Functional imaging of focal brain activation in conscious rats: Impact of [14C] glucose metabolite spreading and release

Journal of Neuroscience Research

Volumn 85, Issue 15, 2007, Pages 3254-3266

  Cruz, Nancy F ^a   Ball, Kelly K ^a   Dienel, Gerald A ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Brain imaging; Deoxyglucose; Gap junctions; Glucose; Lactate; Metabolism

Indexed keywords

DEOXYGLUCOSE; GLUCOSE C 14; HALOTHANE; PROBENECID; UNCLASSIFIED DRUG;

ASTROCYTE; AUDITORY STIMULATION; BRAIN FUNCTION; CONFERENCE PAPER; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; IMAGING SYSTEM; ISOTOPE LABELING; LACTATE BLOOD LEVEL; MALE; METABOLIC ACTIVATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ACOUSTIC STIMULATION; ANIMALS; AUDITORY PATHWAYS; BRAIN; BRAIN CHEMISTRY; BRAIN MAPPING; CARBON RADIOISOTOPES; CONSCIOUSNESS; GLUCOSE; MALE; MICRODIALYSIS; RATS; RATS, WISTAR;

EID: 34347237157     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21193     Document Type: Conference Paper

References (41)

1. Ackermann RF, Lear JL. 1989. Glycolysis-induced discordance between glucose metabolic rates measured with radiolabeled fluorodeoxyglucose and glucose. J Cereb Blood Flow Metab 9:774-785.
2. +-induced stimulation of glucose utilization in rat brain. J Cereb Blood Flow Metab 15:97-110.
3. 11C]D-glucose. J Cereb Blood Flow Metab 10:467-483.
4. 14C]-labeled inulin. Anal Biochem 31:539-544.
5. 14C]glucose quantitative autoradiography. J Neurochem 49:1564-1570.
6. +-induced spreading cortical depression: rapid efflux of lactate from cerebral cortex. J Cereb Blood Flow Metab 19:380-392.
7. De Bruin LA, Schasfoort EM, Steffens AB, Korf J. 1990. Effects of stress and exercise on rat hippocampus and striatum extracellular lactate. Am J Physiol 259:R773-R779.
8. Dienel GA, Cruz NF. 2004. Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought? Neurochem Int 45:321-351.
9. Dienel GA, Wang RY, Cruz NF. 2002. Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises. J Cereb Blood Flow Metab 22:1490-1502.
10. Duffy TE, Cavazzuti M, Cruz NF, Sokoloff L. 1982. Local cerebral glucose metabolism in newborn dogs: effects of hypoxia and halothane anesthesia. Ann Neurol 11:233-246.
11. Frey KA, Agranoff BW. 1983. Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography. Science 219:879-881.
12. Giaume C, Tabernero A, Medina JM. 1997. Metabolic trafficking through astrocytic gap junctions. Glia 21:114-123.
13. Gross PM, Sposito NM, Pettersen SE, Fenstermacher JD. 1986. Differences in function and structure of the capillary endothelium in gray matter, white matter and a circumventricular organ of rat brain. Blood Vessels 23:261-270.
14. Gross PM, Sposito NM, Pettersen SE, Panton DG, Fenstermacher JD. 1987. Topography of capillary density, glucose metabolism, and microvascular function within the rat inferior colliculus. J Cereb Blood Flow Metab 7:154-160.
15. 14C]glucose. In: Passonneau JV, Hawkins RA, Lust WD, Welsh FA, editors. Cerebral metabolism and neural function. Baltimore: Wilkins & Williams, p 367-381.
16. Hertz L, Peng L, Dienel GA. 2006. Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J Cereb Blood Flow Metab [Jul 12, E-pub ahead of print].
17. Korf J. 1996. Intracerebral trafficking of lactate in vivo during stress, exercise, electroconvulsive shock and ischemia as studied with microdialysis. Dev Neurosci 18:405-414.
18. Korf J. 2006. Is brain lactate metabolized immediately after neuronal activity through the oxidative pathway? J Cereb Blood Flow Metab [Apr 26, E-pub ahead of print).
19. Kuhr WG, van den Berg CJ, Korf J. 1988. In vivo identification and quantitative evaluation of carrier-mediated transport of lactate at the cellular level in the striatum of conscious, freely moving rats. J Cereb Blood Flow Metab 8:848-856.
