-
1
-
-
0022307020
-
Henry Hyde Salter (1823-71): a biographical sketch
-
Sakula A. Henry Hyde Salter (1823-71): a biographical sketch. Thorax 1985; 40: 887-888.
-
(1985)
Thorax
, vol.40
, pp. 887-888
-
-
Sakula, A.1
-
2
-
-
79959512168
-
The history of Ephedra (ma-huang)
-
Lee MR. The history of Ephedra (ma-huang). J R Coll Physicians Edinb 2011; 41: 78-84.
-
(2011)
J R Coll Physicians Edinb
, vol.41
, pp. 78-84
-
-
Lee, M.R.1
-
3
-
-
77957577242
-
Methylxanthines in asthma
-
Tilley SL. Methylxanthines in asthma. Handb Exp Pharmacol 2011; 200: 439-456.
-
(2011)
Handb Exp Pharmacol
, vol.200
, pp. 439-456
-
-
Tilley, S.L.1
-
4
-
-
77950508505
-
Takamine, and the isolation of epinephrine
-
Parascandola J. Abel, Takamine, and the isolation of epinephrine. J Allergy Clin Immunol 2010; 125: 514-517.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 514-517
-
-
Parascandola, J.A.1
-
5
-
-
0034221926
-
Inhaled adrenergic bronchodilators: historical development and clinical application
-
Rau JL. Inhaled adrenergic bronchodilators: historical development and clinical application. Respir Care 2000; 45: 854-862.
-
(2000)
Respir Care
, vol.45
, pp. 854-862
-
-
Rau, J.L.1
-
6
-
-
33751327296
-
A brief history of inhaled asthma therapy over the last fifty years
-
Crompton G. A brief history of inhaled asthma therapy over the last fifty years. Prim Care Respir J 2006; 1: 326-331.
-
(2006)
Prim Care Respir J
, vol.1
, pp. 326-331
-
-
Crompton, G.1
-
7
-
-
79959363358
-
Indacaterol: a new once daily long-acting beta(2) adrenoceptor agonist
-
Beeh KM, Beier J. Indacaterol: a new once daily long-acting beta(2) adrenoceptor agonist. Core Evid 2010; 4: 37-41.
-
(2010)
Core Evid
, vol.4
, pp. 37-41
-
-
Beeh, K.M.1
Beier, J.2
-
8
-
-
0027129373
-
Beta-agonists and death from asthma
-
Pearce N, Crane J, Burgess C, Beasley R, Jackson R. Beta-agonists and death from asthma. N Engl J Med 1992; 327: 355-357.
-
(1992)
N Engl J Med
, vol.327
, pp. 355-357
-
-
Pearce, N.1
Crane, J.2
Burgess, C.3
Beasley, R.4
Jackson, R.5
-
9
-
-
0017736361
-
Beta-adrenergic agonist resistance in normal human airways
-
Holgate ST, Baldwin CJ, Tattersfield AE. Beta-adrenergic agonist resistance in normal human airways. Lancet 1977; 2: 375-377.
-
(1977)
Lancet
, vol.2
, pp. 375-377
-
-
Holgate, S.T.1
Baldwin, C.J.2
Tattersfield, A.E.3
-
10
-
-
0024384265
-
Inflammatory processes in bronchial asthma
-
Beasley R, Roche W, Holgate ST. Inflammatory processes in bronchial asthma. Drugs 1989; 37: (Suppl. 1): 117-122.
-
(1989)
Drugs
, vol.37
, Issue.SUPPL. 1
, pp. 117-122
-
-
Beasley, R.1
Roche, W.2
Holgate, S.T.3
-
11
-
-
0026590451
-
Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma
-
Djukanović R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, Howarth PH, Holgate ST. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992; 145: 669-674.
-
(1992)
Am Rev Respir Dis
, vol.145
, pp. 669-674
-
-
Djukanović, R.1
Wilson, J.W.2
Britten, K.M.3
Wilson, S.J.4
Walls, A.F.5
Roche, W.R.6
Howarth, P.H.7
Holgate, S.T.8
-
13
-
-
0015493603
-
Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma
-
Brown HM, Storey G, George WH. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br Med J 1972; 1: 585-590.
-
(1972)
Br Med J
, vol.1
, pp. 585-590
-
-
Brown, H.M.1
Storey, G.2
George, W.H.3
-
14
-
-
33746311831
-
Developing the ideal inhaled corticosteroid
-
Cerasoli F Jr. Developing the ideal inhaled corticosteroid. Chest 2006; 130: (1 Suppl.): 54S-64S.
-
(2006)
Chest
, vol.130
, Issue.1 SUPPL.
-
-
Cerasoli Jr., F.1
-
15
-
-
80053018467
-
Biochemical basis of asthma therapy
-
Barnes PJ. Biochemical basis of asthma therapy. J Biol Chem 2011; 286: 32899-32905.
-
(2011)
J Biol Chem
, vol.286
, pp. 32899-32905
-
-
Barnes, P.J.1
-
16
-
-
34247862197
-
Inhalation therapy: an historical review
-
Sanders M. Inhalation therapy: an historical review. Prim Care Respir J 2007; 16: 71-81.
-
(2007)
Prim Care Respir J
, vol.16
, pp. 71-81
-
-
Sanders, M.1
-
17
-
-
55849150176
-
Achieving asthma control in practice: understanding the reasons for poor control
-
Haughney J, Price D, Kaplan A, Chrystyn H, Horne R, May N, Moffat M, Versnel J, Shanahan ER, Hillyer EV, Tunsäter A, Bjermer L. Achieving asthma control in practice: understanding the reasons for poor control. Respir Med 2008; 102: 1681-1693.
-
(2008)
Respir Med
, vol.102
, pp. 1681-1693
-
-
Haughney, J.1
Price, D.2
Kaplan, A.3
Chrystyn, H.4
Horne, R.5
May, N.6
Moffat, M.7
Versnel, J.8
Shanahan, E.R.9
Hillyer, E.V.10
Tunsäter, A.11
Bjermer, L.12
-
20
-
-
23744471092
-
Impact of smoking on asthma therapy: a critical review of clinical evidence
-
Livingston E, Thomson NC, Chalmers GW. Impact of smoking on asthma therapy: a critical review of clinical evidence. Drugs 2005; 65: 1521-1536.
-
(2005)
Drugs
, vol.65
, pp. 1521-1536
-
-
Livingston, E.1
Thomson, N.C.2
Chalmers, G.W.3
-
21
-
-
80052272493
-
Asthma: a simple concept but in reality a complex disease
-
Holgate ST. Asthma: a simple concept but in reality a complex disease. Eur J Clin Invest 2011; 41: 1339-1352.
-
(2011)
Eur J Clin Invest
, vol.41
, pp. 1339-1352
-
-
Holgate, S.T.1
-
22
-
-
34648820354
-
The allergic cascade: review of the most important molecules in the asthmatic lung
-
Bloemen K, Verstraelen S, Van Den Heuvel R, Witters H, Nelissen I, Schoeters G. The allergic cascade: review of the most important molecules in the asthmatic lung. Immunol Lett 2007; 113: 6-18.
-
(2007)
Immunol Lett
, vol.113
, pp. 6-18
-
-
Bloemen, K.1
Verstraelen, S.2
Van Den Heuvel, R.3
Witters, H.4
Nelissen, I.5
Schoeters, G.6
-
23
-
-
21344450322
-
Allergen avoidance in asthma: what do we do now?
-
O'Connor GT. Allergen avoidance in asthma: what do we do now? J Allergy Clin Immunol 2005; 116: 26-30.
-
(2005)
J Allergy Clin Immunol
, vol.116
, pp. 26-30
-
-
O'Connor, G.T.1
-
24
-
-
0029849324
-
Is there a role for immunotherapy in the treatment of asthma? No
-
Barnes PJ. Is there a role for immunotherapy in the treatment of asthma? No. Am J Respir Crit Care Med 1996; 154: 1227-1228.
-
(1996)
Am J Respir Crit Care Med
, vol.154
, pp. 1227-1228
-
-
Barnes, P.J.1
-
25
-
-
80051797386
-
Specific immunotherapy in asthma: efficacy and safety
-
Passalacqua G, Canonica GW. Specific immunotherapy in asthma: efficacy and safety. Clin Exp Allergy 2011; 41: 1247-1255.
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 1247-1255
-
-
Passalacqua, G.1
Canonica, G.W.2
-
26
-
-
33846817376
-
Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study
-
Arshad SH, Bateman B, Sadeghnejad A, Gant C, Matthews SM. Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. J Allergy Clin Immunol 2007; 119: 307-313.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 307-313
-
-
Arshad, S.H.1
Bateman, B.2
Sadeghnejad, A.3
Gant, C.4
Matthews, S.M.5
-
27
-
-
0021992611
-
Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma
-
Robinson C, Holgate ST. Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. Clin Sci (Lond) 1985; 68: 103-112.
