TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts

Arthritis Research and Therapy

Volumn 14, Issue 2, 2012, Pages

  Connor, Alison M ^a   Mahomed, Nizar ^a,b   Gandhi, Rajiv ^a   Keystone, Edward C ^c,d   Berger, Stuart A ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; EPOXOMICIN; HYDROXYCHLOROQUINE; PROTEASOME; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN;

ADULT; ARTICLE; AUTOPHAGY; CELL VIABILITY; EMBRYO; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LYSOSOME; MOUSE; NONHUMAN; PROTEIN DEGRADATION; RHEUMATOID ARTHRITIS; SYNOVIUM; CELL CULTURE; CYTOLOGY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNOVIAL FLUID;

ADULT; ARTHRITIS, RHEUMATOID; AUTOPHAGY; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; FIBROBLASTS; HUMANS; PROTEOLYSIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860516885     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3778     Document Type: Article

References (48)

1. Pope RM. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol 2002, 2:527-535. 10.1038/nri846, 12094227.
2. McAnulty RJ. Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol 2007, 39:666-671. 10.1016/j.biocel.2006.11.005, 17196874.
3. Vembar SS, Brodsky JL. One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol 2008, 9:944-957. 10.1038/nrm2546, 2654601, 19002207.
4. Mori K. Signalling pathways in the unfolded protein response: development from yeast to mammals. J Biochem 2009, 146:743-750. 10.1093/jb/mvp166, 19861400.
5. Ding WX, Yin XM. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 2008, 4:141-150.
6. Mizushima N, Ohsumi Y, Yoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct 2002, 27:421-429. 10.1247/csf.27.421, 12576635.
7. Fribley A, Zhang K, Kaufman RJ. Regulation of apoptosis by the unfolded protein response. Methods Mol Biol 2009, 559:191-204. 10.1007/978-1-60327-017-5_14, 19609758.
8. Yamasaki S, Yagishita N, Tsuchimochi K, Kato Y, Sasaki T, Amano T, Beppu M, Aoki H, Nakamura H, Nishioka K, Nakajima T. Resistance to endoplasmic reticulum stress is an acquired cellular characteristic of rheumatoid synovial cells. Int J Mol Med 2006, 18:113-117.
9. Shin YJ, Han SH, Kim DS, Lee GH, Yoo WH, Kang YM, Choi JY, Lee YC, Park SJ, Jeong SK, Kim HT, Chae SW, Jeong HJ, Kim HR, Chae HJ. Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress. Arthritis Res Ther 2010, 12:R19. 10.1186/ar2921, 2875648, 20122151.
10. Connor AM, Berger S, Narendran A, Keystone EC. Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts. Arthritis Res Ther 2006, 8:R94. 10.1186/ar1968, 1779395, 16774691.
11. Wibo M, Poole B. Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1. J Cell Biol 1974, 63:430-440. 10.1083/jcb.63.2.430, 2110942, 4607946.
12. Paludan C, Schmid D, Landthaler M, Vockerodt M, Kube D, Tuschl T, Munz C. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 2005, 307:593-596. 10.1126/science.1104904, 15591165.
13. Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000, 275:992-998. 10.1074/jbc.275.2.992, 10625637.
14. Tkacz JS, Lampen O. Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes. Biochem Biophys Res Commun 1975, 65:248-257. 10.1016/S0006-291X(75)80086-6, 167767.
15. Jung T, Catalgol B, Grune T. The proteasomal system. Mol Aspects Med 2009, 30:191-296. 10.1016/j.mam.2009.04.001, 19371762.
16. Eskelinen EL, Schmidt CK, Neu S, Willenborg M, Fuertes G, Salvador N, Tanaka Y, Lullmann-Rauch R, Hartmann D, Heeren J, von Figura K, Knecht E, Saftig P. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell 2004, 15:3132-3145. 10.1091/mbc.E04-02-0103, 452571, 15121881.
17. Pacheco CD, Kunkel R, Lieberman AP. Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Hum Mol Genet 2007, 16:1495-1503. 10.1093/hmg/ddm100, 17468177.
18. Meng L, Mohan R, Kwok BH, Elofsson M, Sin N, Crews CM. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci USA 1999, 96:10403-10408. 10.1073/pnas.96.18.10403, 17900, 10468620.
19. Xue X, Piao JH, Nakajima A, Sakon-Komazawa S, Kojima Y, Mori K, Yagita H, Okumura K, Harding H, Nakano H. Tumor necrosis factor alpha (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα. J Biol Chem 2005, 280:33917-33925. 10.1074/jbc.M505818200, 16107336.
20. Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003, 23:7448-7459. 10.1128/MCB.23.21.7448-7459.2003, 207643, 14559994.
21. Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007, 3:542-545.
22. Eskelinen EL. New insights into the mechanisms of macroautophagy in mammalian cells. Int Rev Cell Mol Biol 2008, 266:207-247.
23. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008, 4:151-175. 2654259, 18188003.
