-
1
-
-
7644238181
-
Biological robustness
-
15520792 10.1038/nrg1471 1:CAS:528:DC%2BD2cXptFenurg%3D
-
Kitano H (2004) Biological robustness. Nat Rev Genet 5:826-837
-
(2004)
Nat Rev Genet
, vol.5
, pp. 826-837
-
-
Kitano, H.1
-
2
-
-
4544346660
-
Robustness of cellular functions
-
15369668 10.1016/j.cell.2004.09.008 1:CAS:528:DC%2BD2cXnvFehtLc%3D
-
Stelling J, Sauer U, Szallasi Z, Doyle FJ, Doyle J (2004) Robustness of cellular functions. Cell 118:675-685
-
(2004)
Cell
, vol.118
, pp. 675-685
-
-
Stelling, J.1
Sauer, U.2
Szallasi, Z.3
Doyle, F.J.4
Doyle, J.5
-
3
-
-
81955161928
-
We are all individuals: Causes and consequences of non-genetic heterogeneity in mammalian cells
-
22005655 10.1016/j.gde.2011.09.010 1:CAS:528:DC%2BC3MXhsFegsrzE
-
Loewer A, Lahav G (2011) We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev 21:753-758
-
(2011)
Curr Opin Genet Dev
, vol.21
, pp. 753-758
-
-
Loewer, A.1
Lahav, G.2
-
5
-
-
77955986202
-
Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells
-
20663918 10.1242/jcs.069641 1:CAS:528:DC%2BC3cXht1ejtbrP
-
Turner DA, Paszek P, Woodcock DJ, Nelson DE, Horton CA, Wang Y, Spiller DG, Rand DA, White MRH, Harper CV (2010) Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells. J Cell Sci 123:2834-2843
-
(2010)
J Cell Sci
, vol.123
, pp. 2834-2843
-
-
Turner, D.A.1
Paszek, P.2
Woodcock, D.J.3
Nelson, D.E.4
Horton, C.A.5
Wang, Y.6
Spiller, D.G.7
Rand, D.A.8
White, M.R.H.9
Harper, C.V.10
-
6
-
-
80054841161
-
Information transduction capacity of noisy biochemical signaling networks
-
21921160 10.1126/science.1204553 1:CAS:528:DC%2BC3MXhtlahsr%2FF
-
Cheong R, Rhee A, Wang CJ, Nemenman I, Levchenko A (2011) Information transduction capacity of noisy biochemical signaling networks. Science 334:354-358
-
(2011)
Science
, vol.334
, pp. 354-358
-
-
Cheong, R.1
Rhee, A.2
Wang, C.J.3
Nemenman, I.4
Levchenko, A.5
-
7
-
-
0029790351
-
Ultrasensitivity in the mitogen-activated protein kinase cascade
-
8816754 10.1073/pnas.93.19.10078 1:CAS:528:DyaK28XlslGksbc%3D
-
Huang CY, Ferrell JE (1996) Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 93:10078-10083
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10078-10083
-
-
Huang, C.Y.1
Ferrell, J.E.2
-
8
-
-
71149092283
-
Dynamics and variability of ERK2 response to EGF in individual living cells
-
20005850 10.1016/j.molcel.2009.11.025 1:CAS:528:DC%2BC3cXht1Cjsro%3D
-
Cohen-Saidon C, Cohen AA, Sigal A, Liron Y, Alon U (2009) Dynamics and variability of ERK2 response to EGF in individual living cells. Mol Cell 36:885-893
-
(2009)
Mol Cell
, vol.36
, pp. 885-893
-
-
Cohen-Saidon, C.1
Cohen, A.A.2
Sigal, A.3
Liron, Y.4
Alon, U.5
-
9
-
-
71149092489
-
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling
-
20005849 10.1016/j.molcel.2009.11.017 1:CAS:528:DC%2BC3cXht1Cjsr0%3D
-
Goentoro L, Kirschner MW (2009) Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell 36:872-884
-
(2009)
Mol Cell
, vol.36
, pp. 872-884
-
-
Goentoro, L.1
Kirschner, M.W.2
-
10
-
-
17644446947
-
How robust are switches in intracellular signaling cascades?
