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Volumn 4 MAR, Issue , 2013, Pages

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease

Author keywords

Abca1; Abcb1; Alzheimer's disease, blood brain barrier; Apolipoprotein E; Beta amyloid clearance; Neurovascular unit

Indexed keywords

ABC TRANSPORTER A1; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BEXAROTENE; DOXYCYCLINE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR; RIFAMPICIN;

EID: 84879495507     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2013.00045     Document Type: Short Survey
Times cited : (84)

References (69)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott, N. J., Rönnbäck, L., and Hansson, E. (2006). Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7, 41-53.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 2
    • 84869748975 scopus 로고    scopus 로고
    • Role of ABC transporters in the pathogenesis of Alzheimer's disease
    • Abuznait, A. H., and Kaddoumi, A. (2012). Role of ABC transporters in the pathogenesis of Alzheimer's disease. A.C.S. Chem. Neurosci. 3, 820-831.
    • (2012) A.C.S. Chem. Neurosci. , vol.3 , pp. 820-831
    • Abuznait, A.H.1    Kaddoumi, A.2
  • 3
    • 40949149021 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier
    • Akanuma, S., Ohtsuki, S., Doi, Y., Tachikawa, M., Ito, S., Hori, S., et al. (2008). ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier. Neurochem. Int. 52, 956-961.
    • (2008) Neurochem. Int. , vol.52 , pp. 956-961
    • Akanuma, S.1    Ohtsuki, S.2    Doi, Y.3    Tachikawa, M.4    Ito, S.5    Hori, S.6
  • 4
    • 79551646454 scopus 로고    scopus 로고
    • Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult
    • Al Ahmad, A., Taboada, C. B., Gassmann, M., and Ogunshola, O. O. (2011). Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult. J. Cereb. Blood Flow Metab. 31, 693-705.
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 693-705
    • Al Ahmad, A.1    Taboada, C.B.2    Gassmann, M.3    Ogunshola, O.O.4
  • 5
    • 0037099306 scopus 로고    scopus 로고
    • LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes
    • Arélin, K., Kinoshita, A., Whelan, C. M., Irizarry, M. C., Rebeck, G. W., Strickland, D. K., et al. (2002). LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes. Brain Res. Mol. Brain Res. 104, 38-46.
    • (2002) Brain Res. Mol. Brain Res. , vol.104 , pp. 38-46
    • Arélin, K.1    Kinoshita, A.2    Whelan, C.M.3    Irizarry, M.C.4    Rebeck, G.W.5    Strickland, D.K.6
  • 6
    • 79961230399 scopus 로고    scopus 로고
    • Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
    • Armulik, A., Genové, G., and Betsholtz, C. (2011). Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev. Cell 21, 193-215.
    • (2011) Dev. Cell , vol.21 , pp. 193-215
    • Armulik, A.1    Genové, G.2    Betsholtz, C.3
  • 7
    • 70049084419 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration
    • Bartels, A. L., Kortekaas, R., Bart, J., Willemsen, A. T., de Klerk, O. L., de Vries, J. J., et al. (2009). Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration. Neurobiol. Aging 30, 1818-1824.
    • (2009) Neurobiol. Aging , vol.30 , pp. 1818-1824
    • Bartels, A.L.1    Kortekaas, R.2    Bart, J.3    Willemsen, A.T.4    de Klerk, O.L.5    de Vries, J.J.6
  • 8
    • 33748950454 scopus 로고    scopus 로고
    • In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation
    • Bauer, B., Yang, X., Hartz, A. M., Olson, E. R., Zhao, R., Kalvass, J. C., et al. (2006). In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol. Pharmacol. 70, 1212-1219.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1212-1219
    • Bauer, B.1    Yang, X.2    Hartz, A.M.3    Olson, E.R.4    Zhao, R.5    Kalvass, J.C.6
  • 9
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell, R. D., and Zlokovic, B. V. (2009). Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 118, 103-113.
    • (2009) Acta Neuropathol. , vol.118 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 10
    • 84862747370 scopus 로고    scopus 로고
    • The neuroendocrine control of the innate immune system in health and brain diseases
    • Bellavance, M. A., and Rivest, S. (2012). The neuroendocrine control of the innate immune system in health and brain diseases. Immunol. Rev. 248, 36-55.
