An Insight into the Changes in Human Plasma Proteome on Adaptation to Hypobaric Hypoxia

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Ahmad, Yasmin ^a   Sharma, Narendra K ^a   Garg, Iti ^a   Ahmad, Mohammad Faiz ^b   Sharma, Manish ^a   Bhargava, Kalpana ^a  

^a DEFENCE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES   (India)

^b JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; AMYLOID; APOLIPOPROTEIN A1; COMPLEMENT COMPONENT 4A; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; HAPTOGLOBIN; HEMOGLOBIN BETA CHAIN; HEMOPEXIN; IMMUNOGLOBULIN G; PLASMA PROTEIN; PREALBUMIN; RETINOL BINDING PROTEIN; TRANSFERRIN; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN;

ADULT; ALTITUDE ACCLIMATIZATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HYPOBARISM; HYPOXIA; MALE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEOMICS; UPREGULATION; WESTERN BLOTTING;

ADAPTATION, PHYSIOLOGICAL; ADULT; ALTITUDE; ANOXIA; CHEMICAL PRECIPITATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN G; INFLAMMATION; MALE; MOLECULAR SEQUENCE ANNOTATION; PROTEOME; SERUM ALBUMIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ANIMALIA;

EID: 84879757255     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067548     Document Type: Article

References (97)