-
14604583 10.1016/S0022-5193(03)00247-9
-
Blüthgen N, Herzel H (2003) How robust are switches in intracellular signaling cascades? J Theor Biol 225:293-300
-
(2003)
J Theor Biol
, vol.225
, pp. 293-300
-
-
Blüthgen, N.1
Herzel, H.2
-
11
-
-
66249136447
-
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
-
19363473 10.1038/nature08012 1:CAS:528:DC%2BD1MXksVemsb8%3D
-
Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK (2009) Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459:428-432
-
(2009)
Nature
, vol.459
, pp. 428-432
-
-
Spencer, S.L.1
Gaudet, S.2
Albeck, J.G.3
Burke, J.M.4
Sorger, P.K.5
-
12
-
-
84856264773
-
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision
-
22206868 10.1016/j.molcel.2011.11.023 1:CAS:528:DC%2BC38XhsFCku7w%3D
-
Chen J-Y, Lin J-R, Cimprich KA, Meyer T (2012) A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol Cell 45:196-209
-
(2012)
Mol Cell
, vol.45
, pp. 196-209
-
-
Chen, J.-Y.1
Lin, J.-R.2
Cimprich, K.A.3
Meyer, T.4
-
13
-
-
77951107351
-
Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression
-
20393579 10.1038/msb.2010.13
-
Mariani L, Schulz EG, Lexberg MH, Helmstetter C, Radbruch A, Löhning M, Höfer T (2010) Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Mol Syst Biol 6:359
-
(2010)
Mol Syst Biol
, vol.6
, pp. 359
-
-
Mariani, L.1
Schulz, E.G.2
Lexberg, M.H.3
Helmstetter, C.4
Radbruch, A.5
Löhning, M.6
Höfer, T.7
-
14
-
-
77954920254
-
Population robustness arising from cellular heterogeneity
-
20534546 10.1073/pnas.0913798107 1:CAS:528:DC%2BC3cXot1ektrw%3D
-
Paszek P, Ryan S, Ashall L, Sillitoe K, Harper CV, Spiller DG, Rand DA, White MRH (2010) Population robustness arising from cellular heterogeneity. Proc Natl Acad Sci USA 107:11644-11649
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 11644-11649
-
-
Paszek, P.1
Ryan, S.2
Ashall, L.3
Sillitoe, K.4
Harper, C.V.5
Spiller, D.G.6
Rand, D.A.7
White, M.R.H.8
-
15
-
-
65949109918
-
Getting the measure of positional information
-
19338391 10.1371/journal.pbio.1000081
-
Jaeger J, Martinez-Arias A (2009) Getting the measure of positional information. PLoS Biol 7:e81
-
(2009)
PLoS Biol
, vol.7
, pp. 81
-
-
Jaeger, J.1
Martinez-Arias, A.2
-
16
-
-
81955160711
-
Systems control of BMP morphogen flow in vertebrate embryos
-
21937218 10.1016/j.gde.2011.09.001 1:CAS:528:DC%2BC3MXhsFegsrzM
-
Plouhinec J-L, Zakin L, De Robertis EM (2011) Systems control of BMP morphogen flow in vertebrate embryos. Curr Opin Genet Dev 21:696-703
-
(2011)
Curr Opin Genet Dev
, vol.21
, pp. 696-703
-
-
Plouhinec, J.-L.1
Zakin, L.2
De Robertis, E.M.3
-
17
-
-
77952092577
-
Cis-interactions between Notch and Delta generate mutually exclusive signalling states
-
20418862 10.1038/nature08959 1:CAS:528:DC%2BC3cXltFKlsbY%3D
-
Sprinzak D, Lakhanpal A, Lebon L, Santat LA, Fontes ME, Anderson GA, Garcia-Ojalvo J, Elowitz MB (2010) Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature 465:86-90
-
(2010)
Nature
, vol.465
, pp. 86-90
-
-
Sprinzak, D.1
Lakhanpal, A.2
Lebon, L.3
Santat, L.A.4
Fontes, M.E.5
Anderson, G.A.6
Garcia-Ojalvo, J.7
Elowitz, M.B.8
-
19
-
-
70349466529
-
Population context determines cell-to-cell variability in endocytosis and virus infection
-
19710653 10.1038/nature08282 1:CAS:528:DC%2BD1MXhtVGitbfO
-
Snijder B, Sacher R, Rämö P, Damm E-M, Liberali P, Pelkmans L (2009) Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 461:520-523
-
(2009)
Nature
, vol.461
, pp. 520-523
-
-
Snijder, B.1
Sacher, R.2
Rämö, P.3
Damm, E.-M.4
Liberali, P.5
Pelkmans, L.6
-
20
-
-
33845257870
-
Variability and memory of protein levels in human cells
-
17122776 10.1038/nature05316 1:CAS:528:DC%2BD28Xht1KjurjL
-
Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, Liron Y, Rosenfeld N, Danon T, Perzov N, Alon U (2006) Variability and memory of protein levels in human cells. Nature 444:643-646
