Ischemic pre-conditioning in deceased donor liver transplantation: A prospective randomized clinical trial

American Journal of Transplantation

Volumn 7, Issue 9, 2007, Pages 2180-2189

  Amador, A ^a   Grande, L ^b   Marti J ^c   Deulofeu, R ^c   Miquel, R ^c   Sola A ^d   Rodriguez Laiz, G ^e   Ferrer, J ^c   Fondevila, C ^c   Charco, R ^c   Fuster, J ^c   Hotter, G ^d   Garcia Valdecasas J C ^c  

^a HOSPITAL DE SABADELL   (Spain)

^b HOSPITAL DEL MAR   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d INST D INVESTIGACIONS B   (Spain)

^e MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Clinical application; Cold ischemia; Graft function; Initial poor function; Ischemia reperfusion injury; Ischemic preconditioning; Liver transplantation; Primary nonfunction liver; Transplantation research

Indexed keywords

HYALURONIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; URIC ACID;

ADULT; AGED; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DECEASED DONOR; DONOR; FEMALE; HUMAN; INCIDENCE; ISCHEMIC PRECONDITIONING; LIVER FUNCTION; LIVER TRANSPLANTATION; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION;

APOPTOSIS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CASPASE 3; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYALURONIC ACID; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IN SITU NICK-END LABELING; ISCHEMIC PRECONDITIONING; LIVER; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; REPERFUSION INJURY; SURVIVAL RATE; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS; URIC ACID;

EID: 34547838835     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01914.x     Document Type: Article

References (42)

