Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks

Modern Pathology

Volumn 22, Issue 7, 2009, Pages 895-905

  Bertram, Helge ^a   Nerlich, Andreas ^b   Omlor, Georg ^a   Geiger, Florian ^a   Zimmermann, Gerald ^c   Fellenberg, Joerg ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b KLINIKUM BOGENHAUSEN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Apoptosis; Degeneration; DR4; DR5; Intervertebral disk; TRAIL

Indexed keywords

CASPASE 8; CYTOKINE; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FAS LIGAND; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADOLESCENT; ADULT; AGED; APOPTOSIS; ARTICLE; BACKACHE; CELL DEATH; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOLOGY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; APOPTOSIS; BIOLOGICAL MARKERS; CELLS, CULTURED; CHILD; DISEASE PROGRESSION; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; GENE EXPRESSION; HUMANS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; MALE; MIDDLE AGED; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA, MESSENGER; TNF-RELATED APOPTOSIS-INDUCING LIGAND; YOUNG ADULT;

EID: 67650695424     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.39     Document Type: Article

References (57)

1. Macfarlane GJ, Thomas E, Croft PR, et al. Predictors of early improvement in low back pain amongst consulters to general practice: the influence of pre-morbid and episode-related factors. Pain 1999;80:113-119.
2. Gruber HE, Hanley Jr EN. Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine 1998;23:751-757.
3. Gruber HE, Norton HJ, Hanley Jr EN. Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine 2000;25:2153-2157.
4. Lotz JC, Colliou OK, Chin JR, et al. Compressioninduced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study. Spine 1998;23:2493-2506.
5. Lotz JC, Chin JR. Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading. Spine 2000;25:1477-1483.
6. Park JB, Chang H, Kim KW. Expression of Fas ligand and apoptosis of disc cells in herniated lumbar disc tissue. Spine 2001;26:618-621.
7. Park JB, Kim KW, Han CW, et al. Expression of Fas receptor on disc cells in herniated lumbar disc tissue. Spine 2001;26:142-146.
8. Wang YJ, Shi Q, Lu WW, et al. Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: a novel in vivo rat model. Spine 2006; 31:1532-1538.
9. Anderson DG, Tannoury C.Molecular pathogenic factors in symptomatic disc degeneration. Spine J 2005;5: 260S-266S.
10. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine 1995;20:1307-1314.
11. Freemont AJ, Watkins A, Le Maitre C, et al. Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J Pathol 2002;196:374-379.
12. Horner HA, Urban JP. 2001 Volvo award winner in basic science studies: effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine 2001;26:2543-2549.
13. Nerlich AG, Schleicher ED, Boos N. 1997 Volvo award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs. Spine 1997;22:2781-2795.
14. Weiler C, Nerlich AG, Bachmeier BE, et al. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 2005;30:44-53.
15. Bibby SR, Jones DA, Ripley RM, et al. Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine 2005;30:487-496.
16. Boos N, Weissbach S, Rohrbach H, et al. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo award in basic science. Spine 2002;27: 2631-2644.
17. Chen B, Fellenberg J, Wang H, et al. Occurrence and regional distribution of apoptosis in scoliotic discs. Spine 2005;30:519-524.
18. Melrose J, Gurr KR, Cole TC, et al. The influence of scoliosis and ageing on proteoglycan heterogeneity in the human intervertebral disc. J Orthop Res 1991;9: 68-77.
19. Bechmann I, Mor G, Nilsen J, et al. FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier. Glia 1999;27:62-74.
20. Bellgrau D, Gold D, Selawry H, et al. A role for CD95 ligand in preventing graft rejection. Nature 1995;377: 630-632.
21. Griffith TS, Brunner T, Fletcher SM, et al. Fas ligandinduced apoptosis as a mechanism of immune privilege. Science 1995;270:1189-1192.
22. Greil R, Egle A, Villunger A. On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model. Leuk Lymphoma 1998;31:477-490.
23. Nagata S, Golstein P. The Fas death factor. Science 1995;267:1449-1456.
24. Nagata S. Apoptosis by death factor. Cell 1997;88: 355-365.
25. Suda T, Takahashi T, Golstein P, et al. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993;75:1169-1178.
