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Volumn 16, Issue 3-4, 2011, Pages 107-118

Iminosugars past, present and future: Medicines for tomorrow

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXYNOJIRIMYCIN; ACICLOVIR; AFEGOSTAT; ANTINEOPLASTIC AGENT; AT 2220; C 2100; CASTANOSPERMINE; CASTANOSPERMINE 6 BUTYRATE; CYTARABINE; DAPAGLIFLOZIN; GD 0039; GEMCITABINE; IDOXURIDINE; IMINOSUGAR; ISOLAB; LAMIVUDINE; MIGALASTAT; MIGLITOL; MIGLUSTAT; PEGINTERFERON ALPHA; RIBAVIRIN; SMT 14224; SWAINSONINE; TRIFLURIDINE; UNCLASSIFIED DRUG; VIDARABINE;

EID: 79851508769     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.08.017     Document Type: Review
Times cited : (307)

References (109)
  • 5
    • 65549125296 scopus 로고    scopus 로고
    • Iminosugars: From botanical curiosities to licensed drugs
    • B.G. Winchester Iminosugars: from botanical curiosities to licensed drugs Tetrahedron Asymmetry 20 2009 645 651
    • (2009) Tetrahedron Asymmetry , vol.20 , pp. 645-651
    • Winchester, B.G.1
  • 6
    • 62349103279 scopus 로고    scopus 로고
    • Glycomimetics at the mirror: Medicinal chemistry of L-iminosugars
    • D. D'Alonzo Glycomimetics at the mirror: medicinal chemistry of L-iminosugars Curr. Med. Chem. 16 2009 473 505
    • (2009) Curr. Med. Chem. , vol.16 , pp. 473-505
    • D'Alonzo, D.1
  • 7
    • 0037832251 scopus 로고    scopus 로고
    • Naturally occurring iminosugars and related compounds: Structure, distribution, and biological activity
    • N. Asano Naturally occurring iminosugars and related compounds: structure, distribution, and biological activity Curr. Top. Med. Chem. 3 2003 471 484
    • (2003) Curr. Top. Med. Chem. , vol.3 , pp. 471-484
    • Asano, N.1
  • 9
    • 39649089378 scopus 로고    scopus 로고
    • Iminosugars from Baphia nitida Lodd
    • A. Kato Iminosugars from Baphia nitida Lodd Phytochemistry 69 2008 1261 1265
    • (2008) Phytochemistry , vol.69 , pp. 1261-1265
    • Kato, A.1
  • 10
    • 0013969908 scopus 로고
    • The structure of nojirimycin, a piperidinose sugar antibiotic
    • S. Inoue The structure of nojirimycin, a piperidinose sugar antibiotic J. Antibiotics Ser. A 19 1966 288 292
    • (1966) J. Antibiotics Ser. A , vol.19 , pp. 288-292
    • Inoue, S.1
  • 11
    • 0016318699 scopus 로고
    • Purification and characterization of a sialidase inhibitor, siastatin, produced by Streptomyces
    • H. Umezawa Purification and characterization of a sialidase inhibitor, siastatin, produced by Streptomyces J. Antibiot. (Tokyo) 27 1974 963 969
    • (1974) J. Antibiot. (Tokyo) , vol.27 , pp. 963-969
    • Umezawa, H.1
  • 12
    • 0035925104 scopus 로고    scopus 로고
    • Polyhydroxylated alkaloids - Natural occurrence and therapeutic applications
    • DOI 10.1016/S0031-9422(00)00451-9, PII S0031942200004519
    • A.A. Watson Polyhydroxylated alkaloids: natural occurrence and therapeutic applications Phytochemistry 56 2001 265 295 (Pubitemid 32162799)
    • (2001) Phytochemistry , vol.56 , Issue.3 , pp. 265-295
    • Watson, A.A.1    Fleet, G.W.J.2    Asano, N.3    Molyneux, R.J.4    Nash, R.J.5
  • 13
    • 79959754227 scopus 로고    scopus 로고
    • Water soluble bioactive alkaloids
    • A.A. Watson Water soluble bioactive alkaloids Spec. Publ. R. Soc. Chem. 257 2000 169 204
    • (2000) Spec. Publ. R. Soc. Chem. , vol.257 , pp. 169-204
    • Watson, A.A.1
  • 14
    • 35648940330 scopus 로고    scopus 로고
    • Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins
    • J.R. Jacob Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins J. Microbiol. 45 2007 431 440 (Pubitemid 350023378)
    • (2007) Journal of Microbiology , vol.45 , Issue.5 , pp. 431-440
    • Jacob, J.R.1    Mansfield, K.2    You, J.E.3    Tennant, B.C.4    Kim, Y.H.5
  • 16
    • 0023693720 scopus 로고
    • Inhibition of HIV replication by amino-sugar derivatives
    • G.W.J. Fleet Inhibition of HIV replication by amino-sugar derivatives FEBS Lett. 237 1988 128 132
    • (1988) FEBS Lett. , vol.237 , pp. 128-132
    • Fleet, G.W.J.1
  • 18
