메뉴 건너뛰기




Volumn 5, Issue 236, 2012, Pages

The abluminal endothelial membrane in neurovascular remodeling in health and disease

Author keywords

[No Author keywords available]

Indexed keywords

ABLUMINAL ENDOTHELIAL MEMBRANE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN DISEASE; BRAIN INJURY; CELL POLARITY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; MEMBRANE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 84864880815     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002886     Document Type: Review
Times cited : (71)

References (125)
  • 1
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • E. H. Lo, T. Dalkara, M. A. Moskowitz, Mechanisms, challenges and opportunities in stroke. Nat. Rev. Neurosci. 4, 399-415 (2003).
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 2
    • 84858601983 scopus 로고    scopus 로고
    • Promoting brain remodelling and plasticity for stroke recovery: Therapeutic promise and potential pitfalls of clinical translation
    • D. M. Hermann, M. Chopp, Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol. 11, 369-380 (2012).
    • (2012) Lancet Neurol. , vol.11 , pp. 369-380
    • Hermann, D.M.1    Chopp, M.2
  • 3
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • B. V. Zlokovic, Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci. 12, 723-738 (2011).
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 4
    • 3042590902 scopus 로고    scopus 로고
    • Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis
    • G. Bazzoni, E. Dejana, Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis. Physiol. Rev. 84, 869-901 (2004).
    • (2004) Physiol. Rev. , vol.84 , pp. 869-901
    • Bazzoni, G.1    Dejana, E.2
  • 5
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/ neurovascular unit in health and disease
    • B. T. Hawkins, T. P. Davis, The blood-brain barrier/ neurovascular unit in health and disease. Pharmacol. Rev. 57, 173-185 (2005).
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 6
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyteendothelial interactions at the blood-brain barrier
    • N. J. Abbott, L. Rönnbäck, E. Hansson, Astrocyteendothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7, 41-53 (2006).
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 7
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug effl ux transporters
    • W. Löscher, H. Potschka, Drug resistance in brain diseases and the role of drug effl ux transporters. Nat. Rev. Neurosci. 6, 591-602 (2005).
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 591-602
    • Löscher, W.1    Potschka, H.2
  • 8
    • 33847139661 scopus 로고    scopus 로고
    • Implications of ATP-binding cassette transporters for brain pharmacotherapies
    • D. M. Hermann, C. L. Bassetti, Implications of ATP-binding cassette transporters for brain pharmacotherapies. Trends Pharmacol. Sci. 28, 128- 134 (2007).
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 128-134
    • Hermann, D.M.1    Bassetti, C.L.2
  • 11
    • 79958815444 scopus 로고    scopus 로고
    • ATP-binding cassette transporters and their roles in protecting the brain
    • A. ElAli, D. M. Hermann, ATP-binding cassette transporters and their roles in protecting the brain. Neuroscientist 17, 423-436 (2011).
    • (2011) Neuroscientist , vol.17 , pp. 423-436
    • ElAli, A.1    Hermann, D.M.2
  • 13
    • 79960998682 scopus 로고    scopus 로고
    • Current concepts of blood-brain barrier development
    • S. Liebner, C. J. Czupalla, H. Wolburg, Current concepts of blood-brain barrier development. Int. J. Dev. Biol. 55, 467-476 (2011).
    • (2011) Int. J. Dev. Biol. , vol.55 , pp. 467-476
    • Liebner, S.1    Czupalla, C.J.2    Wolburg, H.3
  • 14
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • R. D. Bell, E. A. Winkler, A. P. Sagare, I. Singh, B. LaRue, R. Deane, B. V. Zlokovic, Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427 (2010).
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    LaRue, B.5    Deane, R.6    Zlokovic, B.V.7
  • 15
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFRbeta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • M. Hellström, M. Kalén, P. Lindahl, A. Abramsson, C. Betsholtz, Role of PDGF-B and PDGFRbeta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126, 3047-3055 (1999).
    • (1999) Development , vol.126 , pp. 3047-3055
    • Hellström, M.1    Kalén, M.2    Lindahl, P.3    Abramsson, A.4    Betsholtz, C.5
  • 16
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and infl uence vascular pattern formation in tumors
    • A. Abramsson, P. Lindblom, C. Betsholtz, Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and infl uence vascular pattern formation in tumors. J. Clin. Invest. 112, 1142-1151 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 17
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • E. A. Winkler, R. D. Bell, B. V. Zlokovic, Central nervous system pericytes in health and disease. Nat. Neurosci. 14, 1398-1405 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 18
    • 0035282791 scopus 로고    scopus 로고
    • Induction of astrocyte differentiation by endothelial cells
    • H. Mi, H. Haeberle, B. A. Barres, Induction of astrocyte differentiation by endothelial cells. J. Neurosci. 21, 1538-1547 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 1538-1547
    • Mi, H.1    Haeberle, H.2    Barres, B.A.3
  • 19
    • 77958450885 scopus 로고    scopus 로고
    • The role of wnt signaling in physiological and pathological angiogenesis
    • E. Dejana, The role of wnt signaling in physiological and pathological angiogenesis. Circ. Res. 107, 943-952 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 943-952
    • Dejana, E.1
  • 20
    • 33747417084 scopus 로고    scopus 로고
    • Integrin-matrix interactions in the cerebral microvasculature
    • G. J. del Zoppo, R. Milner, Integrin-matrix interactions in the cerebral microvasculature. Arterioscler. Thromb. Vasc. Biol. 26, 1966-1975 (2006).
