Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1- kinase tetramers down-regulating the enzyme and muscle glycolysis

Biochemical Journal

Volumn 408, Issue 1, 2007, Pages 123-130

  Costa Leite, Tiago ^a   Da Silva, Daniel ^a   Guimarães Coelho, Raquel ^a   Zancan, Patricia ^a   Sola Penna, Mauro ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Glycolysis; Lactate; Metabolism; Phosphofructokinase; Regulation; Tetramer

Indexed keywords

DISSOCIATION; ENERGY RESOURCES; ENZYMES; FRUCTOSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

LACTATES; PHOSPHOFRUCTOKINASE; REGULATION; TETRAMERS;

MUSCLE;

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIMER; F ACTIN; FRUCTOSE 2,6 BISPHOSPHATE; FRUCTOSE 6 PHOSPHATE; GLYCOLYTIC ENZYME; LACTIC ACID; TETRAMER;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL METABOLISM; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; GLUCOSE METABOLISM; GLYCOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE, TUMOR; DOWN-REGULATION; GLYCOLYSIS; HYDROGEN-ION CONCENTRATION; KINETICS; LACTATES; MICE; MUSCLE, SKELETAL; PHOSPHOFRUCTOKINASE-1; PROTEIN KINASE INHIBITORS; RABBITS; SUBSTRATE SPECIFICITY;

EID: 36349004121     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070687     Document Type: Article

References (47)