    • (2012) Immunol. Rev. , vol.248 , pp. 36-55
    • Bellavance, M.A.1    Rivest, S.2
  • 11
    • 33748949567 scopus 로고    scopus 로고
    • In situ localization of P-glycoprotein (ABCB1) in human and rat brain
    • Bendayan, R., Ronaldson, P. T., Gingras, D., and Bendayan, M. (2006). In situ localization of P-glycoprotein (ABCB1) in human and rat brain. J. Histochem. Cytochem. 54, 1159-1167.
    • (2006) J. Histochem. Cytochem. , vol.54 , pp. 1159-1167
    • Bendayan, R.1    Ronaldson, P.T.2    Gingras, D.3    Bendayan, M.4
  • 12
    • 3242682550 scopus 로고    scopus 로고
    • Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier
    • Berezowski, V., Landry, C., Dehouck, M. P., Cecchelli, R., and Fenart, L. (2004). Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier. Brain Res. 1018, 1-9.
    • (2004) Brain Res. , vol.1018 , pp. 1-9
    • Berezowski, V.1    Landry, C.2    Dehouck, M.P.3    Cecchelli, R.4    Fenart, L.5
  • 13
    • 0014767029 scopus 로고
    • Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies
    • Biedler, J. L., and Riehm, H. (1970). Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies. Cancer Res. 30, 1174-1184.
    • (1970) Cancer Res. , vol.30 , pp. 1174-1184
    • Biedler, J.L.1    Riehm, H.2
  • 14
    • 42949175211 scopus 로고    scopus 로고
    • Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance
    • Bolmont, T., Haiss, F., Eicke, D., Radde, R., Mathis, C. A., Klunk, W. E., et al. (2008). Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J. Neurosci. 28, 4283-4292.
    • (2008) J. Neurosci. , vol.28 , pp. 4283-4292
    • Bolmont, T.1    Haiss, F.2    Eicke, D.3    Radde, R.4    Mathis, C.A.5    Klunk, W.E.6
  • 15
    • 34548258322 scopus 로고    scopus 로고
    • Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
    • Cheng, I. H., Scearce-Levie, K., Legleiter, J., Palop, J. J., Gerstein, H., Bien-Ly, N., et al. (2007). Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J. Biol. Chem. 282, 23818-23828.
    • (2007) J. Biol. Chem. , vol.282 , pp. 23818-23828
    • Cheng, I.H.1    Scearce-Levie, K.2    Legleiter, J.3    Palop, J.J.4    Gerstein, H.5    Bien-Ly, N.6
  • 16
    • 27644489474 scopus 로고    scopus 로고
    • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    • Cirrito, J. R., Deane, R., Fagan, A. M., Spinner, M. L., Parsadanian, M., Finn, M. B., et al. (2005). P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J. Clin. Invest. 115, 3285-3290.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3285-3290
    • Cirrito, J.R.1    Deane, R.2    Fagan, A.M.3    Spinner, M.L.4    Parsadanian, M.5    Finn, M.B.6
  • 17
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
    • Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y., Karlo, J. C., Zinn, A. E., et al. (2012). ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335, 1503-1506.
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3    Lee, C.Y.4    Karlo, J.C.5    Zinn, A.E.6
  • 18
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • Daneman, R., Zhou, L., Kebede, A. A., and Barres, B. A. (2010). Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468, 562-566.
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 20
    • 4644292545 scopus 로고    scopus 로고
    • Potential role of ABC transporters as a detoxification system at the blood-CSF barrier
    • de Lange, E. C. (2004). Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Adv. Drug Deliv. Rev. 56, 1793-1809.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1793-1809
    • de Lange, E.C.1
  • 22
    • 34250623663 scopus 로고    scopus 로고
    • Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy
    • Desai, B. S., Monahan, A. J., Carvey, P. M., and Hendey, B. (2007). Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy. Cell Transplant. 16, 285-299.
