Detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gavage of trans-4-hydroxy-2-nonenal or induction of lipid peroxidation with carbon tetrachloride in F344 rats

Chemico-Biological Interactions

Volumn 137, Issue 3, 2001, Pages 269-283

  Wacker, M ^a   Wanek, P ^a   Eder, E ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

1,N2 Propanodeoxyguanosine adducts of 4 hydroxynonenal; Cancer risk marker; Lipidperoxidation; Oxidative stress

Indexed keywords

1,2 N PROPANEDEOXYGUANOSINE; 4 HYDROXYNONENAL; ADENOSINE TRIPHOSPHATE; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; DEOXYGUANOSINE DERIVATIVE; DNA; NUCLEASE; PHOSPHATE; UNCLASSIFIED DRUG; 1,N(2) PROPANODEOXYGUANOSINE; 1,N(2)-PROPANODEOXYGUANOSINE; 4-HYDROXY-2-NONENAL; ALDEHYDE; DEOXYGUANOSINE; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; COLON; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; FEEDING; FEMALE; FORESTOMACH; KIDNEY; LIPID PEROXIDATION; LIVER; LUNG; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ASSAY; RAT; RAT STRAIN; TECHNIQUE; TISSUE LEVEL; TISSUE METABOLISM; ANIMAL; DRUG EFFECT; FISCHER 344 RAT; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; SENSITIVITY AND SPECIFICITY; THIN LAYER CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ALDEHYDES; ANIMALS; AUTORADIOGRAPHY; CARBON TETRACHLORIDE; CHROMATOGRAPHY, THIN LAYER; DEOXYGUANOSINE; DNA; DNA ADDUCTS; FEMALE; INJECTIONS, INTRAPERITONEAL; LIPID PEROXIDATION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RATS; RATS, INBRED F344; SENSITIVITY AND SPECIFICITY;

EID: 0035964580     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00259-9     Document Type: Article

References (39)

1. 2+ in rat liver microsomes
2. Possible mutagens derived from lipids and lipid precursors
3. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
4. Postischemic accumulation of the lipid peroxidation product 4-hydroxynonenal in rat small intestine
5. 4-Hydroxynonenal and other lipid peroxidation products are formed in mouse liver following intoxication with allyl alcohol
6. Detection of 4-hydroxynonenal and other lipid peroxidation products in the liver of bromobenzene-poisoned mice
7. Formation and metabolism of the lipid peroxidation product 4-hydroxynonenal in liver and small intestine
8. Metabolism of 4-hydroxynonenal, a cytotoxic product of lipid peroxidation, in rat precision-cut liver slices
9. Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes
10. Formation of cyclic adducts of deoxyguanosine with aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro
11. 32P-postlabelling
12. Influence of an exocyclic guanine adduct on the thermal stability, conformation and melting thermodynamics of a DNA duplex
13. Genotoxicity and mutagenicity of the α,β-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector
14. 4-etheno-2′-deoxycytidine
15. 2-propanodeoxyguanosine
16. Mammalian enzymatic repair of etheno and para-benzoquinone exocyclic adducts derived from the carcinogens vinyl chloride and benzene
17. Repair of propanodeoxyguanosine by nucleotide excision repair in vivo and in vitro
18. 2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in vivo
19. Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: Detection and potential sources
20. Roles of ethenoadducts in tumorigenesis of olefins
21. Vinyl halides, haloaldehydes and monoalkanes
22. 2-Ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal
23. 1,4-Dihydroxynonene mercapturic acid, the major end metabolite of exogenous 4-hydroxy-2-nonenal, is a physiological component of rat and human urine
24. Mercapturic acid conjugates as urinary end metabolites of lipid peroxidation product 4-hydroxynonenal in the rat
25. Mechanisms of multistep carcinogenesis and carcinogenic risk assessment
26. 32P-postlabelling for detection of DNA adducts
27. 2-propanodeoxyguanosine adducts of 2-hexenal in vivo
28. 2-(1,3-propano)-2′-deoxyguanosine 3′-phosphate adducts formed from 4-hydroxy-2-nonenal
29. Oxygen and xenobiotic reductase activities of cytochrome P450
30. Quantitative determination of the lipid peroxidation product 4-hydroxynonenal by high performance liquid chromatography
31. Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver
32. Extrahepatic sites of metabolism of carbon tetrachloride in rats
33. Uptake, distribution, and elimination of carbon tetrachloride in rat tissues following inhalation and ingestion exposures
34. Carbon tetrachloride hepatotoxicity: An example of lethal cleavage
35. 4 intoxication
36. The pulmonary Clara cell as a target for toxic chemicals requiring metabolic activation; studies with carbon tetrachloride
37. Cancer risk assessment for crotonaldehyde and 2-hexenal: An approach
38. 32P-postlabeling technique
39. Acute toxicity of trans-4-hydroxy-2-nonenal in Fisher 344 rats