A high-throughput continuous assay for screening and characterization of inhibitors of HIV reverse-transcriptase DNA polymerase activity

Journal of Biomolecular Screening

Volumn 16, Issue 5, 2011, Pages 518-524

  Cauchon, Elizabeth ^a   Falgueyret, Jean Pierre ^a   Auger, Anick ^a   Melnyk, Roman A ^a,b  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

continuous; FRET; HIV reverse transcriptase; homogeneous

Indexed keywords

EFAVIRENZ; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; DNA TEMPLATE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; NONHUMAN; PRIORITY JOURNAL;

DNA-DIRECTED DNA POLYMERASE; DRUG DISCOVERY; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH-THROUGHPUT SCREENING ASSAYS; HIV REVERSE TRANSCRIPTASE; KINETICS; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 79959406264     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111402201     Document Type: Article

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