    • 0022475489 scopus 로고
    • Inhibition of experimental metastasis by castanospermine in mice: Blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors
    • M.J. Humphries Inhibition of experimental metastasis by castanospermine in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors Cancer Res. 46 1986 5215 5222 (Pubitemid 16008292)
    • (1986) Cancer Research , vol.46 , Issue.10 , pp. 5215-5222
    • Humphries, M.J.1    Matsumoto, K.2    White, S.L.3    Olden, K.4
  • 20
    • 66749184678 scopus 로고    scopus 로고
    • Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13
    • L.G. Monovich Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13 J. Med. Chem. 52 2009 3523 3538
    • (2009) J. Med. Chem. , vol.52 , pp. 3523-3538
    • Monovich, L.G.1
  • 22
    • 0034938797 scopus 로고    scopus 로고
    • Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis
    • DOI 10.1016/S1074-5521(01)00045-X, PII S107455210100045X
    • J. Liu Hexosaminidase inhibitors as new drug candidates for therapy of osteoarthritis Chem. Biol. 8 2001 701 711 (Pubitemid 32632536)
    • (2001) Chemistry and Biology , vol.8 , Issue.7 , pp. 701-711
    • Liu, J.1    Shikhman, A.R.2    Lotz, M.K.3    Wong, C.-H.4
  • 23
    • 2242477522 scopus 로고    scopus 로고
    • Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes
    • DOI 10.1042/BJ20021070
    • T. Latsis Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes Biochem. J. 368 2002 309 316 (Pubitemid 35463434)
    • (2002) Biochemical Journal , vol.368 , Issue.1 , pp. 309-316
    • Latsis, T.1    Andersen, B.2    Agius, L.3
  • 24
    • 0038643501 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of iminosugar-based glycosyltransferase inhibitors
    • P. Compain, and O.R. Martin Design, synthesis and biological evaluation of iminosugar-based glycosyltransferase inhibitors Curr. Top. Med. Chem. 3 2003 541 560
    • (2003) Curr. Top. Med. Chem. , vol.3 , pp. 541-560
    • Compain, P.1    Martin, O.R.2
  • 30
  • 31
    • 76649109891 scopus 로고    scopus 로고
    • Gaucher's disease
    • C. Dulsat, and N. Mealy Gaucher's disease Drugs Future 34 2009 147 149
    • (2009) Drugs Future , vol.34 , pp. 147-149
    • Dulsat, C.1    Mealy, N.2
  • 32
    • 77949469173 scopus 로고    scopus 로고
    • New therapies in the management of Niemann-Pick type C disease: Clinical utility of Miglustat
    • J.E. Wraith, and J. Imrie New therapies in the management of Niemann-Pick type C disease: clinical utility of Miglustat Ther. Clin. Risk Manage. 5 2009 877 887
    • (2009) Ther. Clin. Risk Manage. , vol.5 , pp. 877-887
    • Wraith, J.E.1    Imrie, J.2
  • 34
    • 79851512260 scopus 로고    scopus 로고
    • Iminosugars as active-site specific chaperones for the treatment of lysosomal storage disorders
    • J.-Q. Fan Iminosugars as active-site specific chaperones for the treatment of lysosomal storage disorders Abstracts of Papers 230th ACS National Meeting, CARB-033 2005
    • (2005) Abstracts of Papers 230th ACS National Meeting, CARB-033
    • Fan, J.-Q.1
  • 35
    • 84889493257 scopus 로고    scopus 로고
    • Iminosugars as active-site specific chaperones for the treatment of lysosomal storage disorders
    • J.-Q. Fan Iminosugars as active-site specific chaperones for the treatment of lysosomal storage disorders P. Compain, O.R. Martin, Iminosugars: From Synthesis to Therapeutic Applications 2007 John Wiley and Sons Ltd. pp. 225-247
    • (2007) Iminosugars: From Synthesis to Therapeutic Applications
    • Fan, J.-Q.1
  • 36
    • 66249144983 scopus 로고    scopus 로고
    • Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease
    • G.-N. Wang Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease J. Med. Chem. 52 2009 3146 3149
    • (2009) J. Med. Chem. , vol.52 , pp. 3146-3149
    • Wang, G.-N.1
  • 37
    • 33847220777 scopus 로고    scopus 로고
    • Pharmacological enhancement of mutated alpha-glucosidase activity in fibroblasts from patients with Pompe disease
    • G. Parenti Pharmacological enhancement of mutated alpha-glucosidase activity in fibroblasts from patients with Pompe disease Mol. Ther. 15 2007 508 514
