A formulated red ginseng extract upregulates CHOP and increases TRAIL-mediated cytotoxicity in human hepatocellular carcinoma cells

International Journal of Oncology

Volumn 43, Issue 2, 2013, Pages 591-599

  Lee, Yun Sun ^a   Lee, D A Gyum ^a   Lee, J U Yeon ^a   Kim, Tae Ryong ^b   Hong, Soon Sun ^c   Kwon, Sung Won ^b   Kim, You Sun ^a  

^a Ajou University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Inha University School of Medicine   (South Korea)

Author keywords

Apoptosis; CHOP; DR5; Ginsenoside

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CELL NUCLEUS DNA; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GINSENG EXTRACT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RED GINSENG EXTRACT; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CARCINOMA CELL; CELL DEATH; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIET SUPPLEMENTATION; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DOWN-REGULATION; DRUG SYNERGISM; GINSENOSIDES; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; PANAX; PLANT EXTRACTS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA INTERFERENCE; RNA, SMALL INTERFERING; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 84879641191     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1964     Document Type: Article

References (44)

1. Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ and Ashkenazi A: Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 12: 611-620, 2000.
2. Deveraux QL, Roy N, Stennicke HR, et al : IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 17: 2215-2223, 1998. (Pubitemid 28171907)
3. Hu W, Johnson H and Shu H: Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-κB and JNK activation and apoptosis through distinct pathways. J Biol Chem 274: 30603, 1999.
4. Lin B, Williams-Skipp C, Tao Y, et al : NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ 6: 570-582, 1999. (Pubitemid 29292113)
5. Son YG, Kim EH, Kim JY, et al: Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin. Cancer Res 67: 8274-8284, 2007.
6. Ding L, Yuan C, Wei F, et al : Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP. Cancer Invest 29: 511-520, 2011.
7. Park SJ, Bijangi-Vishehsaraei K and Safa AR: Selective TRAIL-triggered apoptosis due to overexpression of TRAIL death receptor 5 (DR5) in P-glycoprotein-bearing multidrug resistant CEM/VBL1000 human leukemia cells. Int J Biochem Mol Biol 1: 90-100, 2010.
8. Fossati S, Ghiso J and Rostagno A: TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Aβ. Cell Death Dis 3: e321, 2012.
9. Griffith TS, Fialkov JM, Scott DL, et al: Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma. Cancer Res 62: 3093-3099, 2002. (Pubitemid 34602400)
10. Kim JY, Lee JY, Kim DG, Koo GB, Yu JW and Kim YS: TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation. FEBS Lett 585: 2144-2150, 2011.
11. Tian X, Ye J, Alonso-Basanta M, Hahn SM, Koumenis C and Dorsey JF: Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem 286: 29408-29416, 2011.
12. Carr BI: Hepatocellular carcinoma: current management and future trends. Gastroenterology 127: S218-S224, 2004.
13. Yang JF, Cao JG, Tian L and Liu F: 5,7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells. Cancer Chemother Pharmacol 69: 195-206, 2012.
14. Zhang B, Shan H, Li D, et al: Cisplatin sensitizes human hepato-cellular carcinoma cells, but not hepatocytes and mesenchymal stem cells, to TRAIL within a therapeutic window partially depending on the upregulation of DR5. Oncol Rep 25: 461-468, 2011.
15. Lee SA, Jo HK, Im BO, Kim SU, Whang WK and Ko SK: Changes in the Contents of Prosapogenin in the Red Ginseng (Panax ginseng) Depending on Steaming Batches. J Ginseng Res 36: 102-106, 2012.
16. In G, Ahn NG, Bae BS, Han ST, Noh KB and Kim CS: New method for simultaneous quantification of 12 ginsenosides in red ginseng powder and extract: in-house method validation. J Ginseng Res 36: 205-210, 2012.
17. Sun S, Qi LW, Du GJ, Mehendale SR, Wang CZ and Yuan CS: Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng. Food Chem 125: 1299-1305, 2011.