20. Kurumaji A, McCulloch J. 1989. Effects of MK-801 upon local cerebral glucose utilisation in conscious rats and in rats anaesthetised with halothane. J Cereb Blood Flow Metab 9:786-794.
21. Lear J. 1990. Glycolysis: link between PET and proton MR spectroscopic studies of the brain. Radiology 174:328-330.
22. Lear JL, Ackermann RF. 1988. Comparison of cerebral glucose metabolic rates measured with fluorodeoxyglucose and glucose labeled in the 1, 2, 3-4, and 6 positions using double label quantitative digital autoradiography. J Cereb Blood Flow Metab 8:575-585.
23. Lear J, Ackermann RF. 1989. Why the deoxyglucose method has proven so useful in cerebral activation studies: The unappreciated prevalence of stimulation-induced glycolysis. J Cereb Blood Flow Metab 9:911-913.
24. Lear J, Ackermann R. 1991. Autoradiographic comparison of FDG-based and GLU-based measurements of cerebral glucose transport and metabolism: Normal and activated conditions. In: Lassen N, Ingvar D, Raichle M, Friberg L. Brain work and mental activity, Alfred Benzon Symposium 31. Copenhagen: Munskgaard. p 142-152.
25. MacMillan V. 1987. Effect of probenecid on cerebral and cisternal cerebrospinal fluid lactate content. J Cereb Blood Flow Metab 7:118-123.
26. Madsen PL, Cruz NF, Sokoloff L, Dienel GA. 1999. Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J Cereb Blood Flow Metab 19:393-400.
27. McCandless DW, Wiggins RC. 1981. Cerebral energy metabolism during the onset and recovery from halothane anesthesia. Neurochem Res 6:1319-1326.
28. Olds JL, Frey KA, Ehrenkaufer RL, Agranoff BW. 1985. A sequential double-label autoradiographic method that quantifies altered rates of regional glucose metabolism. Brain Res 361:217-224.
29. Pellerin L, Magistretti PJ. 1994. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A 91:10625-10629.
30. Rosental E, Srinivas M, Spray DC. 2001. How to close a gap junction: Efficacies and potencies of uncoupling agents. Methods Mol Biol 154:447-476.
31. Ryan AF, Woolf NK, Sharp FR. 1982. Tonotopic organization in the central auditory pathway of the Mongolian gerbil: a 2-deoxyglucose study. J Comp Neurol 207:369-380.
32. Schasfoort EM, De Bruin LA, Korf J. 1988. Mild stress stimulates rat hippocampal glucose utilization transiently via NMDA receptors, as assessed by lactography. Brain Res 13:58-63.
33. Schmidt KC, Mies G, Dienel GA, Cruz NF, Crane AM, Sokoloff L. 1995. Analysis of time courses of metabolic precursors and products in heterogeneous rat brain tissue: limitations of kinetic modeling for predictions of intracompartmental concentrations from total tissue activity. J Cereb Blood Flow Metab 15:474-484.
34. Schurr A. 2006. Lactate: the ultimate cerebral oxidative energy substrate? J Cereb Blood Flow Metab 26:142-152.
35. 14C]2-deoxyglucose study of the frequency organization of the inferior colliculus of the cat. Neurosci Lett 27:113-118.
36. 14C]deoxyglucose produce selective iso-frequency labelling in the inferior colliculus of the cat with short stimulation periods. Neurosci Lett 59:127-134.
37. Shapiro HM, Greenberg JH, Reivich M, Ashmead G, Sokoloff L. 1978. Local cerebral glucose uptake in awake and halothane-anesthetized primates. Anesthesiology 48:97-103.
38. Sokoloff L. 1986. Cerebral circulation, energy metabolism, and protein synthesis: General characteristics and principles of measurement. In: Phelps M, Mazziotta J, Schelbert H, editors. Positron emission tomography and autoradiography: principles and applications for the brain and heart. New York: Raven Press. p 1-71.
39. 14C]deoxyglucose method for the measurement of local glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-916.
40. Webster WR, Serviere J, Crewther D, Crewther S. 1984. Iso-frequency 2-DG contours in the inferior colliculus of the awake monkey. Exp Brain Res 56:425-37.
41. Zar JH. 1974. Biostatistical analysis. Englewood Cliffs, NJ: Prentice-Hall.