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 1966-1975
    • Del Zoppo, G.J.1    Milner, R.2
  • 22
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the blood-cerebrospinal fl uid barriers: Function and dysfunction
    • B. Engelhardt, L. Sorokin, The blood-brain and the blood-cerebrospinal fl uid barriers: Function and dysfunction. Semin. Immunopathol. 31, 497- 511 (2009).
    • (2009) Semin. Immunopathol. , vol.31 , pp. 497-511
    • Engelhardt, B.1    Sorokin, L.2
  • 24
    • 73949086144 scopus 로고    scopus 로고
    • Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation
    • A. N. Stratman, K. M. Malotte, R. D. Mahan, M. J. Davis, G. E. Davis, Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood 114, 5091-5101 (2009).
    • (2009) Blood , vol.114 , pp. 5091-5101
    • Stratman, A.N.1    Malotte, K.M.2    Mahan, R.D.3    Davis, M.J.4    Davis, G.E.5
  • 25
    • 80053924042 scopus 로고    scopus 로고
    • Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke
    • K. M. Baeten, K. Akassoglou, Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke. Dev. Neurobiol. 71, 1018-1039 (2011).
    • (2011) Dev. Neurobiol. , vol.71 , pp. 1018-1039
    • Baeten, K.M.1    Akassoglou, K.2
  • 26
    • 32344432793 scopus 로고    scopus 로고
    • Differential, strain-specifi c cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier
    • A. Soontornmalai, M. L. Vlaming, J. M. Fritschy, Differential, strain-specifi c cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier. Neuroscience 138, 159-169 (2006).
    • (2006) Neuroscience , vol.138 , pp. 159-169
    • Soontornmalai, A.1    Vlaming, M.L.2    Fritschy, J.M.3
  • 27
    • 0032769544 scopus 로고    scopus 로고
    • Quantitative immunocytochemical study of blood-brain barrier glucose transporter (GLUT-1) in four regions of mouse brain
    • D. H. Dobrogowska, A. W. Vorbrodt, Quantitative immunocytochemical study of blood-brain barrier glucose transporter (GLUT-1) in four regions of mouse brain. J. Histochem. Cytochem. 47, 1021- 1030 (1999).
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1021-1030
    • Dobrogowska, D.H.1    Vorbrodt, A.W.2
  • 28
    • 59649102234 scopus 로고    scopus 로고
    • A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation
    • S. Vemula, K. E. Roder, T. Yang, G. J. Bhat, T. J. Thekkumkara, T. J. Abbruscato, A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation. J. Pharmacol. Exp. Ther. 328, 487-495 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 487-495
    • Vemula, S.1    Roder, K.E.2    Yang, T.3    Bhat, G.J.4    Thekkumkara, T.J.5    Abbruscato, T.J.6
  • 29
    • 0028967989 scopus 로고
    • Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier
    • R. Hallmann, D. N. Mayer, E. L. Berg, R. Broermann, E. C. Butcher, Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev. Dyn. 202, 325-332 (1995).
    • (1995) Dev. Dyn. , vol.202 , pp. 325-332
    • Hallmann, R.1    Mayer, D.N.2    Berg, E.L.3    Broermann, R.4    Butcher, E.C.5
  • 30
    • 78149456928 scopus 로고    scopus 로고
    • The mouse blood-brain barrier transcriptome: A new resource for understanding the development and function of brain endothelial cells
    • R. Daneman, L. Zhou, D. Agalliu, J. D. Cahoy, A. Kaushal, B. A. Barres, The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS ONE 5, e13741 (2010).
    • (2010) PLoS ONE , vol.5
    • Daneman, R.1    Zhou, L.2    Agalliu, D.3    Cahoy, J.D.4    Kaushal, A.5    Barres, B.A.6
  • 31
    • 38749096624 scopus 로고    scopus 로고
    • Multiphasic roles for matrix metalloproteinases after stroke
    • A. Rosell, E. H. Lo, Multiphasic roles for matrix metalloproteinases after stroke. Curr. Opin. Pharmacol. 8, 82-89 (2008).
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 82-89
    • Rosell, A.1    Lo, E.H.2
  • 32
    • 58249118833 scopus 로고    scopus 로고
    • Tissuetype plasminogen activator in the ischemic brain: More than a thrombolytic
    • M. Yepes, B. D. Roussel, C. Ali, D. Vivien, Tissuetype plasminogen activator in the ischemic brain: More than a thrombolytic. Trends Neurosci. 32, 48-55 (2009).