    • (2007) Cell Transplant. , vol.16 , pp. 285-299
    • Desai, B.S.1    Monahan, A.J.2    Carvey, P.M.3    Hendey, B.4
  • 23
    • 77958594257 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice
    • Donkin, J. J., Stukas, S., Hirsch-Reinshagen, V., Namjoshi, D., Wilkinson, A., May, S., et al. (2010). ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J. Biol. Chem. 285, 34144-34154.
    • (2010) J. Biol. Chem. , vol.285 , pp. 34144-34154
    • Donkin, J.J.1    Stukas, S.2    Hirsch-Reinshagen, V.3    Namjoshi, D.4    Wilkinson, A.5    May, S.6
  • 24
    • 79958815444 scopus 로고    scopus 로고
    • ATP-binding cassette transporters and their roles in protecting the brain
    • ElAli, A., and Hermann, D. M. (2011). ATP-binding cassette transporters and their roles in protecting the brain. Neuroscientist 17, 423-436.
    • (2011) Neuroscientist , vol.17 , pp. 423-436
    • ElAli, A.1    Hermann, D.M.2
  • 25
    • 84857647007 scopus 로고    scopus 로고
    • Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells
    • ElAli, A., and Hermann, D. M. (2012). Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. Brain Pathol. 22, 175-187.
    • (2012) Brain Pathol. , vol.22 , pp. 175-187
    • ElAli, A.1    Hermann, D.M.2
  • 26
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick, A., Eichelbaum, M., and Burk, O. (2001). Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 276, 14581-14587.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 27
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass, C., and Selkoe, D. J. (2007). Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8, 101-112.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 28
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy, J., and Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 29
    • 77951078680 scopus 로고    scopus 로고
    • Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease
    • Hartz, A. M., Miller, D. S., and Bauer, B. (2010). Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol. Pharmacol. 77, 715-723.
    • (2010) Mol. Pharmacol. , vol.77 , pp. 715-723
    • Hartz, A.M.1    Miller, D.S.2    Bauer, B.3
  • 30
    • 0035972251 scopus 로고    scopus 로고
    • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    • Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H., et al. (2001). Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J. Cell Biol. 153, 543-553.
    • (2001) J. Cell Biol. , vol.153 , pp. 543-553
    • Hellström, M.1    Gerhardt, H.2    Kalén, M.3    Li, X.4    Eriksson, U.5    Wolburg, H.6
  • 31
    • 84864880815 scopus 로고    scopus 로고
    • The abluminal endothelial membrane in neurovascular remodeling in health and disease
    • doi: 10.1126/scisignal.2002886
    • Hermann, D. M., and ElAli, A. (2012). The abluminal endothelial membrane in neurovascular remodeling in health and disease. Sci. Signal. 5:re4. doi: 10.1126/scisignal.2002886
    • (2012) Sci. Signal. , vol.5 , Issue.RE4
    • Hermann, D.M.1    ElAli, A.2
  • 33
    • 84863504256 scopus 로고    scopus 로고
    • Apolipoprotein e and apolipoprotein e receptors: normal biology and roles in Alzheimer disease
    • doi: 10.1101/cshperspect.a006312
    • Holtzman, D. M., Herz, J., and Bu, G. (2012). Apolipoprotein e and apolipoprotein e receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb. Perspect. Med. 2:a006312. doi: 10.1101/cshperspect.a006312
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2
    • Holtzman, D.M.1    Herz, J.2    Bu, G.3
  • 34
    • 0037969631 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    • Koldamova, R. P., Lefterov, I. M., Ikonomovic, M. D., Skoko, J., Lefterov, P. I., Isanski, B. A., et al. (2003). 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J. Biol. Chem. 278, 13244-13256.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13244-13256
    • Koldamova, R.P.1    Lefterov, I.M.2    Ikonomovic, M.D.3    Skoko, J.4    Lefterov, P.I.5    Isanski, B.A.6
  • 35
    • 80053929920 scopus 로고    scopus 로고
    • Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide
    • doi: 10.1186/1742-2094-8-139
    • Kovac, A., Erickson, M. A., and Banks, W. A. (2011). Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J. Neuroinflammation 8:139. doi: 10.1186/1742-2094-8-139
    • (2011) J. Neuroinflammation , vol.8 , pp. 139
    • Kovac, A.1    Erickson, M.A.2    Banks, W.A.3
  • 36
    • 35148859731 scopus 로고    scopus 로고
    • MDR1-P-Glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-beta peptides-implications for the mechanisms of Abeta clearance at the blood-brain barrier
    • Kuhnke, D., Jedlitschky, G., Grube, M., Krohn, M., Jucker, M., Mosyagin, I., et al. (2007). MDR1-P-Glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-beta peptides-implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol. 17, 347-353.
