-
1
-
-
0029150042
-
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors
-
Rittinger K., Divita G., and Goody R.S. Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors Proc. Natl Acad. Sci. USA 92 1995 8046 8049
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 8046-8049
-
-
Rittinger, K.1
Divita, G.2
Goody, R.S.3
-
2
-
-
0029670612
-
HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors
-
Spence R.A., Anderson K.S., and Johnson K.A. HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors Biochemistry 35 1996 1054 1063
-
(1996)
Biochemistry
, vol.35
, pp. 1054-1063
-
-
Spence, R.A.1
Anderson, K.S.2
Johnson, K.A.3
-
3
-
-
33845410116
-
Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action
-
Jochmans D., Deval J., Kesteleyn B., Van Marck H., Bettens E., and De Baere I. Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action J. Virol. 80 2006 12283 12292
-
(2006)
J. Virol.
, vol.80
, pp. 12283-12292
-
-
Jochmans, D.1
Deval, J.2
Kesteleyn, B.3
Van Marck, H.4
Bettens, E.5
De Baere, I.6
-
4
-
-
57649233039
-
Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors"
-
Ehteshami M., Scarth B.J., Tchesnokov E.P., Dash C., Le Grice S.F., and Hallenberger S. Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors" J. Biol. Chem. 283 2008 29904 29911
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 29904-29911
-
-
Ehteshami, M.1
Scarth, B.J.2
Tchesnokov, E.P.3
Dash, C.4
Le Grice, S.F.5
Hallenberger, S.6
-
5
-
-
0042316944
-
Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance
-
Marchand B., and Gotte M. Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance J. Biol. Chem. 278 2003 35362 35372
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35362-35372
-
-
Marchand, B.1
Gotte, M.2
-
6
-
-
33646516020
-
Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation
-
Gotte M. Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation Curr. Pharm. Des. 12 2006 1867 1877
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 1867-1877
-
-
Gotte, M.1
-
7
-
-
34047257841
-
The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation
-
Marchand B., Tchesnokov E.P., and Gotte M. The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation J. Biol. Chem. 282 2007 3337 3346
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 3337-3346
-
-
Marchand, B.1
Tchesnokov, E.P.2
Gotte, M.3
-
8
-
-
0034737638
-
Mechanism by which phosphonoformic acid resistance mutations restore 3′-azido-3′-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase
-
Arion D., Sluis-Cremer N., and Parniak M.A. Mechanism by which phosphonoformic acid resistance mutations restore 3′-azido-3′- deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase J. Biol. Chem. 275 2000 9251 9255
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9251-9255
-
-
Arion, D.1
Sluis-Cremer, N.2
Parniak, M.A.3
-
9
-
-
0029792446
-
Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet
-
Tachedjian G., Mellors J., Bazmi H., Birch C., and Mills J. Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet J. Virol. 70 1996 7171 7181
-
(1996)
J. Virol.
, vol.70
, pp. 7171-7181
-
-
Tachedjian, G.1
Mellors, J.2
Bazmi, H.3
Birch, C.4
Mills, J.5
-
10
-
-
0037689445
-
Relationship between 3′-azido-3′-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase
-
Meyer P.R., Matsuura S.E., Zonarich D., Chopra R.R., Pendarvis E., and Bazmi H.Z. Relationship between 3′-azido-3′-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase J. Virol. 77 2003 6127 6137
-
(2003)
J. Virol.
, vol.77
, pp. 6127-6137
-
-
Meyer, P.R.1
Matsuura, S.E.2
Zonarich, D.3
Chopra, R.R.4
Pendarvis, E.5
Bazmi, H.Z.6
-
11
-
-
2342631381
-
Foscarnet used in salvage therapy of HIV-1 patients harbouring multiple nucleotide excision mutations
-
Mathiesen S., Roge B.T., Weis N., Lundgren J.D., Obel N., and Gerstoft J. Foscarnet used in salvage therapy of HIV-1 patients harbouring multiple nucleotide excision mutations AIDS 18 2004 1076 1078
-
(2004)
AIDS
, vol.18
, pp. 1076-1078
-
-
Mathiesen, S.1
Roge, B.T.2
Weis, N.3
Lundgren, J.D.4
Obel, N.5
Gerstoft, J.6
-
12
-
-
0032506228
-
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism
-
Meyer P.R., Matsuura S.E., So A.G., and Scott W.A. Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism Proc. Natl Acad. Sci. USA 95 1998 13471 13476
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13471-13476
-
-
Meyer, P.R.1
Matsuura, S.E.2
So, A.G.3
Scott, W.A.4
-
13
-
-
0033165851
-
A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
-
Meyer P.R., Matsuura S.E., Mian A.M., So A.G., and Scott W.A. A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase Mol. Cell 4 1999 35 43
-
(1999)
Mol. Cell
, vol.4
, pp. 35-43
-
-
Meyer, P.R.1
Matsuura, S.E.2
Mian, A.M.3
So, A.G.4
Scott, W.A.5
-
14
-
-
18744365757
-
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA
-
Sarafianos S.G., Clark A.D. Jr, Das K., Tuske S., Birktoft J.J., and Ilankumaran P. Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA EMBO J. 21 2002 6614 6624
-
(2002)
EMBO J.
