Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 13, 2009, Pages 5123-5128

  Nevozhay, Dmitry ^a   Adams, Rhys M ^a   Murphy, Kevin F ^b,d   Josić, Krešimir ^c   Balázsi, Gábor ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b Boston University   (United States)

^c University of Houston   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Gene expression noise; Gene networks; Linearizer negative feedback; Synthetic biology

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN;

ARTICLE; AUTOREGULATION; CHROMOSOME; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GENETIC HETEROGENEITY; GENETIC TRANSCRIPTION; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; NOISE REDUCTION; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REPRESSOR GENE; TETR REPRESSOR GENE; YEAST CELL;

COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION, FUNGAL; GENE REGULATORY NETWORKS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; TETRACYCLINE; TRANSCRIPTION, GENETIC;

EUKARYOTA;

EID: 62549083590     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809901106     Document Type: Article

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