Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17336-17346

  Ehteshami, Maryam ^a,d   Nijhuis, Monique ^b   Bernatchez, Jean A ^a   Ablenas, Christopher J ^a   McCormick, Suzanne ^a   De Jong, Dorien ^b   Jochmans, Dirk ^c   Götte, Matthias ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; HIV-1 REVERSE TRANSCRIPTASE; HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; NUCLEOTIDE-BINDING SITES; REVERSE TRANSCRIPTASES; SIMULTANEOUS BINDINGS; STRUCTURE ACTIVITY RELATIONSHIPS; SUSCEPTIBILITY MEASUREMENTS;

AMINO ACIDS; ENZYME INHIBITION; NUCLEIC ACIDS; NUCLEOTIDES;

VIRUSES;

ADENOSINE TRIPHOSPHATE; ARGININE; GLYCINE; INDOLOPYRIDONE 1; LYSINE; NUCLEOTIDE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THREONINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; DRUG BINDING SITE; DRUG EFFECT; ENHANCER REGION; ENZYME INHIBITION; ENZYME STABILITY; MOLECULAR DYNAMICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT;

DNA POLYMERASE; DRUG ACTION; DRUG RESISTANCE; HIV-1; REVERSE TRANSCRIPTION;

ADENOSINE TRIPHOSPHATE; ANTI-HIV AGENTS; DNA, VIRAL; ENZYME STABILITY; FOSCARNET; HEK293 CELLS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; INDOLES; NITRILES; PROTEIN BINDING; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84879045198     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.433441     Document Type: Article

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