, vol.21
, pp. 6614-6624
-
-
Sarafianos, S.G.1
Clark Jr., A.D.2
Das, K.3
Tuske, S.4
Birktoft, J.J.5
Ilankumaran, P.6
-
15
-
-
34547641773
-
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir
-
Marchand B., White K.L., Ly J.K., Margot N.A., Wang R., and McDermott M. Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir Antimicrob. Agents Chemother. 51 2007 2911 2919
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 2911-2919
-
-
Marchand, B.1
White, K.L.2
Ly, J.K.3
Margot, N.A.4
Wang, R.5
McDermott, M.6
-
16
-
-
0035031936
-
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
-
Boyer P.L., Sarafianos S.G., Arnold E., and Hughes S.H. Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase J. Virol. 75 2001 4832 4842
-
(2001)
J. Virol.
, vol.75
, pp. 4832-4842
-
-
Boyer, P.L.1
Sarafianos, S.G.2
Arnold, E.3
Hughes, S.H.4
-
17
-
-
0038521318
-
Trapping HIV-1 reverse transcriptase before and after translocation on DNA
-
Sarafianos S.G., Clark A.D. Jr, Tuske S., Squire C.J., Das K., and Sheng D. Trapping HIV-1 reverse transcriptase before and after translocation on DNA J. Biol. Chem. 278 2003 16280 16288
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16280-16288
-
-
Sarafianos, S.G.1
Clark Jr., A.D.2
Tuske, S.3
Squire, C.J.4
Das, K.5
Sheng, D.6
-
18
-
-
0032509101
-
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 Å resolution
-
Ding J., Das K., Hsiou Y., Sarafianos S.G., Clark A.D. Jr, and Jacobo-Molina A. Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 Å resolution J. Mol. Biol. 284 1998 1095 1111
-
(1998)
J. Mol. Biol.
, vol.284
, pp. 1095-1111
-
-
Ding, J.1
Das, K.2
Hsiou, Y.3
Sarafianos, S.G.4
Clark Jr., A.D.5
Jacobo-Molina, A.6
-
19
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang H., Chopra R., Verdine G.L., and Harrison S.C. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance Science 282 1998 1669 1675
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
20
-
-
0030987309
-
Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase
-
Tong W., Lu C.D., Sharma S.K., Matsuura S., So A.G., and Scott W.A. Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase Biochemistry 36 1997 5749 5757
-
(1997)
Biochemistry
, vol.36
, pp. 5749-5757
-
-
Tong, W.1
Lu, C.D.2
Sharma, S.K.3
Matsuura, S.4
So, A.G.5
Scott, W.A.6
-
21
-
-
0033133780
-
Touching the heart of HIV-1 drug resistance: The fingers close down on the dNTP at the polymerase active site
-
Sarafianos S.G., Das K., Ding J., Boyer P.L., Hughes S.H., and Arnold E. Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site Chem. Biol. 6 1999 R137 146
-
(1999)
Chem. Biol.
, vol.6
, pp. 137-146
-
-
Sarafianos, S.G.1
Das, K.2
Ding, J.3
Boyer, P.L.4
Hughes, S.H.5
Arnold, E.6
-
22
-
-
33744547623
-
Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function
-
Mandal D., Dash C., Le Grice S.F., and Prasad V.R. Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function Nucleic Acids Res. 34 2006 2853 2863
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 2853-2863
-
-
Mandal, D.1
Dash, C.2
Le Grice, S.F.3
Prasad, V.R.4
-
23
-
-
0037150445
-
Substitutions of Phe61 located in the vicinity of template 5′-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase
-
Fisher T.S., and Prasad V.R. Substitutions of Phe61 located in the vicinity of template 5′-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase J. Biol. Chem. 277 2002 22345 22352
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22345-22352
-
-
Fisher, T.S.1
Prasad, V.R.2
-
24
-
-
0037229160
-
Substitutions at Phe61 in the β3-β4 hairpin of HIV-1 reverse transcriptase reveal a role for the fingers subdomain in strand displacement DNA synthesis
-
Fisher T.S., Darden T., and Prasad V.R. Substitutions at Phe61 in the β3-β4 hairpin of HIV-1 reverse transcriptase reveal a role for the fingers subdomain in strand displacement DNA synthesis J. Mol. Biol. 325 2003 443 459
-
(2003)
