메뉴 건너뛰기




Volumn 30, Issue SUPPL. 1, 2012, Pages 100-105

New drug therapies on the horizon for IBD

Author keywords

Adhesion molecules; Biological therapy; Crohn's disease; Interleukins; Janus kinase; Ulcerative colitis

Indexed keywords

ADALIMUMAB; BRIAKINUMAB; CERTOLIZUMAB PEGOL; ETROLIZUMAB; GAMMA INTERFERON; GOLIMUMAB; IMMUNOMODULATING AGENT; INFLIXIMAB; INTERLEUKIN 12; INTERLEUKIN 23; JANUS KINASE; NATALIZUMAB; PALCEBO; RECOMBINANT TUMOR NECROSIS FACTOR; TOFACITINIB; TUMOR NECROSIS FACTOR KINOID; UNCLASSIFIED DRUG; USTEKINUMAB; VEDOLIZUMAB;

EID: 84867693650     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000341133     Document Type: Article
Times cited : (20)

References (29)
  • 1
    • 62949219864 scopus 로고    scopus 로고
    • Biological therapies for inflammatory bowel diseases
    • Rutgeerts P, Vermeire S, van Assche G: Biological therapies for inflammatory bowel diseases. Gastroenterology 2009; 136: 1182-1197.
    • (2009) Gastroenterology , vol.136 , pp. 1182-1197
    • Rutgeerts, P.1    Vermeire, S.2    Van Assche, G.3
  • 4
    • 77952514447 scopus 로고    scopus 로고
    • Active immunization to tumor necrosis factoralpha is effective in treating chronic established inflammatory disease: A long-term study in a transgenic model of arthritis
    • Delavallee L, Semerano L, Assier E, et al: Active immunization to tumor necrosis factoralpha is effective in treating chronic established inflammatory disease: A long-term study in a transgenic model of arthritis. Arthritis Res Ther 2009; 11:R195.
    • (2009) Arthritis Res Ther , vol.11
    • Delavallee, L.1    Semerano, L.2    Assier, E.3
  • 5
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • Sandborn WJ, Feagan BG, Fedorak RN, et al: A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 2008; 135: 1130-1141.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 8
    • 81255206921 scopus 로고    scopus 로고
    • A multicenter, randomized double-blind placebocontrolled phase 2b study of ustekinumab, a human monoclonal antibody to IL-12/23 p40 in patients with moderately to severely active Crohn's disease: Results through week 22 from the Certifi trial
    • Sandborn W, Gasink C, Gao L, et al: A multicenter, randomized double-blind placebocontrolled phase 2b study of ustekinumab, a human monoclonal antibody to IL-12/23 p40 in patients with moderately to severely active Crohn's disease: Results through week 22 from the Certifi trial. DDW 2011;A-145: 592.
    • (2011) DDW , vol.A145 , pp. 592
    • Sandborn, W.1    Gasink, C.2    Gao, L.3
  • 12
    • 22844439662 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
    • Kleinschmidt-Demasters BK, Tyler KI: Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 2005; 353: 369-374.
    • (2005) N Engl J Med , vol.353 , pp. 369-374
    • Kleinschmidt-Demasters, B.K.1    Tyler, K.I.2
  • 16
    • 84856980173 scopus 로고    scopus 로고
    • Vedolizumab for the treatment of active ulcerative colitis: A randomized controlled phase 2 dose-ranging study
    • E-pub Ahead Of Print
    • Parikh A, Leach T, Wyant T, et al: Vedolizumab for the treatment of active ulcerative colitis: A randomized controlled phase 2 dose-ranging study. Inflamm Bowel Dis 2011, E-pub ahead of print.
    • (2011) Inflamm Bowel Dis
    • Parikh, A.1    Leach, T.2    Wyant, T.3
  • 17
    • 57249089077 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al: Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 2008; 6: 1370-1377.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1370-1377
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 18
    • 84883347641 scopus 로고    scopus 로고
    • Vedolizumab induction therapy for ulcerative colitis: Results of GEMINI I, a randomized, placebo-controlled, double-blind, multicenter phase 3 Trial
    • abstract 943b
    • Feagan B, Rutgeerts P, Sands B, et al: Vedolizumab induction therapy for ulcerative colitis: Results of GEMINI I, a randomized, placebo-controlled, double-blind, multicenter phase 3 Trial. DDW 2012, abstract 943b.
    • (2012) DDW
    • Feagan, B.1    Rutgeerts, P.2    Sands, B.3
  • 20
    • 79960336916 scopus 로고    scopus 로고
    • The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: A randomised study
    • Vermeire S, Ghosh S, Panes J, et al: The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: A randomised study. Gut 2011; 60: 1068-1075.