    • (2009) Trends Neurosci. , vol.32 , pp. 48-55
    • Yepes, M.1    Roussel, B.D.2    Ali, C.3    Vivien, D.4
  • 33
    • 77951686244 scopus 로고    scopus 로고
    • Extracellular matrix, infl ammation, and the angiogenic response
    • A. G. Arroyo, M. L. Iruela-Arispe, Extracellular matrix, infl ammation, and the angiogenic response. Cardiovasc. Res. 86, 226-235 (2010).
    • (2010) Cardiovasc. Res. , vol.86 , pp. 226-235
    • Arroyo, A.G.1    Iruela-Arispe, M.L.2
  • 34
    • 34147143557 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptorrelated protein increases the permeability of the neurovascular unit
    • R. Polavarapu, M. C. Gongora, H. Yi, S. Ranganthan, D. A. Lawrence, D. Strickland, M. Yepes, Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptorrelated protein increases the permeability of the neurovascular unit. Blood 109, 3270-3278 (2007).
    • (2007) Blood , vol.109 , pp. 3270-3278
    • Polavarapu, R.1    Gongora, M.C.2    Yi, H.3    Ranganthan, S.4    Lawrence, D.A.5    Strickland, D.6    Yepes, M.7
  • 35
    • 69949172891 scopus 로고    scopus 로고
    • Pericyte contraction induced by oxidative-nitrative stress impairs capillary refl ow despite successful opening of an occluded cerebral artery
    • M. Yemisci, Y. Gursoy-Ozdemir, A. Vural, A. Can, K. Topalkara, T. Dalkara, Pericyte contraction induced by oxidative-nitrative stress impairs capillary refl ow despite successful opening of an occluded cerebral artery. Nat. Med. 15, 1031-1037 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 1031-1037
    • Yemisci, M.1    Gursoy-Ozdemir, Y.2    Vural, A.3    Can, A.4    Topalkara, K.5    Dalkara, T.6
  • 36
    • 59649092177 scopus 로고    scopus 로고
    • The control of vascular integrity by endothelial cell junctions: Molecular basis and pathological implications
    • E. Dejana, E. Tournier-Lasserve, B. M. Weinstein, The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev. Cell 16, 209-221 (2009).
    • (2009) Dev. Cell , vol.16 , pp. 209-221
    • Dejana, E.1    Tournier-Lasserve, E.2    Weinstein, B.M.3
  • 37
    • 0142137232 scopus 로고    scopus 로고
    • Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
    • X. Wang, S. R. Lee, K. Arai, S. R. Lee, K. Tsuji, G. W. Rebeck, E. H. Lo, Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat. Med. 9, 1313-1317 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 1313-1317
    • Wang, X.1    Lee, S.R.2    Arai, K.3    Lee, S.R.4    Tsuji, K.5    Rebeck, G.W.6    Lo, E.H.7
  • 38
    • 50349092250 scopus 로고    scopus 로고
    • LDL receptor-related protein 1: Unique tissue-specifi c functions revealed by selective gene knockout studies
    • A. P. Lillis, L. B. Van Duyn, J. E. Murphy-Ullrich, D. K. Strickland, LDL receptor-related protein 1: unique tissue-specifi c functions revealed by selective gene knockout studies. Physiol. Rev. 88, 887-918 (2008).
    • (2008) Physiol. Rev. , vol.88 , pp. 887-918
    • Lillis, A.P.1    Van Duyn, L.B.2    Murphy-Ullrich, J.E.3    Strickland, D.K.4
  • 40
    • 78149255128 scopus 로고    scopus 로고
    • Low-density lipoprotein receptorrelated protein-1: A serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain
    • B. V. Zlokovic, R. Deane, A. P. Sagare, R. D. Bell, E. A. Winkler, Low-density lipoprotein receptorrelated protein-1: A serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J. Neurochem. 115, 1077-1089 (2010).
    • (2010) J. Neurochem. , vol.115 , pp. 1077-1089
    • Zlokovic, B.V.1    Deane, R.2    Sagare, A.P.3    Bell, R.D.4    Winkler, E.A.5
  • 41
    • 0034774402 scopus 로고    scopus 로고
    • Plasminogen activators in multiple sclerosis lesions: Implications for the infl ammatory response and axonal damage
    • D. Gveric, R. Hanemaaijer, J. Newcombe, N. A. van Lent, C. F. Sier, M. L. Cuzner, Plasminogen activators in multiple sclerosis lesions: implications for the infl ammatory response and axonal damage. Brain 124, 1978-1988 (2001).
    • (2001) Brain , vol.124 , pp. 1978-1988
    • Gveric, D.1    Hanemaaijer, R.2    Newcombe, J.3    Van Lent, N.A.4    Sier, C.F.5    Cuzner, M.L.6
  • 42
    • 0038241040 scopus 로고    scopus 로고
    • Pathogenic Aβ induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells
    • S. S. Jung, W. Zhang, W. E. Van Nostrand, Pathogenic Aβ induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells. J. Neurochem. 85, 1208-1215 (2003).