-
(1985)
Clin Sci (Lond)
, vol.68
, pp. 103-112
-
-
Robinson, C.1
Holgate, S.T.2
-
28
-
-
16244422285
-
The discovery of cromolyn sodium and its effect on research and practice in allergy and immunology
-
Edwards AM. The discovery of cromolyn sodium and its effect on research and practice in allergy and immunology. J Allergy Clin Immunol 2005; 115: 885-888.
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 885-888
-
-
Edwards, A.M.1
-
29
-
-
0014196954
-
A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma
-
Howell JB, Altounyan RE. A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet 1967; 2: 539-542.
-
(1967)
Lancet
, vol.2
, pp. 539-542
-
-
Howell, J.B.1
Altounyan, R.E.2
-
30
-
-
0022462162
-
Clinical evaluation of nedocromil sodium in asthma
-
Holgate ST. Clinical evaluation of nedocromil sodium in asthma. Eur J Respir Dis Suppl 1986; 147: 149-159.
-
(1986)
Eur J Respir Dis Suppl
, vol.147
, pp. 149-159
-
-
Holgate, S.T.1
-
31
-
-
0036185549
-
Inhaled sodium cromoglycate in children with asthma
-
Edwards A, Stevens M, Holgate S, Iikura Y, Aberg N, König P, Reinhardt D, Stenius-Aarniala B, Warner J, Weinberg E, Callaghan B, Howell J. Inhaled sodium cromoglycate in children with asthma. Thorax 2002; 57: 282.
-
(2002)
Thorax
, vol.57
, pp. 282
-
-
Edwards, A.1
Stevens, M.2
Holgate, S.3
Iikura, Y.4
Aberg, N.5
König, P.6
Reinhardt, D.7
Stenius-Aarniala, B.8
Warner, J.9
Weinberg, E.10
Callaghan, B.11
Howell, J.12
-
32
-
-
55049138055
-
Inhaled sodium cromoglycate for asthma in children
-
CD002173.
-
van der Wouden JC, Uijen JH, Bernsen RM, Tasche MJ, de Jongste JC, Ducharme F. Inhaled sodium cromoglycate for asthma in children. Cochrane Database Syst Rev 2008; (4) CD002173.
-
(2008)
Cochrane Database Syst Rev
, Issue.4
-
-
van der Wouden, J.C.1
Uijen, J.H.2
Bernsen, R.M.3
de Tasche, M.J.4
Jongste, J.C.5
Ducharme, F.6
-
33
-
-
34250672803
-
Sodium cromoglicate: an ineffective drug or meta-analysis misused?
-
Stevens MT, Edwards AM, Howell JB. Sodium cromoglicate: an ineffective drug or meta-analysis misused? Pharm Stat 2007; 6: 123-137.
-
(2007)
Pharm Stat
, vol.6
, pp. 123-137
-
-
Stevens, M.T.1
Edwards, A.M.2
Howell, J.B.3
-
34
-
-
0029853996
-
Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma
-
Alton EW, Norris AA. Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma. J Allergy Clin Immunol 1996; 98: S102-105.
-
(1996)
J Allergy Clin Immunol
, vol.98
-
-
Alton, E.W.1
Norris, A.A.2
-
35
-
-
77951620943
-
Reagan JD GPR35 is a novel lysophosphatidic acid receptor
-
Oka S, Lu JY, Wu X, Summer S, Whoriskey J, Saris C. Reagan JD GPR35 is a novel lysophosphatidic acid receptor. Biochem Biophys Res Commun 2010; 395: 232-237.
-
(2010)
Biochem Biophys Res Commun
, vol.395
, pp. 232-237
-
-
Oka, S.1
Lu, J.Y.2
Wu, X.3
Summer, S.4
Whoriskey, J.5
Saris, C.6
-
36
-
-
77953577324
-
G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium
-
Yang Y, Lu JY, Wu X, Summer S, Whoriskey J, Saris C, Reagan JD. G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium. Pharmacology 2010; 86: 1-5.
-
(2010)
Pharmacology
, vol.86
, pp. 1-5
-
-
Yang, Y.1
Lu, J.Y.2
Wu, X.3
Summer, S.4
Whoriskey, J.5
Saris, C.6
Reagan, J.D.7
-
37
-
-
10244227889
-
Lysophosphatidic acid accelerates the development of human mast cells
-
Bagga S, Price KS, Lin DA, Friend DS, Austen KF, Boyce JA. Lysophosphatidic acid accelerates the development of human mast cells. Blood 2004; 104: 4080-4087.
-
(2004)
Blood
, vol.104
, pp. 4080-4087
-
-
Bagga, S.1
Price, K.S.2
Lin, D.A.3
Friend, D.S.4
Austen, K.F.5
Boyce, J.A.6
-
38
-
-
0023088497
-
Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol
-
Church MK, Hiroi J. Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. Br J Pharmacol 1987; 90: 421-429.
-
(1987)
Br J Pharmacol
, vol.90
, pp. 421-429
-
-
Church, M.K.1
Hiroi, J.2
-
39
-
-
82555168341
-
Histamine and H1-antihistamines: celebrating a century of progress
-
Simons FE, Simons KJ. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol 2011; 128: 1139-1150.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 1139-1150
-
-
Simons, F.E.1
Simons, K.J.2
-
41
-
-
0038415974
-
The ups and downs of Gs- to Gi-protein switching
-
Hill SJ, Baker JG. The ups and downs of Gs- to Gi-protein switching. Br J Pharmacol 2003; 138: 1188-1189.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 1188-1189
-
-
Hill, S.J.1
Baker, J.G.2
-
42
-
-
0018659686
-
Prostaglandins, thromboxanes, and leukotrienes: formation and biological roles
-
Samuelsson B. Prostaglandins, thromboxanes, and leukotrienes: formation and biological roles. Harvey Lect 1979-1980; 75: 1-40.
-
(1979)
Harvey Lect
, vol.75
, pp. 1-40
-
-
Samuelsson, B.1
-
43
-
-
0023589276
-
Leukotrienes and airway responses
-
Drazen JM, Austen KF. Leukotrienes and airway responses. Am Rev Respir Dis 1987; 136: 985-998.
-
(1987)
Am Rev Respir Dis
, vol.136
, pp. 985-998
-
-
Drazen, J.M.1
Austen, K.F.2
-
44
-
-
0033600291
-
Characterization of the human cysteinyl leukotriene CysLT1 receptor
-
Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999; 399: 789-793.
-
(1999)
Nature
, vol.399
, pp. 789-793
-
-
Lynch, K.R.1
O'Neill, G.P.2
Liu, Q.3
Im, D.S.4
Sawyer, N.5
Metters, K.M.6
Coulombe, N.7
Abramovitz, M.8
Figueroa, D.J.9
Zeng, Z.10
IConnolly, B.M.11
Bai, C.12
Austin, C.P.13
Chateauneuf, A.14
Stocco, R.15
Greig, G.M.16
Kargman, S.17
Hooks, S.B.18
Hosfield, E.19
Williams Jr., D.L.20
Ford-Hutchinson, A.W.21
Caskey, C.T.22
Evans, J.F.23
more..
-
45
-
-
0142074290
-
Montelukast and fluticasone compared with Salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial
-
Bjermer L, Bisgaard H, Bousquet J, Fabbri LM, Greening AP, Haahtela T, Holgate ST, Picado C, Menten J, Dass SB, Leff JA, Polos PG. Montelukast and fluticasone compared with Salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial. BMJ 2003; 327: 891.
-
(2003)
BMJ
, vol.327
, pp. 891
-
-
Bjermer, L.1
Bisgaard, H.2
Bousquet, J.3
Fabbri, L.M.4
Greening, A.P.5
Haahtela, T.6
Holgate, S.T.7
Picado, C.8
Menten, J.9
Dass, S.B.10
Leff, J.A.11
Polos, P.G.12
-
46
-
-
79955716906
-
Leukotriene antagonists as first-line or add-on asthma-controller therapy
-
Price D, Musgrave SD, Shepstone L, Hillyer EV, Sims EJ, Gilbert RF, Juniper EF, Ayres JG, Kemp L, Blyth A, Wilson EC, Wolfe S, Freeman D, Mugford HM, Murdoch J, Harvey I. Leukotriene antagonists as first-line or add-on asthma-controller therapy. N Engl J Med 2011; 364: 1695-1707.