1. Gladden, L. B. (2004) Lactate metabolism: a new paradigm for the third millennium. J. Physiol. 558, 5-30
2. Kristensen, M., Albertsen, J., Rentsch, M. and Juel, C. (2005) Lactate and force production in skeletal muscle. J. Physiol. 562, 521-526
3. Philp, A., Macdonald, A. L. and Watt, P. W. (2005) Lactate: a signal coordinating cell and systemic function. J. Exp. Biol. 208, 4561-4575
4. Robinson, B. H. (2006) Lactic acidemia and mitochondrial disease. Mol. Genet. Metab. 89, 3-13
5. Boussouar, F. and Benahmed, M. (2004) Lactate and energy metabolism in male germ cells. Trends Endocrinol. Metab. 15, 345-350
6. Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S. et al. (2007) Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812-3819
7. Kim, J. W. and Dang, C. V. (2006) Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 66, 8927-8930
8. Mathuoala, S. P., Colen, C. B., Parajuli, P. and Sloan, A. E. (2007) Lactate and malignant tumors: a therapeutic target at the end stage of glycolysis. J. Bioenerg. Biomembr. 39, 73-77
9. Voit, E., Neves, A. R. and Santos, H. (2006) The intricate side of systems biology. Proc. Natl. Acad. Sci. U.S.A. 103, 9452-9457
10. Uyeda, K. (1979) Phosphofructokinase. Adv. Enzymol. 48, 193-244
11. Beitner, R. (1979) The role of glucose-1,6-bisphosphate in the regulation of carbohydrate metabolism in muscle. Trends Biochem. Sci. 4, 228-230
12. Hers, H. G. and van Schaftingen, E. (1982) Fructose 2,6-bisphosphate 2 years after its discovery. Biochem. J. 206, 1-12
13. Luther, M. A., Cai, G.-Z. and Lee, J. C. (1986) Thermodynamics of dimer and tetramer formations in rabbit muscle phosphofructokinase. Biochemistry 25, 7931-7937
14. Aragon, J. J. and Sols, A. (1991) Regulation of enzyme activity in the cell: effect of enzyme concentration. FASEB J. 5, 2945-2950
15. Lee, J. C., Hesterberg, L. K., Luther, M. A. and Cai, G.-Z. (1989) Rabbit muscle phosphofructokinase. In Allosteric Enzymes (Herve, G., ed.), pp. 231-254, CRC Press, Boca Raton, FL
16. Hesterberg, L. K. and Lee, J. C. (1981) Self-association of rabbit muscle phosphofructokinase at pH 7.0: stoichiometry. Biochemistry 20, 2974-2980
17. El-Bacha, T., de Freitas, M. S. and Sola-Penna, M. (2003) Cellular distribution of phosphofructokinase activity and implications to metabolic regulation in human breast cancer. Mol. Genet. Metab. 79, 294-299
18. El-Bacha, T., Menezes, M. M., Azevedo e Silva, M. C., Sola-Penna, M. and Da Poian, A. T. (2004) Mayaro virus infection alters glucose metabolism in cultured cells through activation of the enzyme 6-phosphofructo 1-kinase. Mol. Cell Biochem. 266, 191-198
19. Meira, D. D., Marinho-Carvalho, M. M., Teixeira, C. A., Veiga, V. F., Da Poian, A. T., Holandino, C., de Freitas, M. S. and Sola-Penna, M. (2005) Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes. Mol. Genet. Metab. 84, 354-362
20. Zancan, P. and Sola-Penna, M. (2005) Regulation of human erythrocyte metabolism by insulin: cellular distribution of 6-phosphofructo-1-kinase and its implication for red blood cell function. Mol. Genet. Metab. 86, 401-411
21. Zancan, P. and Sola-Penna, M. (2005) Calcium influx: a possible role for insulin modulation of intracellular distribution and activity of 6-phosphofructo-1-kinase in human erythrocytes. Mol. Genet. Metab. 86, 392-400
22. Zancan, P., Rosas, A. O., Marcondes, M. C., Marinho-Carvalho, M. M. and Sola-Penna, M. (2007) Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase. Biochem. Pharmacol. 73, 1520-1527
23. Marin-Hernandez, A., Rodriguez-Enriquez, S., Vital-Gonzalez, P. A., Flores-Rodriguez, F. L., Macias-Silva, M., Sosa-Garrocho, M. and Moreno-Sanchez, R. (2006) Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J. 273, 1975-1988
24. Reference deleted
25. 32P]-nucleoside triphosphate, with high specific activity. In Genes and Antigenes of Parasites, a Laboratory Manual (Morel, C. M., ed.), pp. 146-157, Fundação Oswaldo Cruz, Rio de Janeiro
26. Kemp, R. G. (1975) Phosphofructokinase. Methods Enzymol. 42, 72-77
27. Kuo, H.-J., Malencik, D. A., Liou, R.-S. and Anderson, S. R. (1986) Factors affecting the activation of rabbit muscle phosphofructokinase by actin. Biochemistry 25, 1278-1286
28. Lowry, O. H., Rosenbrough, N. L., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
29. Sola-Penna, M., Santos, A. C., Serejo, F. C., Alves, G. G., El-Bacha, T., Faber-Barata, J., Pereira, M. F., Da Poian, A. T. and Sorenson, M. M. (2002) A radioassay for phosphofructokinase-1 activity in cell extracts and purified enzyme. J. Biochem. Biophys. Methods 50, 129-140
30. Lakowicz, J. R. (1999) Principles of Fluorescence Spectroscopy, Kluwer Academic/Plenum, New York
31. Lowry, O. H. and Passonneau, J. V. (1972) A flexible system of enzymatic analysis. Academic Press, New York
32. CRC (1997) Haodbook of Chemistry and Physics (77th ed.) (Lide, D. R., ed.), CRC, New York
33. Alves, G. G., Marinho-Carvalho, M. M., Atella, G. C., Silva-Neto, M. A. and Sola-Penna, M. (2007) Allosteric regulation of 6-phosphofructo-1-kinase activity of fat body and flight muscle from the bloodsucking bug Rhodnius prolixus. Ann. Acad. Bras. Cienc. 79, 53-62
34. Marinho-Carvalho, M. M., Zancan, P. and Sola-Penna, M. (2006) Modulation of 6-phosphofructo-1-kinase oligomeric equilibrium by calmodulin: formation of active dimers. Mol. Genet. Metab, 87, 253-261
35. Silva, A. P., Alves, G. G., Araujo, A. H. and Sola-Penna, M. (2004) Effects of insulin and actin on phosphofructokinase activity and cellular distribution in skeletal muscle. Ann. Acad. Bras. Cienc. 76, 541-548
36. Bock, P. E. and Frieden, C. (1976) Phosphofructokinase. II. Role of ligands in pH-dependent structural changes of the rabbit muscle enzyme. J. Biol. Chem. 251, 5637-5643
37. Alves, G. G. and Sola-Penna, M. (2003) Epinephrine modulates cellular distribution of muscle phosphofructokinase. Mol. Genet. Metab. 78, 302-306
38. Liou, R.-S. and Anderson, S. (1980) Activation of rabbit muscle phosphofructokinase by F-actin and reconstituted thin filaments. Biochemistry 19, 2684-2688
39. Clarke, F., Stephan, P., Morton, D. J. and Wiedemann, J. (1983) The role of actin and associated structural proteins in the organization of glycolytic enzymes. In Actin: Structure and Function in Muscle and Non-Muscle Cells (Barden, J. and Dos Remedios, C., eds), pp. 249-257, Academic Press, Sydney
40. Ashkenazy-Shahar, M. and Beitner, R. (1997) Serotonin decreases cytoskeletal and cytosolic glycolytic enzymes and the levels of ATP and glucose 1,6-bisphosphate in skin, which is prevented by the calmodulin antagonists thioridazine and clotrimazole. Biochem. Mol. Med. 60, 187-193
41. Ashkenazy-Shahar, M., Ben-Porat, H. and Beitner, B. (1998) Insulin stimulates binding of phosphofructokioase to cytoskeleton and increases glucose 1,6-bisphosphate levels in NIH-3T3 fibroblasts, which is prevented by calmodulin antagonists. Mol. Genet. Metab. 65, 213-219
42. Assouline-Cohen, M., Ben-Porat, H. and Beitner, R. (1998) Activation of membrane skeleton-bound phosphofructokinase in erythrocytes induced by serotonin. Mol. Genet. Metab. 63, 235-238
43. 2+ on erythrocyte membrane skeleton-bound phosphofructokinase, ATP levels, and hemolysis. Mol. Genet. Metab. 66, 56-61
44. Glass-Marmor, L. and Beitner, R. (1997) Detachment of glycolytic enzymes from cytoskeleton of melanoma cells induced by calmodulin antagonists. Eur. J. Pharmacol. 328, 241-248
45. Glass-Marmor, L. and Beitner, R. (1999) Taxol (paclitaxel) induces a detachment of phosphofructokinase from cytoskeleton of melanoma cells and decreases the levels of glucose 1,6-bisphosphate, fructose 1,6-bisphosphate and ATP. Eur. J. Pharmacol. 370, 195-199
46. Schwartz, D. and Beitner, R. (2000) Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics. Mol. Genet. Metab. 69, 159-164
47. 2-linked transition of hemoglobin. FEBS Lett. 390, 25-28