1. Frisancho AR, (1975) Functional adaptation to high altitude hypoxia. Science 187: 313-319.
2. Jessen TH, Weber RE, Fermi G, Tame J, Braunitzer G, (1991) Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein engineering. Proc Natl Acad Sci U S A 88: 6519-6522.
3. Storz JF, Runck AM, Sabatino SJ, Kelly JK, Ferrand N, et al. (2009) Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin. Proc Natl Acad Sci U S A 106: 14450-14455.
4. Jiang BH, Rue E, Wang GL, Roe R, Semenza GL, (1996) Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778.
5. Wang GL, Jiang BH, Rue EA, Semenza GL, (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92: 5510-5514.
6. Rolfs A, Kvietikova I, Gassmann M, Wenger RH, (1997) Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem 272: 20055-20062.
7. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, et al. (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394: 485-490.
8. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, et al. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613.
9. Melillo G, Musso T, Sica A, Taylor LS, Cox GW, et al. (1995) A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182: 1683-1693.
10. Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: 149-162.
11. Wang GL, Semenza GL, (1993) General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A 90: 4304-4308.
12. Futcher B, Latter GI, Monardo P, McLaughlin CS, Garrels JI, (1999) A sampling of the yeast proteome. Mol Cell Biol 19: 7357-7368.
13. Gygi SP, Rochon Y, Franza BR, Aebersold R, (1999) Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19: 1720-1730.
14. Varshavsky A, (1996) The N-end rule: functions, mysteries, uses. Proc Natl Acad Sci U S A 93: 12142-12149.
15. Hulmes JD, Bethea D, Ho K, Huang S-P, Ricci DL, et al. (2004) An Investigation of Plasma Collection, Stabilization, and Storage Procedures for Proteomic Analysis of Clinical Samples. Clinical Proteomics 1: 017-032.
16. Laemmli UK, (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
17. Ahmad Y, Sharma N, (2009) An Effective Method for the Analysis of Human Plasma Proteome using Two-dimensional Gel Electrophoresis. Journal of Proteomics & Bioinformatics 02: 495-499.
18. Son WK, Lee DY, Lee SH, Joo WA, Kim CW, (2003) Analysis of proteins expressed in rat plasma exposed to dioxin using 2-dimensional gel electrophoresis. Proteomics 3: 2393-2401.
19. Yan JX, Wait R, Berkelman T, Harry RA, Westbrook JA, et al. (2000) A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometry. Electrophoresis 21: 3666-3672.
20. Turko IV, Murad F, (2003) Quantitative protein profiling in heart mitochondria from diabetic rats. J Biol Chem 278: 35844-35849.
21. Ahmad Y, Shukla D, Garg I, Sharma NK, Saxena S, et al. (2011) Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema. Funct Integr Genomics 11: 407-417.
22. Chen J, Bardes EE, Aronow BJ, Jegga AG, (2009) ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res 37: W305-311.
23. Chandel NS, Budinger GR, Schumacker PT, (1996) Molecular oxygen modulates cytochrome c oxidase function. J Biol Chem 271: 18672-18677.
24. Schumacker PT, Chandel N, Agusti AG, (1993) Oxygen conformance of cellular respiration in hepatocytes. Am J Physiol 265: L395-402.
25. Amador A, Grande L, Marti J, Deulofeu R, Miquel R, et al. (2007) Ischemic pre-conditioning in deceased donor liver transplantation: a prospective randomized clinical trial. Am J Transplant 7: 2180-2189.
26. Massip-Salcedo M, Rosello-Catafau J, Prieto J, Avila MA, Peralta C, (2007) The response of the hepatocyte to ischemia. Liver Int 27: 6-16.
27. Jungermann K, Kietzmann T, (2000) Oxygen: modulator of metabolic zonation and disease of the liver. Hepatology 31: 255-260.
28. Hochachka PW, Lutz PL, (2001) Mechanism, origin, and evolution of anoxia tolerance in animals. Comp Biochem Physiol B Biochem Mol Biol 130: 435-459.
29. Subramanian RM, Chandel N, Budinger GR, Schumacker PT, (2007) Hypoxic conformance of metabolism in primary rat hepatocytes: a model of hepatic hibernation. Hepatology 45: 455-464.
30. Storey KB, (1996) Metabolic adaptations supporting anoxia tolerance in reptiles: recent advances. Comp Biochem Physiol B Biochem Mol Biol 113: 23-35.
31. Yamamoto N, Homma S, Haddad JG, Kowalski MA, (1991) Vitamin D3 binding protein required for in vitro activation of macrophages after alkylglycerol treatment of mouse peritoneal cells. Immunology 74: 420-424.
32. Gomme PT, Bertolini J, (2004) Therapeutic potential of vitamin D-binding protein. Trends Biotechnol 22: 340-345.
33. Lind SE, Smith DB, Janmey PA, Stossel TP, (1988) Depression of gelsolin levels and detection of gelsolin-actin complexes in plasma of patients with acute lung injury. Am Rev Respir Dis 138: 429-434.