    • (2007) Mol. Ther. , vol.15 , pp. 508-514
    • Parenti, G.1
  • 38
    • 76649093920 scopus 로고    scopus 로고
    • Isofagomine tartrate: Glycogen phosphorylase inhibitor treatment of Gaucher's disease
    • C. Dulsat, and N. Mealy Isofagomine tartrate: glycogen phosphorylase inhibitor treatment of Gaucher's disease Drugs Future 34 2009 23 25
    • (2009) Drugs Future , vol.34 , pp. 23-25
    • Dulsat, C.1    Mealy, N.2
  • 39
    • 53749104902 scopus 로고    scopus 로고
    • Fabry's disease
    • Y.A. Zarate, and R.J. Hopkin Fabry's disease Lancet 372 2008 1427 1435
    • (2008) Lancet , vol.372 , pp. 1427-1435
    • Zarate, Y.A.1    Hopkin, R.J.2
  • 40
    • 61849099371 scopus 로고    scopus 로고
    • Molecular interaction of imino sugars with human alpha-galactosidase: Insights into the mechanism of complex formation and pharmacological chaperone action in Fabry disease
    • K. Sugawara Molecular interaction of imino sugars with human alpha-galactosidase: insights into the mechanism of complex formation and pharmacological chaperone action in Fabry disease Mol. Genet. Metab. 96 2009 233 238
    • (2009) Mol. Genet. Metab. , vol.96 , pp. 233-238
    • Sugawara, K.1
  • 41
    • 0021891884 scopus 로고
    • Assembly of asparagine-linked oligosaccharides
    • R. Kornfeld, and S. Kornfeld Assembly of asparagine-linked oligosaccharides Annu. Rev. Biochem. 54 1985 631 664 (Pubitemid 15073660)
    • (1985) Annual Review of Biochemistry , vol.VOL. 54 , pp. 631-664
    • Kornfeld, R.1    Kornfeld, S.2
  • 42
    • 23744436074 scopus 로고    scopus 로고
    • Celgosivir
    • L.A. Sorbera Celgosivir Drugs Future 30 2005 545 552
    • (2005) Drugs Future , vol.30 , pp. 545-552
    • Sorbera, L.A.1
  • 43
    • 0031957011 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteins
    • A. Choukhi Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteins J. Virol. 72 1998 3851 3858 (Pubitemid 28188685)
    • (1998) Journal of Virology , vol.72 , Issue.5 , pp. 3851-3858
    • Choukhi, A.1    Ung, S.2    Wychowski, C.3    Dubuisson, J.4
  • 44
    • 68649083959 scopus 로고    scopus 로고
    • Celgosivir, an α-glucosidase i inhibitor for the potential treatment of hepatitis C virus infection
    • D. Durantel Celgosivir, an α-glucosidase I inhibitor for the potential treatment of hepatitis C virus infection Curr. Opin. Invest. Drugs. 10 2009 860 870
    • (2009) Curr. Opin. Invest. Drugs. , vol.10 , pp. 860-870
    • Durantel, D.1
  • 46
    • 23944482913 scopus 로고    scopus 로고
    • A rapid synthesis of hexofuranose-like iminosugars using ring-closing metathesis
    • DOI 10.1021/ol051232b
    • S. Cren A rapid synthesis of hexofuranose-like iminosugars using ring-closing metastasis Org. Lett. 7 2005 3521 3523 (Pubitemid 41186821)
    • (2005) Organic Letters , vol.7 , Issue.16 , pp. 3521-3523
    • Cren, S.1    Wilson, C.2    Thomas, N.R.3
  • 47
    • 49649087984 scopus 로고    scopus 로고
    • Rapid synthesis of iminosugar derivatives for cell-based in situ screening discovery of "hit" compounds with anticancer activity
    • L. Zhang Rapid synthesis of iminosugar derivatives for cell-based in situ screening discovery of "hit" compounds with anticancer activity ChemMedChem 2 2007 1594 1597
    • (2007) ChemMedChem , vol.2 , pp. 1594-1597
    • Zhang, L.1
  • 48
    • 70449629295 scopus 로고    scopus 로고
    • A concise synthesis of castanospermine by the use of a transannular cyclization
    • T. Jensen A concise synthesis of castanospermine by the use of a transannular cyclization J. Org. Chem. 74 2009 8886 8889
    • (2009) J. Org. Chem. , vol.74 , pp. 8886-8889
    • Jensen, T.1
  • 49
    • 77949334636 scopus 로고    scopus 로고
    • Looking glass inhibitors: Scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases
    • D. Best Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases Tetrahedron Asymmetry 21 2010 311 319
    • (2010) Tetrahedron Asymmetry , vol.21 , pp. 311-319
    • Best, D.1
  • 50
