4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway

Journal of Biological Chemistry

Volumn 288, Issue 28, 2013, Pages 20532-20546

  Chaudhary, Pankaj ^a   Sharma, Rajendra ^a   Sahu, Mukesh ^a   Vishwanatha, Jamboor K ^a   Awasthi, Sanjay ^b   Awasthi, Yogesh C ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA TELANGIECTASIA; ATAXIA-TELANGIECTASIA MUTATED; CELL-CYCLE ARREST; DNA DOUBLE STRAND BREAKS; GENOMIC INTEGRITY; HEPATOCELLULAR CARCINOMA; PROTEASOMAL PATHWAY; SIGNALING PATHWAYS;

CELLS; CYTOLOGY; ENZYMES; PHOSPHORYLATION; PROTEINS;

CELL SIGNALING;

4 HYDROXYNONENAL; ATM PROTEIN; CAFFEINE; CHECKPOINT KINASE 1; CHECKPOINT KINASE RAD3; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; GLUTATHIONE TRANSFERASE A4; HISTONE H2AX; PROTEASOME; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; SERINE; UBIQUITIN;

ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; COMET ASSAY; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME INACTIVATION; GENE; GENE OVEREXPRESSION; GSTA4 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

4-HYDROXYNONENAL; CELL CYCLE; CELL CYCLE ARREST; DNA DAMAGE; GLUTATHIONE S-TRANFERASE; LIPID PEROXIDATION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ALDEHYDES; ANIMALS; BLOTTING, WESTERN; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN B1; CYSTEINE PROTEINASE INHIBITORS; G2 PHASE CELL CYCLE CHECKPOINTS; GLUTATHIONE TRANSFERASE; HEP G2 CELLS; HISTONES; HUMANS; LIVER; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84880052663     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.467662     Document Type: Article

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