    • (2003) J. Neurochem. , vol.85 , pp. 1208-1215
    • Jung, S.S.1    Zhang, W.2    Van Nostrand, W.E.3
  • 43
    • 0028670833 scopus 로고
    • Integrin α v β 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • P. C. Brooks, A. M. Montgomery, M. Rosenfeld, R. A. Reisfeld, T. Hu, G. Klier, D. A. Cheresh, Integrin α v β 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164 (1994).
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6    Cheresh, D.A.7
  • 45
    • 0036025181 scopus 로고    scopus 로고
    • Developmental regulation of beta1 integrins during angiogenesis in the central nervous system
    • R. Milner, I. L. Campbell, Developmental regulation of beta1 integrins during angiogenesis in the central nervous system. Mol. Cell. Neurosci. 20, 616-626 (2002).
    • (2002) Mol. Cell. Neurosci. , vol.20 , pp. 616-626
    • Milner, R.1    Campbell, I.L.2
  • 46
    • 33644836179 scopus 로고    scopus 로고
    • Fibronectin promotes brain capillary endothelial cell survival and proliferation through αn;5β1 and alphavbeta3 integrins via MAP kinase signalling
    • J. Wang, R. Milner, Fibronectin promotes brain capillary endothelial cell survival and proliferation through αn;5β1 and alphavbeta3 integrins via MAP kinase signalling. J. Neurochem. 96, 148-159 (2006).
    • (2006) J. Neurochem. , vol.96 , pp. 148-159
    • Wang, J.1    Milner, R.2
  • 47
    • 0023905973 scopus 로고
    • Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis
    • W. Risau, V. Lemmon, Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev. Biol. 125, 441- 450 (1988).
    • (1988) Dev. Biol. , vol.125 , pp. 441-450
    • Risau, W.1    Lemmon, V.2
  • 48
    • 43049153372 scopus 로고    scopus 로고
    • Increased expression of fi bronectin and the α 5 β 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia
    • R. Milner, S. Hung, B. Erokwu, P. Dore-Duffy, J. C. LaManna, G. J. del Zoppo, Increased expression of fi bronectin and the α 5 β 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia. Mol. Cell. Neurosci. 38, 43-52 (2008).
    • (2008) Mol. Cell. Neurosci. , vol.38 , pp. 43-52
    • Milner, R.1    Hung, S.2    Erokwu, B.3    Dore-Duffy, P.4    LaManna, J.C.5    Del Zoppo, G.J.6
  • 50
    • 77958065460 scopus 로고    scopus 로고
    • Apolipoprotein e controls ATP-binding cassette transporters in the ischemic brain
    • A. ElAli, D. M. Hermann, Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain. Sci. Signal. 3, ra72 (2010).
    • (2010) Sci. Signal. , vol.3
    • ElAli, A.1    Hermann, D.M.2
  • 51
    • 79955691577 scopus 로고    scopus 로고
    • Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
    • S. S. Reddy, T. E. Connor, E. J. Weeber, W. Rebeck, Similarities and differences in structure, expression, and functions of VLDLR and ApoER2. Mol. Neurodegener. 6, 30 (2011).
    • (2011) Mol. Neurodegener. , vol.6 , pp. 30
    • Reddy, S.S.1    Connor, T.E.2    Weeber, E.J.3    Rebeck, W.4
  • 53
    • 2442762441 scopus 로고    scopus 로고
    • Apolipoprotein e (ApoE), a Bmp-2 (bone morphogenetic protein) upregulated gene in mesenchymal progenitors (C3H10T1/2), is highly expressed in murine embryonic development
    • D. Bächner, D. Schröder, N. Betat, M. Ahrens, G. Gross, Apolipoprotein E (ApoE), a Bmp-2 (bone morphogenetic protein) upregulated gene in mesenchymal progenitors (C3H10T1/2), is highly expressed in murine embryonic development. Biofactors 9, 11-17 (1999).
    • (1999) Biofactors , vol.9 , pp. 11-17
    • Bächner, D.1    Schröder, D.2    Betat, N.3    Ahrens, M.4    Gross, G.5
  • 54
    • 80053090288 scopus 로고    scopus 로고
    • ApoE is required for maintenance of the dentate gyrus neural progenitor pool
    • C. P. Yang, J. A. Gilley, G. Zhang, S. G. Kernie, ApoE is required for maintenance of the dentate gyrus neural progenitor pool. Development 138, 4351-4362 (2011).
    • (2011) Development , vol.138 , pp. 4351-4362
    • Yang, C.P.1    Gilley, J.A.2    Zhang, G.3    Kernie, S.G.4
  • 55
    • 0037385034 scopus 로고    scopus 로고
    • Increased expression of neuronal apolipoprotein e in human brain with cerebral infarction
    • K. Aoki, T. Uchihara, N. Sanjo, A. Nakamura, K. Ikeda, K. Tsuchiya, Y. Wakayama, Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction. Stroke 34, 875-880 (2003).
    • (2003) Stroke , vol.34 , pp. 875-880
    • Aoki, K.1    Uchihara, T.2    Sanjo, N.3    Nakamura, A.4    Ikeda, K.5    Tsuchiya, K.6    Wakayama, Y.7
  • 56
    • 23444452042 scopus 로고    scopus 로고
    • Molecular basis of the effects of shear stress on vascular endothelial cells
    • Y. S. Li, J. H. Haga, S. Chien, Molecular basis of the effects of shear stress on vascular endothelial cells. J. Biomech. 38, 1949-1971 (2005).