26. Suda T, Okazaki T, Naito Y, et al. Expression of the Fas ligand in cells of T cell lineage. J Immunol 1995;154: 3806-3813.
27. Asahara H, Hasumuna T, Kobata T, et al. Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue. Clin Immunol Immunopathol 1996;81:27-34.
28. Krammer PH. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv Immunol 1999;71:163-210.
29. Mita E, Hayashi N. [Molecular biology of Fas antigen- Fas ligand system]. Nippon Rinsho 1996;54:1736-1740.
30. Nagata S. Fas-induced apoptosis. Intern Med 1998;37: 179-181.
31. Hashimoto S, Setareh M, Ochs RL, et al. Fas/Fas ligand expression and induction of apoptosis in chondrocytes. Arthritis Rheum 1997;40:1749-1755.
32. Takada T, Nishida K, Doita M, et al. Fas ligand exists on intervertebral disc cells: a potential molecular mechanism for immune privilege of the disc. Spine 2002;27:1526-1530.
33. Lippke JA, Gu Y, Sarnecki C, et al. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. J Biol Chem 1996; 271:1825-1828.
34. Schreiber V, de Murcia G, de Murcia JM. A eukaryotic expression vector for the study of nuclear localization signals. Gene 1994;150:411-412.
35. Park JB, Park IC, Park SJ, et al. Anti-apoptotic effects of caspase inhibitors on rat intervertebral disc cells. J Bone Joint Surg Am 2006;88:771-779.
36. Bhardwaj A, Aggarwal BB. Receptor-mediated choreography of life and death. J Clin Immunol 2003;23: 317-332.
37. Kim KW, Kim YS, Ha KY, et al. An autocrine or paracrine Fas-mediated counterattack: a potential mechanism for apoptosis of notochordal cells in intact rat nucleus pulposus. Spine 2005;30:1247-1251.
38. Kischkel FC, Lawrence DA, Chuntharapai A, et al. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 2000;12:611-620.
39. Kohyama K, Saura R, Doita M, et al. Intervertebral disc cell apoptosis by nitric oxide: biological understanding of intervertebral disc degeneration. Kobe J Med Sci 2000;46:283-295.
40. Ariga K, Miyamoto S, Nakase T, et al. The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc. Spine 2001;26:2414-2420.
41. Ariga K, Yonenobu K, Nakase T, et al. Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study. Spine 2003;28:1528-1533.
42. Heyde CE, Tschoeke SK, Hellmuth M, et al. Trauma induces apoptosis in human thoracolumbar intervertebral discs. BMC Clin Pathol 2006;6:5.
43. Zhao CQ, Jiang LS, Dai LY. Programmed cell death in intervertebral disc degeneration. Apoptosis 2006;11: 2079-2088.
44. Tschoeke SK, Hellmuth M, Hostmann A, et al. Apoptosis of human intervertebral discs after trauma compares to degenerated discs involving both receptor- mediated and mitochondrial-dependent pathways. J Orthop Res 2008;26:999-1006.
45. Seguin CA, Pilliar RM, Roughley PJ, et al. Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine 2005;30:1940-1948.
46. Sobajima S, Kompel JF, Kim JS, et al. A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine 2005;30:15-24.
47. Le Maitre CL, Pockert A, Buttle DJ, et al. Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 2007;35:652-655.
48. Kaneyama S, Nishida K, Takada T, et al. Fas ligand expression on human nucleus pulposus cells decreases with disc degeneration processes. J Orthop Sci 2008;13:130-135.
49. Takeuchi T, Ueki T, Nishimatsu H, et al. Accelerated rejection of Fas ligand-expressing heart grafts. J Immunol 1999;162:518-522.
50. Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997;276:111-113.
51. Chaudhary PM, Eby M, Jasmin A, et al. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NFkappaB pathway. Immunity 1997;7:821-830.
52. Zhang L, Niu T, Yang SY, et al. The occurrence and regional distribution of DR4 on herniated disc cells: a potential apoptosis pathway in lumbar intervertebral disc. Spine 2008;33:422-427.
53. Burke JG, Watson RW, McCormack D, et al. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002;84:196-201.
54. Anderson DG, Albert TJ, Fraser JK, et al. Cellular therapy for disc degeneration. Spine 2005;30:S14-S19.
55. Le Visage C, Kim SW, Tateno K, et al. Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis. Spine 2006;31:2036-2042.
56. Levicoff EA, Gilbertson LG, Kang JD. Gene therapy for disc repair. Spine J 2005;5:287S-296S.
57. Demjen D, Klussmann S, Kleber S, et al. Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nat Med 2004;10: 389-395.