24. Moravec RA, O'Brien MA, Daily WJ, Scurria MA, Bernad L, Riss TL. Cell-based bioluminescent assays for all three proteasome activities in a homogeneous format. Anal Biochem 2009, 387:294-302. 10.1016/j.ab.2009.01.016, 19454251.
25. Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, Murachi T. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. J Biol Chem 1984, 259:12489-12494.
26. Mizushima N, Klionsky DJ. Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr 2007, 27:19-40. 10.1146/annurev.nutr.27.061406.093749, 17311494.
27. Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009, 34:259-269. 10.1016/j.molcel.2009.04.026, 19450525.
28. Kim PK, Hailey DW, Mullen RT, Lippincott-Schwartz J. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci USA 2008, 105:20567-20574. 10.1073/pnas.0810611105, 2602605, 19074260.
29. Wang Y, Singh R, Massey AC, Kane SS, Kaushik S, Grant T, Xiang Y, Cuervo AM, Czaja MJ. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem 2008, 283:4766-4777. 2754125, 18073215.
30. Djavaheri-Mergny M, Amelotti M, Mathieu J, Besancon F, Bauvy C, Souquere S, Pierron G, Codogno P. NF-κB activation represses tumor necrosis factor-alpha-induced autophagy. J Biol Chem 2006, 281:30373-30382. 10.1074/jbc.M602097200, 16857678.
31. Sivaprasad U, Basu A. Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells. J Cell Mol Med 2008, 12:1265-1271. 10.1111/j.1582-4934.2008.00282.x, 18266953.
32. Keller CW, Fokken C, Turville SG, Lunemann A, Schmidt J, Munz C, Lunemann JD. TNF-α induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells. J Biol Chem 2011, 286:3970-3980. 10.1074/jbc.M110.159392, 3030397, 20980264.
33. Gao B, Calhoun K, Fang D. The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway. Arthritis Res Ther 2006, 8:R172. 10.1186/ar2081, 1794516, 17105652.
34. Steffen BT, Lees SJ, Booth FW. Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia. J Appl Physiol 2008, 105:1950-1958. 10.1152/japplphysiol.90884.2008, 18801959.
35. Zhang F, Hu Y, Huang P, Toleman CA, Paterson AJ, Kudlow JE. Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6. J Biol Chem 2007, 282:22460-22471. 10.1074/jbc.M702439200, 17565987.
36. Drews O, Tsukamoto O, Liem D, Streicher J, Wang Y, Ping P. Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy. Circ Res 2010, 107:1094-1101. 10.1161/CIRCRESAHA.110.222364, 20814020.
37. Wu WK, Sakamoto KM, Milani M, Aldana-Masankgay G, Fan D, Wu K, Lee CW, Cho CH, Yu J, Sung JJ. Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy. Drug Resist Updat 2010, 13:87-92. 10.1016/j.drup.2010.04.003, 20462785.
38. Qiao L, Zhang J. Inhibition of lysosomal functions reduces proteasomal activity. Neurosci Lett 2009, 456:15-19. 10.1016/j.neulet.2009.03.085, 19429125.
39. Myeku N, Figueiredo-Pereira ME. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem 2011, 286:22426-22440. 10.1074/jbc.M110.149252, 21536669.
40. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 1994, 78:773-785. 10.1016/S0092-8674(94)90482-0, 8087845.
41. Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation 2009, 6:41. 10.1186/1742-2094-6-41, 2806266, 20035627.
42. McGuckin MA, Eri RD, Das I, Lourie R, Florin TH. ER stress and the unfolded protein response in intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 2010, 298:G820-G832. 10.1152/ajpgi.00063.2010, 20338921.
43. Palombella VJ, Conner EM, Fuseler JW, Destree A, Davis JM, Laroux FS, Wolf RE, Huang J, Brand S, Elliott PJ, Lazarus D, McCormack T, Parent L, Stein R, Adams J, Grisham MB. Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis. Proc Natl Acad Sci USA 1998, 95:15671-15676. 10.1073/pnas.95.26.15671, 28102, 9861028.
44. Ahmed AS, Li J, Ahmed M, Hua L, Yakovleva T, Ossipov MH, Bakalkin G, Stark A. Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132. Arthritis Rheum 2010, 62:2160-2169.
45. McLachlan AJ, Tett SE, Cutler DJ, Day RO. Bioavailability of hydroxychloroquine tablets in patients with rheumatoid arthritis. Br J Rheumatol 1994, 33:235-239. 10.1093/rheumatology/33.3.235, 8156285.
46. Lockwood TD. The lysosome among targets of metformin: new anti-inflammatory uses for an old drug?. Expert Opin Ther Targets 2010, 14:467-478. 10.1517/14728221003774135, 20392164.
47. Gao Z, Gammoh N, Wong PM, Erdjument-Bromage H, Tempst P, Jiang X. Processing of autophagic protein LC3 by the 20S proteasome. Autophagy 2010, 6:126-137. 10.4161/auto.6.1.10928, 20061800.
48. Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007, 282:24131-24145. 10.1074/jbc.M702824200, 17580304.