Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes

Journal of Immunology

Volumn 161, Issue 10, 1998, Pages 5681-5686

  Scherle, Peggy A ^a   Jones, Elizabeth A ^a   Favata, Margaret F ^a   Daulerio, Andrea J ^a   Covington, Maryanne B ^a   Nurnberg, Sherrill A ^a   Magolda, Ronald L ^a   Trzaskos, James M ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR;

ARTICLE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; MONOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BUTADIENES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOKINES; DINOPROSTONE; ENZYME ACTIVATION; HUMANS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN KINASE INHIBITORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0032533838     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Ulevitch, R. J. 1993. Recognition of bacterial endotoxins by receptor-dependent mechanisms. Adv. Immunol. 53:267.
2. Haziot, A. S., S. Chen, E. Ferrero, M. G. Low, R. Silber, and S. M. Goyert. 1988. The monocyte differentiation antigen CD14 is anchored to the cell membrane by a phosphatidylinositol linkage. J. Immunol. 141:547.
3. English, B. K., J. N. Ihle, A. Myracle, and T. Yi. 1993. Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages. J. Exp. Med. 178:1017.
4. lyn. J. Biol. Chem. 268:20725.
5. Beaty, C. D., T. L. Fanklin, Y. Uehara, and C. B. Wilson. 1994. Lipopolysaccharide induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction. Eur. J. Immunol. 24:1278.
6. Geng, Y., B. Zhang, and M. Lotz. 1993. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J. Immunol. 151:6692.
7. Liu, M. K., P. Herrera-Velit, R. W. Brownsey, and N. E. Reiner. 1994. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J. Immunol. 153:2642.
8. Shapira, L., S. Takashiba, C. Champagne, S. Amar, and T. E. Van Dyke. 1994. Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-α and IL-1β production by human monocytes. J. Immunol. 153:1818.
9. lyn and phosphatidylinositol 3-kinase in human monocytes. J. Immunol. 156:1157.
10. Weinstein, S. L., J. S. Sanghera, K. Lemke, A. L. DeFranco, and S. L. Pelech. 1992. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J. Biol. Chem. 267: 14955.
11. TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414.
12. Nakajima, T., S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, and S. Akira. 1993. Phosphorylation at threonine-235 by a ras-dependent mitogen activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207.
13. Karin, M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483.
14. Natsuka, S., S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto. 1992. Macrophage differentiation specific expression of NF-IL6, a transcription factor for IL-6. Blood 79:460.
15. Zhang, Y., and W. N. Ron. 1993. Regulation of the interleukin-1b (IL-1b) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor IL-6 motifs. Mol. Cell. Biol. 13:3831.
16. Mukaida, N., Y. Mahe, and K. Matsushima. 1990. Cooperative interaction of NF-[kapa]B and C/EBP-like factor binding elements in activating the interleukin-8 gene by proinflammatory cytokines. J. Biol. Chem. 265:21128.
17. Lowenstein, C. J., E. W. Alley, P. Raval, A. M. Snowman, S. M. Snyder, S. W. Russell, and W. J. Murphy. 1993. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90:9730.
18. 2 is phosphorylated and activated by MAP kinase. Cell 72:269.
19. Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:7420.
20. Hambleton, J., S. L. Weinstein, L. Lem, and A. L. DeFranco. 1996. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93:2774.
21. Hwang, D., B. C. Jang, G. Yu, and M. Boudreau. 1997. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide. Biochem. Pharm. 54: 87.
22. Swantek, J. L., M. H. Cobb, and T. D. Geppert. 1997. Jun N-terminal kinase/ stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-α) translation. Mol. Cell. Biol. 17:6274.
23. Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F., Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R Heys, S. W. Landvatter, et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739.
24. Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8:402.
25. Newton, R. C. 1986 Human monocyte production of IL-1: parameters of the induction of IL-1 secretion by lipopolysaccharides. J. Leukococyte Biol. 39:299.
26. Newton, R. C., and J. Uhl. 1989. Assays relevant to the detection and quantitation of cytokines and their inhibitors. In: Pharmacological Methods in the Control of Inflammation. J.Y. Chang and A.J. Leins, eds. Alan R. Liss, New York, NY, p. 83.
27. 3-cotransport in lipopolysaccharide-activated human monocytes. Immunopharmacology 30:41.
28. DeSilva, D. R., W. S. Feeser, E. J. Tancula, and P. A. Scherle. 1996. Anergic T cells are defective in both Jun N-terminal kinase (JNK) and mitogen-activated protein kinase (MAPK) signaling pathways. J. Exp. Med. 183:2017.
29. DeSilva, D. R., E. A. Jones, W. S. Feeser, E. J. Manos, and P. A. Scherle 1997. The p38 mitogen activated protein kinase pathway in activated and anergic Th1 cells. Cell. Immunol. 180:116.
30. Davis, L. G., M. D. Dibner, and J. F. Battey. 1986. Basic Methods in Molecular Biology. Elsevier Press, New York, NY, p. 143.
31. Favata, M. F., K. Y. Horiuchi, E. J. Manos, A. J. Daulerio, D. A. Stradley, W. S. Feeser, D. E. VanDyk, W. J. Pitts, R. A. Earl, F. Hobbs, R. A. Copeland, R. L. Magolda, P. A. Scherle, and J. M. Trzaskos. 1998. Identification of a novel inhibitor of mitogen activated protein kinase kinase (MEK). J. Biol. Chem. 273: 18623.
32. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. J. Biol. Chem. 270:27489.
33. DeWitt, D. L. 1991. Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim. Biophys. Acta 1083:121.
34. Smith, W. L., and L. J. Marnett. 1991. Prostaglandin endoperoxide synthase: structure and catalysis. Biochim. Biophys. Acta 1083:1.
35. Herschmann, H. R. 1996. Prostaglandin synthase 2. Biochim. Biophys. Acta 1299:125.
36. Lee, S. H., E. Soyoola, P. Chanmugam, S. Harr, W. Sun, H. Zhong, S. Liou, D. Simmons, and D. Hwang. 1992. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem. 267:25934.
37. Raabe, T., M. Bukrinsky, and R. A. Currie. 1998. Relative contribution of transcription and translation to the induction of tumor necrosis factor-α by lipopolysaccharide. J. Biol. Chem. 273:974.
38. Hambleton, J., M. McMahon, and A. L. DeFranco. 1995. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J. Exp. Med. 182:145.
39. Winston, B. W., L. K. Remigio, and D. W. Riches. 1995. Preferential involvement of MEK1 in the tumor necrosis factor-α-induced activation of p42 mapk/ erk2 in mouse macrophages. J. Biol. Chem. 270:27391.
40. Foey, A. D, S. L. Perry, L. M. Williams, M. Feldmann, B. M. J. Foxwell, and F. M. Brennan. 1998. Regulatin of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p38 and p42/44 mitogen-activated protein kinases. J. Immunol. 160:920.
41. Berghe, W. V., S. Plaisance, E. Boone, K. De Bosscher, M. L. Schmitz, W. Fiers, and G. Haegeman. 1998. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273:3285.
42. Xie, W., and H. R. Herschmann. 1996. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet derived growth factor and serum. J. Biol. Chem. 271:31742.
43. Hwang, D., B. C. Jang, G. Yu, and M. Boudreau. 1997. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide. Biochem. Pharm. 54: 87.
44. Inoue, H., C. Yokoyama, S. Hara, Y. Tone, and T. Tanabe. 1995. Transcriptional regulation of human prostaglandin endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. J. Biol. Chem. 270: 24965.
45. Murakami, M., Y. Nakatani, G. Atsumi, K. Inoue, and I. Kudo. 1997. Regulatory functions of phospholipase a2. Crit. Rev Immunol. 17:225.
46. Badger, A. M., J. N. Bradbeer, B. Votta, J. C. Lee, J. L. Adams, and D. E. Griswold. 1996. Pharmacologic profile of SB203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279:1453.