J. Mol. Biol.
, vol.325
, pp. 443-459
-
-
Fisher, T.S.1
Darden, T.2
Prasad, V.R.3
-
25
-
-
33751401607
-
Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the β3-β4 hairpin loop in dNTP selection
-
Garforth S.J., Kim T.W., Parniak M.A., Kool E.T., and Prasad V.R. Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the β3-β4 hairpin loop in dNTP selection J. Mol. Biol. 365 2007 38 49
-
(2007)
J. Mol. Biol.
, vol.365
, pp. 38-49
-
-
Garforth, S.J.1
Kim, T.W.2
Parniak, M.A.3
Kool, E.T.4
Prasad, V.R.5
-
26
-
-
77951294291
-
Impact of template overhang-binding region of HIV-1 RT on the binding and orientation of the duplex region of the template-primer
-
Upadhyay A.K., Talele T.T., and Pandey V.N. Impact of template overhang-binding region of HIV-1 RT on the binding and orientation of the duplex region of the template-primer Mol. Cell. Biochem. 338 2010 19 33
-
(2010)
Mol. Cell. Biochem.
, vol.338
, pp. 19-33
-
-
Upadhyay, A.K.1
Talele, T.T.2
Pandey, V.N.3
-
27
-
-
2642518791
-
Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: Effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNA primers
-
Matamoros T., Franco S., Vazquez-Alvarez B.M., Mas A., Martinez M.A., and Menendez-Arias L. Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNA primers J. Biol. Chem. 279 2004 24569 24577
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 24569-24577
-
-
Matamoros, T.1
Franco, S.2
Vazquez-Alvarez, B.M.3
Mas, A.4
Martinez, M.A.5
Menendez-Arias, L.6
-
28
-
-
0034329473
-
Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance
-
Mas A., Parera M., Briones C., Soriano V., Martinez M.A., Domingo E., and Menendez-Arias L. Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance EMBO J. 19 2000 5752 5761
-
(2000)
EMBO J.
, vol.19
, pp. 5752-5761
-
-
Mas, A.1
Parera, M.2
Briones, C.3
Soriano, V.4
Martinez, M.A.5
Domingo, E.6
Menendez-Arias, L.7
-
29
-
-
33751552155
-
Mutational patterns associated with the 69 insertion complex in multi-drug-resistant HIV-1 reverse transcriptase that confer increased excision activity and high-level resistance to zidovudine
-
Cases-Gonzalez C.E., Franco S., Martinez M.A., and Menendez-Arias L. Mutational patterns associated with the 69 insertion complex in multi-drug-resistant HIV-1 reverse transcriptase that confer increased excision activity and high-level resistance to zidovudine J. Mol. Biol. 365 2007 298 309
-
(2007)
J. Mol. Biol.
, vol.365
, pp. 298-309
-
-
Cases-Gonzalez, C.E.1
Franco, S.2
Martinez, M.A.3
Menendez-Arias, L.4
-
30
-
-
0028940084
-
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
-
Shirasaka T., Kavlick M.F., Ueno T., Gao W.Y., Kojima E., and Alcaide M.L. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides Proc. Natl Acad. Sci. USA 92 1995 2398 2402
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 2398-2402
-
-
Shirasaka, T.1
Kavlick, M.F.2
Ueno, T.3
Gao, W.Y.4
Kojima, E.5
Alcaide, M.L.6
-
31
-
-
0031948662
-
Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance
-
Maeda Y., Venzon D.J., and Mitsuya H. Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance J. Infect. Dis. 177 1998 1207 1213
-
(1998)
J. Infect. Dis.
, vol.177
, pp. 1207-1213
-
-
Maeda, Y.1
Venzon, D.J.2
Mitsuya, H.3
-
32
-
-
0036406111
-
Multidrug-resistant HIV-1 reverse transcriptase: Involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors
-
Mas A., Vazquez-Alvarez B.M., Domingo E., and Menendez-Arias L. Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors J. Mol. Biol. 323 2002 181 197
-
(2002)
J. Mol. Biol.
, vol.323
, pp. 181-197
-
-
Mas, A.1
Vazquez-Alvarez, B.M.2
Domingo, E.3
Menendez-Arias, L.4
-
33
-
-
0036720770
-
Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision
-
Boyer P.L., Sarafianos S.G., Arnold E., and Hughes S.H. Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision J. Virol. 76 2002 9143 9151
-
(2002)