-
(2006)
Nature
, vol.444
, pp. 643-646
-
-
Sigal, A.1
Milo, R.2
Cohen, A.3
Geva-Zatorsky, N.4
Klein, Y.5
Liron, Y.6
Rosenfeld, N.7
Danon, T.8
Perzov, N.9
Alon, U.10
-
21
-
-
53549123008
-
Nature, nurture, or chance: Stochastic gene expression and its consequences
-
18957198 10.1016/j.cell.2008.09.050 1:CAS:528:DC%2BD1cXhtlWhsr%2FK
-
Raj A, van Oudenaarden A (2008) Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135:216-226
-
(2008)
Cell
, vol.135
, pp. 216-226
-
-
Raj, A.1
Van Oudenaarden, A.2
-
22
-
-
81955168000
-
Scaling of morphogen gradients
-
21873045 10.1016/j.gde.2011.07.011 1:CAS:528:DC%2BC3MXhsFegsrzN
-
Ben-Zvi D, Shilo B-Z, Barkai N (2011) Scaling of morphogen gradients. Curr Opin Genet Dev 21:704-710
-
(2011)
Curr Opin Genet Dev
, vol.21
, pp. 704-710
-
-
Ben-Zvi, D.1
Shilo, B.-Z.2
Barkai, N.3
-
23
-
-
3042737691
-
Regionally specific induction by the Spemann-Mangold organizer
-
15153995 10.1038/nrg1347 1:CAS:528:DC%2BD2cXktV2rsrs%3D
-
Niehrs C (2004) Regionally specific induction by the Spemann-Mangold organizer. Nat Rev Genet 5:425-434
-
(2004)
Nat Rev Genet
, vol.5
, pp. 425-434
-
-
Niehrs, C.1
-
24
-
-
84879094983
-
Development genes and evolution
-
Spemann H, Mangold H (1924) Development genes and evolution. Dev Genes Evol 100:3-4
-
(1924)
Dev Genes Evol
, vol.100
, pp. 3-4
-
-
Spemann, H.1
Mangold, H.2
-
25
-
-
23844525556
-
Quantitative analysis of ultrasensitive responses
-
16098190 10.1111/j.1742-4658.2005.04818.x 1:CAS:528:DC%2BD2MXps1Kqs7k%3D
-
Legewie S, Blüthgen N, Herzel H (2005) Quantitative analysis of ultrasensitive responses. FEBS J 272:4071-4079
-
(2005)
FEBS J
, vol.272
, pp. 4071-4079
-
-
Legewie, S.1
Blüthgen, N.2
Herzel, H.3
-
26
-
-
0015989446
-
A linear steady-state treatment of enzymatic chains. General properties, control and effector strength
-
10.1111/j.1432-1033.1974.tb03318.x 1:CAS:528:DyaE2cXktFSltL0%3D
-
Heinrich R, Rapoport TA (1974) A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem/FEBS 42:89-95
-
(1974)
Eur J Biochem/FEBS
, vol.42
, pp. 89-95
-
-
Heinrich, R.1
Rapoport, T.A.2
-
27
-
-
24644456999
-
Control of MAPK signalling: From complexity to what really matters
-
16007170 10.1038/sj.onc.1208817 1:CAS:528:DC%2BD2MXovVOntr8%3D
-
Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV (2005) Control of MAPK signalling: from complexity to what really matters. Oncogene 24:5533-5542
-
(2005)
Oncogene
, vol.24
, pp. 5533-5542
-
-
Hornberg, J.J.1
Binder, B.2
Bruggeman, F.J.3
Schoeberl, B.4
Heinrich, R.5
Westerhoff, H.V.6
-
28
-
-
43449107085
-
Signalling control strength
-
18222488 10.1016/j.jtbi.2007.11.035 1:CAS:528:DC%2BD1cXlvFynsbc%3D
-
Westerhoff HV (2008) Signalling control strength. J Theor Biol 252:555-567
-
(2008)
J Theor Biol
, vol.252
, pp. 555-567
-
-
Westerhoff, H.V.1
-
29
-
-
0036500834
-
Reverse engineering of biological complexity
-
11872830 10.1126/science.1069981 1:CAS:528:DC%2BD38Xhsleitbk%3D
-
Csete ME, Doyle JC (2002) Reverse engineering of biological complexity. Science 295:1664-1669
-
(2002)
Science
, vol.295
, pp. 1664-1669
-
-
Csete, M.E.1
Doyle, J.C.2
-
30
-
-
0027365278
-
A second-order approach to metabolic control analysis
-
8264245 10.1006/jtbi.1993.1141
-
Höfer T, Heinrich R (1993) A second-order approach to metabolic control analysis. J Theor Biol 164:85-102
-
(1993)
J Theor Biol
, vol.164
, pp. 85-102
-
-
Höfer, T.1
Heinrich, R.2
-
31
-
-
80053935888
-
Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty
-
21880701 10.1093/bioinformatics/btr496 1:CAS:528:DC%2BC3MXht12qsLrK
-
Soltis AR, Saucerman JJ (2011) Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty. Bioinformatics 27:2888-2894
-
(2011)
Bioinformatics
, vol.27
, pp. 2888-2894
-
-
