IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B

European Journal of Immunology

Volumn 43, Issue 6, 2013, Pages 1630-1642

  Over, Benjamin ^a   Ziegler, Saskia ^a   Foermer, Sandra ^a   Weber, Alexander N R ^b   Bode, Konrad A ^a   Heeg, Klaus ^a   Bekeredjian Ding, Isabelle ^a,c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

IRAK4; Monocytes; PKB Akt; TLR

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 10; INTERLEUKIN 12; MAMMALIAN TARGET OF RAPAMYCIN; MONOKINE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE B; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXO;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MONOCYTE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PYOGENIC BACTERIUM; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-10; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; ONCOGENE PROTEIN V-AKT; PNEUMOCOCCAL INFECTIONS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; TOR SERINE-THREONINE KINASES;

EID: 84879482843     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201243217     Document Type: Article

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