    • (2005) J. Biomech. , vol.38 , pp. 1949-1971
    • Li, Y.S.1    Haga, J.H.2    Chien, S.3
  • 57
    • 33646127598 scopus 로고    scopus 로고
    • Shear stress regulates forward and reverse planar cell polarity of vascular endothelium in vivo and in vitro
    • S. McCue, D. Dajnowiec, F. Xu, M. Zhang, M. R. Jackson, B. L. Langille, Shear stress regulates forward and reverse planar cell polarity of vascular endothelium in vivo and in vitro. Circ. Res. 98, 939-946 (2006).
    • (2006) Circ. Res. , vol.98 , pp. 939-946
    • McCue, S.1    Dajnowiec, D.2    Xu, F.3    Zhang, M.4    Jackson, M.R.5    Langille, B.L.6
  • 60
    • 85027933832 scopus 로고    scopus 로고
    • Pointing in the right direction: New developments in the fi eld of planar cell polarity
    • R. Bayly, J. D. Axelrod, Pointing in the right direction: New developments in the fi eld of planar cell polarity. Nat. Rev. Genet. 12, 385-391 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 385-391
    • Bayly, R.1    Axelrod, J.D.2
  • 64
    • 77951888466 scopus 로고    scopus 로고
    • Dishevelled: The hub of Wnt signaling
    • C. Gao, Y. G. Chen, Dishevelled: The hub of Wnt signaling. Cell. Signal. 22, 717-727 (2010).
    • (2010) Cell. Signal. , vol.22 , pp. 717-727
    • Gao, C.1    Chen, Y.G.2
  • 65
    • 34748863572 scopus 로고    scopus 로고
    • Mechanisms of integrinvascular endothelial growth factor receptor crossactivation in angiogenesis
    • G. H. Mahabeleshwar, W. Feng, K. Reddy, E. F. Plow, T. V. Byzova, Mechanisms of integrinvascular endothelial growth factor receptor crossactivation in angiogenesis. Circ. Res. 101, 570- 580 (2007).
    • (2007) Circ. Res. , vol.101 , pp. 570-580
    • Mahabeleshwar, G.H.1    Feng, W.2    Reddy, K.3    Plow, E.F.4    Byzova, T.V.5
  • 66
    • 14244262503 scopus 로고    scopus 로고
    • Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2
    • H. Hall, J. A. Hubbell, Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc. Res. 68, 169-178 (2004).
    • (2004) Microvasc. Res. , vol.68 , pp. 169-178
    • Hall, H.1    Hubbell, J.A.2
  • 67
    • 12444280044 scopus 로고    scopus 로고
    • Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo
    • H. Hall, V. Djonov, M. Ehrbar, M. Hoechli, J. A. Hubbell, Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis 7, 213-223 (2004).
    • (2004) Angiogenesis , vol.7 , pp. 213-223
    • Hall, H.1    Djonov, V.2    Ehrbar, M.3    Hoechli, M.4    Hubbell, J.A.5
  • 68
    • 0034745356 scopus 로고    scopus 로고
    • Rac recruits high-affi nity integrin alphavbeta3 to lamellipodia in endothelial cell migration
    • W. B. Kiosses, S. J. Shattil, N. Pampori, M. A. Schwartz, Rac recruits high-affi nity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat. Cell Biol. 3, 316-320 (2001).
    • (2001) Nat. Cell Biol. , vol.3 , pp. 316-320
    • Kiosses, W.B.1    Shattil, S.J.2    Pampori, N.3    Schwartz, M.A.4
  • 69
    • 0037097589 scopus 로고    scopus 로고
    • Arp2/3 complex is required for actin polymerization during platelet shape change
    • Z. Li, E. S. Kim, E. L. Bearer, Arp2/3 complex is required for actin polymerization during platelet shape change. Blood 99, 4466-4474 (2002).
    • (2002) Blood , vol.99 , pp. 4466-4474
    • Li, Z.1    Kim, E.S.2    Bearer, E.L.3
  • 70
    • 0141814993 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates focal adhesion assembly in human brain micro vascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase
    • H. K. Avraham, T. H. Lee, Y. Koh, T. A. Kim, S. Jiang, M. Sussman, A. M. Samarel, S. Avraham, Vascular endothelial growth factor regulates focal adhesion assembly in human brain micro vascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J. Biol. Chem. 278, 36661-36668 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 36661-36668
    • Avraham, H.K.1    Lee, T.H.2    Koh, Y.3    Kim, T.A.4    Jiang, S.5    Sussman, M.6    Samarel, A.M.7    Avraham, S.8
  • 71
    • 27944431593 scopus 로고    scopus 로고
    • Mechanotransduction in endothelial cell migration
    • S. Li, N. F. Huang, S. Hsu, Mechanotransduction in endothelial cell migration. J. Cell. Biochem. 96, 1110-1126 (2005).