Soltis, A.R.1
Saucerman, J.J.2
-
32
-
-
67650760503
-
Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood
-
19505944 10.1093/bioinformatics/btp358 1:CAS:528:DC%2BD1MXovVektbg%3D
-
Raue A, Kreutz C, Maiwald T, Bachmann J, Schilling M, Klingmüller U, Timmer J (2009) Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood. Bioinformatics 25:1923-1929
-
(2009)
Bioinformatics
, vol.25
, pp. 1923-1929
-
-
Raue, A.1
Kreutz, C.2
Maiwald, T.3
Bachmann, J.4
Schilling, M.5
Klingmüller, U.6
Timmer, J.7
-
33
-
-
81355133291
-
Robust signal processing in living cells
-
22215991 10.1371/journal.pcbi.1002218 1:CAS:528:DC%2BC3MXhs1SjsrzJ
-
Steuer R, Waldherr S, Sourjik V, Kollmann M (2011) Robust signal processing in living cells. PLoS Comput Biol 7:e1002218
-
(2011)
PLoS Comput Biol
, vol.7
, pp. 1002218
-
-
Steuer, R.1
Waldherr, S.2
Sourjik, V.3
Kollmann, M.4
-
34
-
-
77949398351
-
Structural sources of robustness in biochemical reaction networks
-
20223989 10.1126/science.1183372 1:CAS:528:DC%2BC3cXivFensr0%3D
-
Shinar G, Feinberg M (2010) Structural sources of robustness in biochemical reaction networks. Science 327:1389-1391
-
(2010)
Science
, vol.327
, pp. 1389-1391
-
-
Shinar, G.1
Feinberg, M.2
-
35
-
-
33750809764
-
Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour
-
10.1049/ip-syb:20050065 1:STN:280:DC%2BD28jkvVSnsw%3D%3D
-
Aldridge BB, Haller G, Sorger PK, Lauffenburger DA (2006) Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst Biol (Stevenage) 153:425-432
-
(2006)
Syst Biol (Stevenage)
, vol.153
, pp. 425-432
-
-
Aldridge, B.B.1
Haller, G.2
Sorger, P.K.3
Lauffenburger, D.A.4
-
36
-
-
34249079154
-
Network motifs: Theory and experimental approaches
-
17510665 10.1038/nrg2102 1:CAS:528:DC%2BD2sXlsVSktro%3D
-
Alon U (2007) Network motifs: theory and experimental approaches. Nat Rev Genet 8:450-461
-
(2007)
Nat Rev Genet
, vol.8
, pp. 450-461
-
-
Alon, U.1
-
37
-
-
77957766590
-
SnapShot: Network motifs
-
20946989 10.1016/j.cell.2010.09.050 e1
-
Shoval O, Alon U (2010) SnapShot: network motifs. Cell 143:326 e1
-
(2010)
Cell
, vol.143
, pp. 326
-
-
Shoval, O.1
Alon, U.2
-
38
-
-
80051486871
-
Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template
-
21811230 10.1038/msb.2011.49
-
Bleris L, Xie Z, Glass D, Adadey A, Sontag E, Benenson Y (2011) Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template. Mol Syst Biol 7:519
-
(2011)
Mol Syst Biol
, vol.7
, pp. 519
-
-
Bleris, L.1
Xie, Z.2
Glass, D.3
Adadey, A.4
Sontag, E.5
Benenson, Y.6
-
39
-
-
78650718305
-
Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli
-
21211727 10.1016/j.molcel.2010.12.023 1:CAS:528:DC%2BC3MXktFSgtQ%3D%3D
-
Hart Y, Madar D, Yuan J, Bren A, Mayo AE, Rabinowitz JD, Alon U (2011) Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol Cell 41:117-127
-
(2011)
Mol Cell
, vol.41
, pp. 117-127
-
-
Hart, Y.1
Madar, D.2
Yuan, J.3
Bren, A.4
Mayo, A.E.5
Rabinowitz, J.D.6
Alon, U.7
-
40
-
-
28544450485
-
Design principles of a bacterial signalling network
-
16306993 10.1038/nature04228 1:CAS:528:DC%2BD2MXht1Gis7jF
-
Kollmann M, Lovdok L, Bartholome K, Timmer J, Sourjik V (2005) Design principles of a bacterial signalling network. Nature 438:504-507
-
(2005)
Nature
, vol.438
, pp. 504-507
-
-
Kollmann, M.1
Lovdok, L.2
Bartholome, K.3
Timmer, J.4
Sourjik, V.5
-
41
-
-
69349099313
-
Role of translational coupling in robustness of bacterial chemotaxis pathway
-
19688030 10.1371/journal.pbio.1000171
-
Lovdok L, Bentele K, Vladimirov N, Müller A, Pop FS, Lebiedz D, Kollmann M, Sourjik V (2009) Role of translational coupling in robustness of bacterial chemotaxis pathway. PLoS Biol 7:e1000171
-
(2009)
PLoS Biol
, vol.7
, pp. 1000171
-
-
Lovdok, L.1
Bentele, K.2
Vladimirov, N.3
Müller, A.4
Pop, F.S.5
Lebiedz, D.6
Kollmann, M.7
Sourjik, V.8