34. Speeckaert M, Huang G, Delanghe JR, Taes YE, (2006) Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 372: 33-42.
35. Dahl B, Schiodt FV, Rudolph S, Ott P, Kiaer T, et al. (2001) Trauma stimulates the synthesis of Gc-globulin. Intensive Care Med 27: 394-399.
36. Meier U, Gressner O, Lammert F, Gressner AM, (2006) Gc-globulin: roles in response to injury. Clin Chem 52: 1247-1253.
37. Schellenberg D, Pare PD, Weir TD, Spinelli JJ, Walker BA, et al. (1998) Vitamin D binding protein variants and the risk of COPD. Am J Respir Crit Care Med 157: 957-961.
38. Yamamoto N, Naraparaju VR, (1997) Immunotherapy of BALB/c mice bearing Ehrlich ascites tumor with vitamin D-binding protein-derived macrophage activating factor. Cancer Res 57: 2187-2192.
39. Li RC, Saleem S, Zhen G, Cao W, Zhuang H, et al. (2009) Heme-hemopexin complex attenuates neuronal cell death and stroke damage. J Cereb Blood Flow Metab 29: 953-964.
40. Congote LF, Temmel N, Sadvakassova G, Dobocan MC, (2008) Comparison of the effects of serpin A1, a recombinant serpin A1-IGF chimera and serpin A1 C-terminal peptide on wound healing. Peptides 29: 39-46.
41. van Pel M, van Os R, Velders GA, Hagoort H, Heegaard PM, et al. (2006) Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization. Proc Natl Acad Sci U S A 103: 1469-1474.
42. Mangan MS, Kaiserman D, Bird PI, (2008) The role of serpins in vertebrate immunity. Tissue Antigens 72: 1-10.
43. Ledoux-Corbusier M, Achten G, (1975) alpha1-Antitrypsin deficiency and skin abnormalities. J Cutan Pathol 2: 25-29.
44. Lomas DA, Mahadeva R, (2002) Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy. J Clin Invest 110: 1585-1590.
45. Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, et al. (2000) Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med 6: 698-702.
46. Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, et al. (2006) alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol 169: 1155-1166.
47. Teichert-Kuliszewska K, Kutryk MJ, Kuliszewski MA, Karoubi G, Courtman DW, et al. (2006) Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res 98: 209-217.
48. Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, et al. (2005) Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 96: 442-450.
49. Tuder RM, Cool CD, Yeager M, Taraseviciene-Stewart L, Bull TM, et al. (2001) The pathobiology of pulmonary hypertension. Endothelium. Clin Chest Med 22: 405-418.
50. Napoli C, Loscalzo J, (2004) Nitric oxide and other novel therapies for pulmonary hypertension. J Cardiovasc Pharmacol Ther 9: 1-8.
51. Bowman BH, Kurosky A (1982) Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet 12: 189-261, 453-184.
52. Langlois MR, Delanghe JR, (1996) Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 42: 1589-1600.
53. Tseng CF, Lin CC, Huang HY, Liu HC, Mao SJ, (2004) Antioxidant role of human haptoglobin. Proteomics 4: 2221-2228.
54. Van Vlierberghe H, Langlois M, Delanghe J, (2004) Haptoglobin polymorphisms and iron homeostasis in health and in disease. Clin Chim Acta 345: 35-42.
55. Lim SK, Kim H, bin Ali A, Lim YK, Wang Y, et al. (1998) Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 92: 1870-1877.
56. Hanley JM, Heath EC, (1985) A novel proteolytic activity in serum processes rat prohaptoglobin. Arch Biochem Biophys 239: 404-419.
57. Xie Y, Li Y, Zhang Q, Stiller MJ, Wang CL, et al. (2000) Haptoglobin is a natural regulator of Langerhans cell function in the skin. J Dermatol Sci 24: 25-37.
58. Oh SK, Very DL, Walker J, Raam S, Ju ST, (1987) An analogy between fetal haptoglobin and a potent immunosuppressant in cancer. Cancer Res 47: 5120-5126.
59. Cid MC, Grant DS, Hoffman GS, Auerbach R, Fauci AS, et al. (1993) Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis. J Clin Invest 91: 977-985.
60. Haugen TH, Hanley JM, Heath EC, (1981) Haptoglobin. A novel mode of biosynthesis of a liver secretory glycoprotein. J Biol Chem 256: 1055-1057.
61. Anderson L, Anderson NG, (1977) High resolution two-dimensional electrophoresis of human plasma proteins. Proc Natl Acad Sci U S A 74: 5421-5425.
62. Han C, Zhang HT, Du L, Liu X, Jing J, et al. (2005) Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Endocrine 26: 19-24.
63. Anantharamaiah GM, Mishra VK, Garber DW, Datta G, Handattu SP, et al. (2007) Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides. J Lipid Res 48: 1915-1923.
64. Bates SR, Tao JQ, Collins HL, Francone OL, Rothblat GH, (2005) Pulmonary abnormalities due to ABCA1 deficiency in mice. Am J Physiol Lung Cell Mol Physiol 289: L980-989.
65. Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, et al. (2010) Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. J Lipid Res 51: 2560-2570.