18. Keum YS, Park KK, Lee JM, et al: Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett 150: 41-48, 2000.
19. Li J, Huang M, Teoh H and Man RY: Panax quinquefolium saponins protects low density lipoproteins from oxidation. Life Sci 64: 53-62, 1999. (Pubitemid 29012749)
20. Chang MS, Lee SG and Rho HM: Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Phytother Res 13: 641-644, 1999.
21. Ji HY, Lee HW, Kim HK, et al: Simultaneous determination of ginsenoside Rb(1) and Rg(1) in human plasma by liquid chromatography-mass spectrometry. J Pharm Biomed Anal 35: 207-212, 2004. (Pubitemid 38368876)
22. Cai F, Sun L, Gao S, Yang Y, Yang Q and Chen W: A rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of timosaponin B-II in blood plasma and a study of the pharmacokinetics of saponin in the rat. J Pharm Biomed Anal 48: 1411-1416, 2008.
23. Woo SS, Song JS, Lee JY, et al: Selection of high ginsenoside producing ginseng hairy root lines using targeted metabolic analysis. Phytochemistry 65: 2751-2761, 2004.
24. Park JD, Rhee DK and Lee YH: Biological activities and chemistry of saponins from Panax ginseng CA Meyer. Phytochem Rev 4: 159-175, 2005. (Pubitemid 41752174)
25. Lee DCW and Lau ASY: Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: a mini-review. Molecules 16: 2802-2816, 2011.
26. Sayers TJ: Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunology, Immunotherapy: pp1-8, 2011.
27. Ravi R, Bedi GC, Engstrom LW, et al: Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB. Nat Cell Biol 3: 409-416, 2001. (Pubitemid 32288449)
28. Ganten TM, Koschny R, Sykora J, et al: Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin Cancer Res 12: 2640-2646, 2006.
29. Baritaki S, Huerta-Yepez S, Sakai T, Spandidos DA and Bonavida B: Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1. Mol Cancer Ther 6: 1387-1399, 2007. (Pubitemid 46712002)
30. Mellier G, Huang S, Shenoy K and Pervaiz S: TRAILing death in cancer. Mol Aspects Med 31: 93-112, 2010.
31. Kouhara J, Yoshida T, Nakata S, et al: Fenretinide upregulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. Int J Oncol 30: 679-687, 2007.
32. Bertram H, Nerlich A, Omlor G, Geiger F, Zimmermann G and Fellenberg J: Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks. Mod Pathol 22: 895-905, 2009.
33. Xiaowen H and Yi S: Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation. Mol Biol Rep 39: 8763-8770, 2012.
34. Lin FL, Hsu JL, Chou CH, Wu WJ, Chang CI and Liu HJ: Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways. Eur J Pharmacol 650: 120-129, 2011.
35. Deng Z, Yan H, Hu J, et al: Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. PloS One 7: e37700, 2012.
36. Shiraishi T, Yoshida T, Nakata S, et al: Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. Cancer Res 65: 6364-6370, 2005. (Pubitemid 40994423)
37. Chen CY, Yiin SJ, Hsu JL, Wang WC, Lin SC and Chern CL: Isoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5. J Agric Food Chem 60: 3533-3539, 2012.
38. Oyadomari S and Mori M: Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389, 2003.
39. Bin L, Thorburn J, Thomas LR, Clark PE, Humphreys R and Thorburn A: Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J Biol Chem 282: 28189-28194, 2007. (Pubitemid 47529548)
40. Sheridan JP, Marsters SA, Pitti RM, et al : Control of TRAIL?induced apoptosis by a family of signaling and decoy receptors. Science 277: 818-821, 1997. (Pubitemid 27366733)
41. Seol DW: p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis. Biochem Biophys Res Commun 416: 222-225, 2011.
42. Sung B, Ravindran J, Prasad S, Pandey MK and Aggarwal BB: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem 285: 35418-35427, 2010.
43. Zinszner H, Kuroda M, Wang X, et al: CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12: 982-995, 1998. (Pubitemid 28204605)
44. Zou W, Yue P, Khuri F and Sun S: Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation. Cancer Res 68: 7484-7492, 2008.