-
42
-
-
67649669252
-
A systems-level analysis of perfect adaptation in yeast osmoregulation
-
19596242 10.1016/j.cell.2009.04.047 1:CAS:528:DC%2BD1MXps1ygurc%3D
-
Muzzey D, Gómez-Uribe CA, Mettetal JT, van Oudenaarden A (2009) A systems-level analysis of perfect adaptation in yeast osmoregulation. Cell 138:160-171
-
(2009)
Cell
, vol.138
, pp. 160-171
-
-
Muzzey, D.1
Gómez-Uribe, C.A.2
Mettetal, J.T.3
Van Oudenaarden, A.4
-
43
-
-
0034712843
-
Robust perfect adaptation in bacterial chemotaxis through integral feedback control
-
10781070 10.1073/pnas.97.9.4649 1:CAS:528:DC%2BD3cXivFKjt7s%3D
-
Yi TM, Huang Y, Simon MI, Doyle J (2000) Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc Natl Acad Sci USA 97:4649-4653
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4649-4653
-
-
Yi, T.M.1
Huang, Y.2
Simon, M.I.3
Doyle, J.4
-
44
-
-
78650635354
-
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier
-
21177493 10.1126/scisignal.2001212 1:CAS:528:DC%2BC3MXhs1Sqtbs%3D
-
Sturm OE, Orton R, Grindlay J, Birtwistle M, Vyshemirsky V, Gilbert D, Calder M, Pitt A, Kholodenko B, Kolch W (2010) The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier. Sci Signal 3(153):ra90
-
(2010)
Sci Signal
, vol.3
, Issue.153
, pp. 90
-
-
Sturm, O.E.1
Orton, R.2
Grindlay, J.3
Birtwistle, M.4
Vyshemirsky, V.5
Gilbert, D.6
Calder, M.7
Pitt, A.8
Kholodenko, B.9
Kolch, W.10
-
45
-
-
3242729569
-
Quantitative analysis of signaling networks
-
15261524 10.1016/j.pbiomolbio.2004.03.002 1:CAS:528:DC%2BD2cXlvVSqtL8%3D
-
Sauro HM, Kholodenko BN (2004) Quantitative analysis of signaling networks. Prog Biophys Mol Biol 86:5-43
-
(2004)
Prog Biophys Mol Biol
, vol.86
, pp. 5-43
-
-
Sauro, H.M.1
Kholodenko, B.N.2
-
46
-
-
0036789922
-
Untangling the wires: A strategy to trace functional interactions in signaling and gene networks
-
12242336 10.1073/pnas.192442699 1:CAS:528:DC%2BD38XnvFGhsbk%3D
-
Kholodenko BN, Kiyatkin A, Bruggeman FJ, Sontag E, Westerhoff HV, Hoek JB (2002) Untangling the wires: a strategy to trace functional interactions in signaling and gene networks. Proc Natl Acad Sci USA 99:12841-12846
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12841-12846
-
-
Kholodenko, B.N.1
Kiyatkin, A.2
Bruggeman, F.J.3
Sontag, E.4
Westerhoff, H.V.5
Hoek, J.B.6
-
47
-
-
0034019315
-
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
-
10.1046/j.1432-1327.2000.01197.x 1:CAS:528:DC%2BD3cXit1ars74%3D
-
Kholodenko BN (2000) Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur J Biochem/FEBS 267:1583-1588
-
(2000)
Eur J Biochem/FEBS
, vol.267
, pp. 1583-1588
-
-
Kholodenko, B.N.1
-
48
-
-
0032077377
-
From specific gene regulation to genomic networks: A global analysis of transcriptional regulation in Escherichia coli
-
9670816 10.1002/(SICI)1521-1878(199805)20:5<433: AID-BIES10>3.0. CO;2-2 1:STN:280:DyaK1czjsFCksA%3D%3D
-
Thieffry D, Huerta AM, Pérez-Rueda E, Collado-Vides J (1998) From specific gene regulation to genomic networks: a global analysis of transcriptional regulation in Escherichia coli. BioEssays 20:433-440
-
(1998)
BioEssays
, vol.20
, pp. 433-440
-
-
Thieffry, D.1
Huerta, A.M.2
Pérez-Rueda, E.3
Collado-Vides, J.4
-
49
-
-
52449123371
-
Transcriptional autoregulatory loops are highly conserved in vertebrate evolution
-
18791639 10.1371/journal.pone.0003210
-
Kiełbasa SM, Vingron M (2008) Transcriptional autoregulatory loops are highly conserved in vertebrate evolution. PLoS one 3:e3210
-
(2008)
PLoS One
, vol.3
, pp. 3210
-
-
Kiełbasa, S.M.1
Vingron, M.2
-
50
-
-
0036428761
-
Negative autoregulation speeds the response times of transcription networks
-
12417193 10.1016/S0022-2836(02)00994-4 1:CAS:528:DC%2BD38Xot1Knu70%3D
-
Rosenfeld N, Elowitz MB, Alon U (2002) Negative autoregulation speeds the response times of transcription networks. J Mol Biol 323:785-793