66. Ingenbleek Y, Young V, (1994) Transthyretin (prealbumin) in health and disease: nutritional implications. Annu Rev Nutr 14: 495-533.
67. Palha JA, (2002) Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med 40: 1292-1300.
68. Chang MH, Hua CT, Isaac EL, Litjens T, Hodge G, et al. (2004) Transthyretin interacts with the lysosome-associated membrane protein (LAMP-1) in circulation. Biochem J 382: 481-489.
69. Lasztity N, Biro L, Nemeth E, Pap A, Antal M, (2002) Protein status in pancreatitis-transthyretin is a sensitive biomarker of malnutrition in acute and chronic pancreatitis. Clin Chem Lab Med 40: 1320-1324.
70. Zhang Z, Bast RC Jr, Yu Y, Li J, Sokoll LJ, et al. (2004) Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res 64: 5882-5890.
71. Schweigert FJ, Sehouli J (2005) Transthyretin, a biomarker for nutritional status and ovarian cancer. Cancer Res 65: 1114; author reply 1114.
72. Santos SD, Lambertsen KL, Clausen BH, Akinc A, Alvarez R, et al. (2010) CSF transthyretin neuroprotection in a mouse model of brain ischemia. J Neurochem 115: 1434-1444.
73. Schlossmacher P, Hasselmann M, Meyer N, Kara F, Delabranche X, et al. (2002) The prognostic value of nutritional and inflammatory indices in critically ill patients with acute respiratory failure. Clin Chem Lab Med 40: 1339-1343.
74. Melo MB, Bordin S, Duarte AS, Ogo SH, Torsoni MA, et al. (2003) Molecular characterization of hemoglobin alpha-D chains from Geochelone carbonaria and Geochelone denticulata land turtles. Comp Biochem Physiol B Biochem Mol Biol 134: 389-395.
75. Mairbaurl H, (1994) Red blood cell function in hypoxia at altitude and exercise. Int J Sports Med 15: 51-63.
76. Cavill I, (2002) Erythropoiesis and iron. Best Pract Res Clin Haematol 15: 399-409.
77. Handelman GJ, Levin NW, (2008) Iron and anemia in human biology: a review of mechanisms. Heart Fail Rev 13: 393-404.
78. Lok CN, Ponka P, (1999) Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem 274: 24147-24152.
79. Tacchini L, Bianchi L, Bernelli-Zazzera A, Cairo G, (1999) Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J Biol Chem 274: 24142-24146.
80. Bradbury MW, (1997) Transport of iron in the blood-brain-cerebrospinal fluid system. J Neurochem 69: 443-454.
81. Anderson GJ, Frazer DM, (2005) Hepatic iron metabolism. Semin Liver Dis 25: 420-432.
82. Wood SP, Oliva G, O'Hara BP, White HE, Blundell TL, et al. (1988) A pentameric form of human serum amyloid P component. Crystallization, X-ray diffraction and neutron scattering studies. J Mol Biol 202: 169-173.
83. Pepys MB, Butler PJ, (1987) Serum amyloid P component is the major calcium-dependent specific DNA binding protein of the serum. Biochem Biophys Res Commun 148: 308-313.
84. Noursadeghi M, Bickerstaff MC, Gallimore JR, Herbert J, Cohen J, et al. (2000) Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Proc Natl Acad Sci U S A 97: 14584-14589.
85. Tennent GA, Lovat LB, Pepys MB, (1995) Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. Proc Natl Acad Sci U S A 92: 4299-4303.
86. Botto M, Hawkins PN, Bickerstaff MC, Herbert J, Bygrave AE, et al. (1997) Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene. Nat Med 3: 855-859.
87. Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, et al. (2002) Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417: 254-259.
88. Cook HT, Botto M, (2006) Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus. Nat Clin Pract Rheumatol 2: 330-337.
89. Truedsson L, Bengtsson AA, Sturfelt G, (2007) Complement deficiencies and systemic lupus erythematosus. Autoimmunity 40: 560-566.
90. Abdul-Salam VB, Paul GA, Ali JO, Gibbs SR, Rahman D, et al. (2006) Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension. Proteomics 6: 2286-2294.
91. Zhang J, Zhang Y, Li N, Liu Z, Xiong C, et al. (2009) Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension. Respir Med 103: 1801-1806.
92. Bauer EM, Zheng H, Comhair S, Erzurum S, Billiar TR, et al. (2011) Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One 6: e28578.
93. Bellovino D, Morimoto T, Tosetti F, Gaetani S, (1996) Retinol binding protein and transthyretin are secreted as a complex formed in the endoplasmic reticulum in HepG2 human hepatocarcinoma cells. Exp Cell Res 222: 77-83.
94. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436: 356-362.
95. Wolf G, (2007) Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes. Nutr Rev 65: 251-256.
96. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, et al. (2012) Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol 32: 2010-2019.
97. Quadro L, Blaner WS, Salchow DJ, Vogel S, Piantedosi R, et al. (1999) Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J 18: 4633-4644.