    • (2005) J. Cell. Biochem. , vol.96 , pp. 1110-1126
    • Li, S.1    Huang, N.F.2    Hsu, S.3
  • 73
    • 0034707595 scopus 로고    scopus 로고
    • Homeobox B3 promotes capillary morphogenesis and angiogenesis
    • C. Myers, A. Charboneau, N. Boudreau, Homeobox B3 promotes capillary morphogenesis and angiogenesis. J. Cell Biol. 148, 343-351 (2000).
    • (2000) J. Cell Biol. , vol.148 , pp. 343-351
    • Myers, C.1    Charboneau, A.2    Boudreau, N.3
  • 74
    • 54249128761 scopus 로고    scopus 로고
    • Regulation of angiogenesis: Apoptotic cues from the ECM
    • D. A. Cheresh, D. G. Stupack, Regulation of angiogenesis: apoptotic cues from the ECM. Oncogene 27, 6285-6298 (2008).
    • (2008) Oncogene , vol.27 , pp. 6285-6298
    • Cheresh, D.A.1    Stupack, D.G.2
  • 79
    • 0029997061 scopus 로고    scopus 로고
    • Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element
    • F. M. Lu, S. E. Lux, Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Proc. Natl. Acad. Sci. U.S.A. 93, 5663-5667 (1996).
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 5663-5667
    • Lu, F.M.1    Lux, S.E.2
  • 81
    • 60549087930 scopus 로고    scopus 로고
    • Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke
    • A. Zacharek, J. Chen, X. Cui, Y. Yang, M. Chopp, Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke 40, 254-260 (2009).
    • (2009) Stroke , vol.40 , pp. 254-260
    • Zacharek, A.1    Chen, J.2    Cui, X.3    Yang, Y.4    Chopp, M.5
  • 82
    • 77955173972 scopus 로고    scopus 로고
    • Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia
    • A. Al Haj Zen, A. Oikawa, M. Bazan-Peregrino, M. Meloni, C. Emanueli, P. Madeddu, Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Circ. Res. 107, 283-293 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 283-293
    • Al Haj Zen, A.1    Oikawa, A.2    Bazan-Peregrino, M.3    Meloni, M.4    Emanueli, C.5    Madeddu, P.6
  • 83
    • 58549115679 scopus 로고    scopus 로고
    • Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression
    • D. Wågsäter, C. Zhu, H. M. Björck, P. Eriksson, Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. Atherosclerosis 202, 415-423 (2009).
    • (2009) Atherosclerosis , vol.202 , pp. 415-423
    • Wågsäter, D.1    Zhu, C.2    Björck, H.M.3    Eriksson, P.4
  • 84
    • 6344236867 scopus 로고    scopus 로고
    • Tissue plasminogen activator is a potent activator of PDGF-CC
    • L. Fredriksson, H. Li, C. Fieber, X. Li, U. Eriksson, Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23, 3793-3802 (2004).
    • (2004) EMBO J. , vol.23 , pp. 3793-3802
    • Fredriksson, L.1    Li, H.2    Fieber, C.3    Li, X.4    Eriksson, U.5
  • 88
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • B. Z. Qian, J. W. Pollard, Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39-51 (2010).
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 89
    • 0034723358 scopus 로고    scopus 로고
    • Platelet-derived growth factor-stimulated migration of murine fi - Broblasts is associated with epidermal growth factor receptor expression and tyrosine phosphorylation
    • J. Li, Y. N. Kim, P. J. Bertics, Platelet-derived growth factor-stimulated migration of murine fi - broblasts is associated with epidermal growth factor receptor expression and tyrosine phosphorylation. J. Biol. Chem. 275, 2951-2958 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 2951-2958
    • Li, J.1    Kim, Y.N.2    Bertics, P.J.3
  • 92
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-defi cient mice
    • P. Lindahl, B. R. Johansson, P. Levéen, C. Betsholtz, Pericyte loss and microaneurysm formation in PDGF-B-defi cient mice. Science 277, 242-245 (1997).
    • (1997) Science , vol.277 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Levéen, P.3    Betsholtz, C.4
  • 94
    • 0032963643 scopus 로고    scopus 로고
    • Expression of transforming growth factor-β1, 2, 3 isoforms and type i and II receptors in acute focal cerebral ischemia: An immunohistochemical study in rat after transient and permanent occlusion of middle cerebral artery
    • K. A. Ata, F. Lennmyr, K. Funa, Y. Olsson, A. Terént, Expression of transforming growth factor-β1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia: An immunohistochemical study in rat after transient and permanent occlusion of middle cerebral artery. Acta Neuropathol. 97, 447-455 (1999).
    • (1999) Acta Neuropathol. , vol.97 , pp. 447-455
    • Ata, K.A.1    Lennmyr, F.2    Funa, K.3    Olsson, Y.4    Terént, A.5
  • 95
    • 27744514616 scopus 로고    scopus 로고
    • Characterization of vascular protein expression patterns in cerebral ischemia/reperfusion using laser capture microdissection and ICAT-nanoLC-MS/MS
    • A. S. Haqqani, M. Nesic, E. Preston, E. Baumann, J. Kelly, D. Stanimirovic, Characterization of vascular protein expression patterns in cerebral ischemia/reperfusion using laser capture microdissection and ICAT-nanoLC-MS/MS. FASEB J. 19, 1809-1821 (2005).
