The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation

Journal of Biological Chemistry

Volumn 282, Issue 5, 2007, Pages 3337-3346

  Marchand, Bruno ^a   Tchesnokov, Egor P ^a   Götte, Matthias ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b Duff Medical Bldg ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FOOTPRINTING; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1); PYROPHOSPHATE (PPI);

BROWNIAN MOVEMENT; DNA; DRUG DOSAGE; SYNTHESIS (CHEMICAL); VIRUSES;

ENZYMES;

FOSCARNET; PYROPHOSPHORIC ACID DERIVATIVE; RNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE; PRIMER DNA; RECOMBINANT PROTEIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS DNA;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; DRUG BINDING; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENE SEQUENCE; GENE TRANSLOCATION; HUMAN IMMUNODEFICIENCY VIRUS 1; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; BIOLOGICAL MODEL; DNA REPLICATION; DNA TEMPLATE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN TRANSPORT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BASE SEQUENCE; DNA PRIMERS; DNA REPLICATION; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; FOSCARNET; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; TEMPLATES, GENETIC;

EID: 34047257841     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607710200     Document Type: Article

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