-
(2011)
N Engl J Med
, vol.364
, pp. 1695-1707
-
-
Price, D.1
Musgrave, S.D.2
Shepstone, L.3
Hillyer, E.V.4
Sims, E.J.5
Gilbert, R.F.6
Juniper, E.F.7
Ayres, J.G.8
Kemp, L.9
Blyth, A.10
Wilson, E.C.11
Wolfe, S.12
Freeman, D.13
Mugford, H.M.14
Murdoch, J.15
Harvey, I.16
-
47
-
-
34047248519
-
Adherence with montelukast or fluticasone in a long-term clinical trial: results from the mild asthma montelukast versus inhaled corticosteroid trial
-
MIAMI Study Research Group
-
Rand C, Bilderback A, Schiller K, Edelman JM, Hustad CM, Zeiger RS, MIAMI Study Research Group. Adherence with montelukast or fluticasone in a long-term clinical trial: results from the mild asthma montelukast versus inhaled corticosteroid trial. J Allergy Clin Immunol 2007; 119: 916-923.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 916-923
-
-
Rand, C.1
Bilderback, A.2
Schiller, K.3
Edelman, J.M.4
Hustad, C.M.5
Zeiger, R.S.6
-
48
-
-
34247344095
-
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
-
National Heart Lung and Blood Institute's Asthma Clinical Research Network
-
Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF Jr, Leone FT, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME, Fahy JV, National Heart Lung and Blood Institute's Asthma Clinical Research Network. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med 2007; 175: 783-790.
-
(2007)
Am J Respir Crit Care Med
, vol.175
, pp. 783-790
-
-
Lazarus, S.C.1
Chinchilli, V.M.2
Rollings, N.J.3
Boushey, H.A.4
Cherniack, R.5
Craig, T.J.6
Deykin, A.7
DiMango, E.8
Fish, J.E.9
Ford, J.G.10
Israel, E.11
Kiley, J.12
Kraft, M.13
Lemanske Jr., R.F.14
Leone, F.T.15
Martin, R.J.16
Pesola, G.R.17
Peters, S.P.18
Sorkness, C.A.19
Szefler, S.J.20
Wechsler, M.E.21
Fahy, J.V.22
more..
-
49
-
-
10944232455
-
How representative are clinical study patients with asthma or COPD for a larger 'real life' population of patients with obstructive lung disease?
-
Herland K, Akselsen JP, Skjønsberg OH, Bjermer L. How representative are clinical study patients with asthma or COPD for a larger 'real life' population of patients with obstructive lung disease? Respir Med 2005; 99: 11-19.
-
(2005)
Respir Med
, vol.99
, pp. 11-19
-
-
Herland, K.1
Akselsen, J.P.2
Skjønsberg, O.H.3
Bjermer, L.4
-
50
-
-
81155123124
-
Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness
-
Price D, Chisholm A, van der Molen T, Roche N, Hillyer EV, Bousquet J. Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness. Curr Allergy Asthma Rep 2011; 11: 526-538.
-
(2011)
Curr Allergy Asthma Rep
, vol.11
, pp. 526-538
-
-
Price, D.1
van der Chisholm, A.2
Molen, T.3
Roche, N.4
Hillyer, E.V.5
Bousquet, J.6
-
51
-
-
75849155010
-
Lessons learned from variation in response to therapy in clinical trials
-
Szefler SJ, Martin RJ. Lessons learned from variation in response to therapy in clinical trials. J Allergy Clin Immunol 2010; 125: 285-292.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 285-292
-
-
Szefler, S.J.1
Martin, R.J.2
-
52
-
-
0032519008
-
Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma
-
Cowburn AS, Sladek K, Soja J, Adamek L, Nizankowska E, Szczeklik A, Lam BK, Penrose JF, Austen FK, Holgate ST, Sampson AP. Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest 1998; 101: 834-846.
-
(1998)
J Clin Invest
, vol.101
, pp. 834-846
-
-
Cowburn, A.S.1
Sladek, K.2
Soja, J.3
Adamek, L.4
Nizankowska, E.5
Szczeklik, A.6
Lam, B.K.7
Penrose, J.F.8
Austen, F.K.9
Holgate, S.T.10
Sampson, A.P.11
-
53
-
-
0033574195
-
Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/beclomethasone study group
-
Malmström K, Rodriguez-Gomez G, Guerra J, Villaran C, Piñeiro A, Wei LX, Seidenberg BC, Reiss TF. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/beclomethasone study group. Ann Intern Med 1999; 130: 487-495.
-
(1999)
Ann Intern Med
, vol.130
, pp. 487-495
-
-
Malmström, K.1
Rodriguez-Gomez, G.2
Guerra, J.3
Villaran, C.4
Piñeiro, A.5
Wei, L.X.6
Seidenberg, B.C.7
Reiss, T.F.8
-
54
-
-
38349169836
-
Prostaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity
-
Mastalerz L, Sanak M, Gawlewicz-Mroczka A, Gielicz A, Cmiel A, Szczeklik A. Prostaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity. Thorax 2008; 63: 27-34.
-
(2008)
Thorax
, vol.63
, pp. 27-34
-
-
Mastalerz, L.1
Sanak, M.2
Gawlewicz-Mroczka, A.3
Gielicz, A.4
Cmiel, A.5
Szczeklik, A.6
-
55
-
-
34347369535
-
Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics
-
Pierzchalska M, Soja J, Woś M, Szabó Z, Nizankowska-Mogielnicka E, Sanak M, Szczeklik A. Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics. J Physiol Pharmacol 2007; 58: 207-218.
-
(2007)
J Physiol Pharmacol
, vol.58
, pp. 207-218
-
-
Pierzchalska, M.1
Soja, J.2
Woś, M.3
Szabó, Z.4
Nizankowska-Mogielnicka, E.5
Sanak, M.6
Szczeklik, A.7
-
56
-
-
19244370387
-
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics
-
Dahlén B, Nizankowska E, Szczeklik A, Zetterström O, Bochenek G, Kumlin M, Mastalerz L, Pinis G, Swanson LJ, Boodhoo TI, Wright S, Dubé LM, Dahlén SE. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. Am J Respir Crit Care Med 1998; 157: 1187-1194.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 1187-1194
-
-
Dahlén, B.1
Nizankowska, E.2
Szczeklik, A.3
Zetterström, O.4
Bochenek, G.5
Kumlin, M.6
Mastalerz, L.7
Pinis, G.8
Swanson, L.J.9
Boodhoo, T.I.10
Wright, S.11
Dubé, L.M.12
Dahlén, S.E.13
-
57
-
-
0036142418
-
Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
-
Dahlén SE, Malmström K, Nizankowska E, Dahlén B, Kuna P, Kowalski M, Lumry WR, Picado C, Stevenson DD, Bousquet J, Pauwels R, Holgate ST, Shahane A, Zhang J, Reiss TF, Szczeklik A. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med 2002; 165: 9-14.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 9-14
-
-
Dahlén, S.E.1
Malmström, K.2
Nizankowska, E.3
Dahlén, B.4
Kuna, P.5
Kowalski, M.6
Lumry, W.R.7
Picado, C.8
Stevenson, D.D.9
Bousquet, J.10
Pauwels, R.11
Holgate, S.T.12
Shahane, A.13
Zhang, J.14
Reiss, T.F.15
Szczeklik, A.16
-
58
-
-
0032848512
-
Association of urinary leukotriene E4 excretion during aspirin challenges with severity of respiratory responses
-
Daffern PJ, Muilenburg D, Hugli TE, Stevenson DD. Association of urinary leukotriene E4 excretion during aspirin challenges with severity of respiratory responses. J Allergy Clin Immunol 1999; 104: 559-564.
-
(1999)
J Allergy Clin Immunol
, vol.104
, pp. 559-564
-
-
Daffern, P.J.1
Muilenburg, D.2
Hugli, T.E.3
Stevenson, D.D.4
-
59
-
-
77956378266
-
Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
-
Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute
-
Rabinovitch N, Graber NJ, Chinchilli VM, Sorkness CA, Zeiger RS, Strunk RC, Bacharier LB, Martinez FD, Szefler SJ, Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol 2010; 126: 545-551.
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 545-551
-
-
Rabinovitch, N.1
Graber, N.J.2
Chinchilli, V.M.3
Sorkness, C.A.4
Zeiger, R.S.5
Strunk, R.C.6
Bacharier, L.B.7
Martinez, F.D.8
Szefler, S.J.9
-
60
-
-
0035051851
-
Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment
-
Redington AE, Meng QH, Springall DR, Evans TJ, Créminon C, Maclouf J, Holgate ST, Howarth PH, Polak JM. Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax 2001; 56: 351-357.
