Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 25246-25255

  Zahn, Karl E ^a   Tchesnokov, Egor P ^b   Götte, Matthias ^b   Doublié, Sylvie ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTI-VIRAL DRUGS; CLOSED FORM; DNA COMPLEX; DNA POLYMERASE; HUMAN CYTOMEGALOVIRUS; LEAVING GROUPS; SEVERAL VARIABLES; STRUCTURAL REQUIREMENTS; TRANSFER REACTION; TRIPHOSPHATE; VIRAL REPLICATION;

COMPLEXATION; DNA; METAL IONS; NUCLEOTIDES; PHOSPHORYLATION; VIRUSES;

POLYMERS;

ACYCLO GMP; DNA POLYMERASE; FOSCARNET; GUANINE DERIVATIVE; MAGNESIUM ION; PYROPHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHELATION; CHIMERA; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA PROTEIN COMPLEX; DRUG STRUCTURE; ENZYME ACTIVE SITE; HUMAN CYTOMEGALOVIRUS; IC 50; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS INHIBITION; VIRUS REPLICATION;

ACYCLOVIR; AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; CYTOMEGALOVIRUS; DNA-DIRECTED DNA POLYMERASE; FOSCARNET; HUMANS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS;

HERPES; HUMAN HERPESVIRUS 5;

EID: 79960134404     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.248864     Document Type: Article

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