Iminosugars as glycosyltransferase inhibitors: Synthesis of polyhydroxypyrrolidines and their evaluation on chitin synthase activity

European Journal of Medicinal Chemistry

Volumn 40, Issue 12, 2005, Pages 1255-1261

  Gautier Lefebvre, Isabelle ^a   Behr, Jean Bernard ^a   Guillerm, Georges ^a   Muzard, Murielle ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Chitin synthase; Difluoromethylphosphonoazasugars; Glycosyltransferase; Iminosugars; Inhibition

Indexed keywords

2 [(1 ETHYLPHOSPHONYL) 1,1 DIFLUOROMETHYL] 3,4 DIHYDROXY 5 HYDROXYMETHYLPYRROLIDINE; 2,5 DIDEOXY 2,5 IMINO DEXTRO GLUCITOL; 2,5 DIDEOXY 2,5 IMINO LEVO IDITOL; ANTIFUNGAL AGENT; CHITIN SYNTHASE; GLYCOSYLTRANSFERASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; FUNGAL STRAIN; GLYCOSYLATION; MOLECULAR MIMICRY; NONHUMAN; PHASE TRANSITION;

ANTIFUNGAL AGENTS; CHITIN SYNTHASE; FUNGI; GLYCOSYLATION; IMINO SUGARS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; PYRROLIDINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744501181     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.07.001     Document Type: Article

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