1. Muñoz SJ, Friedman LS. Liver transplantation. Med Clin North Am 1989 73:1011 1039.
2. Wang ZF, Liu C. Liver retransplantation: Indications and outcomes. Hepatobiliary Pancreat Dis Int 2004 3:175 178.
3. Miranda B, Canon J, Cuende N, Garrido G, Naya MT, Fernandez-Zincke E. Disparities in access to liver transplantation in Spain. Transplantation 2003 76:1398 1403.
4. Cuende N, Miranda B, Canon JF, Naya T, Garrido G. Priority criteria for the access to transplantation. The case of liver transplant in Spain. Med Clin (Barc) 2003 120:380 386.
5. Rull R, Vidal O, Momblan D et al. Evaluation of potential liver donors: Limits imposed by donor variables in liver transplantation. Liver Transpl 2003 9:389 393.
6. Grande L, Matus D, Rimola A et al. Expanded liver donor age over 60 years for hepatic transplantation. Clin Transpl 1998 297 301.
7. Briceño J, Solorzano G, Pera C. A proposal for scoring marginal liver grafts. Transpl Int 2000 13 (Suppl 1 S249 S252.
8. Cursio R. Ischemia-reperfusion. Presse Med 2001 30 (24 Pt 2 29 30.
9. Kukan M, Haddad PS. Why and how to innovate liver transplantation: A multiple treatment strategy. Hepatology 2001 34:440 441.
10. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986 74:1124 1136.
11. Sola A, Alfaro V, Hotter G. Intestinal ischemic preconditioning: Less xanthine accumulation relates with less apoptosis. Apoptosis 2004 9:353 361.
12. Blondeau N, Heurteaux C. Cerebral tolerance: A new challenge to identify targets for cerebral protection. Med Sci (Paris) 2004 20:1109 1114.
13. Marian CF, Jiga LP, Ionac M. Ischemic preconditioning of free muscle flaps: An experimental study. Microsurgery 2005 25:524 531.
14. Clavien PA, Yadav S, Sindram D, Bentley RC. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Ann Surg 2000 232:155 162.
15. Rudiger HA, Kang KJ, Sindram D, Riehle HM, Clavien PA. Comparison of ischemic preconditioning and intermittent and continuous inflow occlusion in the murine liver. Ann Surg 2002 235:400 407.
16. Peralta C, Serafin A, Fernandez-Zabalegui L, Wu ZY, Rosello-Catafau J. Liver ischemic preconditioning: A new strategy for the prevention of ischemia-reperfusion injury. Transplant Proc 2003 35:1800 1802.
17. Clavien PA, Selzner M, Rudiger HA et al. A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg 2003 238:843 850.
18. Chouker A, Schachtner T, Schauer R et al. Effects of Pringle manoeuvre and ischaemic preconditioning on haemodynamic stability in patients undergoing elective hepatectomy: A randomized trial. Br J Anaesth 2004 93:204 211.
19. Li SQ, Liang LJ, Huang JF, Li Z. Ischemic preconditioning protects liver from hepatectomy under hepatic inflow occlusion for hepatocellular carcinoma patients with cirrhosis. World J Gastroenterol 2004 10:2580 2584.
20. Nuzzo G, Giuliante F, Vellone M et al. Pedicle clamping with ischemic preconditioning in liver resection. Liver Transpl 2004 10 (2 Suppl 1 S53 S57.
21. Koneru B, Fisher A, He Y et al. Ischemic preconditioning in deceased donor liver transplantation: A prospective randomized clinical trial of safety and efficacy. Liver Transpl 2005 11:196 202.
22. Azoulay D, Del Gaudio M, Andreani P et al. Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft's preservation and function: The Ying and the yang. Ann Surg 2005 242:133 139.
23. Jassem W, Fuggle SV, Cerundolo L, Heaton ND, Rela M. Ischemic preconditioning of cadaver donor livers protects allografts following transplantation. Transplantation 2006 81:169 174.
24. Cescon M, Grazi GL, Grassi A, et al. Effect of ischemic preconditioning in whole liver transplantation from deceased donors. A pilot study. Liver Transpl 2006 12:628 635.
25. Fleiss. Statistical methods for rates and proportions. 2nd ed. New York:John Wiley and Sons, 1981.
26. Fernandez L, Heredia N, Grande L et al. Preconditioning protects liver and lung damage in rat liver transplantation: Role of xanthine/xanthine oxidase. Hepatology 2002 36:562 572.
27. Gonzalez FX, Garcia-Valdecasas JC, Grande L et al. Vena cava vascular reconstruction during orthotopic liver transplantation: A comparative study. Liver Transpl Surg 1998 4:133 440.
28. Charco R, Rimola A, Garcia-Valdecasas JC et al. Steroids and living liver donation increase tacrolimus blood levels in living donor liver transplantation. Transplant Proc 2005 37:3930 3931.
29. Kaufmann SH, Shaper JH. A subset of non-histone nuclear proteins reversibly stabilized by the sulfhydryl cross-linking reagent tetrathionate. Polypeptides of the internal nuclear matrix. Exp Cell Res 1984 155:477 495.
30. Yin DP, Sankary HN, Chong AS et al. Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats. Transplantation 1998 66:152 157.
31. Peralta C, Prats N, Xaus C, Gelpi E, Rosello-Catafau J. Protective effect of liver ischemic preconditioning on liver and lung injury induced by hepatic ischemia-reperfusion in the rat. Hepatology 1999 30:1481 1489.
32. Peralta C, Hotter G, Closa D, Gelpi E, Bulbena O, Rosello-Catafau J. Protective effect of preconditioning on the injury associated to hepatic ischemia-reperfusion in the rat: Role of nitric oxide and adenosine. Hepatology 1997 25:934 937.
33. Peralta C, Fernandez L, Panes J et al. Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat. Hepatology 2001 33:100 113.
34. Yoshizumi T, Yanaga K, Soejima Y, Maeda T, Uchiyama H, Sugimachi K. Amelioration of liver injury by ischaemic preconditioning. Br J Surg 1998 85:1636 1640.
35. Peralta C, Bulbena O, Xaus C et al. Ischemic preconditioning: A defense mechanism against the reactive oxygen species generated after hepatic ischemia reperfusion. Transplantation 2002 73:1203 1211.
36. Chamorro A, Planas AM, Muner DS, Deulofeu R. Uric acid administration for neuroprotection in patients with acute brain ischemia. Med Hypotheses 2004 62:173 176.
37. Litvinov DIu, Prasolov VS, Bouton C, Drapier JC, Turpaev KT. Effect of the antioxidants on NO-dependent induction of heme oxigenase 1 gene in U937 monocytes [abstract]. Mol Biol (Mosk) 2005 39:89 95.
38. Net M, Valero R, Almenara R et al. The effect of normothermic recirculation is mediated by ischemic preconditioning in NHBD liver transplantation. Am J Transplant 2005 5:2385 2392.
39. Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW. Hypoxia-inducible factor (HIF-1) alpha: Its protein stability and biological functions. Exp Mol Med 2004 36:1 12.
40. Semenza GL. Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001 7:345 350.
41. Karimova A, Pinsky DJ. The endothelial response to oxygen deprivation: biology and clinical implications. Intensive Care Med 2001 27:19 31.
42. Amador A, Charco R, Marti J et al. One thousand liver transplants. Hospital Clinic i Provincial de Barcelona. Cir Esp 2005 78:231 237.