    • (2007) Brain Pathol. , vol.17 , pp. 347-353
    • Kuhnke, D.1    Jedlitschky, G.2    Grube, M.3    Krohn, M.4    Jucker, M.5    Mosyagin, I.6
  • 38
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie, E. M., Deeley, R. G., and Cole, S. P. (2005). Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204, 216-237.
    • (2005) Toxicol. Appl. Pharmacol. , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 40
    • 12144290676 scopus 로고    scopus 로고
    • A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease
    • Loeb, M. B., Molloy, D. W., Smieja, M., Standish, T., Goldsmith, C. H., Mahony, J., et al. (2004). A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease. J. Am. Geriatr. Soc. 52, 381-387.
    • (2004) J. Am. Geriatr. Soc. , vol.52 , pp. 381-387
    • Loeb, M.B.1    Molloy, D.W.2    Smieja, M.3    Standish, T.4    Goldsmith, C.H.5    Mahony, J.6
  • 41
    • 12344262373 scopus 로고    scopus 로고
    • Blood-brain barrier active efflux transporters: ATP-binding cassette gene family
    • Löscher, W., and Potschka, H. (2005). Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx 2, 86-98.
    • (2005) NeuroRx , vol.2 , pp. 86-98
    • Löscher, W.1    Potschka, H.2
  • 42
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • Lue, L. F., Kuo, Y. M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., et al. (1999). Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155, 853-862.
    • (1999) Am. J. Pathol. , vol.155 , pp. 853-862
    • Lue, L.F.1    Kuo, Y.M.2    Roher, A.E.3    Brachova, L.4    Shen, Y.5    Sue, L.6
  • 43
    • 79954518984 scopus 로고    scopus 로고
    • The role of microglial cell subsets in Alzheimer's disease
    • Naert, G., and Rivest, S. (2011). The role of microglial cell subsets in Alzheimer's disease. Curr. Alzheimer Res. 8, 151-155.
    • (2011) Curr. Alzheimer Res. , vol.8 , pp. 151-155
    • Naert, G.1    Rivest, S.2
  • 44
    • 0037427384 scopus 로고    scopus 로고
    • Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
    • Nagele, R. G., D'Andrea, M. R., Lee, H., Venkataraman, V., and Wang, H. Y. (2003). Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res. 971, 197-209.
    • (2003) Brain Res. , vol.971 , pp. 197-209
    • Nagele, R.G.1    D'Andrea, M.R.2    Lee, H.3    Venkataraman, V.4    Wang, H.Y.5
  • 45
    • 84655160768 scopus 로고    scopus 로고
    • Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J
    • Nalivaeva, N. N., Beckett, C., Belyaev, N. D., and Turner, A. J. (2012). Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J. Neurochem. 120, 167-185.
    • (2012) Neurochem. , vol.120 , pp. 167-185
    • Nalivaeva, N.N.1    Beckett, C.2    Belyaev, N.D.3    Turner, A.J.4
  • 46
    • 79959676154 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
    • doi: 10.1186/1750-1326-6-45
    • Pan, X. D., Zhu, Y. G., Lin, N., Zhang, J., Ye, Q. Y., Huang, H. P., et al. (2011). Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease. Mol. Neurodegener. 6:45. doi: 10.1186/1750-1326-6-45
    • (2011) Mol. Neurodegener. , vol.6 , pp. 45
    • Pan, X.D.1    Zhu, Y.G.2    Lin, N.3    Zhang, J.4    Ye, Q.Y.5    Huang, H.P.6
  • 47
    • 0037044840 scopus 로고    scopus 로고
    • ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells
    • Panzenboeck, U., Balazs, Z., Sovic, A., Hrzenjak, A., Levak-Frank, S., Wintersperger, A., et al. (2002). ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J. Biol. Chem. 277, 42781-42789.