-
(2001)
Thorax
, vol.56
, pp. 351-357
-
-
Redington, A.E.1
Meng, Q.H.2
Springall, D.R.3
Evans, T.J.4
Créminon, C.5
Maclouf, J.6
Holgate, S.T.7
Howarth, P.H.8
Polak, J.M.9
-
61
-
-
79961014913
-
Elevated exhaled nitric oxide is a clinical indicator of future uncontrolled asthma in asthmatic patients on inhaled corticosteroids
-
Zeiger RS, Schatz M, Zhang F, Crawford WW, Kaplan MS, Roth RM, Chen W. Elevated exhaled nitric oxide is a clinical indicator of future uncontrolled asthma in asthmatic patients on inhaled corticosteroids. J Allergy Clin Immunol 2011; 128: 412-414.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 412-414
-
-
Zeiger, R.S.1
Schatz, M.2
Zhang, F.3
Crawford, W.W.4
Kaplan, M.S.5
Roth, R.M.6
Chen, W.7
-
62
-
-
33845987340
-
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
-
National Heart, Lung, Blood Institute's Severe Asthma Research Program
-
Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Chung KF, Clark MP, Dweik RA, Fitzpatrick AM, Gaston B, Hew M, Hussain I, Jarjour NN, Israel E, Levy BD, Murphy JR, Peters SP, Teague WG, Meyers DA, Busse WW, Wenzel SE, National Heart, Lung, Blood Institute's Severe Asthma Research Program. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 2007; 119: 405-413.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 405-413
-
-
Moore, W.C.1
Bleecker, E.R.2
Curran-Everett, D.3
Erzurum, S.C.4
Ameredes, B.T.5
Bacharier, L.6
Calhoun, W.J.7
Castro, M.8
Chung, K.F.9
Clark, M.P.10
Dweik, R.A.11
Fitzpatrick, A.M.12
Gaston, B.13
Hew, M.14
Hussain, I.15
Jarjour, N.N.16
Israel, E.17
Levy, B.D.18
Murphy, J.R.19
Peters, S.P.20
Teague, W.G.21
Meyers, D.A.22
Busse, W.W.23
Wenzel, S.E.24
more..
-
63
-
-
80052028124
-
Treatment of allergic asthma: modulation of Th2 cells and their responses
-
Bosnjak B, Stelzmueller B, Erb KJ, Epstein MM. Treatment of allergic asthma: modulation of Th2 cells and their responses. Respir Res 2011; 12: 114.
-
(2011)
Respir Res
, vol.12
, pp. 114
-
-
Bosnjak, B.1
Stelzmueller, B.2
Erb, K.J.3
Epstein, M.M.4
-
64
-
-
79955603056
-
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcεRI
-
Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ. Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcεRI. Nat Struct Mol Biol 2011; 18: 571-576.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 571-576
-
-
Holdom, M.D.1
Davies, A.M.2
Nettleship, J.E.3
Bagby, S.C.4
Dhaliwal, B.5
Girardi, E.6
Hunt, J.7
Gould, H.J.8
Beavil, A.J.9
McDonnell, J.M.10
Owens, R.J.11
Sutton, B.J.12
-
65
-
-
82955233553
-
The role of mast cells in allergic inflammation
-
Amin K. The role of mast cells in allergic inflammation. Respir Med 2012; 106: 9-14.
-
(2012)
Respir Med
, vol.106
, pp. 9-14
-
-
Amin, K.1
-
66
-
-
0014327944
-
Immunoglobulin E: a new class of human immunoglobulin
-
Bennich HH, Ishizaka K, Johansson SG, Rowe DS, Stanworth DR, Terry WD. Immunoglobulin E: a new class of human immunoglobulin. Immunology 1968; 15: 323-324.
-
(1968)
Immunology
, vol.15
, pp. 323-324
-
-
Bennich, H.H.1
Ishizaka, K.2
Johansson, S.G.3
Rowe, D.S.4
Stanworth, D.R.5
Terry, W.D.6
-
67
-
-
79551647538
-
Xolair in asthma therapy: an overview
-
Di Domenico M, Bisogno A, Polverino M, De Rosa C, Ricci V, Capasso A. Xolair in asthma therapy: an overview. Inflamm Allergy Drug Targets 2011; 10: 2-12.
-
(2011)
Inflamm Allergy Drug Targets
, vol.10
, pp. 2-12
-
-
Di Domenico, M.1
Bisogno, A.2
Polverino, M.3
De Rosa, C.4
Ricci, V.5
Capasso, A.6
-
68
-
-
77950296391
-
Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization
-
Schroeder JT, Bieneman AP, Chichester KL, Hamilton RG, Xiao H, Saini SS, Liu MC. Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J Allergy Clin Immunol 2010; 125: 896-901.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 896-901
-
-
Schroeder, J.T.1
Bieneman, A.P.2
Chichester, K.L.3
Hamilton, R.G.4
Xiao, H.5
Saini, S.S.6
Liu, M.C.7
-
69
-
-
67650938578
-
Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma
-
Lowe PJ, Tannenbaum S, Gautier A, Jimenez P. Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma. Br J Clin Pharmacol 2009; 68: 61-76.
-
(2009)
Br J Clin Pharmacol
, vol.68
, pp. 61-76
-
-
Lowe, P.J.1
Tannenbaum, S.2
Gautier, A.3
Jimenez, P.4
-
70
-
-
58149113160
-
Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment
-
van Rensen EL, Evertse CE, van Schadewijk WA, van Wijngaarden S, Ayre G, Mauad T, Hiemstra PS, Sterk PJ, Rabe KF. Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment. Allergy 2009; 64: 72-80.
-
(2009)
Allergy
, vol.64
, pp. 72-80
-
-
van Rensen, E.L.1
van Evertse, C.E.2
van Schadewijk, W.A.3
Wijngaarden, S.4
Ayre, G.5
Mauad, T.6
Hiemstra, P.S.7
Sterk, P.J.8
Rabe, K.F.9
-
71
-
-
34249799929
-
Predicting and evaluating response to omalizumab in patients with severe allergic asthma
-
Bousquet J, Rabe K, Humbert M, Chung KF, Berger W, Fox H, Ayre G, Chen H, Thomas K, Blogg M, Holgate S. Predicting and evaluating response to omalizumab in patients with severe allergic asthma. Respir Med 2007; 101: 1483-1492.
-
(2007)
Respir Med
, vol.101
, pp. 1483-1492
-
-
Bousquet, J.1
Rabe, K.2
Humbert, M.3
Chung, K.F.4
Berger, W.5
Fox, H.6
Ayre, G.7
Chen, H.8
Thomas, K.9
Blogg, M.10
Holgate, S.11
-
72
-
-
80052265683
-
Development of the Asthma Control Composite outcome measure to predict omalizumab response
-
Harris JM, Wong DA, Kapp AV. Development of the Asthma Control Composite outcome measure to predict omalizumab response. Ann Allergy Asthma Immunol 2011; 107: 273-280.
-
(2011)
Ann Allergy Asthma Immunol
, vol.107
, pp. 273-280
-
-
Harris, J.M.1
Wong, D.A.2
Kapp, A.V.3
-
73
-
-
4444232912
-
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
-
Djukanović R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, Bao W, Fowler-Taylor A, Matthews J, Busse WW, Holgate ST, Fahy JV. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med 2004; 170: 583-593.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 583-593
-
-
Djukanović, R.1
Wilson, S.J.2
Kraft, M.3
Jarjour, N.N.4
Steel, M.5
Chung, K.F.6
Bao, W.7
Fowler-Taylor, A.8
Matthews, J.9
Busse, W.W.10
Holgate, S.T.11
Fahy, J.V.12
-
74
-
-
58149119978
-
Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis
-
Humbert M, Boulet LP, Niven RM, Panahloo Z, Blogg M, Ayre G. Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis. Allergy 2009; 64: 81-84.
-
(2009)
Allergy
, vol.64
, pp. 81-84
-
-
Humbert, M.1
Boulet, L.P.2
Niven, R.M.3
Panahloo, Z.4
Blogg, M.5
Ayre, G.6
-
75
-
-
58149129505
-
Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations
-
Slavin RG, Ferioli C, Tannenbaum SJ, Martin C, Blogg M, Lowe PJ. Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations. J Allergy Clin Immunol 2009; 123: 107-113.
-
(2009)
J Allergy Clin Immunol
, vol.123
, pp. 107-113
-
-
Slavin, R.G.1
Ferioli, C.2
Tannenbaum, S.J.3
Martin, C.4
Blogg, M.5
Lowe, P.J.6
-
76
-
-
84856937184
-
Sequential class switching is required for the generation of high affinity IgE antibodies
-
Xiong H, Dolpady J, Wabl M, Curotto de Lafaille MA, Lafaille JJ. Sequential class switching is required for the generation of high affinity IgE antibodies. J Exp Med 2012; 209: 353-364.
