Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

Journal of Molecular Biology

Volumn 288, Issue 3, 1999, Pages 427-439

  Bruns, Christopher M ^a   Hubatsch, Ina ^b   Ridderström, Marianne ^b   Mannervik, Bengt ^b   Tainer, John A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Alkenals; Glutathione transferase; Modular active site structure; Oxidative stress; Protein evolution

Indexed keywords

ALDEHYDE; GLUTATHIONE TRANSFERASE; TYROSINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; EVOLUTION; HUMAN; HYDROPHOBICITY; LIPID PEROXIDATION; MUTAGENESIS; PRIORITY JOURNAL;

EID: 0033531970     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2697     Document Type: Article

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