    • (2002) J. Biol. Chem. , vol.277 , pp. 42781-42789
    • Panzenboeck, U.1    Balazs, Z.2    Sovic, A.3    Hrzenjak, A.4    Levak-Frank, S.5    Wintersperger, A.6
  • 48
    • 84862700955 scopus 로고    scopus 로고
    • The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease
    • Pimentel-Coelho, P. M., and Rivest, S. (2012). The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur. J. Neurosci. 35, 1917-1937.
    • (2012) Eur. J. Neurosci. , vol.35 , pp. 1917-1937
    • Pimentel-Coelho, P.M.1    Rivest, S.2
  • 50
    • 84873307614 scopus 로고    scopus 로고
    • Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease
    • doi: 10.1101/cshperspect.a011452
    • Sagare, A. P., Bell, R. D., and Zlokovic, B. V. (2012). Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb. Perspect. Med. 2:a011452. doi: 10.1101/cshperspect.a011452
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2
    • Sagare, A.P.1    Bell, R.D.2    Zlokovic, B.V.3
  • 51
    • 84862878635 scopus 로고    scopus 로고
    • Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation
    • doi: 10.3233/JAD-2012-112090
    • Saint-Pol, J., Vandenhaute, E., Boucau, M. C., Candela, P., Dehouck, L., Cecchelli, R., et al. (2012). Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation. J. Alzheimers Dis. 30, 489-503. doi: 10.3233/JAD-2012-112090
    • (2012) J. Alzheimers Dis. , vol.30 , pp. 489-503
    • Saint-Pol, J.1    Vandenhaute, E.2    Boucau, M.C.3    Candela, P.4    Dehouck, L.5    Cecchelli, R.6
  • 52
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe, D. J. (2002). Alzheimer's disease is a synaptic failure. Science 298, 789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 53
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., et al. (1995). Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6
  • 55
    • 0036156280 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    • Sisodiya, S. M., Lin, W. R., Harding, B. N., Squier, M. V., and Thom, M. (2002). Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 125, 22-31.
    • (2002) Brain , vol.125 , pp. 22-31
    • Sisodiya, S.M.1    Lin, W.R.2    Harding, B.N.3    Squier, M.V.4    Thom, M.5
  • 56
    • 0034214329 scopus 로고    scopus 로고
    • Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides
    • Tokuda, T., Calero, M., Matsubara, E., Vidal, R., Kumar, A., Permanne, B., et al. (2000). Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem. J. 348, 359-365.
    • (2000) Biochem. J. , vol.348 , pp. 359-365
    • Tokuda, T.1    Calero, M.2    Matsubara, E.3    Vidal, R.4    Kumar, A.5    Permanne, B.6
  • 57
    • 0031017399 scopus 로고    scopus 로고
    • Rapid degeneration of cultured human brain pericytes by amyloid beta protein
    • Verbeek, M. M., de Waal, R. M., Schipper, J. J., and Van Nostrand, W. E. (1997). Rapid degeneration of cultured human brain pericytes by amyloid beta protein. J. Neurochem. 68, 1135-1141.
    • (1997) J. Neurochem. , vol.68 , pp. 1135-1141
    • Verbeek, M.M.1    de Waal, R.M.2    Schipper, J.J.3    Van Nostrand, W.E.4
  • 58
    • 0036797713 scopus 로고    scopus 로고
    • Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    • Vogelgesang, S., Cascorbi, I., Schroeder, E., Pahnke, J., Kroemer, H. K., Siegmund, W., et al. (2002). Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12, 535-541.
    • (2002) Pharmacogenetics , vol.12 , pp. 535-541
    • Vogelgesang, S.1    Cascorbi, I.2    Schroeder, E.3    Pahnke, J.4    Kroemer, H.K.5    Siegmund, W.6
  • 59
    • 2942723107 scopus 로고    scopus 로고
    • The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
    • Vogelgesang, S., Warzok, R. W., Cascorbi, I., Kunert-Keil, C., Schroeder, E., Kroemer, H. K., et al. (2004). The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr. Alzheimer Res. 1, 121-125.