-
(2012)
J Exp Med
, vol.209
, pp. 353-364
-
-
Xiong, H.1
Dolpady, J.2
Wabl, M.3
Curotto de Lafaille, M.A.4
Lafaille, J.J.5
-
77
-
-
30744466671
-
The role of T lymphocytes in asthma
-
Kay AB. The role of T lymphocytes in asthma. Chem Immunol Allergy 2006; 91: 59-75.
-
(2006)
Chem Immunol Allergy
, vol.91
, pp. 59-75
-
-
Kay, A.B.1
-
78
-
-
62749196135
-
Managing patients with chronic severe asthma: rise to the challenge
-
Polosa R, Benfatto GT. Managing patients with chronic severe asthma: rise to the challenge. Eur J Intern Med 2009; 20: 114-124.
-
(2009)
Eur J Intern Med
, vol.20
, pp. 114-124
-
-
Polosa, R.1
Benfatto, G.T.2
-
79
-
-
0034020371
-
Low-dose methotrexate treatment in severe glucocorticoid-dependent asthma: effect on mucosal inflammation and in vitro sensitivity to glucocorticoids of mitogen-induced T-cell proliferation
-
Vrugt B, Wilson S, Bron A, Shute J, Holgate ST, Djukanovic R, Aalbers R. Low-dose methotrexate treatment in severe glucocorticoid-dependent asthma: effect on mucosal inflammation and in vitro sensitivity to glucocorticoids of mitogen-induced T-cell proliferation. Eur Respir J 2000; 15: 478-485.
-
(2000)
Eur Respir J
, vol.15
, pp. 478-485
-
-
Vrugt, B.1
Wilson, S.2
Bron, A.3
Shute, J.4
Holgate, S.T.5
Djukanovic, R.6
Aalbers, R.7
-
80
-
-
0032480574
-
Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
-
Kon OM, Sihra BS, Compton CH, Leonard TB, Kay AB, Barnes NC. Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet 1998; 352: 1109-1113.
-
(1998)
Lancet
, vol.352
, pp. 1109-1113
-
-
Kon, O.M.1
Sihra, B.S.2
Compton, C.H.3
Leonard, T.B.4
Kay, A.B.5
Barnes, N.C.6
-
81
-
-
0034906753
-
The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma
-
Kon OM, Sihra BS, Loh LC, Barkans J, Compton CH, Barnes NC, Larché M, Kay AB. The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma. Eur Respir J 2001; 18: 45-52.
-
(2001)
Eur Respir J
, vol.18
, pp. 45-52
-
-
Kon, O.M.1
Sihra, B.S.2
Loh, L.C.3
Barkans, J.4
Compton, C.H.5
Barnes, N.C.6
Larché, M.7
Kay, A.B.8
-
82
-
-
79960498901
-
Use of monoclonal antibodies in renal transplantation
-
van den Hoogen MW, Hilbrands LB. Use of monoclonal antibodies in renal transplantation. Immunotherapy 2011; 3: 871-880.
-
(2011)
Immunotherapy
, vol.3
, pp. 871-880
-
-
van den Hoogen, M.W.1
Hilbrands, L.B.2
-
83
-
-
57349179165
-
Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial
-
Daclizumab Asthma Study Group
-
Busse WW, Israel E, Nelson HS, Baker JW, Charous BL, Young DY, Vexler V, Shames RS, Daclizumab Asthma Study Group. Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial. Am J Respir Crit Care Med 2008; 178: 1002-1008.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1002-1008
-
-
Busse, W.W.1
Israel, E.2
Nelson, H.S.3
Baker, J.W.4
Charous, B.L.5
Young, D.Y.6
Vexler, V.7
Shames, R.S.8
-
84
-
-
65249155884
-
Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis
-
Oh U, Blevins G, Griffith C, Richert N, Maric D, Lee CR, McFarland H, Jacobson S. Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis. Arch Neurol 2009; 66: 471-479.
-
(2009)
Arch Neurol
, vol.66
, pp. 471-479
-
-
Oh, U.1
Blevins, G.2
Griffith, C.3
Richert, N.4
Maric, D.5
Lee, C.R.6
McFarland, H.7
Jacobson, S.8
-
86
-
-
84887319804
-
Innate and adapotive immune responses in asthma
-
Holgate ST. Innate and adapotive immune responses in asthma. Nat Med 2012; 18: 1-11.
-
(2012)
Nat Med
, vol.18
, pp. 1-11
-
-
Holgate, S.T.1
-
87
-
-
14744294833
-
Costimulation: critical pathways in the immunologic regulation of asthma
-
Bellou A, Finn PW. Costimulation: critical pathways in the immunologic regulation of asthma. Curr Allergy Asthma Rep 2005; 5: 149-154.
-
(2005)
Curr Allergy Asthma Rep
, vol.5
, pp. 149-154
-
-
Bellou, A.1
Finn, P.W.2
-
88
-
-
84858415050
-
Abatacept in the long-term treatment of rheumatoid arthritis
-
Jani M, Hyrich KL. Abatacept in the long-term treatment of rheumatoid arthritis. Expert Rev Clin Immunol 2012; 8: 231-234.
-
(2012)
Expert Rev Clin Immunol
, vol.8
, pp. 231-234
-
-
Jani, M.1
Hyrich, K.L.2
-
89
-
-
0033800077
-
Regulation of Th2 cytokine gene transcription
-
Lavender P, Cousins D, Lee T. Regulation of Th2 cytokine gene transcription. Chem Immunol 2000; 78: 16-29.
-
(2000)
Chem Immunol
, vol.78
, pp. 16-29
-
-
Lavender, P.1
Cousins, D.2
Lee, T.3
-
90
-
-
84860010929
-
Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor
-
Molfino NA, Gossage D, Kolbeck R, Parker JM, Geba GP. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin Exp Allergy 2012; 42: 712-737.
-
(2012)
Clin Exp Allergy
, vol.42
, pp. 712-737
-
-
Molfino, N.A.1
Gossage, D.2
Kolbeck, R.3
Parker, J.M.4
Geba, G.P.5
-
91
-
-
0036216507
-
Interleukin-5 and eosinophils as therapeutic targets for asthma
-
Foster PS, Hogan SP, Yang M, Mattes J, Young IG, Matthaei KI, Kumar RK, Mahalingam S, Webb DC. Interleukin-5 and eosinophils as therapeutic targets for asthma. Trends Mol Med 2002; 8: 162-167.
-
(2002)
Trends Mol Med
, vol.8
, pp. 162-167
-
-
Foster, P.S.1
Hogan, S.P.2
Yang, M.3
Mattes, J.4
Young, I.G.5
Matthaei, K.I.6
Kumar, R.K.7
Mahalingam, S.8
Webb, D.C.9
-
92
-
-
17844393640
-
Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys
-
Hart TK, Cook RM, Zia-Amirhosseini P, Minthorn E, Sellers TS, Maleeff BE, Eustis S, Schwartz LW, Tsui P, Appelbaum ER, Martin EC, Bugelski PJ, Herzyk DJ. Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys. J Allergy Clin Immunol 2001; 108: 250-257.
-
(2001)
J Allergy Clin Immunol
, vol.108
, pp. 250-257
-
-
Hart, T.K.1
Cook, R.M.2
Zia-Amirhosseini, P.3
Minthorn, E.4
Sellers, T.S.5
Maleeff, B.E.6
Eustis, S.7
Schwartz, L.W.8
Tsui, P.9
Appelbaum, E.R.10
Martin, E.C.11
Bugelski, P.J.12
Herzyk, D.J.13
-
93
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
Leckie MJ, Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, Hansel TT, Holgate ST, Sterk PJ, Barnes PJ. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356: 2144-2148.
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
Brinke, A.2
Khan, J.3
Diamant, Z.4
O'Connor, B.J.5
Walls, C.M.6
Mathur, A.K.7
Cowley, H.C.8
Chung, K.F.9
Djukanovic, R.10
Hansel, T.T.11
Holgate, S.T.12
Sterk, P.J.13
Barnes, P.J.14
-
94
-
-
36749065556
-
International Mepolizumab Study Group. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
-
Flood-Page P, Swenson C, Faiferman I, Matthews J, Williams M, Brannick L, Robinson D, Wenzel S, Busse W, Hansel TT, Barnes NC. International Mepolizumab Study Group. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007; 176: 1062-1107.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 1062-1107
-
-
Flood-Page, P.1
Swenson, C.2
Faiferman, I.3
Matthews, J.4
Williams, M.5
Brannick, L.6
Robinson, D.7
Wenzel, S.8
Busse, W.9
Hansel, T.T.10
Barnes, N.C.11
-
95
-
-
0037869321
-
Eosinophils and interleukin-5: the debate continues
-
Kay AB, Menzies-Gow A. Eosinophils and interleukin-5: the debate continues. Am J Respir Crit Care Med 2003; 167: 1586-1587.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 1586-1587
-
-
Kay, A.B.1
Menzies-Gow, A.2
-
96
-
-
0037393468
-
Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
-
Menzies-Gow AN, Flood-Page PT, Robinson DS, Kay AB. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol 2003; 111: 714-719.
