Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes

Toxicology in Vitro

Volumn 22, Issue 3, 2008, Pages 632-642

  Petit, Elise ^a   Langouet, Sophie ^a   Akhdar, Hanane ^a   Nicolas Nicolaz, Christophe ^a   Guillouzo, André ^a   Morel, Fabrice ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

HepaRG; Hepatocytes; Hepatoma cells; Human; Metabolism; Thiopurine; Toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; AZATHIOPRINE; INOSINATE DEHYDROGENASE; MERCAPTOPURINE; NUCLEOTIDE; TIOGUANINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GLUTATHIONE METABOLISM; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER TOXICITY; NONHUMAN; POLYMERASE CHAIN REACTION; RAT; UPREGULATION;

6-MERCAPTOPURINE; ADENOSINE TRIPHOSPHATE; ANTIMETABOLITES, ANTINEOPLASTIC; AZATHIOPRINE; FLOW CYTOMETRY; HEPATOCYTES; HUMANS; IMP DEHYDROGENASE; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; THIOGUANINE;

RATTUS;

EID: 40049104027     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.12.004     Document Type: Article

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