    • (2005) FASEB J. , vol.19 , pp. 1809-1821
    • Haqqani, A.S.1    Nesic, M.2    Preston, E.3    Baumann, E.4    Kelly, J.5    Stanimirovic, D.6
  • 96
    • 77957689347 scopus 로고    scopus 로고
    • TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke
    • K. P. Doyle, E. Cekanaviciute, L. E. Mamer, M. S. Buckwalter, TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J. Neuroinfl ammation 7, 62 (2010).
    • (2010) J. Neuroinfl Ammation , vol.7 , pp. 62
    • Doyle, K.P.1    Cekanaviciute, E.2    Mamer, L.E.3    Buckwalter, M.S.4
  • 97
    • 0028906190 scopus 로고
    • Processing of transforming growth factor β 1 precursor by human furin convertase
    • C. M. Dubois, M.-H. Laprise, F. Blanchette, L. E. Gentry, R. Leduc, Processing of transforming growth factor β 1 precursor by human furin convertase. J. Biol. Chem. 270, 10618-10624 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 10618-10624
    • Dubois, C.M.1    Laprise, M.-H.2    Blanchette, F.3    Gentry, L.E.4    Leduc, R.5
  • 98
    • 0037439630 scopus 로고    scopus 로고
    • Making sense of latent TGFbeta activation
    • J. P. Annes, J. S. Munger, D. B. Rifkin, Making sense of latent TGFbeta activation. J. Cell Sci. 116, 217-224 (2003).
    • (2003) J. Cell Sci. , vol.116 , pp. 217-224
    • Annes, J.P.1    Munger, J.S.2    Rifkin, D.B.3
  • 99
    • 19544368642 scopus 로고    scopus 로고
    • Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: An angiogenic control switch
    • S. Cambier, S. Gline, D. Mu, R. Collins, J. Araya, G. Dolganov, S. Einheber, N. Boudreau, S. L. Nishimura, Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: An angiogenic control switch. Am. J. Pathol. 166, 1883-1894 (2005).
    • (2005) Am. J. Pathol. , vol.166 , pp. 1883-1894
    • Cambier, S.1    Gline, S.2    Mu, D.3    Collins, R.4    Araya, J.5    Dolganov, G.6    Einheber, S.7    Boudreau, N.8    Nishimura, S.L.9
  • 101
    • 79952525332 scopus 로고    scopus 로고
    • Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch
    • F. Li, Y. Lan, Y. Wang, J. Wang, G. Yang, F. Meng, H. Han, A. Meng, Y. Wang, X. Yang, Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev. Cell 20, 291-302 (2011).
    • (2011) Dev. Cell , vol.20 , pp. 291-302
    • Li, F.1    Lan, Y.2    Wang, Y.3    Wang, J.4    Yang, G.5    Meng, F.6    Han, H.7    Meng, A.8    Wang, Y.9    Yang, X.10
  • 102
    • 0033927061 scopus 로고    scopus 로고
    • N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken
    • H. Gerhardt, H. Wolburg, C. Redies, N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken. Dev. Dyn. 218, 472-479 (2000).
    • (2000) Dev. Dyn. , vol.218 , pp. 472-479
    • Gerhardt, H.1    Wolburg, H.2    Redies, C.3
  • 104
    • 46049083566 scopus 로고    scopus 로고
    • Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
    • S. Yamamoto, O. Nishimura, K. Misaki, M. Nishita, Y. Minami, S. Yonemura, H. Tarui, H. Sasaki, Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15, 23-36 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 23-36
    • Yamamoto, S.1    Nishimura, O.2    Misaki, K.3    Nishita, M.4    Minami, Y.5    Yonemura, S.6    Tarui, H.7    Sasaki, H.8
  • 105
    • 34147101606 scopus 로고    scopus 로고
    • Cthrc1 is a novel inhibitor of transforming growth factor-β signaling and neointimal lesion formation
    • R. J. LeClair, T. Durmus, Q. Wang, P. Pyagay, A. Terzic, V. Lindner, Cthrc1 is a novel inhibitor of transforming growth factor-β signaling and neointimal lesion formation. Circ. Res. 100, 826-833 (2007).
    • (2007) Circ. Res. , vol.100 , pp. 826-833
    • LeClair, R.J.1    Durmus, T.2    Wang, Q.3    Pyagay, P.4    Terzic, A.5    Lindner, V.6
  • 107
    • 56749104928 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates organ-specifi c assembly and differentiation of CNS vasculature
    • J. M. Stenman, J. Rajagopal, T. J. Carroll, M. Ishibashi, J. McMahon, A. P. McMahon, Canonical Wnt signaling regulates organ-specifi c assembly and differentiation of CNS vasculature. Science 322, 1247-1250 (2008).
