Deletion of CDKAL1 Affects High-Fat Diet-Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Okamura, Tadashi ^a   Yanobu Takanashi, Rieko ^a   Takeuchi, Fumihiko ^a   Isono, Masato ^a   Akiyama, Koichi ^a   Shimizu, Yukiko ^a   Goto, Motohito ^a   Liang, Yi Qiang ^a   Yamamoto, Ken ^b   Katsuya, Tomohiro ^c   Fujioka, Akihiro ^d   Ohnaka, Keizo ^e   Takayanagi, Ryoichi ^e   Ogihara, Toshio ^c,f   Yamori, Yukio ^g   Kato, Norihiro ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Amagasaki Health Medical Foundation   (Japan)

^e KYUSHU UNIVERSITY   (Japan)

^f MORINOMIYA UNIVERSITY OF MEDICAL SCIENCES   (Japan)

^g MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN INSULIN; RECOMBINANT HUMAN INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CDKAL1 GENE; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; IN VIVO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID DIET; MAJOR CLINICAL STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOSE TISSUE; ADULT; ANIMALS; BODY MASS INDEX; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; FEMALE; GENE KNOCKOUT TECHNIQUES; GENETIC LOCI; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; MICE; MIDDLE AGED; NERVE TISSUE PROTEINS; OBESITY; PANCREAS; PHENOTYPE;

MUS;

EID: 84869207382     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049055     Document Type: Article

References (45)

1. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, et al. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341.
2. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, et al. (2007) A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39: 770-775.
3. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336.
4. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
5. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, et al. (2009) Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58: 1690-1699.
6. Dehwah MA, Wang M, Huang QY, (2010) CDKAL1 and type 2 diabetes: a global meta-analysis. Genet Mol Res 9: 1109-1120.
7. Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, et al. (2008) Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia 51: 1659-1663.
8. Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, et al. (2008) Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93: 1924-1930.
9. Stancáková A, Kuulasmaa T, Paananen J, Jackson AU, Bonnycastle LL, et al. (2009) Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes 58: 2129-2136.
10. 't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schäfer SA, et al. (2010) Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps. Diabetes 59: 287-292.
11. Zhao J, Li M, Bradfield JP, Wang K, Zhang H, et al. (2009) Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene. Diabetes 58: 2414-2418.
12. Hattersley AT, Tooke JE, (1999) The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet 353: 1789-1792.
13. Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, et al. (1990) Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand) 45: 737-750.
14. Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, et al. (2005) Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Dev Growth Differ 47: 163-172.
15. Yagi T, Tokunaga T, Furuta Y, Nada S, Yoshida M, et al. (1993) A novel ES cell line, TT2, with high germline-differentiating potency. Anal Biochem 214: 70-76.
16. Filipponi P, Marcelli M, Nicoletti I, Pacifici R, Santeusanio F, et al. (1983) Suppressive effect of long term sulfonylurea treatment on A, B, and D cells of normal rat pancreas. Endocrinology 113: 1972-1279.
17. Oyama K, Minami K, Ishizaki K, Fuse M, Miki T, et al. (2006) Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice. Diabetes 55: 1930-1938.
18. Miki T, Minami K, Shinozaki H, Matsumura K, Saraya A, et al. (2005) Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes 54: 1056-1063.
19. Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi F, et al. (2009) Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. 32: 207-213.
20. Nanri A, Yoshida D, Yamaji T, Mizoue T, Takayanagi R, et al. (2008) Dietary patterns and C-reactive protein in Japanese men and women. Am J Clin Nutr 87: 1488-1496.
21. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
22. Quaranta M, Burden AD, Griffiths CE, Worthington J, Barker JN, et al. (2009) Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. Genes Immun 10: 654-658.
23. Ohara-Imaizumi M, Yoshida M, Aoyagi K, Saito T, Okamura T, et al. (2010) Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. PLoS One 5: e15553.
24. Tzanavari T, Giannogonas P, Karalis KP, (2010) TNF-alpha and obesity. Curr Dir Autoimmun 11: 145-156.
25. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
26. Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, et al. (2009) Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 58: 505-510.
27. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
28. Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 40: 716-718.
29. Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, et al. (2012) Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia 54: 1350-1359.
30. Erber E, Hopping BN, Grandinetti A, Park SY, Kolonel LN, et al. (2010) Dietary patterns and risk for diabetes: the multiethnic cohort. Diabetes Care 33: 532-538.
31. Wei FY, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, et al. (2012) Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest 121: 3598-3608.
32. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, et al. (2002) Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297: 240-243.
33. Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, et al. (2011) Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion. J Biol Chem 286: 37458-37469.
34. Pilia G, Chen WM, Scuteri A, Orrú M, Albai G, et al. (2006) Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet 2: e132.
35. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, et al. (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355: 241-250.
36. Cauchi S, Meyre D, Dina C, Choquet H, Samson C, et al. (2006) Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55: 2903-2908.
37. Gambino R, Bo S, Gentile L, Musso G, Pagano G, et al. (2010) Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort. Diabetes Care 33: 1233-1235.
38. Pecioska S, Zillikens MC, Henneman P, Snijders PJ, Oostra BA, et al. (2010) Association between type 2 diabetes loci and measures of fatness. PLoS One 5: e8541.
39. Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, et al. (2009) Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 58: 505-510.
40. Cauchi S, Choquet H, Gutiérrez-Aguilar R, Capel F, Grau K, et al. (2008) Effects of TCF7L2 polymorphisms on obesity in European populations. Obesity (Silver Spring) 16: 476-482.
41. Winzell MS, Ahrén B, (2004) The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 53Suppl 3: S215-219.
42. Ahrén B, Pacini G, (2002) Insufficient islet compensation to insulin resistance vs. reduced glucose effectiveness in glucose-intolerant mice. Am J Physiol Endocrinol Metab 283: E738-744.
43. Winzell MS, Magnusson C, Ahrén B, (2007) Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice. Metabolism 56: 122-128.
44. Okada Y, Kubo M, Ohmiya H, Takahashi A, Kumasaka N, et al. (2012) Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet 44: 302-306.
45. Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, et al. (2012) Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 44: 307-311.