    • (2011) Gut , vol.60 , pp. 1068-1075
    • Vermeire, S.1    Ghosh, S.2    Panes, J.3
  • 21
    • 80755189356 scopus 로고    scopus 로고
    • Cytokine blockade in inflammatory bowel diseases
    • Perrier C, Rutgeerts P: Cytokine blockade in inflammatory bowel diseases. Immunotherapy 2011; 3: 1341-1352.
    • (2011) Immunotherapy , vol.3 , pp. 1341-1352
    • Perrier, C.1    Rutgeerts, P.2
  • 22
    • 33846903838 scopus 로고    scopus 로고
    • Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease
    • DOI 10.1016/j.molimm.2006.11.025, PII S016158900600719X
    • O'Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC: Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. Mol Immunol 2007; 44: 2497-2506. (Pubitemid 46240311)
    • (2007) Molecular Immunology , vol.44 , Issue.10 , pp. 2497-2506
    • O'Sullivan, L.A.1    Liongue, C.2    Lewis, R.S.3    Stephenson, S.E.M.4    Ward, A.C.5
  • 23
    • 77956165442 scopus 로고    scopus 로고
    • Inhibition of JAK kinases in patients with rheumatoid arthritis: Scientific rationale and clinical outcomes
    • Riese RJ, Krishnaswami S, Kremer J: Inhibition of JAK kinases in patients with rheumatoid arthritis: Scientific rationale and clinical outcomes. Best Pract Res Clin Rheumatol 2010; 24: 513-526.
    • (2010) Best Pract Res Clin Rheumatol , vol.24 , pp. 513-526
    • Riese, R.J.1    Krishnaswami, S.2    Kremer, J.3
  • 24
    • 84859050689 scopus 로고    scopus 로고
    • Phase 2 study of CP-690, 550, an oral Janus kinase inhibitor, in active ulcerative colitis
    • abstract 594
    • Sandborn W, Ghosh S, Panes J, et al: Phase 2 study of CP-690, 550, an oral Janus kinase inhibitor, in active ulcerative colitis. DDW 2011, abstract 594.
    • (2011) DDW
    • Sandborn, W.1    Ghosh, S.2    Panes, J.3
  • 25
    • 84859050689 scopus 로고    scopus 로고
    • Phase 2 randomized study of CP-690,550, an oral Janus kinase inhibitor, in active Crohn's disease
    • abstract 745
    • Sandborn W, Ghosh S, Panes J, Vranic I, Spanton J, Niezychowski W: Phase 2 randomized study of CP-690,550, an oral Janus kinase inhibitor, in active Crohn's disease. DDW 2011, abstract 745.
    • (2011) DDW
    • Sandborn, W.1    Ghosh, S.2    Panes, J.3    Vranic, I.4    Spanton, J.5    Niezychowski, W.6
  • 26
    • 67650093218 scopus 로고    scopus 로고
    • The safety and efficacy of A JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind placebo-controlled phase IIa trial of three dosage levels of CP-690 550 versus placebo
    • Kremer JM, Bloom BJ, Breedveld FC, et al: The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690, 550 versus placebo. Arthritis Rheum 2009; 60: 1895-1905.
    • (2009) Arthritis Rheum , vol.60 , pp. 1895-1905
    • Kremer, J.M.1    Bloom, B.J.2    Breedveld, F.C.3
  • 27
    • 84859065561 scopus 로고    scopus 로고
    • Polymeric nanoparticles for the selective therapy of inflammatory bowel disease
    • Wachsmann P, Lamprecht A: Polymeric nanoparticles for the selective therapy of inflammatory bowel disease. Methods Enzymol 2012; 508: 377-397.
    • (2012) Methods Enzymol , vol.508 , pp. 377-397
    • Wachsmann, P.1    Lamprecht, A.2
  • 28
    • 84878265319 scopus 로고    scopus 로고
    • A phase 2a randomized placebo-controlled double-blind multi-center dose escalation study to evaluate the safety, tolerability, pharmacodynamics and efficacy of AG011 in patients with moderately active ulcerative colitis
    • Vermeire S, Rutgeerts P, D'haens G, et al: A phase 2a randomized placebo-controlled double-blind multi-center dose escalation study to evaluate the safety, tolerability, pharmacodynamics and efficacy of AG011 in patients with moderately active ulcerative colitis. DDW 2010;46.
    • (2010) DDW , pp. 46
    • Vermeire, S.1    Rutgeerts, P.2    D'haens, G.3
  • 29
    • 12344291265 scopus 로고    scopus 로고
    • Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
    • DOI 10.1136/gut.2004.045294
    • Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP: Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 2005; 54: 237-241. (Pubitemid 40139240)
    • (2005) Gut , vol.54 , Issue.2 , pp. 237-241
    • Cosnes, J.1    Nion-Larmurier, I.2    Beaugerie, L.3    Afchain, P.4    Tiret, E.5    Gendre, J.-P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.