-
(2003)
J Allergy Clin Immunol
, vol.111
, pp. 714-719
-
-
Menzies-Gow, A.N.1
Flood-Page, P.T.2
Robinson, D.S.3
Kay, A.B.4
-
97
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, Marshall RP, Bradding P, Green RH, Wardlaw AJ, Pavord ID. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360: 973-984.
-
(2009)
N Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
Gupta, S.4
Monteiro, W.5
Sousa, A.6
Marshall, R.P.7
Bradding, P.8
Green, R.H.9
Wardlaw, A.J.10
Pavord, I.D.11
-
98
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, Hargreave FE, O'Byrne PM. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009; 360: 985-993.
-
(2009)
N Engl J Med
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
Inman, M.D.4
Efthimiadis, A.5
Pizzichini, E.6
Hargreave, F.E.7
O'Byrne, P.M.8
-
99
-
-
0038643527
-
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study
-
Kips JC, O'Connor BJ, Langley SJ, Woodcock A, Kerstjens HA, Postma DS, Danzig M, Cuss F, Pauwels RA. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med 2003; 167: 1655-1659.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 1655-1659
-
-
Kips, J.C.1
O'Connor, B.J.2
Langley, S.J.3
Woodcock, A.4
Kerstjens, H.A.5
Postma, D.S.6
Danzig, M.7
Cuss, F.8
Pauwels, R.A.9
-
100
-
-
81455155725
-
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
-
Res-5-0010 Study Group
-
Castro M, Mathur S, Hargreave F, Boulet LP, Xie F, Young J, Wilkins HJ, Henkel T, Nair P, Res-5-0010 Study Group. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med 2011; 184: 1125-1132.
-
(2011)
Am J Respir Crit Care Med
, vol.184
, pp. 1125-1132
-
-
Castro, M.1
Mathur, S.2
Hargreave, F.3
Boulet, L.P.4
Xie, F.5
Young, J.6
Wilkins, H.J.7
Henkel, T.8
Nair, P.9
-
101
-
-
33750508779
-
Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps
-
Gevaert P, Lang-Loidolt D, Lackner A, Stammberger H, Staudinger H, Van Zele T, Holtappels G, Tavernier J, van Cauwenberge P, Bachert C. Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol 2006; 118: 1133-1141.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 1133-1141
-
-
Gevaert, P.1
Lang-Loidolt, D.2
Lackner, A.3
Stammberger, H.4
Staudinger, H.5
Van Zele, T.6
Holtappels, G.7
van Tavernier, J.8
Cauwenberge, P.9
Bachert, C.10
-
102
-
-
80055080497
-
Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis
-
Gevaert P, Van Bruaene N, Cattaert T, Van Steen K, Van Zele T, Acke F, De Ruyck N, Blomme K, Sousa AR, Marshall RP, Bachert C. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol 2011; 128: 989-995.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 989-995
-
-
Gevaert, P.1
Van Bruaene, N.2
Cattaert, T.3
Van Steen, K.4
Van Zele, T.5
Acke, F.6
De Ruyck, N.7
Blomme, K.8
Sousa, A.R.9
Marshall, R.P.10
Bachert, C.11
-
103
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
-
Kolbeck R, Kozhich A, Koike M, Peng L, Andersson CK, Damschroder MM, Reed JL, Woods R, Dall'acqua WW, Stephens GL, Erjefalt JS, Bjermer L, Humbles AA, Gossage D, Wu H, Kiener PA, Spitalny GL, Mackay CR, Molfino NA, Coyle AJ. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol 2010; 125: 1344-1353.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1344-1353
-
-
Kolbeck, R.1
Kozhich, A.2
Koike, M.3
Peng, L.4
Andersson, C.K.5
Damschroder, M.M.6
Reed, J.L.7
Woods, R.8
Dall'acqua, W.W.9
Stephens, G.L.10
Erjefalt, J.S.11
Bjermer, L.12
Humbles, A.A.13
Gossage, D.14
Wu, H.15
Kiener, P.A.16
Spitalny, G.L.17
Mackay, C.R.18
Molfino, N.A.19
Coyle, A.J.20
more..
-
104
-
-
77952683218
-
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma
-
Busse WW, Katial R, Gossage D, Sari S, Wang B, Kolbeck R, Coyle AJ, Koike M, Spitalny GL, Kiener PA, Geba GP, Molfino NA. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol 2010; 125: 1237-1244.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1237-1244
-
-
Busse, W.W.1
Katial, R.2
Gossage, D.3
Sari, S.4
Wang, B.5
Kolbeck, R.6
Coyle, A.J.7
Koike, M.8
Spitalny, G.L.9
Kiener, P.A.10
Geba, G.P.11
Molfino, N.A.12
-
105
-
-
77649198441
-
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
-
Oh CK, Geba GP, Molfino N. Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur Respir Rev 2010; 19: 46-54.
-
(2010)
Eur Respir Rev
, vol.19
, pp. 46-54
-
-
Oh, C.K.1
Geba, G.P.2
Molfino, N.3
-
106
-
-
80051707109
-
Allergic inflammation: role of cytokines with special emphasis on IL-4
-
Saggini A, Maccauro G, Tripodi D, De Lutiis MA, Conti F, Felaco P, Fulcheri M, Galzio R, Caraffa A, Antinolfi P, Felaco M, Pandolfi F, Sabatino G, Neri G, Shaik-Dasthagirisaheb YB. Allergic inflammation: role of cytokines with special emphasis on IL-4. Int J Immunopathol Pharmacol 2011; 24: 305-311.
-
(2011)
Int J Immunopathol Pharmacol
, vol.24
, pp. 305-311
-
-
Saggini, A.1
Maccauro, G.2
Tripodi, D.3
De Lutiis, M.A.4
Conti, F.5
Felaco, P.6
Fulcheri, M.7
Galzio, R.8
Caraffa, A.9
Antinolfi, P.10
Felaco, M.11
Pandolfi, F.12
Sabatino, G.13
Neri, G.14
Shaik-Dasthagirisaheb, Y.B.15
-
107
-
-
79954466335
-
The role of mast cells in the structural alterations of the airways as a potential mechanism in the pathogenesis of severe asthma
-
Carter RJ, Bradding P. The role of mast cells in the structural alterations of the airways as a potential mechanism in the pathogenesis of severe asthma. Curr Pharm Des 2011; 17: 685-698.
-
(2011)
Curr Pharm Des
, vol.17
, pp. 685-698
-
-
Carter, R.J.1
Bradding, P.2
-
108
-
-
0036138963
-
Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
-
Howard TD, Koppelman GH, Xu J, Zheng SL, Postma DS, Meyers DA, Bleecker ER. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet 2002; 70: 230-236.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 230-236
-
-
Howard, T.D.1
Koppelman, G.H.2
Xu, J.3
Zheng, S.L.4
Postma, D.S.5
Meyers, D.A.6
Bleecker, E.R.7
-
109
-
-
84865811792
-
IL-13 and its genetic variants: effect on current asthma treatments
-
Townley RG, Sapkota M, Sapkota K. IL-13 and its genetic variants: effect on current asthma treatments. Discov Med 2011; 12: 513-523.
-
(2011)
Discov Med
, vol.12
, pp. 513-523
-
-
Townley, R.G.1
Sapkota, M.2
Sapkota, K.3
-
110
-
-
70349330351
-
Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction
-
Andrews AL, Nordgren IK, Kirby I, Holloway JW, Holgate ST, Davies DE, Tavassoli A. Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction. Biochem Soc Trans 2009; 37: 873-876.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 873-876
-
-
Andrews, A.L.1
Nordgren, I.K.2
Kirby, I.3
Holloway, J.W.4
Holgate, S.T.5
Davies, D.E.6
Tavassoli, A.7
-
111
-
-
33744919804
-
IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets
-
Andrews AL, Holloway JW, Holgate ST, Davies DE. IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. J Immunol 2006; 176: 7456-7461.