    • 70349495205 scopus 로고    scopus 로고
    • Large scale synthesis of the acetonides of l-glucuronolactone and of l-glucose: Easy access to l-sugar chirons
    • A.C. Weymouth-Wilson Large scale synthesis of the acetonides of l-glucuronolactone and of l-glucose: easy access to l-sugar chirons Tetrahedron Lett. 50 2009 6307 6310
    • (2009) Tetrahedron Lett. , vol.50 , pp. 6307-6310
    • Weymouth-Wilson, A.C.1
  • 51
    • 77949289209 scopus 로고    scopus 로고
    • Recent Developments in the synthesis of pyrrolidine-containing iminosugars
    • B.L. Stocker Recent Developments in the synthesis of pyrrolidine- containing iminosugars Eur. J. Org. Chem. 2010 1615 1637
    • (2010) Eur. J. Org. Chem. , pp. 1615-1637
    • Stocker, B.L.1
  • 52
    • 65549092588 scopus 로고    scopus 로고
    • Tactics and strategies for the synthesis of iminosugar C-glycosides: A review
    • P. Compain Tactics and strategies for the synthesis of iminosugar C-glycosides: a review Tetrahedron Asymmetry 20 2009 672 711
    • (2009) Tetrahedron Asymmetry , vol.20 , pp. 672-711
    • Compain, P.1
  • 53
    • 0034685994 scopus 로고    scopus 로고
    • Synthesis of (+)-casuarine
    • DOI 10.1021/jo991680v
    • S.E. Denmark, and A.R. Hurd Synthesis of (+)-casuarine J. Org. Chem. 65 2000 2875 2886 (Pubitemid 30329143)
    • (2000) Journal of Organic Chemistry , vol.65 , Issue.10 , pp. 2875-2886
    • Denmark, S.E.1    Hurd, A.R.2
  • 54
    • 63849099819 scopus 로고    scopus 로고
    • D-Fructose-6-phosphate aldolase in organic synthesis: Cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds
    • A.L. Concia D-Fructose-6-phosphate aldolase in organic synthesis: cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds Chem. Eur. J. 15 2009 3808 3816
    • (2009) Chem. Eur. J. , vol.15 , pp. 3808-3816
    • Concia, A.L.1
  • 55
    • 34548538250 scopus 로고    scopus 로고
    • A chemoenzymatic-RCM strategy for the enantioselective synthesis of new dihydroxylated 5-hydroxymethyl-indolizidines and 6-hydroxymethyl-quinolizidines
    • DOI 10.1016/j.tetasy.2007.07.017, PII S0957416607005265
    • G. Lesma A chemoenzymatic-RCM strategy for the enantioselective synthesis of new dihydroxylated 5-hydroxymethyl indolizidines and 6-hydroxymethyl- quinolizidines Tetrahedron Asymmetry 18 2007 1948 1954 (Pubitemid 47385163)
    • (2007) Tetrahedron Asymmetry , vol.18 , Issue.16 , pp. 1948-1954
    • Lesma, G.1    Colombo, A.2    Landoni, N.3    Sacchetti, A.4    Silvani, A.5
  • 56
    • 58149188488 scopus 로고    scopus 로고
    • Synthesis of (+)-DGDP and (-)-7-epialexine
    • T.J. Donohoe Synthesis of (+)-DGDP and (-)-7-epialexine Org. Biomol. Chem. 6 2008 3896 3898
    • (2008) Org. Biomol. Chem. , vol.6 , pp. 3896-3898
    • Donohoe, T.J.1
  • 57
    • 65549099060 scopus 로고    scopus 로고
    • Iodine-mediated ring-closing iodoamination with concomitant N-debenzylation for the asymmetric synthesis of polyhydroxylated pyrrolidines
    • S.G. Davies Iodine-mediated ring-closing iodoamination with concomitant N-debenzylation for the asymmetric synthesis of polyhydroxylated pyrrolidines Tetrahedron Asymmetry 20 2009 758 772
    • (2009) Tetrahedron Asymmetry , vol.20 , pp. 758-772
    • Davies, S.G.1
  • 58
    • 67149147439 scopus 로고    scopus 로고
    • De novo asymmetric approach to 8a-epi-swainsonine
    • J.A. Coral De novo asymmetric approach to 8a-epi-swainsonine Heterocycles 79 2009 521 529
    • (2009) Heterocycles , vol.79 , pp. 521-529
    • Coral, J.A.1
  • 59
    • 0000448652 scopus 로고
    • Enantiospecific synthesis of swainsonine, (1S, 2R, 8R, 8aR)-1,2,8-trihydroxyoctahydroindolizine, from d-mannose
    • G.W.J. Fleet Enantiospecific synthesis of swainsonine, (1S, 2R, 8R, 8aR)-1,2,8-trihydroxyoctahydroindolizine, from d-mannose Tetrahedron Lett. 25 1984 1853 1856
    • (1984) Tetrahedron Lett. , vol.25 , pp. 1853-1856
    • Fleet, G.W.J.1
  • 60
    • 10044237855 scopus 로고    scopus 로고
    • Stereoselective synthesis of swainsonines from pyridines
    • DOI 10.1016/j.tet.2004.10.086, PII S0040402004018058
