Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 120-129

  Lin, Feng Lang ^a,b,c   Hsu, Jue Liang ^b   Chou, Chang Hung ^d   Wu, Wen Jun ^e   Chang, Chi I ^b   Liu, Hung Jen ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c TAJEN UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Damnacanthal; Morinda citrifolia; P38 MAPK; P53; TNF ; TRAIL

Indexed keywords

CASPASE 3; CASPASE 8; CYTOCHROME C; DAMNACANTHAL; DEATH RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BID; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEPG2; CELL STRAIN LNCAP; CELL STRAIN MCF 7; CELL STRAIN SKHEP 1; CONTROLLED STUDY; CYTOPLASM; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LIVER CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

ANIMALS; ANTHRAQUINONES; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; CYTOSOL; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN TRANSPORT; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78649751036     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.005     Document Type: Article

References (33)

1. S.S. Bacus, A.V. Gudjov, M. Lowe, L. Lyass, Y. Yung, and A.P. Komarov Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53 Oncogene 20 2001 147 155
2. J. Bain, H. Mclauchlan, M. Elliott, and P. Cohen The specificities of protein kinase inhibitors: an update Biochem. J. 371 2003 199 204
3. I. Berberich, G. Shu, F. Siebelt, J.R. Woodgett, J.M. Kyriakis, and E.A. Clark Cross-linking CD40 on B-cells preferentially induces stress activated protein kinases rather than mitogen-activated protein kinases EMBO J. 15 1996 92 101
4. D. Brancho, N. Tanaka, A. Jaeschke, J.J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R.A. Flavell, and R.J. Davis Mechanism of p38 MAP kinase activation in vivo Genes Dev. 17 2003 1969 1978
5. D.V. Bulavin, S. Saito, M.C. Hollander, K. Sakaguchi, C.W. Anderson, E. Appella, and A.J. Fornace Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to V radiation EMBO J. 18 1999 6845 6854
6. H.J. Chae, S.C. Kim, K.S. Han, S.W. Chae, N.H. An, and H.M. Kim Hypoxia induces apoptosis by caspase activation accompanying cytochrome C release from mitochondria in MC3T3E1 osteoblasts. p38 MAPK is related in hypoxia-induced apoptosis Immunopharmacol. Immunotoxicol. 23 2001 133 152
7. S.M. Chuang, I.C. Wang, and J.L. Yang Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium Carcinogenesis 21 2000 1423 1432
8. S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351 2000 95 105
9. R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239 252
10. M. Dickens, J.S. Rogers, J. Cavanagh, A. Raitano, Z. Xia, J.R. Halpern, M.E. Greenberg, C.L. Sawyers, and R.J. Davis A cytoplasmic inhibitor of the JNK signal transduction pathway Science 277 1997 693 696 (Pubitemid 27373916)
11. G.I. Evan, and K.H. Vousden Proliferation, cell cycle and apoptosis in cancer Nature 411 2001 342 348
12. C.R. Faltynek, J. Schroeder, P. Mauvais, D. Miller, S. Wang, D. Murphy, R. Lehr, M. Kelley, A. Maycock, and M. Michne Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity Biochemistry 34 1995 12404 12410
13. T. Hatai, A. Matsuzawa, S. Inoshita, Y. Mochida, T. Kuroda, K. Sakamaki, K. Kuida, S. Yonehara, H. Ichijo, and K. Takeda Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria- dependent caspase activation J. Biol. Chem. 275 2002 26576 26581
14. T. Hiramatsu, M. Imoto, T. Koyano, and K. Umezawa Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia Cancer Lett. 73 1993 161 166
15. T.C. Huang 2nd Edn Flora of Taiwan vol. 4 1998 299 Taipei, Taiwan, Republic of China
16. K. Iyoda, Y. Sasaki, M. Horimoto, T. Toyama, T. Yakushijin, M. Sakakibara, T. Takehara, J. Fujimoto, M. Hori, J.R. Wands, and N. Hayashi Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma Cancer 97 2003 3017 3026
17. W.T. Ji, L.H. Lee, F.L. Lin, L. Wang, and H.J. Liu AMP-activated protein kinase (AMPK) facilitates avian reovirus to induce MKK3/6 and MAPK p38 signaling that is beneficial for virus replication J. Gen. Virol. 90 2009 3002 3009
18. N. Kalra, and V. Kumar c-Fos is a mediator of the c-myc-induced apoptotic signaling in serum-deprived hepatoma cells via the p38 mitogen-activated protein kinase pathway J. Biol. Chem. 279 2004 25313 25319
19. K. Kamiya, Y. Tanaka, H. Endang, M. Umar, and T. Satake New anthraquinone and iridoid from the fruits of Morinda citrifolia Chem. Pharm. Bull. 53 2005 1597 1599
20. H.C. Kirch, S. Flaswinkel, H. Rumpf, D. Brockmann, and H. Esche Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max Oncogene 18 1999 2728 2738
21. J.M. Kyriakis, and J. Avruch Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Physiol. Rev. 81 2001 807 869
22. T.S. Lewis, P.S. Shapiro, and N.G. Ahn Signal Transduction through MAP kinase cascades Adv. Cancer Res. 74 1998 49 139
23. H. Li, H. Zhu, C.J. Xu, and J. Yuan Cleavage of Bid by caspase mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 1998 491 501
24. P.Y. Lin, J.W. Lee, M.H. Liao, H.Y. Hsu, S.J. Chiu, H.J. Liu, and W.L. Shih Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C delta during avian reovirus S1133-induced apoptosis Virology 385 2009 323 324
25. X. Liu, C.N. Kim, J. Yang, R. Jemmerson, and X. Wang Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c Cell 86 1996 147 157
26. M. Los, M. Mozoluk, D. Ferrari, A. Stepczynska, C. Stroh, and A. Renz Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling Mol. Biol. Cell 13 2002 978 988
27. X. Luo, I. Budihardjo, H. Zuo, C. Slaughter, and X. Wang Bid, a bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Cell 94 1998 481 490
28. S. Nagata Fas ligand-induced apoptosis Annu. Rev. Genet. 33 1999 29 55
29. R.W. Oppenheim Cell death during development of the nervous system Annu. Rev. Neurosci. 14 1991 453 501
30. C. Scaffidi, S. Fulda, A. Srinivasan, C. Friesen, F. Li, and K.J. Tomaselli Two CD95 (APO-1/Fas) signaling pathways EMBO J. 17 1998 1675 1687
31. K. Wang, X.M. Yin, D.T. Chao, C.L. Milliman, and S.J. Korsmeyer BID: a novel BH3 domain-only death agonist Genes Dev. 10 1996 2859 2869
32. M.Y. Wang, B.J. West, C.J. Jensen, D. Nowicki, C. Su, A.K. Palu, and G. Anderson Morinda citrifolia (Noni): a literature review and recent advances in Noni research Acta Pharmacol. Sin. 23 2002 1127 1141
33. X.D. Zhang, X.Y. Zhang, C.P. Gray, T. Nguyen, and P. Hersey Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by sma/DIABLO release from mitochondria Cancer Res. 61 2001 7339 7348