVITY; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DRUG PROTEIN BINDING; GENE MUTATION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROGEN BOND; IC 50; KINETICS; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATIENT COMPLIANCE; PHENOTYPE; POLYMERASE CHAIN REACTION; STEADY STATE; UNSPECIFIED SIDE EFFECT; VIROLOGY; VIRUS ISOLATION; ANTIVIRAL RESISTANCE; COMPUTER SIMULATION; ENZYME ACTIVE SITE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS; ISOLATION AND PURIFICATION; MISSENSE MUTATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADENINE; CATALYTIC DOMAIN; COMPUTER SIMULATION; DRUG RESISTANCE, VIRAL; HIV; HIV REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN BONDING; KINETICS; MUTATION, MISSENSE; PHOSPHONIC ACIDS; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 79251583792     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016242     Document Type: Article

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