    • G. Heimgartner Stereoselective synthesis of swainsonines from pyridines Tetrahedron 61 2005 643 655 (Pubitemid 39602825)
    • (2005) Tetrahedron , vol.61 , Issue.3 , pp. 643-655
    • Heimgartner, G.1    Raatz, D.2    Reiser, O.3
  • 61
    • 0037159762 scopus 로고    scopus 로고
    • A synthesis of (1S, 2R, 8R, 8aR)-8-hydroxy-1,2-(isopropylidenedioxy) indolizin-5-one from d-ribose: Improved access to (-)-swainsonine and its analogs
    • W.H. Pearson A synthesis of (1S, 2R, 8R, 8aR)-8-hydroxy-1,2- (isopropylidenedioxy)indolizin-5-one from d-ribose: improved access to (-)-swainsonine and its analogs Heterocycles 58 2002 421 430
    • (2002) Heterocycles , vol.58 , pp. 421-430
    • Pearson, W.H.1
  • 62
    • 58149141780 scopus 로고    scopus 로고
    • Scale-up synthesis of swainsonine: A potent alpha-mannosidase II inhibitor
    • P.K. Sharma Scale-up synthesis of swainsonine: a potent alpha-mannosidase II inhibitor Org. Process Res. Dev. 12 2008 831 836
    • (2008) Org. Process Res. Dev. , vol.12 , pp. 831-836
    • Sharma, P.K.1
  • 64
    • 55549109436 scopus 로고    scopus 로고
    • Mutation analysis of B3GALTL in Peters Plus syndrome
    • L.M. Reis Mutation analysis of B3GALTL in Peters Plus syndrome Am. J. Med. Genet. A 146A 2008 2603 2610
    • (2008) Am. J. Med. Genet. A , vol.146 , pp. 2603-2610
    • Reis, L.M.1
  • 65
    • 77049121473 scopus 로고    scopus 로고
    • Elevated mRNA level of hST6Gal i and hST3Gal v positively correlates with the high risk of pediatric leukemia
    • S. Mondal Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric leukemia Leuk. Res. 34 2010 463 470
    • (2010) Leuk. Res. , vol.34 , pp. 463-470
    • Mondal, S.1
  • 66
    • 70449358328 scopus 로고    scopus 로고
    • High expression of N-acetylglucosaminyltransferase v in mucinous tumors of the ovary
    • N. Takahashi High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary Oncol. Rep. 22 2009 1027 1032
    • (2009) Oncol. Rep. , vol.22 , pp. 1027-1032
    • Takahashi, N.1
  • 67
    • 38349027300 scopus 로고    scopus 로고
    • Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth
    • Z. Zhang Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth Biochim. Biophys. Acta 1783 2008 287 296
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 287-296
    • Zhang, Z.1
  • 68
    • 77249153689 scopus 로고    scopus 로고
    • Glycan and lectin microarrays for glycomics and medicinal applications
    • J. Katrlik Glycan and lectin microarrays for glycomics and medicinal applications Med. Res. Rev. 30 2010 394 418
    • (2010) Med. Res. Rev. , vol.30 , pp. 394-418
    • Katrlik, J.1
  • 69
    • 74049119815 scopus 로고    scopus 로고
    • Glycan array: A powerful tool for glycomics studies
    • C.H. Liang, and C.Y. Wu Glycan array: a powerful tool for glycomics studies Exp. Rev. Proteom. 6 2009 631 645
    • (2009) Exp. Rev. Proteom. , vol.6 , pp. 631-645
    • Liang, C.H.1    Wu, C.Y.2
  • 70
    • 77749343015 scopus 로고    scopus 로고
    • Glycome profiling using modern glycomics technology: Technical aspects and applications
    • D. Vanderschaeghe Glycome profiling using modern glycomics technology: technical aspects and applications Biol. Chem. 391 2010 149 161
    • (2010) Biol. Chem. , vol.391 , pp. 149-161
    • Vanderschaeghe, D.1
  • 71
    • 33947314170 scopus 로고    scopus 로고
    • The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor miglustat in the rat
    • DOI 10.1080/00498250601094543, PII 773288053
    • A. Treiber The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor Miglustat in the rat Xenobiotica 37 2007 298 314 (Pubitemid 46439676)
    • (2007) Xenobiotica , vol.37 , Issue.3 , pp. 298-314
    • Treiber, A.1    Morand, O.2    Clozel, M.3
  • 72
    • 33645071059 scopus 로고    scopus 로고
    • Miglustat: Substrate reduction therapy for glycoshingolipid lysosomal storage disorders
    • R.H. Lachmann Miglustat: Substrate reduction therapy for glycoshingolipid lysosomal storage disorders Drugs Today (Barc) 42 2006 29 38
    • (2006) Drugs Today (Barc) , vol.42 , pp. 29-38