-
(2002)
J Mol Biol
, vol.323
, pp. 785-793
-
-
Rosenfeld, N.1
Elowitz, M.B.2
Alon, U.3
-
51
-
-
33846108256
-
Noise in transcription negative feedback loops: Simulation and experimental analysis
-
16883354 10.1038/msb4100081
-
Dublanche Y, Michalodimitrakis K, Kümmerer N, Foglierini M, Serrano L (2006) Noise in transcription negative feedback loops: simulation and experimental analysis. Mol Syst Biol 2:41
-
(2006)
Mol Syst Biol
, vol.2
, pp. 41
-
-
Dublanche, Y.1
Michalodimitrakis, K.2
Kümmerer, N.3
Foglierini, M.4
Serrano, L.5
-
52
-
-
0034212551
-
Engineering stability in gene networks by autoregulation
-
10850721 10.1038/35014651 1:STN:280:DC%2BD3czgs1yqtg%3D%3D
-
Becskei A, Serrano L (2000) Engineering stability in gene networks by autoregulation. Nature 405:590-593
-
(2000)
Nature
, vol.405
, pp. 590-593
-
-
Becskei, A.1
Serrano, L.2
-
53
-
-
84857950781
-
Negative feedback confers mutational robustness in yeast transcription factor regulation
-
22355134 10.1073/pnas.1116360109 1:CAS:528:DC%2BC38XjvFymt7o%3D
-
Denby CM, Im JH, Yu RC, Pesce CG, Brem RB (2012) Negative feedback confers mutational robustness in yeast transcription factor regulation. Proc Natl Acad Sci USA 109:3874-3878
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 3874-3878
-
-
Denby, C.M.1
Im, J.H.2
Yu, R.C.3
Pesce, C.G.4
Brem, R.B.5
-
54
-
-
43249098417
-
Recurrent design patterns in the feedback regulation of the mammalian signalling network
-
18463614 10.1038/msb.2008.29
-
Legewie S, Herzel H, Westerhoff HV, Blüthgen N (2008) Recurrent design patterns in the feedback regulation of the mammalian signalling network. Mol Syst Biol 4:190
-
(2008)
Mol Syst Biol
, vol.4
, pp. 190
-
-
Legewie, S.1
Herzel, H.2
Westerhoff, H.V.3
Blüthgen, N.4
-
55
-
-
58849105030
-
A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts
-
19154344 10.1111/j.1742-4658.2008.06846.x
-
Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H, Sers C (2009) A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts. FEBS J 276:1024-1035
-
(2009)
FEBS J
, vol.276
, pp. 1024-1035
-
-
Blüthgen, N.1
Legewie, S.2
Kielbasa, S.M.3
Schramme, A.4
Tchernitsa, O.5
Keil, J.6
Solf, A.7
Vingron, M.8
Schäfer, R.9
Herzel, H.10
Sers, C.11
-
56
-
-
34047174559
-
A module of negative feedback regulators defines growth factor signaling
-
17322878 10.1038/ng1987 1:CAS:528:DC%2BD2sXjsV2hsrs%3D
-
Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, Tarcic G, Siwak D, Lahad J, Jacob-Hirsch J, Amariglio N, Vaisman N, Segal E, Rechavi G, Alon U, Mills GB, Domany E, Yarden Y (2007) A module of negative feedback regulators defines growth factor signaling. Nat Genet 39:503-512
-
(2007)
Nat Genet
, vol.39
, pp. 503-512
-
-
Amit, I.1
Citri, A.2
Shay, T.3
Lu, Y.4
Katz, M.5
Zhang, F.6
Tarcic, G.7
Siwak, D.8
Lahad, J.9
Jacob-Hirsch, J.10
Amariglio, N.11
Vaisman, N.12
Segal, E.13
Rechavi, G.14
Alon, U.15
Mills, G.B.16
Domany, E.17
Yarden, Y.18
-
57
-
-
77953599608
-
Transcriptional feedbacks in mammalian signal transduction pathways facilitate rapid and reliable protein induction
-
20449523 10.1039/c002598d
-
Blüthgen N (2010) Transcriptional feedbacks in mammalian signal transduction pathways facilitate rapid and reliable protein induction. Mol BioSyst 6:1277
-
(2010)
Mol BioSyst
, vol.6
, pp. 1277
-
-
Blüthgen, N.1
-
58
-
-
79957573284
-
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
-
21613978 10.1038/msb.2011.27
-
Fritsche-Guenther R, Witzel F, Sieber A, Herr R, Schmidt N, Braun S, Brummer T, Sers C, Blüthgen N (2011) Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Mol Syst Biol 7:489
-
(2011)
Mol Syst Biol
, vol.7
, pp. 489
-
-
Fritsche-Guenther, R.1
Witzel, F.2
Sieber, A.3
Herr, R.4
Schmidt, N.5
Braun, S.6
Brummer, T.7
Sers, C.8
