Energy-efficient action potentials in hippocampal mossy fibers

Science

Volumn 325, Issue 5946, 2009, Pages 1405-1408

  Alle, Henrik ^a,c   Roth, Arnd ^b   Geiger, Jörg R P ^a,c  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; SODIUM CHANNEL;

BIOCHEMISTRY; BRAIN; ENERGY BUDGET; ENERGY EFFICIENCY; METABOLISM; POTASSIUM; SODIUM;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; ENERGY CONSUMPTION; ENERGY COST; ENERGY EXPENDITURE; HIPPOCAMPUS; ION CURRENT; NERVE CONDUCTION; NONHUMAN; NONMYELINATED NERVE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT; SODIUM TRANSPORT;

ACTION POTENTIALS; ANIMALS; AXONS; ENERGY METABOLISM; MOSSY FIBERS, HIPPOCAMPAL; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; SODIUM; SODIUM CHANNELS; SODIUM-POTASSIUM-EXCHANGING ATPASE; SYNAPTIC TRANSMISSION;

RATTUS;

EID: 70249083369     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1174331     Document Type: Article

References (25)

1. D. Attwell, S. B. Laughlin, J. Cereb. Blood Flow Metab. 21, 1133 (2001).
2. D. Attwell, C. Iadecola, Trends Neurosci. 25, 621 (2002).
3. P. Lennie, Curr. Biol. 13, 493 (2003).
4. J. Niessing et al., Science 309, 948 (2005).
5. R. Mukamel et al., Science 309, 951 (2005).
6. N. K. Logothetis, Nature 453, 869 (2008).
7. S. Mangia et al., J. Cereb. Blood Flow Metab. 29, 441 (2009).
8. V. Braitenberg, A. Schüz, Cortex: Statistics and Geometry of Neuronal Connectivity (Springer, Berlin, ed. 2, 1998).
9. J. C. Nawroth, C. A. Greer, W. R. Chen, S. B. Laughlin, G. M. Shepherd, J. Neurosci. 27, 9790 (2007).
10. S. S.-H. Wang et al., J. Neurosci. 28, 4047 (2008).
11. A. L. Hodgkin, Philos. Trans. R. Soc. London Ser. B 270, 297 (1975).
12. A. L. Hodgkin, A. F. Huxley, J. Physiol. 117, 500 (1952).
13. J. M. Ritchie, Prog. Biophys. Mol. Biol. 26, 147 (1973).
14. J. R. P. Geiger, P. Jonas, Neuron 28, 927 (2000).
15. M. H. P. Kole, J. J. Letzkus, G. J. Stuart, Neuron 55, 633 (2007).
16. D. Engel, P. Jonas, Neuron 45, 405 (2005).
17. Y. Yu, Y. Shu, D. A. McCormick, J. Neurosci. 28, 7260 (2008).
18. H. Alle, J. R. P. Geiger, Science 311, 1290 (2006).
19. L. Acsady, A. Kamondi, A. Sik, T. Freund, G. Buzsaki, J. Neurosci. 18, 3386 (1998).
20. B. P. Bean, Nat. Rev. Neurosci. 8, 451 (2007).
21. A. A. Faisal, S. B. Laughlin, PLoS Comput. Biol. 3, e79 (2007).
22. Materials and methods are available as supporting material on Srience Online.
23. J. R. P. Geiger, J. Lübke, A. Roth, M. Frotscher, P. Jonas, Neuron 18, 1009 (1997).
24. S. B. Laughlin, T. J. Sejnowski, Science 301, 1870 (2003).
25. We thank A. Lampert and C. Schmidt-Hieber for discussion on sodium conductances and M. Häusser for comments on the manuscript. This work was supported by the Max Planck Society, the Hertie Foundation, the Deutsche Forschungsgemeinschaft (AL 1193/2-1), and the Engineering and Physical Sciences Research Council.