    • Lachmann, R.H.1
  • 73
    • 20444438808 scopus 로고    scopus 로고
    • Polyhydroxylated pyrrolizidines. Part 6: A new and concise stereoselective synthesis of (+)-casuarine and its 6,7-diepi isomer, from DMDP
    • DOI 10.1016/j.tet.2005.05.004, PII S0040402005007775
    • I. Izquierdo Polyhydroxylated pyrrolizidines. Part 6: a new and concise stereoselective synthesis of (+)-casuarine and its 6,7-diepi isomer, from DMDP Tetrahedron 61 2005 6527 6533 (Pubitemid 40812953)
    • (2005) Tetrahedron , vol.61 , Issue.27 , pp. 6527-6533
    • Izquierdo, I.1    Plaza, M.T.2    Tamayo, J.A.3
  • 74
    • 33845694135 scopus 로고    scopus 로고
    • Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols
    • DOI 10.1016/j.tet.2006.12.002, PII S0040402006019259
    • M.-Y. Chang Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols Tetrahedron 63 2006 1339 1344 (Pubitemid 44969426)
    • (2007) Tetrahedron , vol.63 , Issue.6 , pp. 1339-1344
    • Chang, M.-Y.1    Kung, Y.-H.2    Ma, C.-C.3    Chen, S.-T.4
  • 77
    • 0023093138 scopus 로고
    • Synthesis of deoxymannojirimycin fagomine deoxynojirimycin 2-acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol 2-acetamido-1,5-imino-1,2,5- trideoxy-D-glucitol 2S, 3R, 4R, 5R-trihydroxypipecolic acid and 2S, 3R, 4R, 5S-trihydroxypipecolic acid from methyl 3-O-benzyl-2,6-dideoxy-2,6-imino- α-D-mannofuranoside
    • DOI 10.1016/S0040-4020(01)90035-3
    • G.W.J. Fleet Synthesis of deoxymannojirimycin, fagomine, and deoxynojirimycin, 2-acetamido-1,5-imino-1,2,5-trideoxy-d-mannitol, 2-acetamido-1,5-imino-1,2,5-trideoxy-d-glucitol, 2S, 3R, 4R, 5R-trihydroxypipecolic acid and 2S, 3R, 4R, 5S-trihydroxypipecolic acid from methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-alpha-d-mannofuranoside Tetrahedron 43 1987 979 990 (Pubitemid 17039614)
    • (1987) Tetrahedron , vol.43 , Issue.5 , pp. 979-990
    • Fleet, G.W.J.1    Fellows, L.E.2    Smith, P.W.3
  • 78
    • 36749022779 scopus 로고    scopus 로고
    • Synthesis of the naringinase inhibitors l-swainsonine and related 6-C-methyl-l-swainsonine analogues: (6R)-C-methyl-l-swainsonine is a more potent inhibitor of l-rhamnosidase by an order of magnitude than l-swainsonine
    • DOI 10.1016/j.tetlet.2007.10.142, PII S0040403907021570
    • A.E. Hakansson Synthesis of the naringinase inhibitors l-swainsonine and related 6-C-methyl-l-swainsonine analogues: (6R)-C-methyl-l-swainsonine is a more potent inhibitor of l-rhamnosidase by an order of magnitude than l-swainsonine Tetrahedron Lett. 49 2007 179 184 (Pubitemid 350199553)
    • (2008) Tetrahedron Letters , vol.49 , Issue.1 , pp. 179-184
    • Hakansson, A.E.1    Van Ameijde, J.2    Horne, G.3    Nash, R.J.4    Wormald, M.R.5    Kato, A.6    Besra, G.S.7    Gurcha, S.8    Fleet, G.W.J.9
  • 79
    • 33847244807 scopus 로고    scopus 로고
    • Looking glass inhibitors: Synthesis of a potent naringinase inhibitor l-DIM [1,4-dideoxy-1,4-imino-l-mannitol], the enantiomer of DIM [1,4-dideoxy-1,4-imino-d-mannitol] a potent alpha-d-mannosidase inhibitor
    • A.E. Hakansson Looking glass inhibitors: synthesis of a potent naringinase inhibitor l-DIM [1,4-dideoxy-1,4-imino-l-mannitol], the enantiomer of DIM [1,4-dideoxy-1,4-imino-d-mannitol] a potent alpha-d-mannosidase inhibitor Tetrahedron Asymmetry 18 2007 282 289
    • (2007) Tetrahedron Asymmetry , vol.18 , pp. 282-289
    • Hakansson, A.E.1
  • 80
    • 30444438410 scopus 로고    scopus 로고
    • Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis
    • DOI 10.1002/cbic.200500321
    • P.-H. Liang Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis ChemBioChem 7 2006 165 173 (Pubitemid 43076300)
    • (2006) ChemBioChem , vol.7 , Issue.1 , pp. 165-173
    • Liang, P.-H.1    Cheng, W.-C.2    Lee, Y.-L.3    Yu, H.-P.4    Wu, Y.-T.5    Lin, Y.-L.6    Wong, C.-H.7
  • 81
  • 83
    • 0033538032 scopus 로고    scopus 로고
    • The first combinatorial library of azasugar glycosidase inhibitors
    • DOI 10.1016/S0040-4039(99)00317-2, PII S0040403999003172
