Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase

Journal of Biological Chemistry

Volumn 286, Issue 23, 2011, Pages 20615-20624

  Kisic, Mónica ^a   Matamoros, Tania ^a   Nevot, María ^b   Mendieta, Jesús ^a   Martinez Picado, Javier ^b,c   Martínez, Miguel A ^b   Menéndez Arias, Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HIV-1 REVERSE TRANSCRIPTASE; HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; REVERSE TRANSCRIPTASES; SIDE-CHAINS; THEORETICAL STUDY; WILD TYPES;

AMINO ACIDS; BEARINGS (STRUCTURAL); BINDING SITES; COMPLEXATION; MOLECULAR DYNAMICS; PATIENT TREATMENT; REACTION KINETICS; VIRUSES;

DISEASES;

ADENOSINE TRIPHOSPHATE; ARGININE; ASPARTIC ACID; LYSINE; MUTANT PROTEIN; PYROPHOSPHATE; RNA DIRECTED DNA POLYMERASE; STAVUDINE; THREONINE; THYMIDINE DERIVATIVE; ZIDOVUDINE;

AMINO ACID SEQUENCE; ANTIVIRAL RESISTANCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG SELECTIVITY; GENE DELETION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; VIRUS RECOMBINANT; WILD TYPE;

DNA, VIRAL; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; KINETICS; MUTATION; STAVUDINE; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79958004160     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.226100     Document Type: Article

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