Blüthgen, N.9
-
59
-
-
79960003271
-
Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development
-
21633009 10.1073/pnas.1100179108 1:CAS:528:DC%2BC3MXot1egu7o%3D
-
Paulsen M, Legewie S, Eils R, Karaulanov E, Niehrs C (2011) Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA 108:10202-10207
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 10202-10207
-
-
Paulsen, M.1
Legewie, S.2
Eils, R.3
Karaulanov, E.4
Niehrs, C.5
-
60
-
-
62449126635
-
Total ERK1/2 activity regulates cell proliferation
-
19242111 10.4161/cc.8.5.7734 1:CAS:528:DC%2BD1MXlvFWju74%3D
-
Lefloch R, Pouysségur J, Lenormand P (2009) Total ERK1/2 activity regulates cell proliferation. Cell Cycle 8:705-711
-
(2009)
Cell Cycle
, vol.8
, pp. 705-711
-
-
Lefloch, R.1
Pouysségur, J.2
Lenormand, P.3
-
61
-
-
58149232582
-
Systems analysis of MAPK signal transduction
-
18793126 10.1042/BSE0450095
-
Blüthgen N, Legewie S (2008) Systems analysis of MAPK signal transduction. Essays Biochem 45:95-107
-
(2008)
Essays Biochem
, vol.45
, pp. 95-107
-
-
Blüthgen, N.1
Legewie, S.2
-
62
-
-
33847355217
-
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
-
17310240 10.1038/ncb1543 1:CAS:528:DC%2BD2sXit12ku7c%3D
-
Santos SDM, Verveer PJ, Bastiaens PIH (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 9:324-330
-
(2007)
Nat Cell Biol
, vol.9
, pp. 324-330
-
-
Santos, S.D.M.1
Verveer, P.J.2
Bastiaens, P.I.H.3
-
63
-
-
57749200702
-
Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
-
19059249 10.1016/j.febslet.2008.11.027 1:CAS:528:DC%2BD1cXhsFCmtrbI
-
Legewie S, Sers C, Herzel H (2009) Kinetic mechanisms for overexpression insensitivity and oncogene cooperation. FEBS Lett 583:93-96
-
(2009)
FEBS Lett
, vol.583
, pp. 93-96
-
-
Legewie, S.1
Sers, C.2
Herzel, H.3
-
64
-
-
78951489049
-
Feedback regulation of EGFR signalling: Decision making by early and delayed loops
-
21252999 10.1038/nrm3048 1:CAS:528:DC%2BC3MXotlSmuw%3D%3D
-
Avraham R, Yarden Y (2011) Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nat Rev Mol Cell Biol 12:104-117
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 104-117
-
-
Avraham, R.1
Yarden, Y.2
-
65
-
-
78449248996
-
Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network
-
20847054 10.1074/jbc.M110.148759 1:CAS:528:DC%2BC3cXhsVWgsrrE
-
Cirit M, Wang C-C, Haugh JM (2010) Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network. J Biol Chem 285:36736-36744
-
(2010)
J Biol Chem
, vol.285
, pp. 36736-36744
-
-
Cirit, M.1
Wang, C.-C.2
Haugh, J.M.3
-
66
-
-
79960594395
-
Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range
-
21772264 10.1038/msb.2011.50
-
Bachmann J, Raue A, Schilling M, Böhm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U (2011) Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Biol 7:516
-
(2011)
Mol Syst Biol
, vol.7
, pp. 516
-
-
Bachmann, J.1
Raue, A.2
Schilling, M.3
Böhm, M.E.4
Kreutz, C.5
Kaschek, D.6
Busch, H.7
Gretz, N.8
Lehmann, W.D.9
Timmer, J.10
Klingmüller, U.11
-
67
-
-
51049113834
-
BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins
-
18676837 10.1158/0008-5472.CAN-08-1430 1:CAS:528:DC%2BD1cXpt1Squro%3D
-
Friday BB, Yu C, Dy GK, Smith PD, Wang L, Thibodeau SN, Adjei AA (2008) BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. Cancer Res 68:6145-6153
-
(2008)
Cancer Res
, vol.68
, pp. 6145-6153
-
-
Friday, B.B.1
Yu, C.2
Dy, G.K.3
Smith, P.D.4
Wang, L.5
Thibodeau, S.N.6
Adjei, A.A.7
-
68
-
-
84863234102
-
Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma
-
22394161 10.1517/13543784.2012.665871 1:CAS:528:DC%2BC38Xjslejsbs%3D
-
Patel SP, Kim KB (2012) Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma. Expert Opin Investig Drugs 21:531-539
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 531-539
-
-
Patel, S.P.1
Kim, K.B.2
-
69
-
-
0033636094
