RNAi Screening in Primary Human Hepatocytes of Genes Implicated in Genome-Wide Association Studies for Roles in Type 2 Diabetes Identifies Roles for CAMK1D and CDKAL1, among Others, in Hepatic Glucose Regulation

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Haney, Steven ^a,b   Zhao, Juan ^a   Tiwari, Shiwani ^a   Eng, Kurt ^a,c   Guey, Lin T ^a,d   Tien, Eric ^a,e  

^a PFIZER INC   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

^d Shire HGT   (United States)

^e AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 5; GLUCAGON; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN S6; PYRUVIC ACID; SMALL INTERFERING RNA;

ARTICLE; CAMK1D GENE; CDKAL1 GENE; CELL NUCLEUS; CELL STRAIN HEPG2; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRTC2 GENE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC SCREENING; GLUCONEOGENESIS; GLYCEMIC CONTROL; GLYCOLYSIS; HUMAN; HUMAN CELL; KIF11 GENE; LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PCK1 GENE; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; TSPAN8 GENE;

CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIN-DEPENDENT KINASE 5; DIABETES MELLITUS, TYPE 2; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE KNOCKDOWN TECHNIQUES; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GLUCAGON; GLUCOSE; GLYCOGEN; HEP G2 CELLS; HEPATOCYTES; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PRIMARY CELL CULTURE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PYRUVIC ACID; RIBOSOMAL PROTEIN S6 KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84879270477     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064946     Document Type: Article

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