α-L-fucosidase inhibition by pyrrolidine-ferrocene hybrids: Rationalization of ligand-binding properties by structural studies

Chemistry - A European Journal

Volumn 19, Issue 29, 2013, Pages 9526-9533

  Hottin, Audrey ^a   Wright, Daniel W ^b   Steenackers, Agata ^c   Delannoy, Philippe ^c   Dubar, Faustine ^c,d   Biot, Christophe ^c   Davies, Gideon J ^b   Behr, Jean Bernard ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIV LILLE   (France)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

antitumor agents; glycosidases; hydrolases; inhibition; protein structures

Indexed keywords

ANTI-PROLIFERATIVE; ANTI-TUMOR AGENTS; ANTIPROLIFERATIVE EFFECT; GLYCOSIDASES; OVER-EXPRESSION; PROTEIN STRUCTURES; STRUCTURAL STUDIES; THREE-DIMENSIONAL STRUCTURE;

BINDING ENERGY; CELL CULTURE; DISEASES; ENZYME INHIBITION; HYDROLASES; ORGANOMETALLICS; THREE DIMENSIONAL;

LIGANDS;

ALPHA LEVO FUCOSIDASE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FERROCENE; FERROUS ION; GLYCOSIDASE; HYDROLASE; PYRROLIDINE; PYRROLIDINE DERIVATIVE;

ANIMAL; ANTITUMOR AGENTS; ARTICLE; CATTLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; GLYCOSIDASES; HUMAN; INHIBITION; METABOLISM; PROTEIN STRUCTURES;

ANTITUMOR AGENTS; GLYCOSIDASES; HYDROLASES; INHIBITION; PROTEIN STRUCTURES;

ALPHA-L-FUCOSIDASE; ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; FERROUS COMPOUNDS; GLYCOSIDE HYDROLASES; HUMANS; HYDROLASES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PYRROLIDINES;

EID: 84879981885     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201301001     Document Type: Article

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