Rapid diversity-oriented synthesis in microtiter plates for in situ screening: Discovery of potent and selective α-fucosidase inhibitors

Angewandte Chemie - International Edition

Volumn 42, Issue 38, 2003, Pages 4661-4664

  Wu, Chung Yi ^a   Chang, Chuan Fa ^a   Chen, Jenny Szu Yu ^a   Wong, Chi Huey ^a,b   Lin, Chun Hung ^a  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Combinatorial chemistry; Iminocyclitol; Inhibitors; Microreactors

Indexed keywords

ASSAYS; REACTION KINETICS;

MICROTITER PLATES;

SYNTHESIS (CHEMICAL);

ALCOHOL; ALPHA LEVO FUCOSIDASE; AMIDE; CARBOXYLIC ACID; FUCONOJIRIMYCIN; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; IMINOCYCLITOL; SELECTIVE ALPHA LEVO FUCOSIDASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; DERIVATIZATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; IC 50; MICROTITER PLATE ASSAY;

ALPHA-L-FUCOSIDASE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLUCOSAMINE; MOLECULAR STRUCTURE;

EID: 0142119368     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351823     Document Type: Article

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