    • A. Lohse The first combinatorial library of azasugar glycosidase inhibitors Tetrahedron Lett. 40 1999 3033 3036 (Pubitemid 29156632)
    • (1999) Tetrahedron Letters , vol.40 , Issue.15 , pp. 3033-3036
    • Lohse, A.1    Jensen, K.B.2    Bols, M.3
  • 84
    • 49649087984 scopus 로고    scopus 로고
    • Rapid synthesis of iminosugar derivatives for cell-based in situ screening: Discovery of "hit" compounds with anticancer activity
    • L. Zhang Rapid synthesis of iminosugar derivatives for cell-based in situ screening: discovery of "hit" compounds with anticancer activity ChemMedChem 2 2007 1594 1597
    • (2007) ChemMedChem , vol.2 , pp. 1594-1597
    • Zhang, L.1
  • 85
    • 33750709250 scopus 로고    scopus 로고
    • Syntheses of peptidomimetics based on pyranose and polyhydroxylated piperidine scaffolds
    • DOI 10.2174/157017906778699530
    • P.V. Murphy, and J.L. Dunne Syntheses of peptidomimetics based on pyranose and poly-hydroxylated piperidine scaffolds Curr. Org. Synth. 3 2006 403 437 (Pubitemid 44697179)
    • (2006) Current Organic Synthesis , vol.3 , Issue.4 , pp. 403-437
    • Murphy, P.V.1    Dunne, J.L.2
  • 86
    • 84889333145 scopus 로고    scopus 로고
    • General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries
    • B. La Ferla General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries P. Compain, O.R. Martin, Iminosugars: From Synthesis to Therapeutic Applications 2007 John Wiley and Sons Ltd. 25 61
    • (2007) Iminosugars: From Synthesis to Therapeutic Applications , pp. 25-61
    • La Ferla, B.1
  • 87
    • 35948955219 scopus 로고    scopus 로고
    • Exploring the structural diversity of mammalian carbohydrates ("Glycospace") by statistical databank analysis
    • D.B. Wertz Exploring the structural diversity of mammalian carbohydrates ("Glycospace") by statistical databank analysis ACS Chem. Biol. 10 2007 685 691
    • (2007) ACS Chem. Biol. , vol.10 , pp. 685-691
    • Wertz, D.B.1
  • 88
    • 70349326274 scopus 로고    scopus 로고
    • The repertoire of glycan determinants in the human glycome
    • R.D. Cummings The repertoire of glycan determinants in the human glycome Mol. Biosyst. 5 2009 1087 1104
    • (2009) Mol. Biosyst. , vol.5 , pp. 1087-1104
    • Cummings, R.D.1
  • 90
    • 0027318961 scopus 로고
    • Biological roles of oligosaccharides: All of the theories are correct
    • A. Varki Biological roles of oligosaccharides: all of the theories are correct Glycobiology 3 1993 97 130 (Pubitemid 23132602)
    • (1993) Glycobiology , vol.3 , Issue.2 , pp. 97-130
    • Varki, A.1
  • 91
    • 0001094662 scopus 로고    scopus 로고
    • Glycobiology: Toward understanding the function of sugars
    • R.A. Dwek Glycobiology: toward understanding the function of sugars Chem. Rev. 96 1996 683 720 (Pubitemid 126649163)
    • (1996) Chemical Reviews , vol.96 , Issue.2 , pp. 683-720
    • Dwek, R.A.1
  • 92
    • 0036019907 scopus 로고    scopus 로고
    • Protein glycosylation: Nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds
    • R.G. Spiro Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds Glycobiology 12 2002 43R 56R (Pubitemid 34760066)
    • (2002) Glycobiology , vol.12 , Issue.4
    • Spiro, R.G.1
  • 93
    • 33745381312 scopus 로고    scopus 로고
    • Genetic defects in the human glycome
    • DOI 10.1038/nrg1894, PII N1894
    • H.H. Freeze Genetic defects in the human glycome Nat. Rev. Genet. 7 2006 537 551 (Pubitemid 43943571)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.7 , pp. 537-551
    • Freeze, H.H.1
  • 94
    • 33748195979 scopus 로고    scopus 로고
    • Glycosylation in cellular mechanisms of health and disease
    • DOI 10.1016/j.cell.2006.08.019, PII S0092867406010865
    • K. Ohtsubo, and J.D. Marth Glycosylation in cellular mechanisms of health and disease Cell 126 2006 855 867 (Pubitemid 44310784)
    • (2006) Cell , vol.126 , Issue.5 , pp. 855-867
    • Ohtsubo, K.1    Marth, J.D.2
  • 95
    • 0004106191 scopus 로고    scopus 로고
    • A. Varki, second edition Cold Spring Harbor Laboratory Press*et al.
