G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium

Pharmacology

Volumn 86, Issue 1, 2010, Pages 1-5

  Yang, Yuhua ^a   Lu, Jenny Ying Lin ^a   Wu, Xiaosu ^a   Summer, Shamin ^a   Whoriskey, John ^a   Saris, Christiaan ^a   Reagan, Jeff D ^a  

^a AMGEN INC   (United States)

Author keywords

Asthma; Cromolyn disodium; G protein coupled receptor 35; Kynurenic acid; Mast cell; Nedocromil sodium; Zaprinast

Indexed keywords

CROMOGLYCATE DISODIUM; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 35; IMMUNOGLOBULIN E ANTIBODY; INOSITOL PHOSPHATE; MESSENGER RNA; NEDOCROMIL SODIUM; PHOSPHODIESTERASE V; UNCLASSIFIED DRUG; ZAPRINAST;

ANIMAL CELL; ARTICLE; ASTHMA; BASOPHIL; CALCIUM TRANSPORT; CONTROLLED STUDY; EOSINOPHIL; HUMAN; HUMAN CELL; MAST CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; UPREGULATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; BASOPHILS; CRICETINAE; CROMOLYN SODIUM; DRUG DELIVERY SYSTEMS; EOSINOPHILS; HUMANS; IMMUNOGLOBULIN E; MAST CELLS; MICE; NEDOCROMIL; PHOSPHODIESTERASE 5 INHIBITORS; PURINONES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER;

EID: 77953577324     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000314164     Document Type: Article

References (16)

1. Wang J, Simonavicius N, Wu X, Swaminath G, Reagan JD, Tian H, Ling L: Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem 2006; 281: 22021-22028.
2. Taniguchi Y, Tonai-Kachi H, Shinjo K: Zaprinast, a well-known cyclic guanosine monophosphate- specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett 2006; 580: 5003-5008.
3. Taniguchi Y, Tonai-Hachi H, Shinjo K: 5-Nitro- 2-(3-phenylpropylamino) benzoic acid is a GPR35 agonist. Pharmacology 2008; 82: 245-249.
4. Ohshiro H, Tonai-Kachi H, Ichikawa K: GPR35 is a functional receptor in rat dorsal root ganglion neurons. Biochem Biophys Res Commun 2008; 365: 344-348.
5. Coward P, Chan SD, Wada HG, Humphries GM, Conklin BR: Chimeric G proteins allow a high-throughput signaling of G i -coupled receptors. Anal Biochem 1999; 270: 242-248.
6. Altounyan REC: Inhibition of experimental asthma by a new compound, disodium cromoglycate, 'Intal'. Acta Allergol 1967; 22: 487-489.
7. Rudd RM, Gellar AR, Study PR, Geddes DM: Inhibition of exercise-induced asthma by an orally absorbed mast cell stabilizer (M&B 22,948). Br J Chest 1983; 77: 78-86.
8. MacGlashan D Jr: IgE receptor and signal transduction in mast cells and basophils. Curr Opin Immunol 2008; 20: 717-723.
9. Kikuchi T, Ishida S, Kinoshita T, Sakuma S, Sugawara N, Yamashita T, Koite K: Il-6 enhances IgE-dependent histamine release from human peripheral blood-derived cultured mast cells. Cytokine 2002; 20: 200-209.
10. Edwards AM: The discovery of cromolyn disodium and its effect on research and practice in allergy and immunology. J Allergy Clin Immunol 2005: 885-888.
11. Soter NA, Austen KF, Wasserman SI: Oral disodium cromoglycate in the treatment of systemic mastocytosis. N Engl J Med 1979; 301: 465-469.
12. Moots RJ, Prouse P, Gumpel JM: Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate. Gut 1988; 29: 1282-1285.
13. Stainer R, Matthews S, Arshad SH, Mcdonald S, Robinson J, Schapira C, et al: Efficacy and acceptability of a new topical skin lotion of sodium chromoglycate (Altoderm) in atopic dermatitis in children aged 2-12 years: a double-blind, randomized, placebo controlled trial. Br J Dermatol 2005; 152: 334-341.
14. Singh LK, Boucher W, Pang X, Letourneau R, Seretakis D, Green M, Theoharides TC: Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotrophin-releasing hormone receptors. J Pharmacol Exp Ther 1999; 288: 1349-1356.
15. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P , Blumberg RS, Kahn BB, Hotmisligil GS, Shi GP: Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 2009; 15: 940-946.
16. Stokes TC, Morley J: Prospects for an oral Intal. Br J Dis Chest 1981; 75: 1-14.