    • (2008) Science , vol.322 , pp. 1247-1250
    • Stenman, J.M.1    Rajagopal, J.2    Carroll, T.J.3    Ishibashi, M.4    McMahon, J.5    McMahon, A.P.6
  • 109
    • 79953014281 scopus 로고    scopus 로고
    • Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury
    • D. Piccin, C. M. Morshead, Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury. Stem Cells 29, 528-538 (2011).
    • (2011) Stem Cells , vol.29 , pp. 528-538
    • Piccin, D.1    Morshead, C.M.2
  • 110
    • 33644624937 scopus 로고    scopus 로고
    • Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling
    • T. J. Park, S. L. Haigo, J. B. Wallingford, Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. Nat. Genet. 38, 303-311 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 303-311
    • Park, T.J.1    Haigo, S.L.2    Wallingford, J.B.3
  • 111
    • 0038006012 scopus 로고    scopus 로고
    • Craniofacial anomalies: Clinical and molecular perspectives
    • M. M. Cohen, Jr., Craniofacial anomalies: Clinical and molecular perspectives. Ann. Acad. Med. Singapore 32, 244-251 (2003).
    • (2003) Ann. Acad. Med. Singapore , vol.32 , pp. 244-251
    • Cohen Jr., M.M.1
  • 112
    • 34948864401 scopus 로고    scopus 로고
    • Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
    • M. F. Bijlsma, K. S. Borensztajn, H. Roelink, M. P. Peppelenbosch, C. A. Spek, Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites. Cell. Signal. 19, 2596-2604 (2007).
    • (2007) Cell. Signal. , vol.19 , pp. 2596-2604
    • Bijlsma, M.F.1    Borensztajn, K.S.2    Roelink, H.3    Peppelenbosch, M.P.4    Spek, C.A.5
  • 113
    • 25444506576 scopus 로고    scopus 로고
    • Caffeine induces sonic hedgehog gene expression in cultured astrocytes and neurons
    • N. Sahir, P. Evrard, P. Gressens, Caffeine induces sonic hedgehog gene expression in cultured astrocytes and neurons. J. Mol. Neurosci. 24, 201- 205 (2004).
    • (2004) J. Mol. Neurosci. , vol.24 , pp. 201-205
    • Sahir, N.1    Evrard, P.2    Gressens, P.3
  • 115
    • 34250622479 scopus 로고    scopus 로고
    • Hedgehog signaling: A biophysical or biomechanical modulator in embryonic development?
    • T. Nagase, M. Nagase, M. Machida, M. Yamagishi, Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development? Ann. N.Y. Acad. Sci. 1101, 412-438 (2007).
    • (2007) Ann. N.Y. Acad. Sci. , vol.1101 , pp. 412-438
    • Nagase, T.1    Nagase, M.2    Machida, M.3    Yamagishi, M.4
  • 116
  • 117
    • 69049100024 scopus 로고    scopus 로고
    • Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related infl ammation
    • N. M. Amankulor, D. Hambardzumyan, S. M. Pyonteck, O. J. Becher, J. A. Joyce, E. C. Holland, Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related infl ammation. J. Neurosci. 29, 10299-10308 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 10299-10308
    • Amankulor, N.M.1    Hambardzumyan, D.2    Pyonteck, S.M.3    Becher, O.J.4    Joyce, J.A.5    Holland, E.C.6
  • 118
    • 0033748331 scopus 로고    scopus 로고
    • Gli2 functions in FGF signaling during antero-posterior patterning
    • R. Brewster, J. L. Mullor, A. Ruiz i Altaba, Gli2 functions in FGF signaling during antero-posterior patterning. Development 127, 4395-4405 (2000).
    • (2000) Development , vol.127 , pp. 4395-4405
    • Brewster, R.1    Mullor, J.L.2    Ruiz I Altaba, A.3
  • 119
    • 0035873922 scopus 로고    scopus 로고
    • Wnt signals are targets and mediators of Gli function
    • J. L. Mullor, N. Dahmane, T. Sun, A. Ruiz i Altaba, Wnt signals are targets and mediators of Gli function. Curr. Biol. 11, 769-773 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 769-773
    • Mullor, J.L.1    Dahmane, N.2    Sun, T.3    Ruiz I Altaba, A.4
  • 120
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • B. V. Zlokovic, The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201 (2008).
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 124
    • 80555145216 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms
    • B. N. Singh, J. Fu, R. K. Srivastava, S. Shankar, Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS ONE 6, e27306 (2011).
    • (2011) PLoS ONE , vol.6
    • Singh, B.N.1    Fu, J.2    Srivastava, R.K.3    Shankar, S.4
  • 125
    • 84255196110 scopus 로고    scopus 로고
    • PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage
    • Q. Ma, B. Huang, N. Khatibi, W. Rolland, 2nd, H. Suzuki, J. H. Zhang, J. Tang, PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage. Ann. Neurol. 70, 920-931 (2011).
    • (2011) Ann. Neurol. , vol.70 , pp. 920-931
    • Ma, Q.1    Huang, B.2    Khatibi, N.3    Rolland II, W.4    Suzuki, H.5    Zhang, J.H.6    Tang, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.