-
Dpp gradient formation in the Drosophila wing imaginal disc
-
11136981 10.1016/S0092-8674(00)00199-9 1:CAS:528:DC%2BD3cXovFCjtLg%3D
-
Teleman AA, Cohen SM (2000) Dpp gradient formation in the Drosophila wing imaginal disc. Cell 103:971-980
-
(2000)
Cell
, vol.103
, pp. 971-980
-
-
Teleman, A.A.1
Cohen, S.M.2
-
70
-
-
0030789367
-
Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus
-
9199359 1:CAS:528:DyaK2sXktlWksLw%3D
-
Dosch R, Gawantka V, Delius H, Blumenstock C, Niehrs C (1997) Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus. Development 124:2325-2334
-
(1997)
Development
, vol.124
, pp. 2325-2334
-
-
Dosch, R.1
Gawantka, V.2
Delius, H.3
Blumenstock, C.4
Niehrs, C.5
-
71
-
-
0037136555
-
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
-
12239569 10.1038/nature01061 1:CAS:528:DC%2BD38XntFSgsL8%3D
-
Eldar A, Dorfman R, Weiss D, Ashe H, Shilo B-Z, Barkai N (2002) Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419:304-308
-
(2002)
Nature
, vol.419
, pp. 304-308
-
-
Eldar, A.1
Dorfman, R.2
Weiss, D.3
Ashe, H.4
Shilo, B.-Z.5
Barkai, N.6
-
72
-
-
46249114829
-
Scaling of the BMP activation gradient in Xenopus embryos
-
18580943 10.1038/nature07059 1:CAS:528:DC%2BD1cXnslGksbw%3D
-
Ben-Zvi D, Shilo B-Z, Fainsod A, Barkai N (2008) Scaling of the BMP activation gradient in Xenopus embryos. Nature 453:1205-1211
-
(2008)
Nature
, vol.453
, pp. 1205-1211
-
-
Ben-Zvi, D.1
Shilo, B.-Z.2
Fainsod, A.3
Barkai, N.4
-
73
-
-
28944438059
-
Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field
-
16360041 10.1016/j.cell.2005.08.047 1:CAS:528:DC%2BD28XptVyh
-
Reversade B, De Robertis EM (2005) Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell 123:1147-1160
-
(2005)
Cell
, vol.123
, pp. 1147-1160
-
-
Reversade, B.1
De Robertis, E.M.2
-
74
-
-
62549083590
-
Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression
-
19279212 10.1073/pnas.0809901106 1:CAS:528:DC%2BD1MXksVertr0%3D
-
Nevozhay D, Adams RM, Murphy KF, Josic K, Balázsi G (2009) Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression. Proc Natl Acad Sci USA 106:5123-5128
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 5123-5128
-
-
Nevozhay, D.1
Adams, R.M.2
Murphy, K.F.3
Josic, K.4
Balázsi, G.5
-
75
-
-
26944476331
-
Regulated cell-to-cell variation in a cell-fate decision system
-
16170311 10.1038/nature03998 1:CAS:528:DC%2BD2MXhtVCjsL%2FO
-
Colman-Lerner A, Gordon A, Serra E, Chin T, Resnekov O, Endy D, Pesce CG, Brent R (2005) Regulated cell-to-cell variation in a cell-fate decision system. Nature 437:699-706
-
(2005)
Nature
, vol.437
, pp. 699-706
-
-
Colman-Lerner, A.1
Gordon, A.2
Serra, E.3
Chin, T.4
Resnekov, O.5
Endy, D.6
Pesce, C.G.7
Brent, R.8
-
76
-
-
0033518256
-
Synexpression groups in eukaryotes
-
10591207 10.1038/990025 1:CAS:528:DyaK1MXotFKhurc%3D
-
Niehrs C, Pollet N (1999) Synexpression groups in eukaryotes. Nature 402:483-487
-
(1999)
Nature
, vol.402
, pp. 483-487
-
-
Niehrs, C.1
Pollet, N.2
-
77
-
-
50149090966
-
Variability and robustness in T cell activation from regulated heterogeneity in protein levels
-
18719282 10.1126/science.1158013 1:CAS:528:DC%2BD1cXhtVSitrbK
-
Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G (2008) Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 321:1081-1084
-
(2008)
Science
, vol.321
, pp. 1081-1084
-
-
Feinerman, O.1
Veiga, J.2
Dorfman, J.R.3
Germain, R.N.4
Altan-Bonnet, G.5
-
78
-
-
33746649199
-
In vivo robustness analysis of cell division cycle genes in Saccharomyces cerevisiae
-
16839182 10.1371/journal.pgen.0020111
-
Moriya H, Shimizu-Yoshida Y, Kitano H (2006) In vivo robustness analysis of cell division cycle genes in Saccharomyces cerevisiae. PLoS Genet 2:e111
-
(2006)
PLoS Genet
, vol.2
, pp. 111
-
-
Moriya, H.1
Shimizu-Yoshida, Y.2
Kitano, H.3
|