Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 25, 2011, Pages 10202-10207

  Paulsen, Malte ^a   Legewie, Stefan ^a,b   Eils, Roland ^a,c   Karaulanov, Emil ^a   Niehrs, Christof ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Canalization; Eye; Systems biology; Tail

Indexed keywords

BAMBI PROTEIN; BONE MORPHOGENETIC PROTEIN 4; CELL PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; EMBRYO; GROWTH RATE; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNEXPRESSION; XENOPUS;

ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEIN 4; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MODELS, THEORETICAL; SIGNAL TRANSDUCTION; SMAD6 PROTEIN; SMAD7 PROTEIN; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 79960003271     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100179108     Document Type: Article

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