J. Virol.
, vol.76
, pp. 9143-9151
-
-
Boyer, P.L.1
Sarafianos, S.G.2
Arnold, E.3
Hughes, S.H.4
-
34
-
-
13544271167
-
Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using α- boranophosphate nucleoside analogs
-
Deval J., Alvarez K., Selmi B., Bermond M., Boretto J., and Guerreiro C. Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using α- boranophosphate nucleoside analogs J. Biol. Chem. 280 2005 3838 3846
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3838-3846
-
-
Deval, J.1
Alvarez, K.2
Selmi, B.3
Bermond, M.4
Boretto, J.5
Guerreiro, C.6
-
35
-
-
0036829992
-
The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using α-boranophosphate nucleotide analogues
-
Deval J., Selmi B., Boretto J., Egloff M.P., Guerreiro C., Sarfati S., and Canard B. The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using α-boranophosphate nucleotide analogues J. Biol. Chem. 277 2002 42097 42104
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42097-42104
-
-
Deval, J.1
Selmi, B.2
Boretto, J.3
Egloff, M.P.4
Guerreiro, C.5
Sarfati, S.6
Canard, B.7
-
36
-
-
0344875232
-
A positively charged side chain at position 154 on the β8-αE loop of HIV-1 RT is required for stable ternary complex formation
-
Sharma B., Kaushik N., Upadhyay A., Tripathi S., Singh K., and Pandey V.N. A positively charged side chain at position 154 on the β8-αE loop of HIV-1 RT is required for stable ternary complex formation Nucleic Acids Res. 31 2003 5167 5174
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 5167-5174
-
-
Sharma, B.1
Kaushik, N.2
Upadhyay, A.3
Tripathi, S.4
Singh, K.5
Pandey, V.N.6
-
37
-
-
2342453265
-
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
-
Tuske S., Sarafianos S.G., Clark A.D. Jr, Ding J., Naeger L.K., and White K.L. Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir Nat. Struct. Mol. Biol. 11 2004 469 474
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 469-474
-
-
Tuske, S.1
Sarafianos, S.G.2
Clark Jr., A.D.3
Ding, J.4
Naeger, L.K.5
White, K.L.6
-
38
-
-
33746883932
-
Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase
-
Zhang Z., Walker M., Xu W., Shim J.H., Girardet J.L., Hamatake R.K., and Hong Z. Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase Antimicrob. Agents Chemother. 50 2006 2772 2781
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 2772-2781
-
-
Zhang, Z.1
Walker, M.2
Xu, W.3
Shim, J.H.4
Girardet, J.L.5
Hamatake, R.K.6
Hong, Z.7
-
39
-
-
56449114709
-
Slide into action: Dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates
-
Liu S., Abbondanzieri E.A., Rausch J.W., Le Grice S.F., and Zhuang X. Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates Science 322 2008 1092 1097
-
(2008)
Science
, vol.322
, pp. 1092-1097
-
-
Liu, S.1
Abbondanzieri, E.A.2
Rausch, J.W.3
Le Grice, S.F.4
Zhuang, X.5
-
40
-
-
77949567911
-
Reverse transcriptase in motion: Conformational dynamics of enzyme-substrate interactions
-
Gotte M., Rausch J.W., Marchand B., Sarafianos S., and Le Grice S.F. Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions Biochim. Biophys. Acta 1804 2010 1202 1212
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1202-1212
-
-
Gotte, M.1
Rausch, J.W.2
Marchand, B.3
Sarafianos, S.4
Le Grice, S.F.5
-
41
-
-
8544267978
-
Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase
-
Meyer P.R., Smith A.J., Matsuura S.E., and Scott W.A. Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase J. Biol. Chem. 279 2004 45389 45398
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45389-45398
-
-
Meyer, P.R.1
Smith, A.J.2
Matsuura, S.E.3
Scott, W.A.4
-
42
-
-
0025191211
-
Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography
-
Le Grice S.F., and Gruninger-Leitch F. Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography Eur. J. Biochem. 187 1990 307 314
-
(1990)
Eur. J. Biochem.
, vol.187
, pp. 307-314
-
-
Le Grice, S.F.1
Gruninger-Leitch, F.2
-
43
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
-
Spence R.A., Kati W.M., Anderson K.S., and Johnson K.A. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors Science 267 1995 988 993
-
(1995)
Science
, vol.267
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anderson, K.S.3
Johnson, K.A.4
-
44
-
-
23844479950
-
The 3′-azido group is not the primary determinant of 3′-azido-3′-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1
-
Sluis-Cremer N., Arion D., Parikh U., Koontz D., Schinazi R.F., Mellors J.W., and Parniak M.A. The 3′-azido group is not the primary determinant of 3′-azido-3′-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1 J. Biol. Chem. 280 2005 29047 29052
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29047-29052
-
-
Sluis-Cremer, N.1
Arion, D.2
Parikh, U.3
Koontz, D.4
Schinazi, R.F.5
Mellors, J.W.6
Parniak, M.A.7
|