-
(2006)
J Immunol
, vol.176
, pp. 7456-7461
-
-
Andrews, A.L.1
Holloway, J.W.2
Holgate, S.T.3
Davies, D.E.4
-
112
-
-
0033454115
-
Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial
-
Borish LC, Nelson HS, Lanz MJ, Claussen L, Whitmore JB, Agosti JM, Garrison L. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am J Respir Crit Care Med 1999; 160: 1816-1823.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 1816-1823
-
-
Borish, L.C.1
Nelson, H.S.2
Lanz, M.J.3
Claussen, L.4
Whitmore, J.B.5
Agosti, J.M.6
Garrison, L.7
-
113
-
-
0034995872
-
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
-
IL-4R Asthma Study Group
-
Borish LC, Nelson HS, Corren J, Bensch G, Busse WW, Whitmore JB, Agosti JM, IL-4R Asthma Study Group. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol 2001; 107: 963-970.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 963-970
-
-
Borish, L.C.1
Nelson, H.S.2
Corren, J.3
Bensch, G.4
Busse, W.W.5
Whitmore, J.B.6
Agosti, J.M.7
-
114
-
-
69549129344
-
Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma
-
Burmeister Getz E, Fisher DM, Fuller R. Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma. J Clin Pharmacol 2009; 49: 1025-1036.
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 1025-1036
-
-
Burmeister Getz, E.1
Fisher, D.M.2
Fuller, R.3
-
115
-
-
35348909044
-
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
-
Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007; 370: 1422-1431.
-
(2007)
Lancet
, vol.370
, pp. 1422-1431
-
-
Wenzel, S.1
Wilbraham, D.2
Fuller, R.3
Getz, E.B.4
Longphre, M.5
-
116
-
-
84860373149
-
Trials and tribulations in identifying new biologic treatments for asthma
-
Holgate ST. Trials and tribulations in identifying new biologic treatments for asthma. Trends Immunol 2012; 33: 238-246.
-
(2012)
Trends Immunol
, vol.33
, pp. 238-246
-
-
Holgate, S.T.1
-
117
-
-
79954583416
-
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
-
Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med 2011; 183: 1007-1014.
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 1007-1014
-
-
Gauvreau, G.M.1
Boulet, L.P.2
Cockcroft, D.W.3
Fitzgerald, J.M.4
Carlsten, C.5
Davis, B.E.6
Deschesnes, F.7
Duong, M.8
Durn, B.L.9
Howie, K.J.10
Hui, L.11
Kasaian, M.T.12
Killian, K.J.13
Strinich, T.X.14
Watson, R.M.15
Y, N.16
Zhou, S.17
Raible, D.18
O'Byrne, P.M.19
-
118
-
-
79960415853
-
IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2
-
Kasaian MT, Raible D, Marquette K, Cook TA, Zhou S, Tan XY, Tchistiakova L. IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2. J Immunol 2011; 187: 561-569.
-
(2011)
J Immunol
, vol.187
, pp. 561-569
-
-
Kasaian, M.T.1
Raible, D.2
Marquette, K.3
Cook, T.A.4
Zhou, S.5
Tan, X.Y.6
Tchistiakova, L.7
-
119
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
-
Corren J, Busse W, Meltzer EO, Mansfield L, Bensch G, Fahrenholz J, Wenzel SE, Chon Y, Dunn M, Weng HH, Lin SL. A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med 2010; 181: 788-796.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 788-796
-
-
Corren, J.1
Busse, W.2
Meltzer, E.O.3
Mansfield, L.4
Bensch, G.5
Fahrenholz, J.6
Wenzel, S.E.7
Chon, Y.8
Dunn, M.9
Weng, H.H.10
Lin, S.L.11
-
120
-
-
80054739802
-
Population PK and IgE pharmacodynamic analysis of a fully human monoclonal antibody against IL4 receptor
-
Kakkar T, Sung C, Gibiansky L, Vu T, Narayanan A, Lin SL, Vincent M, Banfield C, Colbert A, Hoofring S, Starcevic M, Ma P. Population PK and IgE pharmacodynamic analysis of a fully human monoclonal antibody against IL4 receptor. Pharm Res 2011; 28: 2530-2542.
-
(2011)
Pharm Res
, vol.28
, pp. 2530-2542
-
-
Kakkar, T.1
Sung, C.2
Gibiansky, L.3
Vu, T.4
Narayanan, A.5
Lin, S.L.6
Vincent, M.7
Banfield, C.8
Colbert, A.9
Hoofring, S.10
Starcevic, M.11
Ma, P.12
-
121
-
-
84555196323
-
Optimization of CAT-354, a therapeutic antibody directed against interleukin-13, using ribosome display
-
Thom G, Minter R. Optimization of CAT-354, a therapeutic antibody directed against interleukin-13, using ribosome display. Methods Mol Biol 2012; 805: 393-401.
-
(2012)
Methods Mol Biol
, vol.805
, pp. 393-401
-
-
Thom, G.1
Minter, R.2
-
122
-
-
84859720060
-
Preclinical development of CAT-354, an IL-13-neutralising antibody, for the treatment of severe uncontrolled asthma
-
May R, Monk P, Cohen E, Manuel D, Dempsey F, Davis N, Dodd A, Corkill D, Woods J, Joberty-Candotti C, Conroy L, Koentgen F, Martin E, Wilson R, Brennan N, Powell J, Anderson IK. Preclinical development of CAT-354, an IL-13-neutralising antibody, for the treatment of severe uncontrolled asthma. Br J Pharmacol 2012; 166: 177-193.
-
(2012)
Br J Pharmacol
, vol.166
, pp. 177-193
-
-
May, R.1
Monk, P.2
Cohen, E.3
Manuel, D.4
Dempsey, F.5
Davis, N.6
Dodd, A.7
Corkill, D.8
Woods, J.9
Joberty-Candotti, C.10
Conroy, L.11
Koentgen, F.12
Martin, E.13
Wilson, R.14
Brennan, N.15
Powell, J.16
Anderson, I.K.17
-
123
-
-
33747756534
-
Asthma: defining of the persistent adult phenotypes
-
Wenzel SE. Asthma: defining of the persistent adult phenotypes. Lancet 2006; 368: 804-813.
-
(2006)
Lancet
, vol.368
, pp. 804-813
-
-
Wenzel, S.E.1
-
124
-
-
48249085691
-
Cluster analysis and clinical asthma phenotypes
-
Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178: 218-224.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 218-224
-
-
Haldar, P.1
Pavord, I.D.2
Shaw, D.E.3
Berry, M.A.4
Thomas, M.5
Brightling, C.E.6
Wardlaw, A.J.7
Green, R.H.8
-
125
-
-
69249098135
-
Distinct clinical phenotypes of airways disease defined by cluster analysis
-
Weatherall M, Travers J, Shirtcliffe PM, Marsh SE, Williams MV, Nowitz MR, Aldington S, Beasley R. Distinct clinical phenotypes of airways disease defined by cluster analysis. Eur Respir J 2009; 34: 812-818.
-
(2009)
Eur Respir J
, vol.34
, pp. 812-818
-
-
Weatherall, M.1
Travers, J.2
Shirtcliffe, P.M.3
Marsh, S.E.4
Williams, M.V.5
Nowitz, M.R.6
Aldington, S.7
Beasley, R.8
-
126
-
-
76149146032
-
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
-
National Heart, Lung, and Blood Institute's Severe Asthma Research Program
-
Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER, National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181: 315-323.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 315-323
-
-
Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
Teague, W.G.4
Li, H.5
Li, X.6
D'Agostino Jr., R.7
Castro, M.8
Curran-Everett, D.9
Fitzpatrick, A.M.10
Gaston, B.11
Jarjour, N.N.12
Sorkness, R.13
Calhoun, W.J.14
Chung, K.F.15
Comhair, S.A.16
Dweik, R.A.17
Israel, E.18
Peters, S.P.19
Busse, W.W.20
Erzurum, S.C.21
Bleecker, E.R.22
more..
-
127
-
-
80051537670
-
Identifying adult asthma phenotypes using a clustering approach
-
Siroux V, Basagaña X, Boudier A, Pin I, Garcia-Aymerich J, Vesin A, Slama R, Jarvis D, Anto JM, Kauffmann F, Sunyer J. Identifying adult asthma phenotypes using a clustering approach. Eur Respir J 2011; 38: 310-317.
-
(2011)
Eur Respir J
, vol.38
, pp. 310-317
-
-
Siroux, V.1
Basagaña, X.2
Boudier, A.3
Pin, I.4
Garcia-Aymerich, J.5
Vesin, A.6
Slama, R.7
Jarvis, D.8
Anto, J.M.9
Kauffmann, F.10
Sunyer, J.11
-
128
-
-
78649261484
-
Severe asthma in children: insights from the national heart, lung, and blood institute's severe asthma research program
-
Fitzpatrick AM, Teague WG. Severe asthma in children: insights from the national heart, lung, and blood institute's severe asthma research program. Pediatr Allergy Immunol Pulmonol 2010; 23: 131-138.
-
(2010)
Pediatr Allergy Immunol Pulmonol
, vol.23
, pp. 131-138
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
-
129
-
-
0742289428
-
A comparison of in vitro bioassays to determine cellular glucocorticoid sensitivity
-
Vermeer H, Hendriks-Stegeman BI, Verrijn Stuart AA, van Buul-Offers SC, Jansen M. A comparison of in vitro bioassays to determine cellular glucocorticoid sensitivity. Eur J Endocrinol 2004; 150: 41-47.
