Functionalized pyrrolidines inhibit α-mannosidase activity and growth of human glioblastoma and melanoma cells

Journal of Medicinal Chemistry

Volumn 48, Issue 13, 2005, Pages 4237-4246

  Fiaux, Hélène ^a   Popowycz, Florence ^a   Favre, Sylvain ^a   Schütz, Catherine ^a   Vogel, Pierre ^a   Gerber Lemaire, Sandrine ^a   Juillerat Jeanneret, Lucienne ^b  

^a EPFL   (Switzerland)

^b UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[( 2 HYDROXY 1 PHENYLETHYL)AMINO]METHYL]PYRROLIDINE 3,4 DIOL; 2[[(3,4 DIHYDROXYPYRROLIDIN 2 YL)METHYL]AMINO] 2 PHENYLETHYL 4 BROMOBENZOATE; ALPHA MANNOSIDASE; GLYCOSIDASE; HYDROXYL GROUP; PYRROLIDINE DERIVATIVE; SWAINSONINE; UNCLASSIFIED DRUG;

ARTICLE; BEAN; CELL SURVIVAL; CONTROLLED STUDY; DERIVATIZATION; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FIBROBLAST; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPOPHILICITY; MELANOMA CELL; TUMOR CELL; TUMOR GROWTH;

ALPHA-MANNOSIDASE; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TUMOR; ENZYME INHIBITORS; GLIOBLASTOMA; HUMANS; KINETICS; MELANOMA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21244455716     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0409019     Document Type: Article

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