    • A. Varki, Essentials of Glycobiology second edition 2009 Cold Spring Harbor Laboratory Press
    • (2009) Essentials of Glycobiology
  • 97
    • 58149390243 scopus 로고    scopus 로고
    • Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel
    • S. Griffin Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel Hepatology 48 2008 1779 1790
    • (2008) Hepatology , vol.48 , pp. 1779-1790
    • Griffin, S.1
  • 98
    • 65649146500 scopus 로고    scopus 로고
    • Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses
    • J. Chang Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses Antimicrob. Agents Chemother. 53 2009 1501 1508
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1501-1508
    • Chang, J.1
  • 99
    • 53549101911 scopus 로고    scopus 로고
    • N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery
    • S. Pollock N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery AIDS 22 2008 1961 1969
    • (2008) AIDS , vol.22 , pp. 1961-1969
    • Pollock, S.1
  • 100
    • 77955303835 scopus 로고    scopus 로고
    • Cystic fibrosis and diabetes: IsoLAB and isoDAB, enantiomeric carbon branched pyrrolidine iminosugars
    • D. Best Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon branched pyrrolidine iminosugars Tetrahedron Lett. 51 2010 4170 4174
    • (2010) Tetrahedron Lett. , vol.51 , pp. 4170-4174
    • Best, D.1
  • 101
    • 48449088363 scopus 로고    scopus 로고
    • Functionalised pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: Optimizing the fit to the active site
    • H. Fiaux Functionalised pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site Bioorg. Med. Chem. 16 2008 7337 7346
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 7337-7346
    • Fiaux, H.1
  • 102
    • 68549126960 scopus 로고    scopus 로고
    • CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo
    • Y. Chikaraishi CB-12181, a new azasugar-based matrix metalloproteinase/ tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo Curr. Neurovasc. Res. 6 2009 140 147
    • (2009) Curr. Neurovasc. Res. , vol.6 , pp. 140-147
    • Chikaraishi, Y.1
  • 103
    • 77149141692 scopus 로고    scopus 로고
    • Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation
    • T. Wennekes Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation J. Med. Chem. 53 2010 689 698
    • (2010) J. Med. Chem. , vol.53 , pp. 689-698
    • Wennekes, T.1
  • 104
    • 77951475260 scopus 로고    scopus 로고
    • Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits athersclerosis development in APOE*3 Leiden and low-density lipoprotein receptor -/- mice
    • F. Bietrix Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits athersclerosis development in APOE*3 Leiden and low-density lipoprotein receptor -/- mice Arterioscler. Thromb. Vasc. Biol. 30 2010 931 937
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 931-937
    • Bietrix, F.1
  • 105
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • DOI 10.1038/74704
    • R.A. Clynes Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets Nat. Med. 6 2000 443 446 (Pubitemid 30208162)
    • (2000) Nature Medicine , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 106
    • 0028214729 scopus 로고
    • Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin
    • T.M. Block Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin Proc. Natl. Acad. Sci. U. S. A. 91 1994 2235
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 2235
    • Block, T.M.1
  • 107
    • 0034988078 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: Therapeutic implications
    • DOI 10.1053/jhep.2001.25103
    • A. Mehta Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications Hepatology 33 2001 1488 1495 (Pubitemid 32496986)
    • (2001) Hepatology , vol.33 , Issue.6 , pp. 1488-1495
    • Mehta, A.1    Carrouee, S.2    Conyers, B.3    Jordan, R.4    Butters, T.5    Dwek, R.A.6    Block, T.M.7
  • 109
    • 66249120003 scopus 로고    scopus 로고
    • Airway delivery of low-dose Miglustat normalizes nasal potential difference in F508del cystic fibrosis mice
    • B. Lubamba Airway delivery of low-dose Miglustat normalizes nasal potential difference in F508del cystic fibrosis mice Am. J. Respir. Crit. Care Med. 179 2009 1022 1028
    • (2009) Am. J. Respir. Crit. Care Med. , vol.179 , pp. 1022-1028
    • Lubamba, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.