    • (2004) Curr. Alzheimer Res. , vol.1 , pp. 121-125
    • Vogelgesang, S.1    Warzok, R.W.2    Cascorbi, I.3    Kunert-Keil, C.4    Schroeder, E.5    Kroemer, H.K.6
  • 60
    • 30044442937 scopus 로고    scopus 로고
    • Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease
    • Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M., et al. (2005). Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. J. Biol. Chem. 280, 43236-43242.
    • (2005) J. Biol. Chem. , vol.280 , pp. 43236-43242
    • Wahrle, S.E.1    Jiang, H.2    Parsadanian, M.3    Hartman, R.E.4    Bales, K.R.5    Paul, S.M.6
  • 61
    • 38849086036 scopus 로고    scopus 로고
    • Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
    • Wahrle, S. E., Jiang, H., Parsadanian, M., Kim, J., Li, A., Knoten, A., et al. (2008). Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J. Clin. Invest. 118, 671-682.
    • (2008) J. Clin. Invest. , vol.118 , pp. 671-682
    • Wahrle, S.E.1    Jiang, H.2    Parsadanian, M.3    Kim, J.4    Li, A.5    Knoten, A.6
  • 62
    • 4644361588 scopus 로고    scopus 로고
    • ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE
    • Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., et al. (2004). ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J. Biol. Chem. 279, 40987-40993.
    • (2004) J. Biol. Chem. , vol.279 , pp. 40987-40993
    • Wahrle, S.E.1    Jiang, H.2    Parsadanian, M.3    Legleiter, J.4    Han, X.5    Fryer, J.D.6
  • 63
    • 38349026548 scopus 로고    scopus 로고
    • Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
    • Wilhelmus, M. M., Otte-Höller, I., van Triel, J. J., Veerhuis, R., Maat-Schieman, M. L., Bu, G., et al. (2007). Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. Am. J. Pathol. 171, 1989-1999.
    • (2007) Am. J. Pathol. , vol.171 , pp. 1989-1999
    • Wilhelmus, M.M.1    Otte-Höller, I.2    van Triel, J.J.3    Veerhuis, R.4    Maat-Schieman, M.L.5    Bu, G.6
  • 64
    • 84875239504 scopus 로고    scopus 로고
    • ABC transporters and the Alzheimer's disease enigma
    • doi: 10.3389/fpsyt.2012.00054
    • Wolf, A., Bauer, B., and Hartz, A. M. (2012). ABC transporters and the Alzheimer's disease enigma. Front. Psychiatry 3:54. doi: 10.3389/fpsyt.2012.00054
    • (2012) Front. Psychiatry , vol.3 , pp. 54
    • Wolf, A.1    Bauer, B.2    Hartz, A.M.3
  • 65
    • 0037394788 scopus 로고    scopus 로고
    • Adult mouse astrocytes degrade amyloid-beta in vitro and in situ
    • Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., et al. (2003). Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat. Med. 9, 453-457.
    • (2003) Nat. Med. , vol.9 , pp. 453-457
    • Wyss-Coray, T.1    Loike, J.D.2    Brionne, T.C.3    Lu, E.4    Anankov, R.5    Yan, F.6
  • 66
    • 58049199498 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells
    • Yamada, K., Hashimoto, T., Yabuki, C., Nagae, Y., Tachikawa, M., Strickland, D. K., et al. (2008). The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. J. Biol. Chem. 283, 34554-34562.
    • (2008) J. Biol. Chem. , vol.283 , pp. 34554-34562
    • Yamada, K.1    Hashimoto, T.2    Yabuki, C.3    Nagae, Y.4    Tachikawa, M.5    Strickland, D.K.6
  • 67
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • Zlokovic, B. V. (2005). Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 28, 202-208.
    • (2005) Trends Neurosci. , vol.28 , pp. 202-208
    • Zlokovic, B.V.1
  • 68
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic, B. V. (2008). The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 69
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic, B. V. (2011). Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci. 12, 723-738.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 723-738
    • Zlokovic, B.V.1


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