Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition

Journal of Biological Chemistry

Volumn 286, Issue 34, 2011, Pages 29575-29583

  Auger, Anick ^a   Beilhartz, Greg L ^b   Zhu, Siqi ^a   Cauchon, Elizabeth ^a   Falgueyret, Jean Pierre ^a   Grobler, Jay A ^c   Ehteshami, Maryam ^b   Götte, Matthias G ^b   Melnyk, Roman A ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES; CONFORMATIONAL DYNAMICS; DNA POLYMERIZATION; DNA SUBSTRATES; FOOTPRINTING; HIV-1 REVERSE TRANSCRIPTASE; NEGATIVE IMPACTS; RNA PRIMERS; SITE-SPECIFIC;

BINDING ENERGY; DNA; IMPACT RESISTANCE; POLYMERIZATION; RNA; SUBSTRATES;

POLYMERS;

DEOXYRIBONUCLEOTIDE; FOSCARNET; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SCAFFOLD OF INDOLOPYRIDONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; DNA FOOTPRINTING; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SUBSTRATE; NUCLEOTIDE METABOLISM; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ALLOSTERIC SITE; CATALYSIS; DNA PRIMERS; DNA, VIRAL; HIV REVERSE TRANSCRIPTASE; HIV-1; INDOLES; NITRILES; PYRIDONES; REVERSE TRANSCRIPTION; RNA, VIRAL;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80051920501     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.268235     Document Type: Article

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