-
(2004)
Eur J Endocrinol
, vol.150
, pp. 41-47
-
-
Vermeer, H.1
Hendriks-Stegeman, B.I.2
van Verrijn Stuart, A.A.3
Buul-Offers, S.C.4
Jansen, M.5
-
130
-
-
35649028488
-
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
-
Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A 2007; 104: 15858-15863.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 15858-15863
-
-
Woodruff, P.G.1
Boushey, H.A.2
Dolganov, G.M.3
Barker, C.S.4
Yang, Y.H.5
Donnelly, S.6
Ellwanger, A.7
Sidhu, S.S.8
Dao-Pick, T.P.9
Pantoja, C.10
Erle, D.J.11
Yamamoto, K.R.12
Fahy, J.V.13
-
131
-
-
79953854400
-
Dexamethasone-induced FKBP51 expression in peripheral blood mononuclear cells could play a role in predicting the response of asthmatics to treatment with corticosteroids
-
Chun E, Lee HS, Bang BR, Kim TW, Lee SH, Kim JH, Cho SH, Min KU, Kim YY, Park HW. Dexamethasone-induced FKBP51 expression in peripheral blood mononuclear cells could play a role in predicting the response of asthmatics to treatment with corticosteroids. J Clin Immunol 2011; 31: 122-127.
-
(2011)
J Clin Immunol
, vol.31
, pp. 122-127
-
-
Chun, E.1
Lee, H.S.2
Bang, B.R.3
Kim, T.W.4
Lee, S.H.5
Kim, J.H.6
Cho, S.H.7
Min, K.U.8
Kim, Y.Y.9
Park, H.W.10
-
132
-
-
69249150516
-
T-helper type 2-driven inflammation defines major subphenotypes of asthma
-
Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009; 180: 388-395.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
Jia, G.4
Abbas, A.R.5
Ellwanger, A.6
Koth, L.L.7
Arron, J.R.8
Fahy, J.V.9
-
133
-
-
77951672627
-
Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma
-
Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol 2010; 125: 1046-1053.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1046-1053
-
-
Dougherty, R.H.1
Sidhu, S.S.2
Raman, K.3
Solon, M.4
Solberg, O.D.5
Caughey, G.H.6
Woodruff, P.G.7
Fahy, J.V.8
-
134
-
-
77956289251
-
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma
-
Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy JV. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A 2010; 107: 14170-14175.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 14170-14175
-
-
Sidhu, S.S.1
Yuan, S.2
Innes, A.L.3
Kerr, S.4
Woodruff, P.G.5
Hou, L.6
Muller, S.J.7
Fahy, J.V.8
-
135
-
-
33745394558
-
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
-
Takayama G, Arima K, Kanaji T, Toda S, Tanaka H, Shoji S, McKenzie AN, Nagai H, Hotokebuchi T, Izuhara K. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol 2006; 118: 98-104.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 98-104
-
-
Takayama, G.1
Arima, K.2
Kanaji, T.3
Toda, S.4
Tanaka, H.5
Shoji, S.6
McKenzie, A.N.7
Nagai, H.8
Hotokebuchi, T.9
Izuhara, K.10
-
136
-
-
14944365805
-
Epithelial-mesenchymal communication in the pathogenesis of chronic asthma
-
Holgate ST, Holloway J, Wilson S, Bucchieri F, Puddicombe S, Davies DE. Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc Am Thorac Soc 2004; 1: 93-98.
-
(2004)
Proc Am Thorac Soc
, vol.1
, pp. 93-98
-
-
Holgate, S.T.1
Holloway, J.2
Wilson, S.3
Bucchieri, F.4
Puddicombe, S.5
Davies, D.E.6
-
137
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365: 1088-1098.
-
(2011)
N Engl J Med
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
Lemanske, R.F.2
Hanania, N.A.3
Korenblat, P.E.4
Parsey, M.V.5
Arron, J.R.6
Harris, J.M.7
Scheerens, H.8
Wu, L.C.9
Su, Z.10
Mosesova, S.11
Eisner, M.D.12
Bohen, S.P.13
Matthews, J.G.14
-
138
-
-
78650864775
-
Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
-
Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol 2011; 127: 153-160.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 153-160
-
-
Baines, K.J.1
Simpson, J.L.2
Wood, L.G.3
Scott, R.J.4
Gibson, P.G.5
-
139
-
-
84863797299
-
The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
-
Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG. The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest 2012; 142: 86-93.
-
(2012)
Chest
, vol.142
, pp. 86-93
-
-
Wood, L.G.1
Baines, K.J.2
Fu, J.3
Scott, H.A.4
Gibson, P.G.5
-
140
-
-
28244479315
-
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
-
Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConnell W, Beckett P, Al Ali M, Chauhan A, Wilson SJ, Reynolds A, Davies DE, Holgate ST. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 2005; 60: 1012-1018.
-
(2005)
Thorax
, vol.60
, pp. 1012-1018
-
-
Howarth, P.H.1
Babu, K.S.2
Arshad, H.S.3
Lau, L.4
Buckley, M.5
McConnell, W.6
Beckett, P.7
Al Ali, M.8
Chauhan, A.9
Wilson, S.J.10
Reynolds, A.11
Davies, D.E.12
Holgate, S.T.13
-
141
-
-
67650895323
-
TNFalpha inhibitors may improve asthma symptoms: a case series of 12 patients with rheumatoid arthritis and asthma
-
Stoll ML, Solomon DH, Batra KL, Simard JF, Karlson EW, Dellaripa PF, Weinblatt ME, Glass R, Shadick NA. TNFalpha inhibitors may improve asthma symptoms: a case series of 12 patients with rheumatoid arthritis and asthma. J Clin Rheumatol 2009; 15: 198-200.
-
(2009)
J Clin Rheumatol
, vol.15
, pp. 198-200
-
-
Stoll, M.L.1
Solomon, D.H.2
Batra, K.L.3
Simard, J.F.4
Karlson, E.W.5
Dellaripa, P.F.6
Weinblatt, M.E.7
Glass, R.8
Shadick, N.A.9
-
142
-
-
32644490529
-
Evidence of a role of tumor necrosis factor alpha in refractory asthma
-
Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, Bradding P, Brightling CE, Wardlaw AJ, Pavord ID. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 2006; 354: 697-708.
-
(2006)
N Engl J Med
, vol.354
, pp. 697-708
-
-
Berry, M.A.1
Hargadon, B.2
Shelley, M.3
Parker, D.4
Shaw, D.E.5
Green, R.H.6
Bradding, P.7
Brightling, C.E.8
Wardlaw, A.J.9
Pavord, I.D.10
-
143
-
-
47049130758
-
The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial
-
Morjaria JB, Chauhan AJ, Babu KS, Polosa R, Davies DE, Holgate ST. The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial. Thorax 2008; 63: 584-591.
-
(2008)
Thorax
, vol.63
, pp. 584-591
-
-
Morjaria, J.B.1
Chauhan, A.J.2
Babu, K.S.3
Polosa, R.4
Davies, D.E.5
Holgate, S.T.6
-
144
-
-
79957987328
-
Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial
-
Holgate ST, Noonan M, Chanez P, Busse W, Dupont L, Pavord I, Hakulinen A, Paolozzi L, Wajdula J, Zang C, Nelson H, Raible D. Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial. Eur Respir J 2011; 37: 1352-1359.
-
(2011)
Eur Respir J
, vol.37
, pp. 1352-1359
-
-
Holgate, S.T.1
Noonan, M.2
Chanez, P.3
Busse, W.4
Dupont, L.5
Pavord, I.6
Hakulinen, A.7
Paolozzi, L.8
Wajdula, J.9
Zang, C.10
Nelson, H.11
Raible, D.12
-
145
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
-
T03 Asthma Investigators
-
Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlén SE, Holgate ST, Meyers DA, Rabe KF, Antczak A, Baker J, Horvath I, Mark Z, Bernstein D, Kerwin E, Schlenker-Herceg R, Lo KH, Watt R, Barnathan ES, Chanez P, T03 Asthma Investigators. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 2009; 179: 549-558.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
Bousquet, J.4
Busse, W.5
Dahlén, S.E.6
Holgate, S.T.7
Meyers, D.A.8
Rabe, K.F.9
Antczak, A.10
Baker, J.11
Horvath, I.12
Mark, Z.13
Bernstein, D.14
Kerwin, E.15
Schlenker-Herceg, R.16
Lo, K.H.17
Watt, R.18
Barnathan, E.S.19
Chanez, P.20
more..
|